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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

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Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Palibout 0.25 Injection 5 ml

Palibout 0.25 Injection 5 ml belongs to a class of drugs called antiemetics used to prevent nausea and vomiting during chemotherapy. Nausea is a feeling of uneasiness of the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Palibout 0.25 Injection 5 ml contains Palonosetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.

Palibout 0.25 Injection 5 ml will be administered by a healthcare professional; do not self-administer. In some cases, you may experience diarrhoea, constipation, dizziness or headache. Most of these side effects of Palibout 0.25 Injection 5 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Palibout 0.25 Injection 5 ml or any other medicines, please tell your doctor. Palibout 0.25 Injection 5 ml may be given to children above 1 month in doses as advised by a doctor based on the child's body weight. If you are pregnant or breastfeeding, please inform your doctor before taking Palibout 0.25 Injection 5 ml. Drive only if you are alert as Palibout 0.25 Injection 5 ml may cause tiredness or dizziness. You are recommended to avoid heavy meals and take small nourishing snacks throughout the day. Drink plenty of water to avoid dehydration.

Uses of Palibout 0.25 Injection 5 ml

Nausea and vomiting

Directions for Use

Palibout 0.25 Injection 5 ml will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Palibout 0.25 Injection 5 ml contains Palonosetron which blocks the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting during chemotherapy.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Palibout 0.25 Injection 5 ml

  • Diarrhoea
  • Constipation
  • Dizziness
  • Headache

Drug Warnings

If you are allergic to Palibout 0.25 Injection 5 ml or any other medicines, please tell your doctor. Palibout 0.25 Injection 5 ml may be given to children above 1 month in doses as advised by a doctor based on the child's body weight. If you are pregnant or breastfeeding, please inform your doctor before taking Palibout 0.25 Injection 5 ml. Drive only if you are alert as Palibout 0.25 Injection 5 ml may cause tiredness or dizziness. You are recommended to avoid heavy meals and take small nourishing snacks throughout the day. Drink plenty of water to avoid dehydration.

Drug-Drug Interactions

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PalonosetronZiprasidone
Critical
PalonosetronAmitriptyline
Severe

Drug-Drug Interactions

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PalonosetronZiprasidone
Critical
How does the drug interact with Palibout 0.25 Injection 5 ml:
Combining Palibout 0.25 Injection 5 ml with Ziprasidone can increase the risk of side effects.

How to manage the interaction:
Taking Ziprasidone with Palibout 0.25 Injection 5 ml is not recommended, please consult your doctor before taking it.
PalonosetronAmitriptyline
Severe
How does the drug interact with Palibout 0.25 Injection 5 ml:
Combining Palibout 0.25 Injection 5 ml with Amitriptyline can increase the risk of serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although using Palibout 0.25 Injection 5 ml and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
PalonosetronVilazodone
Severe
How does the drug interact with Palibout 0.25 Injection 5 ml:
When Vilazodone is taken with Palibout 0.25 Injection 5 ml, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Vilazodone and Palibout 0.25 Injection 5 ml, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-call a doctor right away. Do not stop using any medications without a doctor's advice.
PalonosetronChloroquine
Severe
How does the drug interact with Palibout 0.25 Injection 5 ml:
Using chloroquine together with Palibout 0.25 Injection 5 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking chloroquine and Palibout 0.25 Injection 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
PalonosetronHydroxychloroquine
Severe
How does the drug interact with Palibout 0.25 Injection 5 ml:
The combined use of Palibout 0.25 Injection 5 ml and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of palponosetron and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
PalonosetronDextromethorphan
Severe
How does the drug interact with Palibout 0.25 Injection 5 ml:
Co-administration of Dextromethorphan and Palibout 0.25 Injection 5 ml may increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although there is a possible interaction between Dextromethorphan and Palibout 0.25 Injection 5 ml, you can take these medicines together if prescribed by a doctor. However, if you experience symptoms such as seizures (fits), extreme changes in blood pressure, confusion, hallucination, increased heart rate, fever, excessive sweating, shivering or shaking, tremors, incoordination, blurred vision, muscle spasms or stiffness, nausea, vomiting, stomach cramp, and diarrhea, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
PalonosetronLinezolid
Severe
How does the drug interact with Palibout 0.25 Injection 5 ml:
When linezolid is taken with Palibout 0.25 Injection 5 ml it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of linezolid along with Palibout 0.25 Injection 5 ml can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.
PalonosetronParoxetine
Severe
How does the drug interact with Palibout 0.25 Injection 5 ml:
Using Palibout 0.25 Injection 5 ml together with paroxetine can increase the risk of condition called the serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Paroxetine with Palibout 0.25 Injection 5 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, diarrhea, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
PalonosetronCeritinib
Severe
How does the drug interact with Palibout 0.25 Injection 5 ml:
Taking Ceritinib with Palibout 0.25 Injection 5 ml can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although taking Ceritinib and Palibout 0.25 Injection 5 ml together can evidently cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PalonosetronDoxepin
Severe
How does the drug interact with Palibout 0.25 Injection 5 ml:
The combined use of Palibout 0.25 Injection 5 ml and doxepin can increase the risk of serotonin syndrome(A condition in which a chemical called serotonin builds up in your body) and increase the risk of irregular heart rhythms.

How to manage the interaction:
Co-administration of Palibout 0.25 Injection 5 ml and Doxepin can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, diarrhoea, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and a low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating over-sweet food and include more salty food, especially if you have been vomiting.
  • Also, if you like to vomit at a specific time, avoid eating your favourite food at that particular time as your taste for that food may get turned off.
  • Drink any other liquid at least 30 minutes after eating food.
  • If the smell of food makes you feel sick (vomit), do not cook food as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Palibout 0.25 Injection 5 ml Substitute

Substitutes safety advice
  • Palonoget 0.25 mg Injection 5 ml

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  • Palmocet 0.25 Injection 5 ml

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CITALOPRAM
  • FLUVOXAMINE
  • PAROXETINE
  • SERTRALINE
  • ESCITALOPRAM
  • DULOXETINE
  • VENLAFAXINE
  • QUINIDINE
  • AMIODARONE
  • NICARDIPINE
  • MOXIFLOXACIN
  • ERYTHROMYCIN
  • DOMPERIDONE
  • THIORIDAZINE
  • QUETIAPINE
  • CHLORPROMAZINE
  • HALOPERIDOL

Disease/Condition Glossary

Nausea and vomiting: Nausea is a feeling of uneasiness of the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth. In short, nausea and vomiting are not diseases but are symptoms of many conditions like infections, motion sickness, an early stage of pregnancy, and gastroparesis (slow stomach emptying). There is a receptor located in our brain known as the chemoreceptor zone (CTZ) that controls vomiting.

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