MONOTRATE 40MG TABLET

MONOTRATE 40MG TABLET belongs to the class of organic nitrates with blood vessel dilating activity. It is used for a heart condition called angina pectoris in which blood vessels of the heart get narrowed in an unexpected and sudden manner leading to decreased blood flow to the muscles of the heart leading to its suffocation & thus leading to a tight pain in the chest, neck or arm area.

MONOTRATE 40MG TABLET a mononitrate form of isosorbide is a powerful vasodilator (widens blood vessels). It works by the formation of the free radical nitric oxide (NO) inside our body which leads to the relaxation of muscles of blood vessels, especially of the heart leading to proper blood flow towards the heart muscle which has been working under immense pressure due to decreased blood flow to it.

MONOTRATE 40MG TABLET should be taken as prescribed by your doctor, with or without a meal at fixed intervals every day for best results. The dose of MONOTRATE 40MG TABLET can vary depending upon your condition and the severity of the condition. Also, it is recommended to complete the course of medicine even if you feel better. The common side effects of MONOTRATE 40MG TABLET include nausea, dizziness & headache. Everyone need not experience the above side effects. In case of any discomfort, speak with a doctor.

Before starting MONOTRATE 40MG TABLET, please inform your doctor if you have any allergy (against any nitrate), have suffered a heart attack/stroke, or have an eye disease called glaucoma. Do not take MONOTRATE 40MG TABLET on your own as, self-medication. If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

MONOTRATE 40MG TABLET belongs to a class of medicines called nitrate vasodilators. These operate by relaxing the blood vessels of the heart, reducing the stress on the heart and making it easier to pump blood. MONOTRATE 40MG TABLET is used to prevent attacks of angina pectoris. Angina usually feels like tight chest pain, neck or arm area. The pain originates from the heart muscle and is a sign that part of it is not getting enough oxygen for the amount of work it is doing.

• Fainting
• Low blood pressure
• Headache
• Dizziness
• Nausea
• Swelling of eyelids, face or lips
• Rash or itching especially those covering your whole body
• Exfoliative dermatitis (serious illness with blistering of the skin, mouth, eyes and genitals)

Communicate to your doctor or pharmacist before taking MONOTRATE 40MG TABLET if a patient has low performing thyroid gland, is undernourished because of a poor diet, has severe liver/kidney problems, suffers from hypothermia (very low body temperature), suffers from very poor blood circulation, has had any lethal damage to heart such as a heart attack or suffers from a disease called glaucoma (increased pressure in the eye).

Drug-Drug Interaction: Care should be exercised when MONOTRATE 40MG TABLET is administered in combination with Sildenafil, tadalafil, and vardenafil used to treat male erection dysfunction,  Isosorbide dinitrate which is used for angina,  Blood pressure-lowering drugs like ACE inhibitors, beta-blockers (atenolol, propranolol), calcium channel blockers (nifedipine, diltiazem), angiotensin-II receptor agonists (olmesartan medoxomil, candesartan cilexetil), clonidine, diazoxide, diuretics, methyldopa, moxonidine,  Dihydorergotamine used for migraine & Tricyclic antidepressants (used to treat depression).

Drug-Food Interaction:  Avoid taking MONOTRATE 40MG TABLET alongside alcohol.

Drug-Disease Interaction: People affected with liver disease low red blood cell count (Anaemia), Kidney failure (dialysis), low blood pressure (hypotension), and Increased pressure inside the eye called glaucoma should not take MONOTRATE 40MG TABLET.

• SILDENAFIL
• ISOSORBIDE DINITRATE
• CAPTOPRIL
• CLONIDINE
• MOXONIDINE
• DIHYDROERGOTAMINE
• AMITRIPTYLINE

• Adopting a heart-healthy lifestyle will help you keep your cholesterol and blood pressure down, keep your arteries clear and avoid angina.
• Eat plenty of fruits, vegetables, whole grains and low-fat sources of protein such as nuts and fish.
• Regularly workout.
• Maintain a healthy weight and keep your diabetes in check.
• Stop smoking.

• Avoid vigorous physical activity that may aggravate anginal attack.
• Avoid smoking.
• A patient should avoid places where airflow is restricted.

Angina or chest pain: It is the most common indication of heart disease caused due to decreased blood flow to heart muscles. The heart is dependent on oxygen for its functioning and pumping of blood yet sometimes due to various genetic and environmental reasons the blood vessels supplying blood to the heart narrow unexpectedly causing decreased blood flow to the heart. This abrupt decrease in blood flow leads to increased stress on the heart to pump blood towards different organs causing an event of acute chest pain that starts from the arm along the jaw and finally involves the chest. Angina pectoris is of 3 types:

1) Stable Angina: is the most common type in which blood flow to the heart is low as compared to what it needs to function, caused by increased physical activity.

2) Unstable angina: is the most lethal type in which blood supply to the heart decreases abruptly due to blockage of the artery by a clot etc.

3) Variant angina: occurs at rest due to spasmic narrowing of the artery.