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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
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Composition :

CARBOPLATIN-450MG

Manufacturer/Marketer :

Biological E Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Neocarb 450 Injection

Neocarb 450 Injection belongs to a group of anti-cancer medicines used for the treatment of ovarian cancer and small-cell lung cancer. It may sometimes be used to treat other cancers. Cancer forms in tissues of the ovary (one of a pair of female reproductive glands in which the ova, or eggs, are formed). Small-cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung.

Neocarb 450 Injection contains 'Carboplatin'. Carboplatin acts by penetrating the cell wall and binding to the cell's DNA, stopping the cell from naturally dividing and functioning, ultimately destroying the cell. These medicines target cancer cells because they often affect rapidly dividing cells.

Neocarb 450 Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection. You may experience nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), peripheral neuropathy (nerves malfunction), nephrotoxicity at high doses and electrolyte disturbances. Most of these side effects of Neocarb 450 Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Neocarb 450 Injection for as long as your doctor has prescribed. Do not stop the Neocarb 450 Injection midway. Talk to your doctor before taking Neocarb 450 Injection if you have severe allergic reactions to Neocarb 450 Injection or other platinum-containing compounds or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Neocarb 450 Injection should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Neocarb 450 Injection if you are pregnant or breastfeeding because this Neocarb 450 Injection can cause harmful effects on the unborn baby. Both women and men using this Neocarb 450 Injection should use birth control to avoid pregnancy.

Uses of Neocarb 450 Injection

Ovarian cancer and Small cell lung cancer

Directions for Use

Parenteral: Neocarb 450 Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

Neocarb 450 Injection contains 'Carboplatin' which belongs to a group of anti-cancer medicines used to treat ovarian cancer and small cell lung cancer. It works by damaging the genetic material (DNA) of the cancer cells, which stops their growth and multiplication. It can be used alone or with other chemotherapy drugs depending on your cancer type.

Storage

Store in a cool and dry place away from sunlight
Side effects of Neocarb 450 Injection
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Avoid loud noises using ear protection aids like earplugs.
  • Take breaks from noisy environments.
  • Consult the doctor if you experience hearing problems; the doctor will monitor your condition and recommend suitable treatment measures.
  • Drink more fluids as dehydration can decrease blood flow to kidneys and increase BUN levels.
  • Eat less protein and stop protein supplements as high protein diet may increase BUN levels.
  • Severe cases may require kidney transplant or dialysis.

Drug Warnings

Neocarb 450 Injection should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Neocarb 450 Injection. To treat your condition effectually, continue taking Neocarb 450 Injection for as long as your doctor has prescribed. Do not stop the Neocarb 450 Injection midway. Talk to your doctor before taking Neocarb 450 Injection if you have severe allergic reactions to Neocarb 450 Injection or other platinum-containing compounds or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Neocarb 450 Injection should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking Neocarb 450 Injection if you are pregnant or breastfeeding because this Neocarb 450 Injection can cause harmful effects on the unborn baby. Both women and men using this Neocarb 450 Injection should use birth control to avoid pregnancy. Peripheral blood counts should be frequently monitored during Neocarb 450 Injection treatment and appropriate until recovery is achieved.

Drug-Drug Interactions

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CarboplatinGolimumab
Severe

Drug-Drug Interactions

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How does the drug interact with Neocarb 450 Injection:
Co-administration of Sorafenib with Neocarb 450 Injection can increase the risk or severity of serious side effects.

How to manage the interaction:
Taking Sorafenib with Neocarb 450 Injection together is not recommended as it can cause an interaction, consult a doctor before taking it. However if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without consulting a doctor.
CarboplatinGolimumab
Severe
How does the drug interact with Neocarb 450 Injection:
Using Neocarb 450 Injection with Golimumab can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Neocarb 450 Injection and Golimumab, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Neocarb 450 Injection:
Using Neocarb 450 Injection with Fingolimod can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Neocarb 450 Injection and Fingolimod, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Neocarb 450 Injection:
Coadministration of baricitinib and Neocarb 450 Injection can raise your risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Neocarb 450 Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Neocarb 450 Injection:
Co-administration of Neocarb 450 Injection with tofacitinib can increase the risk of serous infections.

How to manage the interaction:
Although there is an interaction, Neocarb 450 Injection can be taken with tofacitinib if prescribed by the doctor. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, breathing difficulty, blood in phlegm(mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Neocarb 450 Injection:
When Neocarb 450 Injection is used with topotecan, it may increase the risk of side effects.

How to manage the interaction:
Co-administration of Neocarb 450 Injection with clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Neocarb 450 Injection:
Taking Neocarb 450 Injection with etanercept may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Neocarb 450 Injection and etanercept can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm (mucous secretion), red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarboplatinCertolizumab
Severe
How does the drug interact with Neocarb 450 Injection:
Using Neocarb 450 Injection with Certolizumab can increase the risk of developing serious infections.

How to manage the interaction:
Taking Neocarb 450 Injection with Certolizumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarboplatinPalifermin
Severe
How does the drug interact with Neocarb 450 Injection:
When Palifermin is used with Neocarb 450 Injection, may increase the risk or severity of mouth ulcers.

How to manage the interaction:
Co-administration of Neocarb 450 Injection with Palifermin can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have painful mouth ulcers, contact the doctor right away. It is advised to take Palifermin at least after 24 hours of stopping Neocarb 450 Injection. Do not stop using any medications without a doctor's advice.
How does the drug interact with Neocarb 450 Injection:
Taking cidofovir with Neocarb 450 Injection can increase the risk of kidney problems.

How to manage the interaction:
Although taking Neocarb 450 Injection and cidofovir together can possibly cause an interaction, it can be taken if your doctor has suggested it. However, if you experience loss of hunger, increased or decreased urination, swelling, shortness of breath, bone pain, muscle cramps, irregular heart rhythm, consult a doctor immediately. It is advised to wait at least for 7 days after stopping Neocarb 450 Injection, before taking Cidofovir. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Get optimal sleep; rest well.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Drug-Diseases Interactions

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CARBOPLATIN-450MGOther and unspecified infectious diseases
Moderate
CARBOPLATIN-450MGOther disorders of kidney and ureter, not elsewhere classified
Moderate

Drug-Diseases Interactions

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CARBOPLATIN-450MGOther and unspecified infectious diseases
Moderate
How does the disease interact with Neocarb 450 Injection:
Antineoplastic drugs regularly can, to variable degrees, promote myelosuppression due to their cytotoxic effects on rapidly growing tissues.

How to manage the interaction:
If you experience any signs or symptoms suggesting infection such as fever, sore throat, or local infection during antineoplastic therapy, immediately consult your doctor. Close clinical monitoring of hematopoietic function is recommended.
CARBOPLATIN-450MGOther disorders of kidney and ureter, not elsewhere classified
Moderate
How does the disease interact with Neocarb 450 Injection:
The kidney is the main organ used to remove Neocarb 450 Injection. Patients with a creatinine clearance of less than 60 mL/min had lower total body and renal clearance of Neocarb 450 Injection.

How to manage the interaction:
If you have any kidney related problems, do not forget to mention it to your doctor, a close monitoring is required.
CARBOPLATIN-450MGHaemorrhage, not elsewhere classified
Mild
How does the disease interact with Neocarb 450 Injection:
Patients who have substantial bleeding should not use Neocarb 450 Injection. Both severe myelosuppression and dose-dependent thrombocytopenia are brought on by Neocarb 450 Injection.

How to manage the interaction:
The use of Neocarb 450 Injection is not advisable if you have significant bleeding. If you experience any signs or symptoms suggesting bleeding such as petechiae, purpura, epistaxis, hemoptysis, hematuria, and melena, consult your doctor. Close clinical monitoring of hematopoietic function is recommended.

FAQs

Neocarb 450 Injection contains 'Carboplatin'. Carboplatin works by breaching the cellular wall and binding to the cell’s DNA, preventing the cell from dividing and functioning normally, which eventually kills the cell.

Yes, Neocarb 450 Injection can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.

Neocarb 450 Injection should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.

Before you receive treatment with Neocarb 450 Injection, tell your doctor about all of your medical conditions. You should not receive Neocarb 450 Injection if you are allergic to carboplatin or any contents in Neocarb 450 Injection. It should not be employed in patients with severe bone marrow depression or significant bleeding.

If not given an inappropriate dose, Neocarb 450 Injection can cause toxic effects, although not everyone gets it. So, Neocarb 450 Injection is prescribed by a doctor experienced in the use of medications to treat cancer only.

Avoid taking Neocarb 450 Injection if you are pregnant because Neocarb 450 Injection can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Neocarb 450 Injection.

Drug-Drug Interactions Checker List

  • PEMETREXED
  • GEMCITABINE
  • PEGFILGRASTIM
  • PACLITAXEL
  • PANTOPRAZOLE
  • AMIKACIN
  • GENTAMICIN
  • KANAMYCIN
  • STREPTOMYCIN
  • TOBRAMYCIN
  • DOCETAXEL

Special Advise

  • Peripheral blood counts should be frequently monitored during carboplatin treatment and, when appropriate, until recovery is achieved.
  • Neocarb 450 Injection should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Neocarb 450 Injection.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, and blood cell count in your blood.
  • Avoid unnecessary or prolonged exposure to sunlight and UV light (such as tanning booths) and wear protective clothing, sunglasses, and sunscreen. Neocarb 450 Injection may make your skin sensitive to sunlight.

Disease/Condition Glossary

Ovarian cancer: Cancer that forms in tissues of the ovary (one of a pair of female reproductive glands in which the ova, or eggs, are formed).

Small-cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung.

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