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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Consume Type :

ORAL

Return Policy :

Not Returnable

About Nugine 0.125mg Tablet

Nugine 0.125mg Tablet belongs to the class of medication called semi-synthetic ergot alkaloids used to prevent and control postpartum haemorrhage. It is used after delivery for the routine management of uterine atony, subinvolution of the uterus, and haemorrhage.

Nugine 0.125mg Tablet contains Methylergometrine which works by increasing the smooth muscle contractions of the uterus. This helps compress the blood vessels and controls bleeding after delivery.

Take Nugine 0.125mg Tablet exactly as prescribed by the doctor. In some cases, Nugine 0.125mg Tablet may cause high blood pressure associated with seizures and/or headache, nausea, and vomiting. If the side effects persist or worsen, consult your doctor.

Do not take Nugine 0.125mg Tablet if you are pregnant. Consult your doctor if you are breastfeeding. Nugine 0.125mg Tablet is not recommended for children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medications to rule out any interactions/side effects.

Uses of Nugine 0.125mg Tablet

Postpartum haemorrhage

Directions for Use

Swallow Nugine 0.125mg Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Nugine 0.125mg Tablet is indicated in the prevention and control of postpartum haemorrhage. It is used following delivery of the placenta for the routine management of uterine atony (soft and weak uterus after childbirth), subinvolution of the uterus, and haemorrhage. Nugine 0.125mg Tablet contains Methylergometrine, a semi-synthetic ergot alkaloid which works by increasing the smooth muscle contractions of the uterus. This helps compress the blood vessels and controls bleeding after delivery.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Nugine 0.125mg Tablet

  • Hypertension (high blood pressure) associated with seizures and/or headache
  • Nausea
  • Vomiting

Drug Warnings

Do not take Nugine 0.125mg Tablet if you are allergic to any of its components, if you have high blood pressure, toxaemia (a complication of pregnancy characterised by high blood pressure), or if you are pregnant. Inform your doctor if you have coronary artery disease, sepsis, vascular disease, or liver or kidney impairment. Consult your doctor if you are breastfeeding. The safety and effectiveness of Nugine 0.125mg Tablet in children have not been established. Let your doctor know if you are taking prescription/non-prescription medicines, including herbal products and supplements.

Drug-Drug Interactions

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MethylergometrineKetoconazole
Critical
MethylergometrineItraconazole
Critical

Drug-Drug Interactions

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MethylergometrineKetoconazole
Critical
How does the drug interact with Nugine 0.125mg Tablet:
Using Ketoconazole with Nugine 0.125mg Tablet can increase the concentration of Nugine 0.125mg Tablet, which may lead to side effects.

How to manage the interaction:
Taking Ketoconazole with Nugine 0.125mg Tablet can cause an interaction, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
MethylergometrineItraconazole
Critical
How does the drug interact with Nugine 0.125mg Tablet:
Co-administration of Nugine 0.125mg Tablet and Itraconazole may increase the blood levels of Nugine 0.125mg Tablet.

How to manage the interaction:
Nugine 0.125mg Tablet and itraconazole may interact, but if prescribed by a doctor, they can be used together. Do not discontinue any medications without first consulting your doctor.
MethylergometrineGlyceryl trinitrate
Critical
How does the drug interact with Nugine 0.125mg Tablet:
Coadministration of Nugine 0.125mg Tablet with Glyceryl trinitrate can increase the levels and side effects of Nugine 0.125mg Tablet.

How to manage the interaction:
Taking Nugine 0.125mg Tablet with Glyceryl trinitrate is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, headache, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor. Do not discontinue any medications without first consulting your doctor.
MethylergometrineRitonavir
Critical
How does the drug interact with Nugine 0.125mg Tablet:
Taking Nugine 0.125mg Tablet with Ritonavir can significantly increase the blood levels and effects of Nugine 0.125mg Tablet.

How to manage the interaction:
Taking Nugine 0.125mg Tablet with Ritonavir is not recommended, but can be taken together if prescribed by a doctor. In case you experience any side effects like severe abdominal discomfort, nausea, vomiting, tingling or numbness, weakness or pain in the muscles, pale skin, blue or purple discoloration on fingers or toes, tightness or pain in the chest, irregular heartbeat, intense headache, breathing difficulties, confusion, or slurred speech, consult a doctor. Do not discontinue any medications without consulting a doctor.
MethylergometrineVoriconazole
Critical
How does the drug interact with Nugine 0.125mg Tablet:
Coadministration of Nugine 0.125mg Tablet with Voriconazole may increase the blood level of Nugine 0.125mg Tablet.

How to manage the interaction:
Although Nugine 0.125mg Tablet with Voriconazole can cause an interaction, they can be taken if prescribed by a doctor. Do not discontinue any medication without consulting a doctor.
MethylergometrineSumatriptan
Critical
How does the drug interact with Nugine 0.125mg Tablet:
Coadministration of Sumatriptan with Nugine 0.125mg Tablet can reduce the blood flow and increase the risk of high blood pressure or heart-related problems.

How to manage the interaction:
Taking Sumatriptan with Nugine 0.125mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
MethylergometrineKetoconazole
Critical
How does the drug interact with Nugine 0.125mg Tablet:
Using Ketoconazole with Nugine 0.125mg Tablet can increase the concentration of Nugine 0.125mg Tablet, which may lead to side effects.

How to manage the interaction:
Taking Ketoconazole with Nugine 0.125mg Tablet is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
MethylergometrineClarithromycin
Critical
How does the drug interact with Nugine 0.125mg Tablet:
When Nugine 0.125mg Tablet is taken with Clarithromycin, the amount of Nugine 0.125mg Tablet in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Clarithromycin with Nugine 0.125mg Tablet is generally avoided as it can lead to an interaction, it can be taken only when advised by a doctor. Do not stop using any medications without a doctor's advice.
MethylergometrineEphedrine
Severe
How does the drug interact with Nugine 0.125mg Tablet:
Taking Ephedrine with Nugine 0.125mg Tablet may lead to an increase in the risk of high blood pressure.

How to manage the interaction:
Although taking Ephedrine with Nugine 0.125mg Tablet may lead to an interaction, it can be taken if prescribed by the doctor. It is advised to maintain your blood pressure. Do not discontinue any medications without a doctor's advice.
MethylergometrinePhenylephrine
Severe
How does the drug interact with Nugine 0.125mg Tablet:
Taking Phenylephrine with Nugine 0.125mg Tablet can led to side effects like increased blood pressure.

How to manage the interaction:
Taking Phenylephrine with Nugine 0.125mg Tablet can lead to an interaction but can be taken if prescribed by the doctor. It is advised to monitor your blood pressure regularly. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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METHYLERGOMETRINE-0.125MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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METHYLERGOMETRINE-0.125MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of Nugine 0.125mg Tablet with Grapefruit and Grapefruit may lead to an increase in the effectiveness of Nugine 0.125mg Tablet. Avoid or limit grapefruit and grapefruit juice consumption with Nugine 0.125mg Tablet. This can increase the risk or severity of side effects.

Diet & Lifestyle Advise

  • Include high-fibre foods such as fruits and whole grains.
  • Drink plenty of fluids such as water, fruit juices, and milk.
  • Limit processed/packaged foods, high salt/sugary foods and saturated fats.
  • Get plenty of rest.
  • Eat healthy meals and exercise appropriately.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Nugine 0.125mg Tablet Substitute

Substitutes safety advice
  • Methergin Tablet 10's

    by Others

    8.80per tablet
  • Ergostat Tablet 10's

    by AYUR

    9.00per tablet
  • Ematrin 0.125mg Tablet

    by Others

    4.04per tablet
  • Ergolin 0.125 Tablet 10's

    by Others

    7.81per tablet
  • Ergogem 0.125mg Tablet

    by Others

    4.71per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Nugine 0.125mg Tablet works by increasing the smooth muscle contractions of the uterus. This helps compress the blood vessels and controls bleeding after delivery.

Nugine 0.125mg Tablet is not recommended for use in people with high blood pressure. Consult your doctor if you have hypertension.

Nugine 0.125mg Tablet may cause nausea or vomiting as a side effect. It is not necessary for everyone taking Nugine 0.125mg Tablet to experience this side effect. However, if the condition persists or worsens, consult your doctor.

Nugine 0.125mg Tablet may be indicated in the management of uterine atony. Uterine atony refers to a weak and soft uterus after childbirth.

Drug-Drug Interactions Checker List

  • DIHYDROERGOTAMINE
  • ERGOTAMINE
  • ERYTHROMYCIN
  • TROLEANDOMYCIN
  • CLARITHROMYCIN
  • RITONAVIR
  • INDINAVIR
  • NELFINAVIR
  • DELAVIRDINE
  • KETOCONAZOLE
  • ITRACONAZOLE
  • VORICONAZOLE

Special Advise

 

Disease/Condition Glossary

Postpartum haemorrhage: It is a condition in which excessive bleeding occurs following childbirth. This can lead to a drop in blood pressure. Symptoms include vaginal bleeding that does not stop. Loss of tone in uterine muscles and bleeding disorder could be the causes of postpartum haemorrhage.

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