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MESALAZINE

About

MESALAZINE belongs to a class of anti-inflammatory drugs used to treat ulcerative colitis. Ulcerative colitis is a chronic inflammatory bowel disease that causes inflammation of the large intestine lining (colon). It produces ulcers on the colon's lining, which may cause bleeding and discharge of pus and mucus. Ulcerative proctitis is a condition in which ulcerative colitis solely affects the rear channel (rectum). MESALAZINE used for the treatment of ulcerative proctitis and is exclusively designed for rectal usage.

MESALAZINE contains Mesalazine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (redness and swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding.

Use MESALAZINE as directed by your physician. Sometimes, you may experience diarrhoea, stomach pain, headache or nausea. Most of these side effects of MESALAZINE do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic to Mesalazine, aspirin,  or other medicines. MESALAZINE should be used with caution in the elderly. If pregnant or breastfeeding, please inform your doctor before using the MESALAZINE. Avoid taking MESALAZINE if you have severe kidney failure. Avoid taking MESALAZINE if you have blood abnormalities or kidney problems caused by other medicines such as Sulphasalazine.

Uses of MESALAZINE

Ulcerative colitis, Ulcerative proctitis

Medicinal Benefits

MESALAZINE contains Mesalazine, an anti-inflammatory drug used to treat ulcerative colitis, ulcerative proctitis and Crohn’s disease. It works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thereby helping reduce inflammation (redness and swelling) in the intestines and providing relief from symptoms such as stomach pain or bleeding. Also, MESALAZINE may prevent further episodes of ulcerative colitis. It is especially useful when ulcerative colitis symptoms affect the rectum.

Directions for Use

Suppository: Empty your bowels if required. Wash your hands thoroughly before and after use. Lie down on your left side and raise your right knee to the chest. Remove the wrapper and insert the pointed end of the suppository into the rectum. If necessary, grease the suppository tip with petroleum jelly. Enema: Use it as advised by the doctor. Shake the bottle well and remove the protective shield from the tip. Lie down on your left side, raise your right knee to the chest, or kneel and lean forward so that the head and chest are resting comfortably. Insert the enema bottle into the rectum with the tip pointing towards the navel. Squeeze the bottle gently until it is empty. Remove the bottle from the rectum and wash your hands thoroughly. Rectal foam: MESALAZINE should be used as directed by your doctor. It is exclusively intended for rectal usage. Before using, empty your bowels (if necessary) and wash your hands. Shake the bottle vigorously for at least 30 seconds. Remove the applicator's protective cap and hold the bottle by its top end. Lie on your left side, your left leg extended and your right leg bent. Insert the applicator (lubricant-coated) for easier entry into the rectum. Squeeze the bottle gently while holding it directed towards your navel. When the bottle is empty, remove the applicator from the rectum. Allow the drug to spread throughout the lower section of the large intestine for at least 30 minutes by remaining in this posture. Wash your hands (after usage) and wait till the next morning to empty your bowels. Your doctor will choose the appropriate amount and duration for you based on your age, body weight, and medical state.

Storage

Store in a cool and dry place away from sunlight

Side Effects of MESALAZINE

  • Diarrhoea
  • Stomach pain
  • Headache
  • Nausea

In-Depth Precautions and Warning

Drug Warnings

Please tell your doctor if you are allergic to Mesalazine, aspirin, or sulfasalazine. MESALAZINE should be used with caution in the elderly. If you are pregnant or breastfeeding, please inform your doctor before using the MESALAZINE. Avoid taking MESALAZINE if you have severe kidney failure. Avoid taking MESALAZINE if you have had blood abnormalities or kidney problems while taking other medicines such as Sulphasalazine. Use MESALAZINE in dose and duration as advised by a doctor only. Do not swallow MESALAZINE. In case of accidental swallowing, drink plenty of water and consult a doctor immediately.

Drug Interactions

Drug-Drug Interactions: Inform your doctor if you are taking non-steroidal anti-inflammatory drugs (aspirin, ibuprofen), immunosuppressants (azathioprine) or other medicines.

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: If you have kidney impairment, please inform your doctor before using the MESALAZINE.

Drug-Drug Interactions Checker List:

  • ASPIRIN
  • IBUPROFEN
  • AZATHIOPRINE
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      The interaction of alcohol with MESALAZINE is unknown. However, avoid consuming alcohol while on treatment with this medicine.

    • Safety Warning

      Pregnancy

      consult your doctor

      MESALAZINE should not be used in pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing MESALAZINE.

    • Safety Warning

      Breast Feeding

      consult your doctor

      MESALAZINE should not be used while breastfeeding unless necessary. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing MESALAZINE.

    • Safety Warning

      Driving

      not applicable

      MESALAZINE usually does not affect your ability to drive or operate machinery.

    • Safety Warning

      Liver

      consult your doctor

      Limited information is available on the use of MESALAZINE in patients with liver disease. Inform your doctor before receiving the MESALAZINE if you have a history of liver diseases/conditions. If necessary, your doctor may prescribe a suitable alternative based on your condition.

    • Safety Warning

      Kidney

      caution

      Inform your doctor before receiving the MESALAZINE if you have a history of Kidney diseases/conditions. MESALAZINE should be used with extreme caution in patients with mild to moderate kidney impairment. It is recommended for use in patients with severe kidney impairment.

    • Safety Warning

      Children

      caution

      MESALAZINE is for adult use only and is not recommended for children.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley and berries, which help in healing faster.
    • Opt for food and drinks high in Omega 3 fatty acids to get relief from pain, swelling, and inflammation. Omega 3 fatty acid-enriched foods include flaxseeds, walnut, soybean oil, salmon, and tuna if you prefer non-veg.
    • Eat more fibre-rich foods such as fruits and vegetables.
    • Eat smaller meals all day.
    • Drink small amounts of water throughout the day.
    • If you are intolerant to lactose, lower your intake of milk.
    • Avoid intake of foods high in sugar and fat and processed foods, as these may cause inflammation.
    • Try to avoid alcohol as it can affect your stomach and intestine and also limits the absorption of the important nutrients required by your body.

    Patients Concern

    Disease/Condition Glossary

    Ulcerative colitis: It is a type of chronic inflammatory bowel disease that causes inflammation of the lining of the large intestine (colon) and produces ulcers on the lining of the colon, which may cause bleeding and discharge of pus and mucus. The common symptoms include bloody stools, stomach pain, rectal pain, diarrhoea, fever or weight loss. Additionally, it may cause other problems such as joint pain or swelling, mouth sores, skin problems, decreased appetite or nausea. The factors involved in causing ulcerative colitis include immune disorders and environmental factors like viruses, bacteria or antigens, which may trigger the immune system and genes inherited from the parent. 

    Ulcerative proctitis: It is a condition in which ulcerative colitis solely affects the rear channel (rectum). 

    FAQs

    MESALAZINE contains Mesalazine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (swelling) in the intestines and relieves symptoms such as stomach pain or bleeding.

    MESALAZINE may cause diarrhoea as a common side effect. However, if the condition persists or worsens with fever, watery stools or consistent stomach pain, please consult a doctor. Also, drink plenty of water while using MESALAZINE to prevent dehydration.

    You are not recommended to take MESALAZINE with aspirin as co-administration of these two medicines may increase the risk of kidney problems. However, please consult your doctor before taking MESALAZINE with other medicines.

    No, you are not recommended to stop using MESALAZINE suddenly as it may cause recurring symptoms. Therefore, use MESALAZINE for as long as your doctor has prescribed it and if you experience any difficulty while using MESALAZINE, please consult your doctor.

    Available Medicines for

    MESALAZINE

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