Onglyza 5 mg Tablet 14's contains saxagliptin which belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors used in the treatment of type 2 diabetes in adults. Onglyza 5 mg Tablet 14's is prescribed for the condition of type 2 diabetes when diet and exercise alone cannot control their blood sugar levels. It is the first-line therapy for patients with type 2 diabetes that restores the body's response to insulin. Insulin is the hormone that controls sugar levels in your blood. People with type 2 diabetes either do not produce enough insulin or the insulin produced is unable to perform its function in the body (insulin resistance). Middle-aged or older individuals are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes.

Onglyza 5 mg Tablet 14's work by blocking the action of DPP-4 (an enzyme which destroys hormone ‘Incretin’). The enzyme ‘Incretins’ help to produce more insulin only when required and reduce blood sugar level produced by the liver when not needed. Onglyza 5 mg Tablet 14's should not be used in patients with type 1 diabetes and for the treatment of diabetic ketoacidosis.

Onglyza 5 mg Tablet 14's should be taken with food or empty stomach. However, it should be taken at the same time of the day each time for best results. For better advice, your doctor will decide, what dose should be taken and it can change timely depending upon your condition. The most common side effect of Onglyza 5 mg Tablet 14's are hypoglycemia (low blood glucose levels), upper respiratory tract infection, nasopharyngitis (infection of nose and throat with common cold) and headache.

Prolonged intake of Onglyza 5 mg Tablet 14's may cause acute pancreatitis (swollen pancreas), and critical kidney problem. Increased risk of hypoglycemia (low blood sugar level) can occur when Onglyza 5 mg Tablet 14's is added to other anti-diabetic agents or insulin therapy. In this case, your doctor may adjust the dose of Onglyza 5 mg Tablet 14's. Severe allergic reactions might occur in some patients taking Onglyza 5 mg Tablet 14's like anaphylaxis, angioedema (swelling under the skin), and exfoliative skin conditions including Stevens-Johnson syndrome. Safety and efficacy of Onglyza 5 mg Tablet 14's in children under 18 years have not been established, so it should not be given to them. Patients taking digoxin (a heart medicine) with Onglyza 5 mg Tablet 14's should be closely monitored as severe drug interaction has been observed.

Onglyza 5 mg Tablet 14's work by blocking the action of DPP-4 (an enzyme which destroys hormone ‘Incretin’). The enzyme ‘Incretins’ help to produce more insulin only when required and reduce blood sugar level produced by the liver when not needed. Thus, Onglyza 5 mg Tablet 14's plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

• Hypoglycaemia (low blood glucose levels)
• Upper respiratory tract infection
• Nasopharyngitis (infection of nose and throat with common cold)
• Headache

Increased risk of hypoglycemia (low blood sugar level) can occur when Onglyza 5 mg Tablet 14's is added to other anti-diabetic agents or insulin therapy. In this case, your doctor may adjust the dose of Onglyza 5 mg Tablet 14's. Prolonged intake of Onglyza 5 mg Tablet 14's may cause acute pancreatitis (swollen pancreas), and critical kidney problem. Severe allergic reactions might occur in some patients taking Onglyza 5 mg Tablet 14's like anaphylaxis, angioedema (swelling under the skin), and exfoliative skin conditions including Stevens-Johnson syndrome. Safety and efficacy of Onglyza 5 mg Tablet 14's in children under 18 years have not been established, so it should not be given to them. Patients taking digoxin (a heart medicine) with Onglyza 5 mg Tablet 14's should be closely monitored as severe drug interaction has been observed.

Drug-Drug Interaction: Onglyza 5 mg Tablet 14's interacts with an anti-depressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (digoxin), anti-HIV drugs (dolutegravir), ethanol, saliva reducing drugs (glycopyrrolate), iodinated X-ray contrast agents, anti-epileptic drugs (topiramate, lamotrigine), heart-related chest medicine (ranolazine). Other drug interactions can contribute to an increased low blood sugar including sex hormones (androgens), anti-oxidant (alpha-lipoic acid), painkillers (aspirin), anti TB drugs (prothionamide), growth hormones (pegvisomant), and other antidiabetic medicines.

Drug-Food Interaction: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with Onglyza 5 mg Tablet 14's.

Drug-Disease Interaction: Onglyza 5 mg Tablet 14's should be used with caution in patients with a history of pancreatitis/pancreatic disease and renal dysfunction.

• BUPROPION
• CIPROFLOXACIN
• CIMETIDINE
• DIGOXIN
• DOLUTEGRAVIR
• TOPIRAMATE
• RANOLAZINE
• ASPIRIN

• Invest at least 150 min of your week in moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
• Losing weight gradually to achieve a healthy body mass index (18.5 to 24.9).
• Replacing refined carbohydrates containing foods with whole grain foods and increase intake of fruits and veggies and other fibre enriched foods.
• Reduce intake of saturated fat (or hidden fats) in the food like chips, crisps, pastries, biscuits and samosas. Choose omega 3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
• Avoid taking too much stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes or meditation or yoga.
• Opt for low-fat dairy products (low-fat yoghurt, fat-free milk and cheese etc.).
• Keep your blood pressure as normal (140/90) as possible as it reduces the risk of cardiovascular diseases in diabetes patients.

Type 2 diabetes is a condition where the body is unable to make sufficient insulin, or the insulin that it makes doesn't work properly or utilized by our body. This can cause high blood sugar levels (hyperglycemia). Symptoms of type 2 diabetes include increased thirst, frequent urination,  increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain while in rare cases weight loss may be observed. The complication of type 2 diabetes also includes neuropathy (nerve problems), nephropathy (kidney problems), and retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and increase the chance of heart attack or stroke.