Perinorm Injection 2 ml

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

MRP ₹5.5

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Whats That

About Perinorm Injection 2 ml

Perinorm Injection 2 ml belongs to a group of medicines called anti-emetics and prokinetic agents used to prevent nausea and vomiting caused by chemotherapy, radiotherapy, migraine, and in post-operative conditions. Additionally, Perinorm Injection 2 ml is also used to treat delayed gastric emptying. Perinorm Injection 2 ml may be used to facilitate small bowel intubation and to stimulate gastric emptying and intestinal transit of barium.

Perinorm Injection 2 ml contains ‘metoclopramide’ that works by increasing the motility of the upper gastrointestinal tract; this allows faster transit of food and treats gastric emptying. It also works on the part of the brain that controls vomiting, thereby helps in preventing nausea and vomiting.

In some cases, Perinorm Injection 2 ml may cause common side-effects such as drowsiness, fatigue, dizziness, headache, and bowel disturbances. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.

Consult your doctor if you are pregnant or breastfeeding. Perinorm Injection 2 ml may cause drowsiness and dizziness affecting your ability to drive and operate machinery. Perinorm Injection 2 ml is not recommended for children below one year. Avoid consuming alcohol while on treatment with Perinorm Injection 2 ml as it could lead to increased drowsiness. Treatment with Perinorm Injection 2 ml is not recommended for longer than 12 weeks, except in rare cases.

Uses of Perinorm Injection 2 ml

Nausea, vomiting, delayed gastric emptying

Directions for Use

Perinorm Injection 2 ml will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Perinorm Injection 2 ml belongs to a group of medicines called anti-emetics and prokinetic agents used to prevent nausea and vomiting caused by chemotherapy, radiotherapy, migraine, and in post-operative conditions. Additionally, Perinorm Injection 2 ml is also used to treat delayed gastric emptying. Perinorm Injection 2 ml may be used to facilitate small bowel intubation and to facilitate gastric emptying and intestinal transit of barium in patients where delayed emptying interrupts radiological examination of the stomach and/or small intestine. Perinorm Injection 2 ml contains ‘metoclopramide’ that works by increasing the motility of the upper gastrointestinal tract; this allows faster transit of food and treats gastric emptying. It also works on the part of the brain that controls vomiting, thereby helps in preventing nausea and vomiting.

Storage

Keep Perinorm Injection 2 ml out of the sight and reach of children.

Side effects of Perinorm Injection 2 ml

Extrapyramidal syndromes (Movement Disorders)

Stretching and walking are examples of mild exercises that can improve mobility and reduce muscle stiffness.
Improving posture, mobility, and muscle coordination through physical therapy can help manage slowness or stiffness.
Maintain healthy weight and advance general health depend on eating a balanced diet.
Reducing symptoms like tremors or muscle spasms requires adequate sleep and rest.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Restlessness

Restlessness is related to mental health and needs medical attention if it's severe.
Regular practice of meditation and yoga can help calm your mind. This can reduce restlessness.
Prevent smoking as it can impact your calmness of body and mind.
Talk to your friends and family about restlessness, who can provide a solution for why you feel restless.
Get sufficient sleep for a minimum of 6-7 hours to reduce restlessness.

Sedation

Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Dizziness

Here are the 7 steps to manage Dizziness caused by medication:

Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
When standing up, do so slowly and carefully to avoid sudden dizziness.
Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Drowsiness

Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.

Drug Warnings

Do not take Perinorm Injection 2 ml if you are allergic to any of its components; if you have gastrointestinal bleeding, mechanical obstruction/perforation, pheochromocytoma (tumour in the adrenal glands), or epilepsy. Perinorm Injection 2 ml may cause neuroleptic malignant syndrome (a nervous disorder with high fever and muscle stiffness), extrapyramidal symptoms (shaking, tremor, stiffness and involuntary movement), Tardive dyskinesia (movement disorder), Parkinson-like symptoms (bradykinesia, tremor, cogwheel rigidity, or mask-like facies), and depression. Inform your doctor if you have heart problems, diabetes, depression, high blood pressure, breast cancer, seizures, Parkinson’s disease, methaemoglobinaemia, or liver or kidney problems. Consult your doctor immediately if you cannot stop or control movements like shaking your arms and legs, blinking and moving your eyes, sticking out the tongue, frowning, lip-smacking, chewing, or puckering up the mouth.

Drug-Drug Interactions

MetoclopramideParoxetine

Critical

MetoclopramideTrazodone

Critical

Drug-Drug Interactions

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MetoclopramideParoxetine

Critical

How does the drug interact with Perinorm Injection 2 ml:
Using Perinorm Injection 2 ml with Paroxetine can cause serotonin syndrome. Serotonin syndrome is a condition in which a chemical called serotonin builds up in your body, causing signs and symptoms ranging from mild (shivering and diarrhoea) to severe (muscle rigidity, fever, and seizures).

How to manage the interaction:
Taking Perinorm Injection 2 ml with Paroxetine is not recommended, as it can possibly lead to an interaction, it can be taken if prescribed by your doctor. Do not stop using any medications without a doctor’s advice.

MetoclopramideTrazodone

Critical

How does the drug interact with Perinorm Injection 2 ml:
Coadministration of Perinorm Injection 2 ml with Trazodone can rarely increase serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Perinorm Injection 2 ml with Trazodone is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience any symptoms like dizziness, fever, excessive sweating, shivering, blurred vision, muscle stiffness, stomach cramps, nausea, vomiting, or diarrhoea contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

MetoclopramideTrifluoperazine

Critical

How does the drug interact with Perinorm Injection 2 ml:
Co-administration of Perinorm Injection 2 ml with Trifluoperazine can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Perinorm Injection 2 ml with Trifluoperazine is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping., contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

MetoclopramideFluvoxamine

Critical

How does the drug interact with Perinorm Injection 2 ml:
Coadministration of Fluvoxamine with Perinorm Injection 2 ml increases the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Fluvoxamine with Perinorm Injection 2 ml is not recommended, as it can lead to an interaction, it can be taken if prescribed by your doctor. Do not stop using any medications without a doctor’s advice.

MetoclopramidePimozide

Critical

How does the drug interact with Perinorm Injection 2 ml:
Coadministration of Perinorm Injection 2 ml with Pimozide can increase the risk of negative side effects.

How to manage the interaction:
Taking Pimozide with Perinorm Injection 2 ml is not recommended, as it can possibly lead to an interaction, but it can be taken if prescribed by the doctor. However, if you experience muscle pain or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping, consult a doctor. Do not stop using any medications without a doctor’s advice.

MetoclopramideNefazodone

Critical

How does the drug interact with Perinorm Injection 2 ml:
Coadministration of Perinorm Injection 2 ml with Nefazodone can cause serotonin syndrome. Serotonin syndrome is a condition in which a chemical called serotonin builds up in your body, causing signs and symptoms ranging from mild (shivering and diarrhoea) to severe (muscle rigidity, fever, and seizures).

How to manage the interaction:
Taking Perinorm Injection 2 ml with Nefazodone is generally avoided as it can possibly lead to an interaction, it can be taken if prescribed by your doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhoea, consult the doctor. Do not discontinue any medications without consulting a doctor.

MetoclopramideMethyldopa

Critical

How does the drug interact with Perinorm Injection 2 ml:
Taking Methyldopa and Perinorm Injection 2 ml together can decrease the levels and effects of Methyldopa.

How to manage the interaction:
Taking Perinorm Injection 2 ml with Methyldopa is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.

MetoclopramideVenlafaxine

Critical

How does the drug interact with Perinorm Injection 2 ml:
Coadministration of Perinorm Injection 2 ml with Venlafaxine might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Perinorm Injection 2 ml with Venlafaxine together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.

MetoclopramideCariprazine

Critical

How does the drug interact with Perinorm Injection 2 ml:
Co-administration of Perinorm Injection 2 ml with Cariprazine can increase the risk of side effects.

How to manage the interaction:
Taking Cariprazine with Perinorm Injection 2 ml is generally avoided, but can be taken together if prescribed by a doctor. However, if you experience muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, shaking of hands and legs, jitteriness, restlessness, pacing, and foot tapping, contact a doctor immediately. Do not stop using any medications without talking to a doctor.

MetoclopramideMaprotiline

Critical

How does the drug interact with Perinorm Injection 2 ml:
Co-administration of Perinorm Injection 2 ml with Maprotiline can increase the risk or severity of side effects.

How to manage the interaction:
Taking Maprotiline with Perinorm Injection 2 ml is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. Consult your doctor if you see symptoms like dizziness, drowsiness, confusion, difficulty concentrating, or impairment in thinking, judgment, and motor coordination. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Eat smaller meals more often.
Drink fluids to stay hydrated.
Avoid solid foods until vomiting stops.
Avoid foods that might cause stomach upset.
Take ample rest. Avoid any activity immediately after eating.
Consume plain, light foods such as bread and biscuits.
Avoid food with strong flavours and fried food.
Ginger tea might help in proper digestion.

Side Effects of Perinorm Injection 2 ml

Drowsiness
Fatigue
Dizziness
Headache
Bowel disturbances

Habit Forming

No

Therapeutic Class

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Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:46 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Perinorm Injection 2 ml work?

Perinorm Injection 2 ml works by increasing the motility of the upper gastrointestinal tract; this allows faster transit of food and treats gastric emptying. It also works on the part of the brain that controls vomiting, thereby helps in preventing nausea and vomiting.

Does Perinorm Injection 2 ml cause tardive dyskinesia?

Perinorm Injection 2 ml may cause tardive dyskinesia (movement disorder) that is often irreversible. The risk increases with the duration of treatment and dosage. Perinorm Injection 2 ml therapy should be discontinued in patients who develop the symptoms of tardive dyskinesia. Consult your doctor immediately if you notice symptoms such as involuntary movements of the face, tongue, mouth, jaw, trunk and/or extremities.

Is Perinorm Injection 2 ml indicated in small bowel intubation?

Perinorm Injection 2 ml may be used to facilitate small bowel intubation (the process of passing a small, flexible plastic tube through the nose/mouth into the stomach/small intestine) in adults and pediatric patients in whom the tube does not pass the pylorus (the opening from the stomach into the duodenum) with conventional manoeuvres.

Is Perinorm Injection 2 ml safe for long-term treatment?

Treatment with Perinorm Injection 2 ml should be avoided for longer than 12 weeks except in rare cases where benefits outweigh the risks of developing tardive dyskinesia.

Does Perinorm Injection 2 ml cause depression?

Perinorm Injection 2 ml may cause depression in people with or without a medical history of depression. Consult your doctor immediately if you have any suicidal thoughts, such as killing or harming yourself.

Is Perinorm Injection 2 ml indicated in the radiological examination?

Perinorm Injection 2 ml may be used to facilitate gastric emptying and intestinal transit of barium in patients where delayed emptying interrupts radiological examination of the stomach and/or small intestine.

Drug-Drug Interactions Checker List

LEVODOPA
DIGOXIN

Disease/Condition Glossary

Nausea/Vomiting: Nausea is an uneasy feeling in which the person feels an urge to vomit, whereas vomiting is an uncontrollable reflex that expels the contents of the stomach through the mouth. Nausea and vomiting may occur separately or together. The common causes include motion sickness, emotional stress, indigestion, food poisoning, high fever or overeating. Nausea/vomiting might also occur as an unpleasant effect of therapy, such as chemotherapy and radiation therapy.

Gastroparesis: Gastroparesis or delayed gastric emptying is a condition that occurs when the stomach takes too long to empty the food into the intestine. Symptoms include nausea, vomiting, indigestion, loss of appetite, bloating and heartburn.