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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Whats That

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Manufacturer/Marketer

Admac Lifesciences(Oncology)

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Oxabenz-50 Injection

Oxabenz-50 Injection belongs to the group of medicines called platinum-containing antineoplastic agents used alone or in combination with other anti-cancer medicines to treat cancer of the large bowel/intestine (advanced colon or colorectal cancer). 
 
Oxabenz-50 Injection contains Oxaliplatin, which works by killing the cancer cells. Thereby, it helps treat cancer.
 
In some cases, Oxabenz-50 Injection may cause side effects such as mild nausea, vomiting, diarrhoea, fever, and headache. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.
 
Do not use Oxabenz-50 Injection if you are breastfeeding. Consult a doctor immediately if you become pregnant during treatment with Oxabenz-50 Injection. This medicine is not recommended for children as safety and effectiveness have not been established. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Oxabenz-50 Injection

Colon and rectal cancer

Directions for Use

Oxabenz-50 Injection will be administered by a qualified physician; do not self-administer.

Medicinal Benefits

Oxabenz-50 Injection contains Oxaliplatin, which belongs to the group of medicines called platinum-containing antineoplastic agents used to treat stage III colon cancer after complete removal of the primary tumour and metastatic cancer of the colon and rectum. It is used in combination with other anti-cancer medicines, such as 5-fluorouracil and folinic acid. Oxabenz-50 Injection works by killing the cancer cells. Thereby, it helps treat cancer. Oxabenz-50 Injection may also be used with other medicines to prevent colon cancer from spreading in patients who have had surgery to remove the tumour.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Oxabenz-50 Injection

  • Mild nausea
  • Vomiting
  • Diarrhoea
  • Headache
  • Peripheral neuropathy
  • Fatigue
  • Back pain
  • Stomach pain

Drug Warnings

Do not use Oxabenz-50 Injection if you are allergic to any of its components, if you are breastfeeding, have a low blood cell count, have severe kidney problems, tingling and numbness in the fingers/toes, and have difficulty performing fragile tasks, such as buttoning clothes. Inform the doctor if you ever suffered an allergic reaction to platinum-containing medicines, have mild/moderate kidney problems, liver problems or abnormal liver function tests during therapy, or heart disorders like prolongation of the QT interval (abnormal electrical signal), an irregular heartbeat, or a family history of heart problems. Seek immediate medical attention if you experience symptoms of an allergic reaction (rash, itching, hives, reddening of the skin, hoarseness, difficulty breathing or swallowing, feeling as if your throat is closing, dizziness, swelling of the lips and tongue, lightheadedness, or fainting), unpleasant sensation in the throat, rhabdomyolysis (muscle pain and swelling), nerve problems (sensitivity to cold temperature or cold objects, pain, tingling or burning sensation), Posterior Reversible Encephalopathy Syndrome (headache, confusion, seizures, vision problems), myelosuppression (chills or shivering, burning or pain on urination, pain on swallowing, sore throat, cough with mucus, persistent diarrhoea), lung problems (shortness of breath, wheezing, cough), or bleeding problems (vomit that looks like coffee grounds or bloody vomit, pink or brown urine, weakness, dizziness, changes in speech, confusion, unexplained bleeding or dark-coloured/tarry stools).

Drug-Drug Interactions

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OxaliplatinZiprasidone
Critical
OxaliplatinGatifloxacin
Severe

Drug-Drug Interactions

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OxaliplatinZiprasidone
Critical
How does the drug interact with Oxabenz-50 Injection 25 ml:
Combining Oxabenz-50 Injection 25 ml with Ziprasidone can increase the risk of QTc prolongation.

How to manage the interaction:
Taking Oxabenz-50 Injection 25 ml with Ziprasidone is not recommended, please consult your doctor before taking it.
OxaliplatinGatifloxacin
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Taking Oxabenz-50 Injection 25 ml with Gatifloxacin can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Oxabenz-50 Injection 25 ml with Gatifloxacin together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OxaliplatinSotalol
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Using sotalol together with Oxabenz-50 Injection 25 ml can increase the risk of an irregular heart rhythm. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Oxabenz-50 Injection 25 ml, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
OxaliplatinChloroquine
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Using chloroquine together with Oxabenz-50 Injection 25 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking chloroquine and Oxabenz-50 Injection 25 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
OxaliplatinMifepristone
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Co-administration of Oxabenz-50 Injection 25 ml with mifepristone can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Oxabenz-50 Injection 25 ml with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
OxaliplatinIvabradine
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Using ivabradine together with Oxabenz-50 Injection 25 ml can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is a possible interaction between Oxabenz-50 Injection 25 ml and Ivabradine, you can take these medicines together if prescribed by your doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
OxaliplatinMoxifloxacin
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Using Moxifloxacin together with Oxabenz-50 Injection 25 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Oxabenz-50 Injection 25 ml and Moxifloxacin, you can take these medicines together if prescribed by a doctor. However, consult the doctor immediately if you experience dizziness, shortness of breath, or heart palpitations (irregular heartbeat). Do not stop using any medications without a doctor's advice.
OxaliplatinTofacitinib
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Taking Tofacitinib with Oxabenz-50 Injection 25 ml may increase the risk of infection.

How to manage the interaction:
Although taking Oxabenz-50 Injection 25 ml and Tofacitinib together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to your doctor.
OxaliplatinBaricitinib
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Coadministration of baricitinib and Oxabenz-50 Injection 25 ml can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Oxabenz-50 Injection 25 ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
OxaliplatinHaloperidol
Severe
How does the drug interact with Oxabenz-50 Injection 25 ml:
Co-administration of Oxabenz-50 Injection 25 ml and Haloperidol can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Co-administration of Oxabenz-50 Injection 25 ml and Haloperidol can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat fibre-rich foods, vegetables and fruits.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Oxabenz-50 Injection Substitute

Substitutes safety advice
  • Oxabenz-100 Injection 50 ml

    by Others

    95.81per tablet
  • Oxaliage 100 mg Injection 50 ml

    by Others

    95.78per tablet
  • Oxalee 50 Injection 25 ml

    by Others

    142.00per tablet
  • Oxakem 50 Injection 25 ml

    by Others

    129.20per tablet
  • Caitplatin 100 mg Injection 50 ml

    by Others

    115.80per tablet

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Oxabenz-50 Injection works by killing the cancer cells. Thereby, it helps treat cancer.

Oxabenz-50 Injection may have an anti-fertility effect, which could be irreversible. Therefore, male patients should seek medical advice on the conservation of sperm prior to treatment with Oxabenz-50 Injection.

Avoid drinking or eating anything colder than room temperature. Do not touch any cold objects, wash your hands in cold water, go near air conditioners or freezers, or go outside in cold weather unless absolutely necessary for five days after you receive each dose of Oxabenz-50 Injection. Wear a hat, gloves, and a scarf, and cover your mouth and nose if you must go outside in cold weather.

Oxabenz-50 Injection may decrease the ability to fight infections due to reduced white blood cells. Stay away from sick people during treatment with Oxabenz-50 Injection.

Special Advise

  • Women must use reliable contraception during treatment and for nine months after receiving the last dose.
  • Male patients are advised not to father a child during treatment and for six months after the last dose. Use effective contraception during this time.
  • If you are due to undergo any surgery, including dental surgery, inform the doctor/dentist that you are on treatment with Oxabenz-50 Injection.
  • Avoid eating or drinking anything that is colder than room temperature for five days after receiving each dose of Oxabenz-50 Injection. To reduce side effects caused by cold temperature-cover yourself with a blanket while getting treatment with Oxabenz-50 Injection, wear warm clothing in cold weather at all times, cover your mouth and nose with a scarf and wear gloves whilst touching cold objects. Drink fluid at room/warm temperature and always drink through a straw. Avoid using ice and AC, touching cold metals, and breathing deeply when exposed to cold air.

Disease/Condition Glossary

Colon and rectal cancer: It is a cancer of the colon or rectum. Colorectal cancer is the growth of cells that form in the lower end of the digestive tract. Most of these cancers begin as polyps (non-cancerous growths). Symptoms may include abdominal discomfort, blood in the stool, and changes in bowel habits like constipation or diarrhoea.

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