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Reviewed By Hari Kumar , MBBS
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Composition :

BARICITINIB-2MG

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Olumiant 2 Tablet

Olumiant 2 Tablet belongs to the group of immunomodulators. Olumiant 2 Tablet is used in the treatment of hospitalised cases of coronavirus disease, an infection caused by COVID-19 and is also used to treat Rheumatoid Arthritis. Rheumatoid arthritis is a chronic inflammatory and autoimmune disorder of the joints. Atopic dermatitis is a skin disease in which the skin becomes red, inflamed and itchy.  Coronavirus disease is an infectious disease caused by SARS-CoV-2. It can range from a mild cold to a serious form of pneumonia

Olumiant 2 Tablet contains ‘’Baricitinib.’’ Olumiant 2 Tablet works by inhibiting viral entry into body cells, limits viral replication and also controls the release of inflammatory mediators called cytokines.

Take Olumiant 2 Tablet as prescribed by the doctor. Olumiant 2 Tablet may cause certain common side effects such as throat infection, fatigue and high blood cholesterol. Most of these adverse effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

It is advisable to inform the doctor if you are allergic to Olumiant 2 Tablet or any of its components. Keep your doctor informed if you suffer from any medical disorders. Avoid Olumiant 2 Tablet in case of a history of thromboembolism, abdominal disorders such as diverticulitis, cancer, liver disease, chronic infections such as tuberculosis, hepatitis B and C and shingles, and any anaemias. Keep your doctor informed if you have recently had any surgery or are scheduled for surgery in the near future. Offer a detailed medical and vaccination history. Discuss any recent vaccinations with the doctor. Inform the doctor if you are on any other JAK-2 inhibitor medicines, painkillers, steroids and/or drugs that affect the immunity and immune system of the body. Consult your doctor if you are planning to get pregnant or are breastfeeding. Avoid Olumiant 2 Tablet use with alcohol.

Uses of Olumiant 2 Tablet

Rheumatoid Arthritis, Atopic Dermatitis, COVID-19

Directions for Use

Take Olumiant 2 Tablet with or without food as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Olumiant 2 Tablet is an immunomodulator used in the treatment of various types of cancers and infections such as Covid-19. Olumiant 2 Tablet contains Baricitinib. Baricitinib works by inhibiting the entry of the virus into the body cells. Olumiant 2 Tablet targets an enzyme called Janus kinase (JAK-2), which is responsible for the formation of cytokines. Cytokines are inflammatory mediators. Hence, by inhibiting a cytokine-forming enzyme, Baricitinib reduces the level of cytokines in the body, thus relieving signs of inflammation.  In addition, Baricitinib works by reducing viral replication, thus arresting the progress of the disease.

Storage

Store in a cool and dry place away from sunlight
Side effects of Olumiant 2 Tablet
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • To improve liver health and aid in the removal of toxins, drink lots of water.
  • Alcohol consumption should be reduced or stopped because it can raise ALT levels and impair liver function.
  • Consume a well-rounded diet full of whole grains, fruits, and vegetables. Limit items that strain the liver, such as processed, fatty, or fried foods.
  • You can monitor your ALT levels and make treatment modifications with the support of routine blood tests.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • Eat more plant based foods like vegetables, fruits and whole grains.
  • Reduce intake of foods containing high fat such as dairy, oil and red meat.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking.
  • Control blood sugar and blood pressure.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.
  • If you experience symptoms like difficulty breathing, stridor (high-pitched whistling sound when breathing), high fever or chest pain, consult a doctor immediately.
  • Use a nebulizer or a cool-mist humidifier to help loosen mucus and soothe inflamed airway.
  • Drink lots of water to thin mucus and help with coughing.
  • Get enough sleep to allow the body to heal.
  • Suck on lozenges to soothe sore throat.
  • Quit smoking and alcohol consumption.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Drug Warnings

It is advisable to inform the doctor if you are allergic to Olumiant 2 Tablet or any of its components. Keep your doctor informed if you suffer from any medical disorders. Avoid Olumiant 2 Tablet in case of a history of thromboembolism, abdominal disorders such as diverticulitis, cancer, liver disease, chronic infections such as tuberculosis, hepatitis B and C and shingles, and any anaemias. Keep your doctor informed if you have recently had any surgery or are scheduled for surgery in the near future. Offer a detailed medical and vaccination history. Discuss any recent vaccinations with the doctor. Inform the doctor if you are on any other JAK-2 inhibitor medicines, DMARD’s, painkillers, steroids and/or any drugs that affect the immunity and immune system of the body. Consult your doctor if you are planning to get pregnant or are breastfeeding. Avoid Olumiant 2 Tablet use with alcohol.

Drug-Drug Interactions

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BaricitinibNelarabine
Severe

Drug-Drug Interactions

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How does the drug interact with Olumiant 2 Tablet:
Co-administration of Olumiant 2 Tablet with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Ciclosporin with Olumiant 2 Tablet is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BaricitinibNelarabine
Severe
How does the drug interact with Olumiant 2 Tablet:
Coadministration of Nelarabine with Olumiant 2 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Olumiant 2 Tablet and Nelarabine together can cause an interaction, it can be taken if your doctor has suggested it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
How does the drug interact with Olumiant 2 Tablet:
Taking Dimethyl fumarate with Olumiant 2 Tablet may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Dimethyl fumarate can be taken with Olumiant 2 Tablet if prescribed by the doctor. Consult the prescriber if you experience signs and symptoms of infection like muscle aches, shortness of breath, blood in phlegm, fever, chills, diarrhea, sore throat, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Olumiant 2 Tablet:
Coadministration of Olumiant 2 Tablet and hydrocortisone can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Olumiant 2 Tablet can be taken with hydrocortisone if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, discomfort or burning when you urinate, abdominal pain, nausea, or vomiting, consult a doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Olumiant 2 Tablet:
Coadministration of Olumiant 2 Tablet and cladribine can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Olumiant 2 Tablet can be taken with cladribine if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
BaricitinibPeginterferon alfa-2a
Severe
How does the drug interact with Olumiant 2 Tablet:
Coadministration of Peginterferon alfa-2a with Olumiant 2 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Peginterferon alfa-2a with Olumiant 2 Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
How does the drug interact with Olumiant 2 Tablet:
Coadministration of Olumiant 2 Tablet and midostaurin can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Olumiant 2 Tablet can be taken with midostaurin if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Olumiant 2 Tablet:
Co-administration of Olumiant 2 Tablet and Mercaptopurine can raise the risk of serious infections.

How to manage the interaction:
Although there is an interaction, Olumiant 2 Tablet can be taken with mercaptopurine if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
BaricitinibBelatacept
Severe
How does the drug interact with Olumiant 2 Tablet:
Combining Belatacept with Olumiant 2 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Olumiant 2 Tablet and Belatacept, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BaricitinibPlicamycin
Severe
How does the drug interact with Olumiant 2 Tablet:
Coadministration of Olumiant 2 Tablet and plicamycin can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Olumiant 2 Tablet can be taken with plicamycin if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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BARICITINIB-2MGHigh fat foods
Mild

Drug-Food Interactions

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BARICITINIB-2MGHigh fat foods
Mild
Common Foods to Avoid:
Frozen Meals, Cheese, Red Meat, Potato Chips, Hamburgers, Hot Dogs, Ice Cream

How to manage the interaction:
Coadministration of Olumiant 2 Tablet and high-fat meals can decrease the absorption of Olumiant 2 Tablet. Avoid fatty food and oily food while being treated with Olumiant 2 Tablet.

Diet & Lifestyle Advise

  • Keep a healthy state of mind. Fear is the one of the biggest causes of decreased immunity. See a therapist if you feel the need. 
  • Meditation, music and yoga have also proven very effective in helping with mental health.
  • Keep yourself at a safe distance from people.
  • Always sneeze or cough into your elbow and keep a handkerchief on you.
  • Wash your hands with soap and water and keep yourself clean.
  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. Load up on Vitamin-C rich citrus fruit for enhanced immunity.
  • Do not forget to take your Vitamin B complex and Vitamin C supplements every day as these are essential for the body and immunity.
  • Steam inhalation for 3-5 minutes every day and salt-water gargle with warm water has been proven very effective in keeping respiratory infections at bay and in promoting health. 
  • Avoid taking Olumiant 2 Tablet with alcohol as there may be an interaction.
  • Stay hydrated by drinking plenty of water as dehydration is often seen in pneumonia.
  • Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. Doing weight-bearing exercises can prove very helpful in promoting bone health.
  • Avoid tobacco use as smoking hampers lung health and makes breathing even more difficult.
  • Spend time under the sun (however with proper sunscreen) for quality intake of Vitamin D. Vitamin D is necessary for the absorption of Calcium, which is the most important component of bones and can help with bone and joint pain.

Habit Forming

No

Therapeutic Class

IMMUNOMODULATORS

Olumiant 2 Tablet Substitute

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Olumiant 2 Tablet works by preventing the virus from attaching to the body’s cell receptors and thereby blocking its entry and spread.

If you suffer from Chronic Kidney Disease, please consult with your doctor before using Olumiant 2 Tablet and discuss any concerns with them. Olumiant 2 Tablet is to be used with caution in those suffering from kidney and liver problems.

Not enough literature exists to ascertain the effects of Olumiant 2 Tablet on fertility. However, Olumiant 2 Tablet should be absolutely avoided in pregnancy. Please consult your doctor in case of any concerns.

Advanced age, obesity, chronic kidney disease, lung disease, sickle cell disease, neurodevelopmental disorders (for example cerebral palsy) and diseases of metabolism are some risk factors for disease progression.

Drug-Drug Interactions Checker List

  • TRAMADOL
  • ABATACEPT
  • METHOTREXATE

Special Advise

  • Discuss contraception with your doctor while taking Olumiant 2 Tablet.
  • Use Olumiant 2 Tablet with caution in the elderly as they’re more prone to infections.

Disease/Condition Glossary

Rheumatoid Arthritis: Rheumatoid arthritis is an autoimmune inflammatory disorder of the joints. It is a chronic disease. Autoimmunity is when the body recognises its own cells as foreign and tends to attack them. Rheumatoid arthritis is often seen in conjunction with other autoimmune diseases such as hypothyroidism, inflammatory bowel disease (IBD), vitiligo, lupus etc. Symptoms include stiffness, swelling and weakness at the joints, lumps and redness on the skin, compromised movements, bone erosion and joint deformity. 

Atopic Dermatitis: Atopic dermatitis is a skin condition that makes the skin red, inflamed and itchy. It usually manifests as a rash behind the knees, and on the arms. It is commonly known as eczema.

Coronavirus Disease: Coronavirus disease is an infection caused by the SARS-CoV-2 virus. It can range from a mild cold, cough and fever to full-blown pneumonia. Drop-in oxygen saturations and breathlessness were also common symptoms noted. The new variant omicron however is supposed to cause only a mild disease characterised by a scratchy throat and fatigue only. 

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