Piosafe 15 Tablet 10's is an anti-diabetic medicine belonging to the class of thiazolidinedione (TZD), also called 'glitazones', used to treat type 2 (non-insulin-dependent) diabetes mellitus. Type 2 diabetes is an illness where the body doesn't make enough insulin, or the insulin that it makes doesn't work properly. This is diabetes that usually develops in adulthood.

Piosafe 15 Tablet 10's contains Pioglitazone which helps control the sugar level in your blood when you have type 2 diabetes by helping your body make better use of the insulin it produces. Your doctor will check whether Pioglitazone is working 3-6 months after you start taking it. 

Piosafe 15 Tablet 10's should be taken with food or an empty stomach. However, it should be taken at the same time of the day each time for the best results. For better advice, your doctor will decide what dose should be taken, which can change quickly depending on your condition. The most common side effect of Piosafe 15 Tablet 10's is upper respiratory tract infection, headache, sinusitis, myalgia (muscle pain), and pharyngitis. Most of these side effects of Piosafe 15 Tablet 10's do not require medical attention and gradually resolve over time. Please consult your doctor if these side effects become troublesome.

Piosafe 15 Tablet 10's should not be stopped even if you feel better without consulting your doctor as sugar levels change. If you stop taking Piosafe 15 Tablet 10's suddenly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney damage (nephropathy) and nerve damage (neuropathy). Piosafe 15 Tablet 10's should not be taken if you have type 1 diabetes mellitus, if you are hypersensitive (allergic) to Piosafe 15 Tablet 10's or any of the other ingredients of Piosafe 15 Tablet 10's, have heart failure or have had heart failure in the past, diabetic ketoacidosis (a complication of diabetes causing rapid weight loss, nausea or vomiting), severe kidney or liver disease, bladder cancer. Please inform your doctor if you have any heart disease, are or planning to get pregnant or breastfeeding. The safety and efficacy of Piosafe 15 Tablet 10's in children under 18 years have not been established, so it should not be given to them.

Piosafe 15 Tablet 10's is an antidiabetic drug (thiazolidinedione/glitazones) used along with a proper diet and exercise to control high blood sugar (hyperglycaemia) in patients with type 2 diabetes. Piosafe 15 Tablet 10's works by helping to restore your body's appropriate response to insulin, thereby lowering your blood sugar.

• Upper respiratory tract infection
• Headache
• Sinusitis
• Myalgia (muscle pain)
• Pharyngitis (inflammation of pharynx located back of neck)

Fluid retention (oedema) may occur and can lead to congestive heart failure so, a combination of use with insulin and use in heart failure may increase the risk in patients taking Piosafe 15 Tablet 10's. You should not take Piosafe 15 Tablet 10's if you have kidney disease, as measured by a blood test. Piosafe 15 Tablet 10's, when used with or without insulin, $ name tends to lower the blood sugar level. So, the doctor may lower the dose of insulin. Increased fractures may be reported in some women taking Piosafe 15 Tablet 10's. Patients with bladder cancer and macular oedema (fluid build-up in the macula part of the retina of the eye) should consult the doctor before using Piosafe 15 Tablet 10's.

Drug-Drug Interactions: Piosafe 15 Tablet 10's may interact with antidiabetics (gemfibrozil), and antibiotics (rifampicin). So, tell your doctor if you are using these drugs before taking Piosafe 15 Tablet 10's.

Drug-Food Interactions: Taking Piosafe 15 Tablet 10's with alcoholic beverages may increase the risk of a rare but serious and potentially life-threatening condition known as lactic acidosis (build-up of lactic acid in the blood) and hypoglycaemia.

Drug-Disease Interactions: Piosafe 15 Tablet 10's should be avoided in patients with congestive heart failure (heart-related issues), type I diabetes, bladder cancer, oedema, liver disease, macular oedema, premenopausal anovulation, obesity (weight gain), anaemia as it may worsen the condition.

• GEMFIBROZIL
• RIFAMPICIN

• Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grain.
• Eat at regular interval. Do not take the long gap between a meal or snack.
• Monitor your blood sugar level regularly especially when there are a lot of fluctuations.
• Invest at least 150 min of moderate-intensity physical activity and 15 minutes of high-intensity exercise every week.
• Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
• Replace refined carbohydrates containing foods with whole grain foods and increase intake of fruits and veggies and other fibre enriched foods.
• Reduce intake of saturated fat (or hidden fats) in the food like chips, crisps, pastries, biscuits and samosas. Choose omega 3 fatty acid-containing oils for daily cooking. For frying, you may use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
• Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga or meditation to control stress-related to blood sugar changes.
• Opt for low-fat dairy products (low-fat yoghurt, fat-free milk and cheese etc.).
• Keep your blood pressure as normal (120/80) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.

• Keep taking the drug even if you think your blood sugar levels are under control. If you miss a dose, do not take a larger dose. Consult your treating physician for advice. 
• Take short, frequent meals, and avoid prolonged fasting when taking this drug. Beware of symptoms of hypoglycaemia which include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination etc. Whenever you experience the symptoms mentioned above, immediately consume 5-6 candies, three glucose biscuits, or three teaspoons of honey/sugar and get in touch with your physician. Make sure to carry these with you at all times, especially for long travels. 
• Before the doctor prescribes this medicine, it is always better that your physician knows about any underlying conditions like kidney or liver disease, prior heart attack, alcohol intake, etc.
• Avoid drinking alcohol while on this drug as it increases the risk of hypoglycaemia (decrease in blood sugar which might be fatal in some cases) and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body).
• Try to quit smoking and reduce your intake of carbohydrate-rich food like potatoes, rice, mangoes, bread, sugar etc.

Type 2 diabetes is a chronic or lifelong disease that keeps the body away from properly utilizing insulin. Hence, people affected with type 2 diabetes either do not produce enough insulin or resist insulin action. Middle-aged or older are most likely to suffer from type 2 diabetes, also known as adult-onset diabetes. Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, and blurred vision. There may be weight gain in some cases, while weight loss may be observed in rare cases. The complication of type 2 diabetes also includes neuropathy (nerve problems), nephropathy (kidney problems), and retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and increase the chance of heart attack or stroke.