PIOSAFE MF 15MG TABLET is a combination drug consisting of Pioglitazone (Thiazolidinediones), and Metformin (Biguanides) which are called anti-diabetic drugs & used to lower blood sugar levels in diabetic patients. Type 2 diabetes mellitus used to be known as 'non-insulin-dependent diabetes mellitus (NIDDM)' or 'maturity-onset diabetes'. Type 2 diabetes develops if the body does not produce enough insulin, or where the insulin that your body makes does not work as well as it should. It can also develop if the body produces too much glucagon. Insulin is a substance that helps to lower the level of sugar in your blood, especially after meals.

PIOSAFE MF 15MG TABLET is a blood sugar-lowering drug which contains a combination of Pioglitazone belonging to the class of thiazolidinediones & Metformin belonging to the class of biguanides. Pioglitazone decreases blood sugar and reverses the effects of Type II diabetes by activating switches (PPAR) inside cells to take up free glucose from blood and decrease its levels in blood. Metformin on the other hand decreases blood sugar by decreasing its formation and increasing its consumption by cells thereby decreasing high blood sugar levels. PIOSAFE MF 15MG TABLET is used in adults to treat type 2 (non-insulin dependent) diabetes mellitus when treatment with metformin alone is not sufficient.

PIOSAFE MF 15MG TABLET should be taken with food to avoid an upset stomach. PIOSAFE MF 15MG TABLET should be taken at the same time of the day each time for best results. For better advice, your doctor will decide, what dose should be taken and it can change timely depending upon your condition. Some people may stomach ache, feeling sick (Nausea), vomiting, diarrhoea, loss of appetite, localized swelling (oedema), weight gain, headache, respiratory infection, numbness, taste disturbance etc  . Most of these side effects of PIOSAFE MF 15MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

PIOSAFE MF 15MG TABLET should not be stopped even if you feel better, without consulting your doctor as sugar level keeps changing. If you stop taking PIOSAFE MF 15MG TABLET abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). PIOSAFE MF 15MG TABLET should not be taken if you have type 1 diabetes mellitus, severe kidney or liver disease. Please inform your doctor if you have any heart disease, is or planning to get pregnant or breastfeeding.

PIOSAFE MF 15MG TABLET lowers blood sugar in type II diabetic patients (Non insulin dependent ) & prevents diseases of the heart, kidneys, eyes & blood vessels in feet, which happens due to persistently high levels of blood sugar in diabetic patients. PIOSAFE MF 15MG TABLET plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing. PIOSAFE MF 15MG TABLET lowers blood sugar due to activation of cell switches (PPAR) to take up free glucose from blood & use it for energy production (Pioglitazones)  & decrease production of glucose inside liver (Metformin) .

• Diarrhoea
• Loss of appetite
• Headache
• Nausea
• Vomiting

PIOSAFE MF 15MG TABLET should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. Some diabetic patients, while taking PIOSAFE MF 15MG TABLET, might develop a rare but serious condition called lactic acidosis. In this condition, there is too much lactic acid accumulated in the blood that can damage the working of your liver and kidney required for the elimination of excess lactic acid from the blood. Before you start taking PIOSAFE MF 15MG TABLET, tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, and low vitamin B12 level. PIOSAFE MF 15MG TABLET, when used with insulin, may extremely lower the blood sugar level leading to hypoglycemia condition, which can be fatal. In this case, your doctor may adjust the dose by lowering the dose of insulin or PIOSAFE MF 15MG TABLET. Prolonged intake of PIOSAFE MF 15MG TABLET may lower your thyroid-stimulating hormone (TSH); hence, an annual check-up of TSH is recommended. In rare cases, you may also develop a serious skin reaction known as bullous pemphigoid that requires immediate medical attention. Tell your doctor if you are going to have a diagnostic test with an injection of dye or X-ray contrast agent. The use of PIOSAFE MF 15MG TABLET should be stopped for a short time before having an X-ray procedure.

Drug-Drug Interaction: PIOSAFE MF 15MG TABLET interacts with heart medications like (propranolol), pain killers (aspirin, ibuprofen, and celecoxib), high blood pressure-lowering pills (nifedipine, captopril, enalapril, lisinopril), thyroid hormones (thyroxine), antacid (cimetidine), or certain medicines affecting the nervous system.

Drug-Food Interaction: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with PIOSAFE MF 15MG TABLET.

Drug-Disease Interaction: People affected with heart, liver, kidney diseases (like congestive heart failure and myocardial infarction), vitamin B12 deficiency, and alcoholism should avoid intake of PIOSAFE MF 15MG TABLET.

• GEMFIBROZIL
• RIFAMPICIN
• CIMETIDINE
• DEFLAZACORT
• SPIRONOLACTONE
• IBUPROFEN
• CELECOXIB
• CAPTOPRIL
• TELMISARTAN

• Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grain.
• Eat at regular intervals. Do not take a long gap between a meal or snack.
• Monitor your blood sugar level regularly especially when there are lots of fluctuations.
• Invest at least 150 min of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
• Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
• Replace refined carbohydrates containing foods with whole grain foods and increase the intake of fruits and veggies and other fibre-enriched foods.
• Reduce intake of saturated fat (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega 3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
• Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.
• Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, and cheese, etc.).
• Keep your blood pressure as normal (140/90) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.

Contact your doctor immediately if you have  nausea, vomiting, kussmaul breathing  (laboured and deep), and generalised weakness which are symptoms of Lactic acidosis, a very rare but serious metabolic complication. 

Type 2 diabetes is a condition where the body is unable to make sufficient insulin, or the insulin that it makes doesn't work properly or utilized by our body. This can cause high blood sugar levels (hyperglycaemia). Symptoms of type 2 diabetes include increased thirst, frequent urination, slow , increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain while in rare cases weight loss may be observed. The complication of type 2 diabetes also includes neuropathy (nerve problems), nephropathy (kidney problems), and retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and increase the chance of heart attack or stroke.