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  3. Nindev 100 mg Softgel Capsule 10's

Nindev 100 mg Softgel Capsule 10's, Pack of 10 CapsuleS
Nindev 100 mg Softgel Capsule 10's, Pack of 10 CapsuleS
Nindev 100 mg Softgel Capsule 10's, Pack of 10 CapsuleS
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Sureshvarma D , MPharma
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Whats That

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Composition :

NINTEDANIB-100MG

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About NINDEV 100MG SOFTGEL CAPSULES

NINDEV 100MG SOFTGEL CAPSULES belongs to the category of 'anti-fibrotic medicine', and it is primarily used to treat idiopathic pulmonary fibrosis (IPF) in adults. IPF is an irreversible disease marked by a progressive decline in lung function. The tissues in the lungs become swollen and scarred over time, due to which it gets difficult to breathe deeply. The scarring makes it hard for the lungs to work properly.

NINDEV 100MG SOFTGEL CAPSULES contains 'Nintedanib', which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. NINDEV 100MG SOFTGEL CAPSULES helps in slowing down the progress of idiopathic pulmonary fibrosis.

Always use this medicine as your doctor has told you or per the package leaflet. You must keep to your doctor's instructions to get the maximum benefit. In some cases, you may experience common side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor before taking NINDEV 100MG SOFTGEL CAPSULES if you are pregnant or breastfeeding. NINDEV 100MG SOFTGEL CAPSULES may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with NINDEV 100MG SOFTGEL CAPSULES as it could lead to increased dizziness. NINDEV 100MG SOFTGEL CAPSULES is not recommended for children below 18 years as safety and effectiveness have not been established. NINDEV 100MG SOFTGEL CAPSULES is listed as pregnancy category D. Because NINDEV 100MG SOFTGEL CAPSULES can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with NINDEV 100MG SOFTGEL CAPSULES . Consult your doctor if you are breastfeeding; your doctor will decide whether the NINDEV 100MG SOFTGEL CAPSULES can be taken by breastfeeding mothers or not. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of NINDEV 100MG SOFTGEL CAPSULES

Idiopathic pulmonary fibrosis

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

NINDEV 100MG SOFTGEL CAPSULES is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults. NINDEV 100MG SOFTGEL CAPSULES can help effectively slow the rate of lung function decline by 50%. NINDEV 100MG SOFTGEL CAPSULES helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. NINDEV 100MG SOFTGEL CAPSULES helps in slowing down the progress of idiopathic pulmonary fibrosis.

Storage

Keep NINDEV 100MG SOFTGEL CAPSULES out of sight and reach of children.
Side effects of Nindev 100 mg Softgel Capsule
  • Do not scratch the affected region to avoid discomfort and infection.
  • Avoid spicy and fatty foods and caffeine and alcohol as they can worsen diarrhoea and irritate the skin.
  • Frequently wash your hands to avoid infection.
  • Clean the skin with fragrance-free, soft wipes to reduce inflammation.
  • Let your doctor know if the rash is severe, widespread, or painful.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • To minimize pain and swelling, apply an ice pack or cold compress wrapped in a cloth as soon as there is bleeding or bruises.
  • Use a warm compress 48 hours later to promote blood flow and hasten the healing process.
  • Rest and limit activity to prevent further injury.
  • Elevate the affected area above the level of your heart to reduce blood flow.
  • To treat discomfort, your doctor may offer over-the-counter pain medicines.
  • Inform your doctor if you develop large bruises without injury or experience frequent bruising, as this may indicate an underlying condition.
  • Follow a low-fiber, soft food diet with easily digestible liquids and pureed foods.
  • Begin with clear liquids like water, broth, and electrolyte drinks.
  • Progress to soft foods like mashed potatoes, applesauce, plain yogurt, scrambled eggs, and well-cooked rice.
  • Avoid high-fiber foods, raw vegetables, tough meats, spicy foods, and irritants to the digestive tract.
  • Eat smaller, frequent meals to reduce digestive strain.
  • Stay hydrated with plenty of fluids, avoiding sugary drinks.
  • Chew food thoroughly to aid digestion.
  • Avoid strenuous activities and rest when needed.
  • Before altering your diet, seek guidance from your healthcare provider.
  • Always follow your doctor's instructions on dietary restrictions and medical supervision.

Drug Warnings

Do not use NINDEV 100MG SOFTGEL CAPSULES if you are allergic to any components present in NINDEV 100MG SOFTGEL CAPSULES . NINDEV 100MG SOFTGEL CAPSULES is listed as pregnancy category D; because NINDEV 100MG SOFTGEL CAPSULES can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with NINDEV 100MG SOFTGEL CAPSULES . Consult your doctor if you are breastfeeding; your doctor will decide whether the NINDEV 100MG SOFTGEL CAPSULES can be taken by breastfeeding mothers or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. NINDEV 100MG SOFTGEL CAPSULES may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with NINDEV 100MG SOFTGEL CAPSULES as it could lead to increased dizziness. NINDEV 100MG SOFTGEL CAPSULES is not recommended for children below 18 years as safety and effectiveness have not been established.

Drug-Drug Interactions

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NintedanibPhenytoin
Severe
NintedanibLeflunomide
Severe

Drug-Drug Interactions

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NintedanibPhenytoin
Severe
How does the drug interact with Nindev 100 mg Softgel Capsule:
Coadministration of Phenytoin and Nindev 100 mg Softgel Capsule may decrease the blood levels of Nindev 100 mg Softgel Capsule, which may reduce Nindev 100 mg Softgel Capsule's effectiveness.

How to manage the interaction:
Although taking Phenytoin and Nindev 100 mg Softgel Capsule together can result in an interaction, it can be taken when your doctor has prescribed it. Contact a doctor if your symptoms do not improve. Do not stop taking any drugs without consulting a doctor.
NintedanibLeflunomide
Severe
How does the drug interact with Nindev 100 mg Softgel Capsule:
Co-administration of Leflunomide and Nindev 100 mg Softgel Capsule can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Nindev 100 mg Softgel Capsule can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NintedanibRifapentine
Severe
How does the drug interact with Nindev 100 mg Softgel Capsule:
Coadministration of Nindev 100 mg Softgel Capsule and Rifapentine can reduce the blood levels of Nindev 100 mg Softgel Capsule.

How to manage the interaction:
There may be a possibility of interaction between Nindev 100 mg Softgel Capsule and Rifapentine, but it can be taken if prescribed by a doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without consulting your doctor.
NintedanibTipranavir
Severe
How does the drug interact with Nindev 100 mg Softgel Capsule:
Coadministration of Nindev 100 mg Softgel Capsule and Tipranavir can reduce the blood levels of Nindev 100 mg Softgel Capsule.

How to manage the interaction:
There may be a possibility of interaction between Nindev 100 mg Softgel Capsule and Tipranavir, but it can be taken if prescribed by a doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without first consulting your doctor.
NintedanibFosphenytoin
Severe
How does the drug interact with Nindev 100 mg Softgel Capsule:
Coadministration of Nindev 100 mg Softgel Capsule with Fosphenytoin can reduce the levels of Nindev 100 mg Softgel Capsule. This can lead to low treatment outcomes.

How to manage the interaction:
Although there is a possible interaction between Nindev 100 mg Softgel Capsule and Fosphenytoin, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
NintedanibPhenobarbital
Severe
How does the drug interact with Nindev 100 mg Softgel Capsule:
Taking Phenobarbital and Nindev 100 mg Softgel Capsule can drastically lower Nindev 100 mg Softgel Capsule levels in the blood, making the medicine less effective in treating the illness.

How to manage the interaction:
Although taking phenobarbital with Nindev 100 mg Softgel Capsule can lead to interaction, they can be taken if recommended by a doctor. Contact a doctor if your symptoms do not improve. Do not stop using any medications without talking to a doctor.
NintedanibRifampicin
Severe
How does the drug interact with Nindev 100 mg Softgel Capsule:
Coadministration of Nindev 100 mg Softgel Capsule with Rifampicin can decrease the blood levels of Nindev 100 mg Softgel Capsule, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Nindev 100 mg Softgel Capsule and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
NintedanibCarbamazepine
Severe
How does the drug interact with Nindev 100 mg Softgel Capsule:
Coadministration of Nindev 100 mg Softgel Capsule with Carbamazepine can reduce the levels and effects of Nindev 100 mg Softgel Capsule.

How to manage the interaction:
Although taking carbamazepine and Nindev 100 mg Softgel Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not stop using any medications without first talking to your doctor.
NintedanibLomitapide
Severe
How does the drug interact with Nindev 100 mg Softgel Capsule:
Co-administration of Lomitapide and Nindev 100 mg Softgel Capsule can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Lomitapide and Nindev 100 mg Softgel Capsule can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NintedanibDexamethasone
Severe
How does the drug interact with Nindev 100 mg Softgel Capsule:
Coadministration of Dexamethasone may lower the blood levels of Nindev 100 mg Softgel Capsule, making the medication less effective in treating your condition.

How to manage the interaction:
Although there is a possible interaction, Dexamethasone can be taken with Nindev 100 mg Softgel Capsule if prescribed by the doctor. Contact a doctor if your symptoms do not improve. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking and alcohol.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
  • Avoid processed and refined foods.

Side Effects of NINDEV 100MG SOFTGEL CAPSULES

  • Diarrhoea
  • Feeling and being sick
  • Tummy (Abdominal) Pain
  • Loss of appetite and weight loss

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

NINDEV 100MG SOFTGEL CAPSULES Substitute

Substitutes safety advice

Product Substitutes

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Sureshvarma D

Reviewed By

Sureshvarma D

MPharma

Last Updated

Jul 8, 2025 | 9:40 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

NINDEV 100MG SOFTGEL CAPSULES helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better.

Avoid smoking before starting the treatment while taking NINDEV 100MG SOFTGEL CAPSULES as smoking might alter the effectiveness of NINDEV 100MG SOFTGEL CAPSULES .

NINDEV 100MG SOFTGEL CAPSULES should be stopped when a person faces a serious side effect that affects life quality. Otherwise, it would be best to keep taking NINDEV 100MG SOFTGEL CAPSULES until your doctor asks you to stop it.

If you have any surgery, including dental surgery, please inform your doctor if you are taking NINDEV 100MG SOFTGEL CAPSULES as your doctor might stop NINDEV 100MG SOFTGEL CAPSULES before undergoing surgery.

In elderly patients, the risk of side effects is more if you are taking NINDEV 100MG SOFTGEL CAPSULES . For the patients who are elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.

Idiopathic pulmonary fibrosis is treated with NINDEV 100MG SOFTGEL CAPSULES (IPF; scarring of the lungs with an unknown cause). It's also used to treat fibrosing interstitial lung disorders.

Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • ERYTHROMYCIN
  • CYCLOSPORINE
  • RIFAMPICIN
  • CARBAMAZEPINE
  • PHENYTOIN

Special Advise

  • Regular blood tests and occasional tests of your bone marrow will be carried out to check whether the treatment is working. If it does work, it will usually be taken for life.

Disease/Condition Glossary

Idiopathic pulmonary fibrosis (IPF): Idiopathic pulmonary fibrosis belongs to a group of interstitial lung diseases. It is an irreversible chronic disease marked by a progressive decline in lung function. The tissues in the lungs become inflamed and scarred over time, due to which it gets difficult to breathe properly. The scar tissue, known as fibrosis, becomes thick /stiff over time, making it hard for the lungs to work efficiently. This causes decreased lung function, which leads to increased breathlessness and coughing. Breathing difficulties can lead to other medical problems. Symptoms of IPF are shortness of breath, persistent dry cough, loss of appetite, weight loss, and rounded and widened tips of the fingers and toes.

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