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  3. Pentasa 1 gm Suppository 7's

Pentasa 1 gm Suppository 7's, Pack of 7 SUPPOSITORYS
Pentasa 1 gm Suppository 7's, Pack of 7 SUPPOSITORYS
Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Whats That

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Composition :

MESALAZINE-1000MG

Manufacturer/Marketer :

Ferring Pharmaceuticals Pvt Ltd

Consume Type :

RECTAL

Return Policy :

Not Returnable

Expires on or after :

About Pentasa 1 gm Suppository

Pentasa 1 gm Suppository belongs to a class of anti-inflammatory drugs used to treat ulcerative colitis. Ulcerative colitis is a chronic inflammatory bowel disease that causes inflammation of the large intestine lining (colon). It produces ulcers on the colon's lining, which may cause bleeding and discharge of pus and mucus. Ulcerative proctitis is a condition in which ulcerative colitis solely affects the rear channel (rectum). Pentasa 1 gm Suppository used for the treatment of ulcerative proctitis and is exclusively designed for rectal usage.

Pentasa 1 gm Suppository contains Mesalazine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (redness and swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding.

Use Pentasa 1 gm Suppository as directed by your physician. Sometimes, you may experience diarrhoea, stomach pain, headache or nausea. Most of these side effects of Pentasa 1 gm Suppository do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic to Mesalazine, aspirin,  or other medicines. Pentasa 1 gm Suppository should be used with caution in the elderly. If pregnant or breastfeeding, please inform your doctor before using the Pentasa 1 gm Suppository. Avoid taking Pentasa 1 gm Suppository if you have severe kidney failure. Avoid taking Pentasa 1 gm Suppository if you have blood abnormalities or kidney problems caused by other medicines such as Sulphasalazine.

Uses of Pentasa 1 gm Suppository

Ulcerative colitis, Ulcerative proctitis

Directions for Use

Suppository: Empty your bowels if required. Wash your hands thoroughly before and after use. Lie down on your left side and raise your right knee to the chest. Remove the wrapper and insert the pointed end of the suppository into the rectum. If necessary, grease the suppository tip with petroleum jelly.Enema: Use it as advised by the doctor. Shake the bottle well and remove the protective shield from the tip. Lie down on your left side, raise your right knee to the chest, or kneel and lean forward so that the head and chest are resting comfortably. Insert the enema bottle into the rectum with the tip pointing towards the navel. Squeeze the bottle gently until it is empty. Remove the bottle from the rectum and wash your hands thoroughly.Rectal foam: Pentasa 1 gm Suppository should be used as directed by your doctor. It is exclusively intended for rectal usage. Before using, empty your bowels (if necessary) and wash your hands. Shake the bottle vigorously for at least 30 seconds. Remove the applicator's protective cap and hold the bottle by its top end. Lie on your left side, your left leg extended and your right leg bent. Insert the applicator (lubricant-coated) for easier entry into the rectum. Squeeze the bottle gently while holding it directed towards your navel. When the bottle is empty, remove the applicator from the rectum. Allow the drug to spread throughout the lower section of the large intestine for at least 30 minutes by remaining in this posture. Wash your hands (after usage) and wait till the next morning to empty your bowels. Your doctor will choose the appropriate amount and duration for you based on your age, body weight, and medical state.

Medicinal Benefits

Pentasa 1 gm Suppository contains Mesalazine, an anti-inflammatory drug used to treat ulcerative colitis, ulcerative proctitis and Crohn’s disease. It works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thereby helping reduce inflammation (redness and swelling) in the intestines and providing relief from symptoms such as stomach pain or bleeding. Also, Pentasa 1 gm Suppository may prevent further episodes of ulcerative colitis. It is especially useful when ulcerative colitis symptoms affect the rectum.

Storage

Store in a cool and dry place away from sunlight
Side effects of Pentasa 1 gm Suppository
  • Eating and drinking slowly can help swallow less air, which reduces burps.
  • Avoid consuming foods like gum and hard candy and drinking carbonated drinks as they release carbon dioxide gas in your body.
  • Prevent smoking as it can impact your whole body.
  • Seek medical help to treat gastric problems and heart burn that may lead to frequent burps.
  • Check your dentures because if they are loosely fit, excess air can be swallowed that causes burbs more frequently.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Get ample rest; this helps your stomach to settle.
  • Eat soft and easy-to-digest foods like white rice, bananas, crackers and apple sauce.
  • Include probiotics-rich food like yoghurt, kefir, or miso, as they help maintain gut functioning.
  • Wash your hands properly before preparing/eating food and after using the toilet.
  • Drink water, broth or diluted fruit juice to replace electrolytes and lost fluids.
  • Avoid caffeine, alcohol, high-fat, fried and fast foods, as well as sweetened beverages.

Drug Warnings

Please tell your doctor if you are allergic to Mesalazine, aspirin, or sulfasalazine. Pentasa 1 gm Suppository should be used with caution in the elderly. If you are pregnant or breastfeeding, please inform your doctor before using the Pentasa 1 gm Suppository. Avoid taking Pentasa 1 gm Suppository if you have severe kidney failure. Avoid taking Pentasa 1 gm Suppository if you have had blood abnormalities or kidney problems while taking other medicines such as Sulphasalazine. Use Pentasa 1 gm Suppository in dose and duration as advised by a doctor only. Do not swallow Pentasa 1 gm Suppository. In case of accidental swallowing, drink plenty of water and consult a doctor immediately.

Drug-Drug Interactions

verifiedApollotooltip
MesalazineCidofovir
Critical
MesalazineIomeprol
Severe

Drug-Drug Interactions

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MesalazineCidofovir
Critical
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Pentasa 1 gm Suppository with Cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Pentasa 1 gm Suppository with Cidofovir is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience increased or decreased urination, sudden weight gain or loss, shortness of breath, consult a doctor. Do not discontinue any medications without consulting a doctor.
MesalazineIomeprol
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Iomeprol with Pentasa 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Pentasa 1 gm Suppository and Iomeprol they can be taken together if your doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineTenofovir alafenamide
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Tenofovir alafenamide with Pentasa 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
There is a possibility of interaction between Pentasa 1 gm Suppository with Tenofovir alafenamide, but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience increased or decreased urination, swelling, shortness of breath, bone pain, cramping in the muscles. Do not discontinue the medication without consulting a doctor.
MesalazineMetrizamide
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Metrizamide with Pentasa 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Pentasa 1 gm Suppository with Metrizamide they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, dry, itchy skin, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineOmeprazole
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of omeprazole with Pentasa 1 gm Suppository can decrease the effects of Pentasa 1 gm Suppository.

How to manage the interaction:
There could be a possible interaction between Pentasa 1 gm Suppository and omeprazole, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineNizatidine
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Nizatidine with Pentasa 1 gm Suppository can decrease the level or effect of Mesalamine by increasing gastric pH.

How to manage the interaction:
Although there may be a possible interaction between Pentasa 1 gm Suppository with Nizatidine, they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineDeferasirox
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Deferasirox with Pentasa 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possibility of interaction between Pentasa 1 gm Suppository and Deferasirox but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as increased or decreased urination, abrupt weight gain or loss, weakness, or dizziness. Do not discontinue the medication without consulting a doctor.
MesalazineRanitidine
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Ranitidine with Pentasa 1 gm Suppository can decrease the levels of Pentasa 1 gm Suppository, which may be less effective in treating a condition.

How to manage the interaction:
There may be a possible interaction between Pentasa 1 gm Suppository with Ranitidine, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineIodamide
Severe
How does the drug interact with Pentasa 1 gm Suppository:
Co-administration of Iodamide with Pentasa 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesalamine with Iodamine they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, itchy skin, shortness of breath, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley and berries, which help in healing faster.
  • Opt for food and drinks high in Omega 3 fatty acids to get relief from pain, swelling, and inflammation. Omega 3 fatty acid-enriched foods include flaxseeds, walnut, soybean oil, salmon, and tuna if you prefer non-veg.
  • Eat more fibre-rich foods such as fruits and vegetables.
  • Eat smaller meals all day.
  • Drink small amounts of water throughout the day.
  • If you are intolerant to lactose, lower your intake of milk.
  • Avoid intake of foods high in sugar and fat and processed foods, as these may cause inflammation.
  • Try to avoid alcohol as it can affect your stomach and intestine and also limits the absorption of the important nutrients required by your body.

Habit Forming

No

Therapeutic Class

ANTI- INFLAMMATORY AGENTS

Pentasa 1 gm Suppository Substitute

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:34 AM IST

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Pentasa 1 gm Suppository contains Mesalazine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (swelling) in the intestines and relieves symptoms such as stomach pain or bleeding.

Pentasa 1 gm Suppository may cause diarrhoea as a common side effect. However, if the condition persists or worsens with fever, watery stools or consistent stomach pain, please consult a doctor. Also, drink plenty of water while using Pentasa 1 gm Suppository to prevent dehydration.

You are not recommended to take Pentasa 1 gm Suppository with aspirin as co-administration of these two medicines may increase the risk of kidney problems. However, please consult your doctor before taking Pentasa 1 gm Suppository with other medicines.

No, you are not recommended to stop using Pentasa 1 gm Suppository suddenly as it may cause recurring symptoms. Therefore, use Pentasa 1 gm Suppository for as long as your doctor has prescribed it and if you experience any difficulty while using Pentasa 1 gm Suppository, please consult your doctor.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • IBUPROFEN
  • AZATHIOPRINE

Disease/Condition Glossary

Ulcerative colitis: It is a type of chronic inflammatory bowel disease that causes inflammation of the lining of the large intestine (colon) and produces ulcers on the lining of the colon, which may cause bleeding and discharge of pus and mucus. The common symptoms include bloody stools, stomach pain, rectal pain, diarrhoea, fever or weight loss. Additionally, it may cause other problems such as joint pain or swelling, mouth sores, skin problems, decreased appetite or nausea. The factors involved in causing ulcerative colitis include immune disorders and environmental factors like viruses, bacteria or antigens, which may trigger the immune system and genes inherited from the parent. 

Ulcerative proctitis: It is a condition in which ulcerative colitis solely affects the rear channel (rectum). 

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