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Reviewed By Sunny S , MBBS

About NEXVENLA OD PLUS 50MG TABLET

NEXVENLA OD PLUS 50MG TABLET belongs to a group of medicines called 'antidepressants'. It is used in the treatment of depression. Depression is a common mood disorder which negatively affects a person's daily life, described as feelings of sadness, loss, or anger. Depression symptoms can vary from mild to severe and include sadness, thoughts of death or suicide, loss of interest, weight loss or gain unrelated to dieting, trouble sleeping, loss of energy, feeling worthless or guilty, and difficulty thinking.

NEXVENLA OD PLUS 50MG TABLET is a combination of two drugs: clonazepam and desvenlafaxine. Clonazepam (benzodiazepine) works by increasing levels of a calming chemical, gamma-amino-butyric acid (GABA), in your brain. Desvenlafaxine (selective serotonin and norepinephrine reuptake inhibitors (SNRIs)) works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the brain that helps to maintain mental balance. Together, both of them help to elevate mood and treat depression.

Take NEXVENLA OD PLUS 50MG TABLET with or without food. The tablet form should be swallowed as a whole with a glass of water, do not chew or crush the tablet. In some cases, you may experience common side effects such as nausea, tiredness, constipation, confusion, insomnia (difficulty in sleeping), memory impairment, uncoordinated body movements, low sexual desire, depression, erectile dysfunction, and ejaculation disorder. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking NEXVENLA OD PLUS 50MG TABLET for as long as your doctor has prescribed. Do not take NEXVENLA OD PLUS 50MG TABLET if you are pregnant or breastfeeding unless specified by the doctor. NEXVENLA OD PLUS 50MG TABLET causes drowsiness, and sleepiness, do not drive unless you are alert. NEXVENLA OD PLUS 50MG TABLET should not be given to children and adolescents aged 18 years to treat depression. NEXVENLA OD PLUS 50MG TABLET is habit-forming so take it only if prescribed by a doctor. Avoid consuming alcohol with NEXVENLA OD PLUS 50MG TABLET as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

rxMedicinePrescription drug

Whats That

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Non returnable*
COD available

Online payment accepted

Manufacturer/Marketer

Alkem Laboratories Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of NEXVENLA OD PLUS 50MG TABLET

Depression (Mood Disorder)

Medicinal Benefits

NEXVENLA OD PLUS 50MG TABLET belongs to a group of medicines called 'antidepressants', containing clonazepam and desvenlafaxine. It is used in the treatment of depression. It improves mood, helps relieve anxiety and tension, and helps you sleep better. It also prevents extreme mood changes and increases your energy level, so you do not feel low. Clonazepam increases levels of a calming chemical, gamma-amino-butyric-acid (GABA), in your brain. Desvenlafaxine (selective serotonin and norepinephrine reuptake inhibitors (SNRIs)) works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the brain that helps to maintain mental balance. Together, both of them help to elevate mood and treat depression.

Side Effects of NEXVENLA OD PLUS 50MG TABLET

  • Headache
  • Nausea
  • Tiredness
  • Dry mouth
  • Constipation
  • Confusion
  • Insomnia (difficulty in sleeping)
  • Memory impairment
  • Ejaculation disorder
  • Difficulty in urination
  • Uncoordinated body movements
  • Depression
  • Erectile dysfunction
  • Low sexual desire

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take NEXVENLA OD PLUS 50MG TABLET if you are allergic to any ingredients present in it. Inform your doctor if you are taking antidepressants, antipsychotic medication, antihypertensives, or pain medication. Talk to your doctor if you have a history of seizures, bipolar disorder, suicide attempts, or schizophrenia. Patients with liver diseases, diabetes, heart disease, lung disease, and bleeding disorders should use NEXVENLA OD PLUS 50MG TABLET with caution. Please do not stop the treatment abruptly, as it can cause withdrawal reactions. NEXVENLA OD PLUS 50MG TABLET is not recommended for children and adolescents under 18 years of age as it increases suicidal tendencies in this population. NEXVENLA OD PLUS 50MG TABLET is habit-forming so take it only if prescribed by a doctor. Consult your doctor immediately if you experience suicidal thoughts like killing or harming yourself while on this medication. Do not take NEXVENLA OD PLUS 50MG TABLET if you are pregnant or breastfeeding unless prescribed. NEXVENLA OD PLUS 50MG TABLET causes drowsiness and dizziness, do not drive unless you are alert. Avoid consuming alcohol along with NEXVENLA OD PLUS 50MG TABLET as it could lead to increased drowsiness and dizziness.

Therapeutic Class

ANTIDEPRESSANT

Drug-Drug Interactions

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ClonazepamSodium oxybate
Critical
DesvenlafaxineIsocarboxazid
Critical

Drug-Drug Interactions

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ClonazepamSodium oxybate
Critical
How does the drug interact with NEXVENLA OD PLUS 50MG TABLET:
Taking NEXVENLA OD PLUS 50MG TABLET with Sodium oxybate can enhance the sedative effects on the central nervous system.

How to manage the interaction:
Taking NEXVENLA OD PLUS 50MG TABLET and Tramadol together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms such as dizziness, drowsiness, difficulty concentrating, numbness and tingling of extremities, or hypersensitivity to light and noise, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineIsocarboxazid
Critical
How does the drug interact with NEXVENLA OD PLUS 50MG TABLET:
Combining Isocarboxazid and NEXVENLA OD PLUS 50MG TABLET might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Isocarboxazid and NEXVENLA OD PLUS 50MG TABLET together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineRasagiline
Critical
How does the drug interact with NEXVENLA OD PLUS 50MG TABLET:
Taking rasagiline with NEXVENLA OD PLUS 50MG TABLET can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking NEXVENLA OD PLUS 50MG TABLET with Rasagiline together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineSafinamide
Critical
How does the drug interact with NEXVENLA OD PLUS 50MG TABLET:
Taking Safinamide with NEXVENLA OD PLUS 50MG TABLET can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking NEXVENLA OD PLUS 50MG TABLET with Safinamide is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
DesvenlafaxineTranylcypromine
Critical
How does the drug interact with NEXVENLA OD PLUS 50MG TABLET:
Taking tranylcypromine with NEXVENLA OD PLUS 50MG TABLET might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Tranylcypromine and NEXVENLA OD PLUS 50MG TABLET together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineProcarbazine
Critical
How does the drug interact with NEXVENLA OD PLUS 50MG TABLET:
Combining Procarbazine and NEXVENLA OD PLUS 50MG TABLET can increase the risk of a rare but serious condition called the serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Procarbazine and NEXVENLA OD PLUS 50MG TABLET together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. you should wait at least 14 days after stopping isocarboxazid before you start treatment with NEXVENLA OD PLUS 50MG TABLET and do not discontinue any medications without first consulting your doctor.
ClonazepamAlfentanil
Severe
How does the drug interact with NEXVENLA OD PLUS 50MG TABLET:
Co-administration of Alfentanil with NEXVENLA OD PLUS 50MG TABLET can increase the risk of adverse effects.

How to manage the interaction:
Although there is a possible interaction between NEXVENLA OD PLUS 50MG TABLET and Alfentanil, you can take these medicines together if prescribed by a doctor. If you notice any symptoms like feeling dizzy, having trouble breathing, or feeling very tired, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
ClonazepamPentazocine
Severe
How does the drug interact with NEXVENLA OD PLUS 50MG TABLET:
Co-administration of Pentazocine with NEXVENLA OD PLUS 50MG TABLET can increase the risk of side effects.

How to manage the interaction:
Taking NEXVENLA OD PLUS 50MG TABLET with Pentazocine together can possibly result in an interaction, but it can be taken if a doctor has advised it. They can recommend different options that won't cause any problems. If you notice any symptoms like feeling dizzy, having trouble breathing, or feeling very tired, make sure to call a doctor immediately. Do not discontinue any medications without consulting a doctor.
ClonazepamFentanyl
Severe
How does the drug interact with NEXVENLA OD PLUS 50MG TABLET:
Co-administration of fentanyl and NEXVENLA OD PLUS 50MG TABLET can increase the risk of side effects.

How to manage the interaction:
Although combining Fentanyl and NEXVENLA OD PLUS 50MG TABLET can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor immediately if you feel sleepiness, loss of balance, or confusion. Do not stop taking any medication without consulting a doctor.
ClonazepamOxycodone
Severe
How does the drug interact with NEXVENLA OD PLUS 50MG TABLET:
Co-administration of NEXVENLA OD PLUS 50MG TABLET with Oxycodone may cause serious side effects like respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Consult the doctor if you are taking NEXVENLA OD PLUS 50MG TABLET with Oxycodone. Until you know how these medicines affect you, avoid driving or operating hazardous machinery as these medications may cause dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination. Do not exceed the dose and duration prescribed by your doctor. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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DESVENLAFAXINE-50MG+CLONAZEPAM-0.5MGCaffeine containing foods/drinks

Drug-Food Interactions

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DESVENLAFAXINE-50MG+CLONAZEPAM-0.5MGCaffeine containing foods/drinks
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Limit or avoid caffeine intake while taking desvenlafaxine and clonazepam as it increases the risk of side effects. Limit or avoid caffeine intake while being treated with desvenlafaxine and clonazepam.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • TRAMADOL
  • ASPIRIN
  • ACETAMINOPHEN
  • PETHIDINE
  • MORPHINE
  • CODEINE
  • PRAVASTATIN
  • PHENOBARBITAL
  • PHENYTOIN
  • SODIUM VALPROATE
  • CARBAMAZEPINE
  • ARIPIPRAZOLE
  • ESCITALOPRAM
  • METOPROLOL
  • CIMETIDINE

Diet & Lifestyle Advise

  • Maintain a healthy and well-balanced diet. 
  • Do not take stress as it may aggravate your condition.
  • Limit alcohol intake and quit smoking.
  • Engage in social activities frequently as it may improve self-esteem and confidence. 
  • Limit caffeine intake.
  • Maintaining a healthy diet and exercising regularly helps improve overall health and boost self-esteem.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help properly maintain neurotransmitters. 
  • Complex carbohydrates help stimulate serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.
  • Exercising helps in the production of the body’s natural antidepressants. It also helps relieve stress, improve mood, boost self-esteem, and provide restful sleep.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

Yes

Special Advise

  • NEXVENLA OD PLUS 50MG TABLET causes drowsiness. Avoid doing activities that require your complete focus and attention, like driving when on this drug.
  • An abrupt stoppage of NEXVENLA OD PLUS 50MG TABLET can lead to significant withdrawal symptoms. Always discuss with your doctor about decreasing the dosage before completely stopping its usage.
  • NEXVENLA OD PLUS 50MG TABLET is habit-forming so take it only if prescribed by a doctor.
  • Avoid consuming alcohol while on this medication, as it can lead to dangerous side effects.
  • NEXVENLA OD PLUS 50MG TABLET is unsafe for usage if you're pregnant or are planning to get pregnant. Discuss with your doctor about changing/replacing the medicine with safer alternatives.
  • To avoid getting addicted to this drug, take it in prescribed quantities and as directed by your doctor. Do not self-medicate.

Disease/Condition Glossary

Depression: It is a mood disorder characterized by sadness, unhappiness, anger, hopelessness, or loss that interferes with a person's daily activities. Depression can also influence some chronic health conditions and relationships. The exact cause of depression is unknown, but it may be associated with mental problems, trauma, family history, drug use, and medical conditions.

NEXVENLA OD PLUS 50MG TABLET Substitute

Substitutes safety advice
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  • VENTABLET PLUS TABLET 10'S

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    19.08per tablet
  • Desrina Plus Tablet 10's

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    18.90per tablet
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