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Written By Divya L , PharmaD
Reviewed By Sureshvarma D , MPharma
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Consume Type :

OPHTHALMIC

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Not Returnable

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About Neosporin-H Ointment 5 gm

Neosporin-H Ointment 5 gm belongs to the class of 'antibiotics' and is primarily used to treat bacterial infections of the external eye and uveitis (inflammation of the middle layer of the eye (uvea)). Bacterial infection occurs when harmful bacteria grow in the body and causes illness. Neosporin-H Ointment 5 gm will not work for infections caused by fungi and viruses.

Neosporin-H Ointment 5 gm is composed of four medicines: Bacitracin, Hydrocortisone, Neomycin, and Polymyxin B. Bacitracin is a bacteriostatic medicine (stops the growth or reproduction of bacteria). It works by inhibiting bacterial cell wall synthesis. Hydrocortisone belongs to the class of corticosteroids. It blocks the production of prostaglandins (chemical messengers) that make the affected area red, swollen and itchy. On the other hand, Neomycin is an aminoglycoside antibiotic and prevents the synthesis of essential proteins required by bacteria to carry out vital functions. Polymyxin B, an antibiotic, destroys the bacterial membranes by binding to the phospholipids on cell membranes of gram-negative bacteria. This process of binding causes the loss of essential metabolites in bacteria.

Your doctor will advise the appropriate dose that suits your infection. Common side effects of Neosporin-H Ointment 5 gm include itching, redness, dryness, and eye irritation. These side effects may not occur in every patient using this medication and differ individually. If the side effects persist longer or worsen, please seek a doctor's advice.

Let your doctor know if you are sensitive to Neosporin-H Ointment 5 gm or any other medications. Let your doctor know if you have kidney disease, myasthenia gravis (neuromuscular disease), or Parkinson's disease (a brain disorder that affects movement) before using Neosporin-H Ointment 5 gm. Avoid contact of the dispensing container with the eye, eyelids, fingers, and other surfaces to prevent contamination. Pregnant and breastfeeding women should consult their doctor before starting Neosporin-H Ointment 5 gm. 

Uses of Neosporin-H Ointment 5 gm

Bacterial infections. 

Directions for Use

Wash your hands thoroughly before applying the medicine to your eye to avoid contamination. Please do not touch the ointment tube tip or let it touch your eye or any other surface. Tilt your head back, look upward and create a pouch by pulling your lower eyelid down. Squeeze the tube gently and place a 1/2 strip of ointment into the pouch. Close your eye and roll the eyeball to ease the spreading of medication. Do not try to blink, and avoid rubbing the eye. After using, wipe the tip of the tube with a clean tissue and close the cap tightly.

Medicinal Benefits

Neosporin-H Ointment 5 gm treats bacterial eye infections. It comprises four medicines, namely Bacitracin, Hydrocortisone, Neomycin, and Polymyxin B. Bacitracin is a bacteriostatic medicine (stops the growth or reproduction of bacteria) and works by inhibiting the bacterial cell wall synthesis. Bacitracin is active against many gram-positive and some gram-negative bacteria. Hydrocortisone is a corticosteroid and blocks prostaglandins' production (chemical messengers) that make the affected area red, swollen and itchy. Neomycin is an aminoglycoside antibiotic and prevents the synthesis of essential proteins required by bacteria to carry out vital functions. Polymyxin B, an antibiotic, destroys the bacterial membranes by binding to the phospholipids on cell membranes of gram-negative bacteria. This process of binding causes the loss of essential metabolites in bacteria. It is bactericidal against most gram-negative bacteria and has no in-vitro activity against gram-positive bacteria.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Let your doctor know if you are sensitive to Neosporin-H Ointment 5 gm or any other medications.  Let your doctor know if you have any kidney disease, myasthenia gravis (neuromuscular disease), or Parkinson's disease (a brain disorder that affects movement) before using Neosporin-H Ointment 5 gm. Avoid contact of the dispensing container with the eye, eyelids, fingers, and other surfaces to prevent contamination. Let your doctor know if you plan to become pregnant or are already pregnant and a lactating mother. Avoid driving or operating machines since the administration of eye ointment may cause temporary blurred vision for a while after use. Neosporin-H Ointment 5 gm should be used for children only when advised by a doctor.

Drug-Drug Interactions

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Critical

Drug-Drug Interactions

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How does the drug interact with Neosporin-H Ointment 5 gm:
Combining Mifepristone and Neosporin-H Ointment 5 gm can reduce the effects of Neosporin-H Ointment 5 gm.

How to manage the interaction:
Taking Neosporin-H Ointment 5 gm with Mifepristone is not recommended, consult a doctor before taking it. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Critical
How does the drug interact with Neosporin-H Ointment 5 gm:
Taking Iopamidol and Neosporin-H Ointment 5 gm together can increase the risk of seizures, meningitis, and inflammation of the spinal membranes.

How to manage the interaction:
Taking Neosporin-H Ointment 5 gm with Iopamidol is not recommended, please consult your doctor before taking it. If you experience any symptoms , consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Bacitracinvalacyclovir
Severe
How does the drug interact with Neosporin-H Ointment 5 gm:
Co-administration of Neosporin-H Ointment 5 gm with valacyclovir may increase the risk of kidney problems.

How to manage the interaction:
Although taking Neosporin-H Ointment 5 gm and tretinoin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not stop using any medications without consulting a doctor.
BacitracinCarboplatin
Severe
How does the drug interact with Neosporin-H Ointment 5 gm:
Taking carboplatin and Neosporin-H Ointment 5 gm can increase the risk of nephrotoxicity(kidney damage).

How to manage the interaction:
Co-administration of carboplatin and Neosporin-H Ointment 5 gm can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult the doctor. Do not discontinue any medications without a doctor's advice.
Severe
How does the drug interact with Neosporin-H Ointment 5 gm:
Hydroxycarbamide when used in conjunction with Neosporin-H Ointment 5 gm may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between hydroxycarbamide with Neosporin-H Ointment 5 gm, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
BacitracinClindamycin
Severe
How does the drug interact with Neosporin-H Ointment 5 gm:
Co-administration of Clindamycin with Neosporin-H Ointment 5 gm may increase the risk of kidney and/or nerve damage.

How to manage the interaction:
Although there is a possible interaction, clindamycin can be taken with Neosporin-H Ointment 5 gm if prescribed by the doctor. Consult the prescriber if you experience signs and symptoms of kidney damage such as sudden weight gain or weight loss, nausea, vomiting, fluid retention, loss of appetite, increased or decreased urination, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Let your doctor know if you develop seizures; hearing problems; or numbness, burning or tingling in your hands and feet. If you develop diarrhoea or vomiting during treatment with these medications, drink plenty of fluids to prevent dehydration, as dehydration may harm the kidney.
BacitracinDeferasirox
Severe
How does the drug interact with Neosporin-H Ointment 5 gm:
Deferasirox may cause kidney problems and combining it with Neosporin-H Ointment 5 gm may increase that risk.

How to manage the interaction:
Although taking Neosporin-H Ointment 5 gm and Deferasirox together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhoea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
BacitracinSirolimus
Severe
How does the drug interact with Neosporin-H Ointment 5 gm:
Co-administration of Neosporin-H Ointment 5 gm and Sirolimus can increase the risk or severity of Kidney problems.

How to manage the interaction:
Co-administration of Sirolimus with Neosporin-H Ointment 5 gm can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
Severe
How does the drug interact with Neosporin-H Ointment 5 gm:
Coadministration of Neosporin-H Ointment 5 gm with Tenofovir disoproxil can increase the risk of developing kidney damage and reduced function.

How to manage the interaction:
Although there may be a possibility of interaction between Tenofovir disoproxil and Neosporin-H Ointment 5 gm, it can be taken when prescribed by a doctor. If you experience any symptoms, contact the doctor immediately. Do not stop using any medications without talking to your doctor.
Severe
How does the drug interact with Neosporin-H Ointment 5 gm:
Taking Human immunoglobulin with Neosporin-H Ointment 5 gm, may raise the risk of kidney problems.

How to manage the interaction:
Taking Human immunoglobulin with Neosporin-H Ointment 5 gm together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do not rub your eyes even though some ophthalmic drugs make your eye itchy.
  • If you wear contact lenses: Clean and replace contact lenses more often. Never share contact lenses. Always remember to wash your hands before inserting and after removing the contact lens. 
  • Avoid staring at digital screens for longer durations. Rest your eyes every 20 minutes.
  • Avoid or limit the intake of alcohol and caffeine.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Know your allergy triggers, such as pollen, dust and other factors.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Neosporin-H Ointment 5 gm consists Bacitracin, Neomycin, Hydrocortisone, and Polymyxin B. Neosporin-H Ointment 5 gm inhibits bacteria's growth by causing damage to its cell wall and prevents the synthesis of essential proteins required by bacteria to carry out its vital functions. It also relieves itchiness and redness caused by the infection.

Your doctor will decide the dose and duration of Neosporin-H Ointment 5 gm based on the severity of your infection. It is advised to use Neosporin-H Ointment 5 gm only for the prescribed period since long-term usage of Neosporin-H Ointment 5 gm may increase the severity of side effects. Prolonged use of Neosporin-H Ointment 5 gm can cause an overgrowth of other microorganisms like fungi and develop bacterial resistance.

Please do not stop using Neosporin-H Ointment 5 gm on your own, even if the symptoms are relieved. Your symptoms may improve before the infection is completely cured. Continue the usage of Neosporin-H Ointment 5 gm until your course advised by the doctor is finished.

Avoid the contact of dropper or tip with fingers, eyes, and eyelids when you use eye ointment or eye drops of Neosporin-H Ointment 5 gm. Topical eye products, when contaminated by patients with eye diseases, bacterial keratitis (an infection of the cornea) and ocular infections (eye infections), may occur, which result in vision loss.

If you use other eye ointments/drops along with Neosporin-H Ointment 5 gm, it is advised to maintain a gap of at least 5-10 minutes after each administration. Also, use eye drops before applying any ointments.

Special Advise

It is advised to reach out to your doctor if the bacterial infection symptoms persist or worsen after two weeks of treatment. 

Disease/Condition Glossary

Bacterial eye infection: A bacterial eye infection occurs when bacteria invade any part of the eyeball or its surrounding tissues, including the cornea (clear front surface of the eye) and the conjunctiva (thin membrane lining the outer eye and inner eyelids). A bacterial eye infection symptoms include red eyes, pain, swelling of the eyes, watery eyes, itching, and blurry vision. Some very common eye infections are conjunctivitis (the inflammation and irritation of the eye's mucous membrane (conjunctiva), stye (bump on the eyelid), uveitis inflammation of the uvea (middle layer of the eye), marginal keratitis (inflammation of the cornea), and blepharitis (inflammation of the eyelids).

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