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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

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Consume Type :

Oral

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About Mevotrex 10 Tablet

Mevotrex 10 Tablet belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis, severe psoriasis, and severe psoriatic arthritis. Mevotrex 10 Tablet is used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system).

Mevotrex 10 Tablet contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Mevotrex 10 Tablet prevents and stops the growth of cancer cells, thereby helps treat cancer. Mevotrex 10 Tablet treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

In some cases, Mevotrex 10 Tablet may cause common side-effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, leukopenia (decreased number of white blood cells), and soreness of mouth and lips. You are advised to talk to your doctor if you experience these side effects persistently.

Take Mevotrex 10 Tablet exactly as prescribed by the doctor; daily intake of Mevotrex 10 Tablet could lead to serious toxic effects. Do not take Mevotrex 10 Tablet if you are pregnant or breastfeeding. Mevotrex 10 Tablet may cause dizziness and fatigue, so drive only if you are alert. Avoid consuming alcohol whilst on treatment with Mevotrex 10 Tablet . Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Inform your doctor about your medications and health condition to rule out any unpleasant side effects/interactions.

Uses of Mevotrex 10 Tablet

Rheumatoid arthritis, Psoriatic arthritis, Psoriasis, Cancer

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Directions for Use

Mevotrex 10 Tablet should be taken exactly as prescribed by the doctor. Tablet/capsule: Take it one hour after food in the evening or as advised by the doctor. Swallow the tablet/capsule as a whole with a glass of water whilst standing or sitting upright; do not break or chew it. Oral solution: Take the prescribed quantity by mouth using the dosing syringe.

Key Benefits

Mevotrex 10 Tablet belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis (arthritis in children), severe psoriasis, and severe psoriatic arthritis. Mevotrex 10 Tablet helps treat rheumatoid arthritis and psoriatic arthritis by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Mevotrex 10 Tablet treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis. Mevotrex 10 Tablet is used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system). Mevotrex 10 Tablet prevents and stops the growth of cancer cells by interfering with DNA production. Mevotrex 10 Tablet may also be used to treat inflammatory bowel disease.

Storage

Store in a cool and dry place away from sunlight
Side effects of Mevotrex 10 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Drug Warnings

Do not take Mevotrex 10 Tablet if you are allergic to any of its contents; if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, chronic liver disease; if you are pregnant or breastfeeding. Talk to your doctor before taking Mevotrex 10 Tablet if you have/had liver or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if you are due to have any vaccinations, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs. Mevotrex 10 Tablet may cause dizziness and fatigue, so drive only if you are alert. Take Mevotrex 10 Tablet exactly as directed by the doctor as it may cause serious problems if not taken in the dose and duration prescribed by the doctor. Stop taking Mevotrex 10 Tablet and consult your doctor immediately if you have mouth sores, diarrhoea, a fever, dehydration, cough, bleeding, shortness of breath, any signs of infection, or a skin rash.

Drug-Drug Interactions

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MethotrexateEtretinate
Critical

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Mevotrex 10 Tablet:
Co-administration of Etretinate with Mevotrex 10 Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Mevotrex 10 Tablet is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mevotrex 10 Tablet:
Combine use of entecavir with Mevotrex 10 Tablet may increase the effectiveness of everolimus.

How to manage the interaction:
Although there is a possible interaction between everolimus and Mevotrex 10 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
How does the drug interact with Mevotrex 10 Tablet:
Coadministration of Mevotrex 10 Tablet with Naproxen can increase the levels and side effects of Mevotrex 10 Tablet.

How to manage the interaction:
Taking Mevotrex 10 Tablet with Naproxen together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Mevotrex 10 Tablet:
Coadministration of Mefenamic acid with Mevotrex 10 Tablet may increase the blood levels and side effects of Mevotrex 10 Tablet.

How to manage the interaction:
Although there is a possible interaction between mefenamic acid and Mevotrex 10 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, breathing difficulty, a dry cough, dizziness or fainting, unusual bruising or bleeding, seizures(fits), mouth sores or ulcers, infection, as well as flu-like symptoms(fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
How does the drug interact with Mevotrex 10 Tablet:
Coadministration of Mevotrex 10 Tablet with tofacitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between tofacitinib and Mevotrex 10 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin and pain or burning during urination, consult a doctor. Do not stop using any medications without consulting to a doctor.
How does the drug interact with Mevotrex 10 Tablet:
Using thalidomide together with Mevotrex 10 Tablet can increase the risk of developing blood clots.

How to manage the interaction:
Although there is a possible interaction between thalidoamide and Mevotrex 10 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as chest pain, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness or swelling in an arm or leg, consult your doctor. Do not stop using any medications without consulting to a doctor.
How does the drug interact with Mevotrex 10 Tablet:
Co-administration of Sirolimus with Mevotrex 10 Tablet can increase the risk or severity of kidney damage.

How to manage the interaction:
Although there is a possible interaction between sirolimus and Mevotrex 10 Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Mevotrex 10 Tablet:
Coadministration of Mevotrex 10 Tablet with ibuprofen can increase the effect and side effects of Mevotrex 10 Tablet.

How to manage the interaction:
Although there is a possible interaction between Mevotrex 10 Tablet and ibuprofen, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
How does the drug interact with Mevotrex 10 Tablet:
Co-administration of Mevotrex 10 Tablet with Ampicillin can increase the levels and side effects of Mevotrex 10 Tablet.

How to manage the interaction:
Although there is a possible interaction between Mevotrex 10 Tablet and ampicillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as tiredness, dizziness, fainting, unusual bleeding or bruising, chills, fever, sore throat, body pains. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
How does the drug interact with Mevotrex 10 Tablet:
Co-administration of Baricitinib and Mevotrex 10 Tablet can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Baricitinib and Mevotrex 10 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination. Consult a doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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METHOTREXATE-10MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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METHOTREXATE-10MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Caffeine may reduce the effectiveness of Mevotrex 10 Tablet. Avoid taking caffeine while taking Mevotrex 10 Tablet. This can increase the risk or severity of side effects.

Diet & Lifestyle Advise

Arthritis:

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Psoriasis:

  • Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
  • Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
  • Avoid processed foods, refined sugars, and fatty foods.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
  • Reducing stress and maintaining a good sleep cycle would be helpful.
  • Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS, ANTIMETABOLITES]

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Alcohol

Safe if prescribed

You are recommended to avoid alcohol consumption while taking Mevotrex 10 Tablet .

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Pregnancy

Consult your doctor

Mevotrex 10 Tablet may cause serious birth defects. It is not recommended to take Mevotrex 10 Tablet while you are pregnant.

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Breast Feeding

Consult your doctor

Mevotrex 10 Tablet passes into breast milk. Avoid breastfeeding whilst on treatment with Mevotrex 10 Tablet .

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Driving

Safe if prescribed

Mevotrex 10 Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you experience these symptoms.

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Liver

Consult your doctor

Do not take Mevotrex 10 Tablet if you have chronic liver disease. Please consult your doctor if you have liver impairment before taking Mevotrex 10 Tablet .

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment before taking Mevotrex 10 Tablet .

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Children

Safe if prescribed

Mevotrex 10 Tablet should be used with caution in children and only if prescribed by the doctor.

FAQs

Mevotrex 10 Tablet acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby providing relief from rheumatoid arthritis.

Mevotrex 10 Tablet works by suppressing the overactive immune system that is responsible for causing psoriasis. Mevotrex 10 Tablet interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis and psoriatic arthritis.

Diarrhoea might be a side-effect of Mevotrex 10 Tablet . Stop taking Mevotrex 10 Tablet and consult your doctor if you have diarrhoea. Do not take anti-diarrheal medicine on your own.

Mevotrex 10 Tablet can affect egg and sperm production and could lead to birth defects. Women of child-bearing potential and men using Mevotrex 10 Tablet must use effective contraception while on treatment with Mevotrex 10 Tablet and for at least six months after stopping the treatment. Mevotrex 10 Tablet can lead to infertility. Therefore male patients are advised to talk with their doctor regarding the possibility of sperm preservation before starting the treatment with Mevotrex 10 Tablet .

Mevotrex 10 Tablet causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Mevotrex 10 Tablet may cause mouth sores. Stop taking Mevotrex 10 Tablet and consult your doctor if you have sores in the mouth. Your doctor may recommend folate supplements to treat mouth sores.

Country of origin

INDIA

Manufacturer/Marketer address

Vasu's Pharma House, #3-6-516/4, 5th Floor, St, No.6, Himayath Nagar, Hyderabad - 500 029
Other Info - MEV0012

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