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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Composition :

Consume Type :

Parenteral

Return Policy :

About Pfidex 8mg Injection

Pfidex 8mg Injection belongs to a class of drugs called corticosteroids (hormones). When your body does not produce enough Dexamethasone, Pfidex 8mg Injection is often utilized to replace it. It treats various medical conditions, including severe allergic conditions, collagen diseases, pulmonary disorders, blood disorders, rheumatic diseases, skin diseases, gastrointestinal disorders, oedema, eye disorders, neoplastic states and endocrine disorders. It is also used in preoperative and postoperative support. Furthermore, it is approved for the treatment of coronavirus disease 2019 (COVID-19) in adult and adolescent patients (aged 12 years and older with a body weight of at least 40 kg) who require supplemental oxygen therapy.

Pfidex 8mg Injection contains dexamethasone, a steroid with both anti-inflammatory and immunosuppressant activity. Anti-inflammatory activity relieves the symptoms of inflammatory conditions such as redness, swelling, and tenderness caused by various medical conditions. On the other side, immunosuppressant activity helps to calm your immune system. As a result, it can aid in autoimmune diseases such as rheumatoid arthritis, in which your immune system erroneously destroys your own tissues.

Pfidex 8mg Injection will be administered by a healthcare professional; do not self-administer. Some people may experience mood changes in personality, mental health problems, muscle weakness, increased appetite, irregular or absent menstrual periods, infections and infestations, impaired vision, difficulty falling asleep or staying asleep, heartburn, peptic ulcer, muscle weakness, nausea and injection site pain or redness as side effects of Pfidex 8mg Injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Let your doctor know before prescribing Pfidex 8mg Injection if you are allergic to any content of this medicine or sulphites. Inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before receiving this medicine. Before obtaining the Pfidex 8mg Injection, notify your doctor about your medical history and any other medications you are currently taking to rule out any potentially harmful effects.

Uses of Pfidex 8mg Injection

Allergic or inflammatory conditions, Covid-19.

Have a query?

Directions for Use

Pfidex 8mg Injection will be administered by a healthcare professional; do not self-administer.

Key Benefits

Pfidex 8mg Injection is a steroid (corticosteroids) medication. Corticosteroids occur naturally in the body and contribute to overall health and well-being. Increasing your body's corticosteroid levels (such as dexamethasone) is an effective strategy for treating various disorders involving inflammation. Pfidex 8mg Injection decreases inflammation, otherwise which might worsen your disease. You must take it daily to get the maximum benefits of Pfidex 8mg Injection.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Before prescribing Pfidex 8mg Injection, inform your doctor if you are allergic to any content of this medicine or other steroid medicines. You should disclose to your doctor if you have received any live virus vaccines. You should discuss with your doctor if you have fungal infections, amoebiasis, myasthenia gravis, peptic ulcer, osteoporosis, psychoses, eye infections, glaucoma, mental conditions, TB, bacteraemia (viable bacteria in the bloodstream), joint, liver, kidney, or heart conditions and septic arthritis resulting from gonorrhoea or tuberculosis. If you are pregnant, planning for pregnancy or breastfeeding, inform your doctor before receiving this medicine. Contact your doctor immediately if you notice mood changes or have depression and strange thoughts while Pfidex 8mg Injection therapy.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Pfidex 8mg Injection:
When Regorafenib is taken with Pfidex 8mg Injection, may significantly reduce the blood levels of Regorafenib.

How to manage the interaction:
Co-administration of Regorafenib and Pfidex 8mg Injection can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Pfidex 8mg Injection:
Co-administration of Desmopressin with Pfidex 8mg Injection may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Co-administration of Pfidex 8mg Injection and Desmopressin can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like confusion, hallucination, seizure, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DexamethasoneRilpivirine
Critical
How does the drug interact with Pfidex 8mg Injection:
When Rilpivirine is taken with Pfidex 8mg Injection, may significantly reduce the blood levels of Rilpivirine.

How to manage the interaction:
Co-administration of Rilpivirine and Pfidex 8mg Injection can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Pfidex 8mg Injection:
When Pfidex 8mg Injection is taken with Ranolazine, may significantly reduce the blood levels of Ranolazine.

How to manage the interaction:
Co-administration of Ranolazine and Pfidex 8mg Injection can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Pfidex 8mg Injection:
Co-administration of Pfidex 8mg Injection with Baricitinib can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction, Baricitinib can be taken with Pfidex 8mg Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, severe abdominal pain, nausea, or vomiting, consult a doctor. Do not discontinue the medication without consulting a doctor.
Severe
How does the drug interact with Pfidex 8mg Injection:
Co-administration of Pfidex 8mg Injection with Enoxacin can increase the risk of tendinopathy(conditions of the tendon that cause swelling and pain).

How to manage the interaction:
Taking Enoxacin with Pfidex 8mg Injection together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you experience symptoms like tendon pain, swelling, or difficulty moving, it's important to contact your doctor right away. Do not discontinue any medications without consulting a doctor.
DexamethasoneOxycodone
Severe
How does the drug interact with Pfidex 8mg Injection:
When Oxycodone is taken with Pfidex 8mg Injection, may reduce the blood levels of oxycodone.

How to manage the interaction:
There may be a possibility of interaction between Oxycodone and Pfidex 8mg Injection, but it can be taken if prescribed by a doctor. Your doctor can recommend other options that won't cause any problems when taken together. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pfidex 8mg Injection:
Taking Pfidex 8mg Injection may reduce the blood levels of Axitinib, making the medication less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction, Pfidex 8mg Injection can be taken with axitinib if prescribed by the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pfidex 8mg Injection:
Taking Cladribine with Pfidex 8mg Injection can increase the chances of serious infections.

How to manage the interaction:
Although there is a possible interaction between Cladribine and Pfidex 8mg Injection, you can take these medicines together if prescribed by a doctor. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while peeing - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Pfidex 8mg Injection:
When Pfidex 8mg Injection is taken with Infliximab, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Infliximab with Pfidex 8mg Injection together can result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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DEXAMETHASONE-8MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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DEXAMETHASONE-8MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking Pfidex 8mg Injection with Caffeine may increase the side effects of Pfidex 8mg Injection. Avoid consuming caffeine while taking Pfidex 8mg Injection.

Diet & Lifestyle Advise

Diet & Lifestyle for Allergic or inflammatory conditions:

  • Consume antioxidant-rich food. Blueberries, tomatoes, cherries, squash, and bell peppers are highly antioxidants.
  • Consuming probiotic-rich foods aids in the development of the immune system's resistance to allergies.
  • Consume foods rich in quercetin (a flavonoid), such as apples, cherries, spinach, broccoli, and blueberries.
  • Include seasonal fruits, vegetables, whole grains, healthy fats, and fish in your daily diet.
  • Limit your intake of foods that may cause allergies, such as dairy products, soy, eggs, and nuts.
  • Limit the consumption of foods high in sugar that may aggravate inflammation.
  • Reducing stress and having a regular sleep schedule might be beneficial.
  • Avoid processed meats, refined carbohydrates, sugar, trans fats, and alcohol, as they may aggravate inflammation.

 

Diet & Lifestyle for Covid-19:

  • Remember always to wear a mask when you're around other people. Wearing a mask aids in the prevention of illness spread.
  • Take care of your mental health. Fear and anxiety can hamper the immune system as well. Therapy, yoga, and meditation effectively allow the mind a state of peace.
  • Keep a social distance and avoid social gatherings.
  • Please do not touch your eyes, nose or mouth if your hands are not clean.
  • Hands should be washed with soap and water or an alcohol-based sanitiser on a regular basis.
  • All surfaces should be cleaned and disinfected on a regular basis.
  • Gargling with salt water and inhaling steam would be beneficial.
  • Never exchange personal objects that have been contaminated with bodily fluids or blood, such as razor blades or toothbrushes.
  • Never share used needles and other injections or medical devices, as they may spread viruses.
  • Consume a well-balanced diet. Consume vitamin and nutrient-rich foods like dark green, yellow, orange, and red vegetables and fruits to enhance your immune system. Choose lean protein and whole carbohydrates over-processed foods.
  • Consume no raw meat or eggs. Consume boiled and cooked meat, poultry, or seafood.
  • If you have nausea or vomiting, eat bland, low-fat foods and avoid spicy or greasy foods.
  • Spending time with family or doing whatever makes you happy might help you minimise emotional and physical stress.

Habit Forming

No

Therapeutic Class

[CORTICOSTEROIDS]

All Substitutes & Brand Comparisons

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Alcohol

Safe if prescribed

It is unknown whether alcohol interacts with Pfidex 8mg Injection. Please consult your doctor.

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Pregnancy

Consult your doctor

If you are pregnant, inform your doctor. Your doctor will then decide if the Pfidex 8mg Injection is suitable for you. Your doctor may prescribe this medicine only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Inform your doctor if you are a nursing mother. The doctor will then decide if the injection is suitable for you. Your doctor may prescribe this medicine only if the benefits outweigh the risks.

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Driving

Safe if prescribed

Pfidex 8mg Injection may cause a reduction in mental awareness; thus, avoid operating machinery or driving.

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Liver

Consult your doctor

Inform your doctor before receiving the Pfidex 8mg Injection if you have a history of or ongoing liver disease. Your doctor will adjust the dose of this medicine if required based on your condition.

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Kidney

Consult your doctor

Inform your doctor before receiving the Pfidex 8mg Injection if you have a history of or ongoing kidney disease. Your doctor may carry out extra checks while you are taking this medicine.

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Children

Safe if prescribed

Pfidex 8mg Injection may affect the growth of children. Therefore, your doctor may check the growth of the child regularly while using the Pfidex 8mg Injection.

FAQs

Pfidex 8mg Injection contains dexamethasone, a steroid with both anti-inflammatory and immunosuppressant activity. Anti-inflammatory activity relieves the symptoms of inflammatory conditions such as redness, swelling, and tenderness caused by various medical conditions. On the other side, immunosuppressant activity helps to calm your immune system. As a result, it can aid in autoimmune diseases such as rheumatoid arthritis, in which your immune system erroneously destroys your own tissues.

If you are about to be vaccinated, especially if it is a live vaccine, inform your doctor that you are taking Pfidex 8mg Injection because taking Pfidex 8mg Injection and getting immunised at the same time is not recommended.

Pfidex 8mg Injection is not recommended to be used in fungal infections. If you have any concerns regarding this, please discuss them with your doctor.

Pfidex 8mg Injection may increase the risk of Infections and infestations. Therefore, it is advised to stay away from people having chickenpox (herpes simplex), shingles (herpes zoster) or measles.

Pfidex 8mg Injection is approved for the treatment of coronavirus disease 2019 (COVID-19) in adults and adolescents (aged 12 years and older with a body weight of at least 40 kg) who require supplemental oxygen therapy.

Caution is advised if you are taking anticoagulants while on Pfidex 8mg Injection treatment. Checking your blood clotting time is recommended to lessen the risk of bleeding.

Country of origin

India
Other Info - PF25904

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