Periclin 600 Injection 4 ml

Written By Divya L , PharmaD

Reviewed By Veda Maddala , M Pharmacy

Prescription drug

MRP ₹370

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Whats That

About Periclin 600 Injection 4 ml

Periclin 600 Injection 4 ml belongs to the class of 'antibiotics', primarily used to treat serious bacterial infections such as lower respiratory tract infections like pneumonia, empyema, and lung abscess; gynaecological infections like endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and postsurgical vaginal cuff infection; intra-abdominal infections; septicaemia or sepsis (blood poisoning by bacteria), and bone and joint infections. Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly.

Periclin 600 Injection 4 ml contains 'Clindamycin' that works by preventing bacterial protein synthesis, leading to the inhibition of bacterial growth. It shows a bacteriostatic effect that stops bacterial reproduction. Periclin 600 Injection 4 ml effectively treats infections caused by gram-positive and anaerobic (living without air) bacteria, including susceptible strains of Staphylococcus aureus, Streptococcus pneumoniae, and Clostridium perfringens.

Periclin 600 Injection 4 ml will be administered by a healthcare professional. Periclin 600 Injection 4 ml may cause side effects, although not everybody gets them. Common side effects of Periclin 600 Injection 4 ml include stomach pain, nausea, vomiting, diarrhoea, heartburn, skin rash, pain and swelling at the injection site, and vaginal itching or discharge. Most of these side effects do not require medical attention and gradually resolve over time. If these side effects persist longer, please consult your doctor.

Brief your medical history to the doctor if you are allergic to any of the components in Periclin 600 Injection 4 ml. Let your doctor know if you have any liver disease, kidney disease, yellow food dye allergy, colitis (colon inflammation), severe stomach cramps, diarrhoea, and allergic conditions (asthma, hay fever, eczema). Do not use Periclin 600 Injection 4 ml while getting vaccinated with live bacterial vaccines (typhoid vaccine) since Periclin 600 Injection 4 ml may affect the vaccine's activity. Periclin 600 Injection 4 ml should be used only with a doctor's advice during pregnancy and breastfeeding.

Uses of Periclin 600 Injection 4 ml

Bacterial infections.

Directions for Use

Periclin 600 Injection 4 ml will be injected by a healthcare professional. Do not self-administer.

Medicinal Benefits

Periclin 600 Injection 4 ml is an antibiotic that treats severe/serious bacterial infections. It works by inhibiting bacterial protein synthesis, which inhibits bacterial growth. It shows a bacteriostatic effect, which stops bacterial reproduction but doesn't kill them. Periclin 600 Injection 4 ml effectively treats infections caused by gram-positive and anaerobic (living without air) bacteria, including susceptible strains of Staphylococcus aureus, Streptococcus pneumoniae, and Clostridium perfringens. Periclin 600 Injection 4 ml is useful in treating lower respiratory tract infections like pneumonia, empyema, and lung abscess; gynaecological infections like endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and postsurgical vaginal cuff infection; intra-abdominal infections; septicaemia or sepsis (blood poisoning by bacteria), and bone and joint infections.

Storage

Keep out of sight and reach of children.

Side effects of Periclin 600 Injection 4 ml

Flat Or Raised Red Bump On Skin

Take cold water baths avoiding soap.
Avoid scratching and scrubbing to prevent infections while itching.
Use nets to prevent insects and mosquitoes.
Stop using lotions and creams that cause irritation.
Avoid alcohol and caffeine intake.

Inflammation Of A Vein Due To Iv

Abnormal liver function test

Abnormal liver function requires immediate medical attention. Your doctor may recommend lifestyle modifications along with needed medication.
Avoid intake of alcohol as it has a direct impact on liver functioning.
Prevent medications like paracetamol, over-the-counter painkillers or those mentioned by your doctor, as they may have issues getting metabolised in your body.
If you have overweight issues, losing weight can be a good thing to manage abnormal liver function.
Cut down the number of fatty foods that are taken daily.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Stomach Pain

Drink water or other clear fluids.
To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
Include bland foods like rice, toast, crackers, and rice in your diet.
Avoid lying down immediately after eating as it may cause indigestion or heartburn.
Avoid acidic and spicy food as it may cause indigestion.

Low Blood Pressure

Managing Low Blood Pressure Triggered by Medication: Expert Advice:

If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
Take regular breaks to sit or lie down if you need to stand for long periods.
When lying down, elevate your head with extra pillows to help improve blood flow.
Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

Drug Warnings

Do not use Periclin 600 Injection 4 ml if you are allergic to any of its components. Let your doctor know if you have any liver or kidney diseases, gastrointestinal diseases (colitis, Clostridium difficile-associated diarrhoea), yellow food dye allergy, and allergic conditions (asthma, hay fever, eczema). Do not use Periclin 600 Injection 4 ml while getting vaccinated with live bacterial vaccines (typhoid vaccine) since Periclin 600 Injection 4 ml may affect the vaccine's activity. Pregnant and breastfeeding women should consult their doctor before taking Periclin 600 Injection 4 ml. Avoid alcohol consumption to prevent any undesired effects while using Periclin 600 Injection 4 ml.

Drug-Drug Interactions

ClindamycinItraconazole

Severe

ClindamycinFosphenytoin

Severe

Drug-Drug Interactions

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ClindamycinItraconazole

Severe

How does the drug interact with Periclin 600 Injection 4 ml:
Concomitant use of Periclin 600 Injection 4 ml with itraconazole can reduce the metabolism and increase the levels of Periclin 600 Injection 4 ml in the body. This may increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction, Periclin 600 Injection 4 ml can be taken with itraconazole if prescribed by the doctor. Consult a doctor immediately if you experience persistent vomiting, nausea, abdominal pain, or diarrhea. Do not stop using any medications without first talking to your doctor.

ClindamycinFosphenytoin

Severe

How does the drug interact with Periclin 600 Injection 4 ml:
When Periclin 600 Injection 4 ml is taken with Fosphenytoin, it can cause the body to process Periclin 600 Injection 4 ml faster.

How to manage the interaction:
Although there is a possible interaction between Periclin 600 Injection 4 ml and Fosphenytoin, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like sudden drowsiness, fatigue, confusion, itching, burning, or tingling sensation, abnormal body movements, or loss of coordination, make sure to contact your doctor right away. Do not stop using any medications without first talking to your doctor.

ClindamycinBacitracin

Severe

How does the drug interact with Periclin 600 Injection 4 ml:
Co-administration of Periclin 600 Injection 4 ml with Bacitracin may increase the risk of kidney and/or nerve damage.

How to manage the interaction:
Although there is a possible interaction, Periclin 600 Injection 4 ml can be taken with bacitracin if prescribed by the doctor. Consult the prescriber if you experience signs and symptoms of kidney damage such as sudden weight gain or weight loss, nausea, vomiting, fluid retention, loss of appetite, increased or decreased urination, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Let your doctor know if you develop seizures; hearing problems; or numbness, burning or tingling in your hands and feet. If you develop diarrhoea or vomiting during treatment with these medications, drink plenty of fluids to prevent dehydration, as dehydration may harm the kidney.

ClindamycinAmprenavir

Severe

How does the drug interact with Periclin 600 Injection 4 ml:
Co-administration of Amprenavir together with Periclin 600 Injection 4 ml can increase the effects of Periclin 600 Injection 4 ml.

How to manage the interaction:
Co-administration of Periclin 600 Injection 4 ml with Amprenavir can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have ongoing feelings of sickness, throwing up, having loose stools, or pain in your stomach, it's important to contact your doctor right away. Do not stop using any medications without talking to a doctor.

ClindamycinAtracurium

Severe

How does the drug interact with Periclin 600 Injection 4 ml:
Co-administration of Periclin 600 Injection 4 ml with Atracurium can increase the risk of muscle weakness.

How to manage the interaction:
Taking Periclin 600 Injection 4 ml with Atracurium together can possibly result in an interaction, but it can be taken if a doctor has advised it. "Periclin 600 Injection 4 ml can affect the muscles and nerves in your body. When used with other medications that also affect the muscles and nerves, it can cause a serious problem called neuromuscular blockade. If you have trouble breathing or can't breathe at all, please call your doctor right away." Do not stop using any medications without a doctor's advice.

ClindamycinBoceprevir

Severe

How does the drug interact with Periclin 600 Injection 4 ml:
Co-administration of Boceprevir together with Periclin 600 Injection 4 ml can increase the effects of Periclin 600 Injection 4 ml.

How to manage the interaction:
Although there is a possible interaction between Periclin 600 Injection 4 ml and Boceprevir, you can take these medicines together if prescribed by your doctor. If you have ongoing feelings of sickness, throwing up, having loose stools, or pain in your stomach, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.

ClindamycinIndinavir

Severe

How does the drug interact with Periclin 600 Injection 4 ml:
Concomitant use of Periclin 600 Injection 4 ml with indinavir may increase the effects of Periclin 600 Injection 4 ml.

How to manage the interaction:
Although there is a possible interaction, Periclin 600 Injection 4 ml can be taken with indinavir if prescribed by the doctor. Consult the prescriber if you experience persistent vomiting, nausea, abdominal pain, or diarrhoea.

ClindamycinCarbamazepine

Severe

How does the drug interact with Periclin 600 Injection 4 ml:
Co-administration of Carbamazepine and Periclin 600 Injection 4 ml together may result in reduced blood levels of Periclin 600 Injection 4 ml, which could make it less effective in treating your disease.

How to manage the interaction:
Although taking carbamazepine and Periclin 600 Injection 4 ml together can possibly result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like fever, it is advised to consult a doctor. Without consulting a doctor, never stop taking any medications.

ClindamycinBotulinum toxin

Severe

How does the drug interact with Periclin 600 Injection 4 ml:
Taking Periclin 600 Injection 4 ml with Botulinum toxin can increase the risk or severity of side effects.

How to manage the interaction:
Taking Periclin 600 Injection 4 ml with Botulinum toxin together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

ClindamycinCeritinib

Severe

How does the drug interact with Periclin 600 Injection 4 ml:
Concomitant use of Periclin 600 Injection 4 ml with ceritinib can increase the effects of Periclin 600 Injection 4 ml

How to manage the interaction:
Although there is a possible interaction, Periclin 600 Injection 4 ml can be taken with ceritinib if prescribed by the doctor. Consult the prescriber if you experience persistent vomiting, nausea, abdominal pain, or diarrhoea.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Wash your hands often to maintain cleanliness.
Avoid sharing personal items like shaving razors.
Include whole-grain foods like multigrain bread and brown rice in your diet.
Taking probiotics after an antibiotic treatment reduces the risk of antibiotic-associated diarrhoea.
Try taking yoghurt, cheese, sauerkraut, and kimchi that help restore the intestine's good bacteria.
Include more fibre-enriched food in your diet that is easily digested by your gut bacteria. Fibre foods may also help restore healthy gut bacteria after a course of antibiotics.
Avoid intake of alcoholic beverages as it may cause dehydration and affect your sleep.
Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.

Side Effects of Periclin 600 Injection 4 ml

Pain and swelling at the injection site
Stomach pain
Nausea
Vomiting
Diarrhoea
Heartburn
Skin rash
Vaginal itching or discharge

Habit Forming

No

Therapeutic Class

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Author Details

Written By

Divya L

PharmaD

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Jul 8, 2025 | 9:45 AM IST

We provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

CLINDAMYCIN-150MGOther bacterial intestinal infections

Severe

CLINDAMYCIN-150MGDisorders related to short gestation and low birth weight, not elsewhere classified

Severe

Drug-Diseases Interactions

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CLINDAMYCIN-150MGOther bacterial intestinal infections

Severe

How does the disease interact with Periclin 600 Injection 4 ml:
Almost all antibacterial medications have been associated with reports of Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis. It can vary from mild diarrhoea to deadly colitis.

How to manage the interaction:
Clostridioides difficile-associated diarrhea (CDAD) ranging from mild diarrhoea to colitis has been reported during treatment with antibacterial agents. Therapy should be administered cautiously in patients with history of gastrointestinal disease, particularly colitis and pseudomembranous colitis. Appropriate fluid and electrolyte management, protein supplementation, and antibacterial treatment of C difficile is advised.

CLINDAMYCIN-150MGDisorders related to short gestation and low birth weight, not elsewhere classified

Severe

How does the disease interact with Periclin 600 Injection 4 ml:
Benzyl alcohol is frequently used as a preservative in the formulation of multidose vials for parenteral medicines. Manufacturers of pharmaceuticals believe that using them in neonates, especially preterm and underweight newborns, is contraindicated. In low birth weight preterm newborns, the use of benzyl alcohol in bacteriostatic saline intravascular flush and endotracheal tube lavage solutions has been linked to mortality and serious respiratory and metabolic problems.

How to manage the interaction:
Parenteral medications containing benzyl alcohol as a preservative are contraindicated in neonates, particularly premature infants and infants of low birth weight.

CLINDAMYCIN-150MGOther diseases of liver

Moderate

How does the disease interact with Periclin 600 Injection 4 ml:
The liver is the primary site of Periclin 600 Injection 4 ml metabolism. Patients with significantly impaired hepatic function may have a rise in the blood concentration of Periclin 600 Injection 4 ml and a prolongation of the half-life. Additionally, the drug's usage may result in abnormal liver enzyme levels and jaundice. Patients with liver problems should receive Periclin 600 Injection 4 ml therapy with caution. When given every 8 hours, dosage modifications might not be required. However, with high-dose therapy, serum concentrations should be observed, and during prolonged therapy, regular liver function tests should be carried out.

How to manage the interaction:
Periclin 600 Injection 4 ml is primarily metabolized by the liver. Therapy with Periclin 600 Injection 4 ml should be administered cautiously in patients with liver disease. Serum concentrations should be monitored during high-dose therapy, and periodic liver function tests should be performed during prolonged therapy.

CLINDAMYCIN-150MGOther disorders of kidney and ureter, not elsewhere classified

Moderate

How does the disease interact with Periclin 600 Injection 4 ml:
Periclin 600 Injection 4 ml is partially removed by the kidney. Periclin 600 Injection 4 ml should be used with caution in individuals with significantly impaired renal function. Dosage changes are probably to be required. Serum Periclin 600 Injection 4 ml concentrations should be monitored throughout high-dose therapy, and renal function tests should be conducted on a regular basis during extended medication.

How to manage the interaction:
Therapy with Periclin 600 Injection 4 ml should be administered cautiously in patients with severely impaired renal function. Serum Periclin 600 Injection 4 ml concentrations should be monitored during high-dose therapy, and periodic renal function tests should be performed during prolonged therapy.

CLINDAMYCIN-150MGOther disorders of kidney and ureter, not elsewhere classified

Moderate

How does the disease interact with Periclin 600 Injection 4 ml:
Periclin 600 Injection 4 ml is partially removed by the kidney. Periclin 600 Injection 4 ml should be used with caution in individuals with significantly impaired renal function. Dosage changes are probably to be required. Serum Periclin 600 Injection 4 ml concentrations should be monitored throughout high-dose therapy, and renal function tests should be conducted on a regular basis during extended medication.

How to manage the interaction:
Therapy with Periclin 600 Injection 4 ml should be administered cautiously in patients with severely impaired renal function. Serum Periclin 600 Injection 4 ml concentrations should be monitored during high-dose therapy, and periodic renal function tests should be performed during prolonged therapy.

FAQs

How does Periclin 600 Injection 4 ml work?

Periclin 600 Injection 4 ml is an antibiotic that treats bacterial infections. It works by inhibiting bacterial protein synthesis, which retards bacterial growth.

In which conditions should I stay cautious while using Periclin 600 Injection 4 ml?

Periclin 600 Injection 4 ml should be used with proper caution and doctor consultation if you have any liver disease, kidney disease, gastrointestinal diseases (colitis, severe stomach cramps, diarrhoea), yellow food dye allergy, and allergic conditions (asthma, hay fever, eczema).

I am undergoing vaccination for typhoid this week. Can I use Periclin 600 Injection 4 ml?

Periclin 600 Injection 4 ml can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor before you start Periclin 600 Injection 4 ml if you are undergoing any vaccinations.

Does Periclin 600 Injection 4 ml cause abnormal liver function tests?

Periclin 600 Injection 4 ml may cause abnormal liver function tests as one of its side effects. Please ask your doctor before starting Periclin 600 Injection 4 ml if you have any history of liver problems.

Does Periclin 600 Injection 4 ml cause diarrhoea?

Diarrhoea can be a side-effect of Periclin 600 Injection 4 ml. Clostridium difficile-associated diarrhoea (CDAD) is also reported during usage of antibiotics like Periclin 600 Injection 4 ml. Therefore, if you experience diarrhoea, you are advised to undergo an examination to rule out the chances of CDAD following Periclin 600 Injection 4 ml therapy.

Drug-Drug Interactions Checker List

ERYTHROMYCIN
RIFAMPIN
ATRACURIUM
VECURONIUM

Special Advise

Liver and kidney function monitoring (Liver and kidney function tests) are recommended in patients with severe liver and kidney diseases.
Clostridium difficile-associated diarrhoea (CDAD) is reported during the usage of antibiotics. Please consult your doctor if you experience prolonged diarrhoea.

Disease/Condition Glossary

Bacterial infection: It occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly. Bacteria may be gram-positive (have a thick cell wall) or gram-negative (do not have a cell wall). Some common symptoms of a bacterial infection include cough, fever, shortness of breath, chills, muscle pain, fatigue, and tiredness. Untreated bacterial infections may lead to serious life-threatening conditions like sepsis.