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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
COD available

Online payment accepted

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Whats That

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Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Pirvac 200 mg Tablet

Pirvac 200 mg Tablet is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults. IPF is an irreversible disease that is marked by a progressive decline in lung function. The tissues in the lungs become swollen and scarred over time, due to which it gets difficult to breathe deeply. The scarring makes it hard for the lungs to work properly.
 
Pirvac 200 mg Tablet contains ‘Pirfenidone’, which helps in reducing the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better. Pirvac 200 mg Tablet helps in slowing down the progress of idiopathic pulmonary fibrosis. 

In some cases, you may experience certain common side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor before taking Pirvac 200 mg Tablet if you are pregnant or breastfeeding. Pirvac 200 mg Tablet may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Pirvac 200 mg Tablet as it could lead to increased dizziness. Pirvac 200 mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Pirvac 200 mg Tablet

Idiopathic pulmonary fibrosis

Directions for Use

Take Pirvac 200 mg Tablet with food. Swallow Pirvac 200 mg Tablet as a whole with a glass of water; do not chew or crush it.

Medicinal Benefits

Pirvac 200 mg Tablet is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults. Pirvac 200 mg Tablet can help effectively slow the rate of lung function decline by 50%. Pirvac 200 mg Tablet helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better. Pirvac 200 mg Tablet helps in slowing down the progress of idiopathic pulmonary fibrosis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Pirvac 200 mg Tablet

  • Nausea
  • Tiredness
  • Diarrhoea
  • Indigestion/Stomach upset
  • Loss of appetite
  • Headache
  • Photosensitivity

Drug Warnings

Do not take Pirvac 200 mg Tablet if you are allergic to any of its components; if you have a severe or end-stage liver impairment or kidney disease requiring dialysis; if you are taking fluvoxamine (anti-depressant). Inform your doctor if you are taking any medicines that might make you photosensitive, if you smoke or have kidney or liver problems. Consult your doctor before taking Pirvac 200 mg Tablet if you are pregnant or breastfeeding. Pirvac 200 mg Tablet may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Pirvac 200 mg Tablet as it could lead to increased dizziness. Pirvac 200 mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established.

Drug-Drug Interactions

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PirfenidoneRifampicin
Critical
PirfenidonePrimidone
Critical

Drug-Drug Interactions

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PirfenidoneRifampicin
Critical
How does the drug interact with Pirvac 200 mg Tablet:
Taking Pirvac 200 mg Tablet with rifampicin can reduce the levels and effects of Pirvac 200 mg Tablet

How to manage the interaction:
Although there is an interaction between Pirvac 200 mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidonePrimidone
Critical
How does the drug interact with Pirvac 200 mg Tablet:
Coadministration of Pirvac 200 mg Tablet with primidone can reduce levels and the effects of Pirvac 200 mg Tablet.

How to manage the interaction:
Although there is an interaction between Pirvac 200 mg Tablet and primidone, they can be taken together if advised by your doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneCarbamazepine
Critical
How does the drug interact with Pirvac 200 mg Tablet:
Taking Pirvac 200 mg Tablet with Carbamazepine it reduces the levels and effects of Pirvac 200 mg Tablet.

How to manage the interaction:
Taking Pirvac 200 mg Tablet with Carbamazepine is not recommended but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
PirfenidonePhenobarbital
Critical
How does the drug interact with Pirvac 200 mg Tablet:
When Pirvac 200 mg Tablet is taken with Phenobarbital, it can decrease the effects of Pirvac 200 mg Tablet.

How to manage the interaction:
Taking Pirvac 200 mg Tablet with Phenobarbital is not recommended but can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
PirfenidoneMibefradil
Severe
How does the drug interact with Pirvac 200 mg Tablet:
Taking Pirvac 200 mg Tablet with Mibefradil can increase the risk or severity of its side effects such as liver disease or gastric problems.

How to manage the interaction:
There may be a possibility of interaction between Pirvac 200 mg Tablet and Mibefradil, but it can be taken if prescribed by a doctor. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately.
PirfenidoneVemurafenib
Severe
How does the drug interact with Pirvac 200 mg Tablet:
Taking Pirvac 200 mg Tablet with Vemurafenib can increase the risk or severity of its side effects such as liver disease or gastric problems.

How to manage the interaction:
Although there is a possible interaction between Pirvac 200 mg Tablet and Vemurafenib, you can take these medicines together if prescribed by your doctor. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneAmiodarone
Severe
How does the drug interact with Pirvac 200 mg Tablet:
Co-administration of Amiodarone and Pirvac 200 mg Tablet may raise the risk of liver issues.

How to manage the interaction:
Even though Amiodarone and Pirvac 200 mg Tablet interact, they can be used if a doctor prescribes them. Seek medical attention if you have a fever, chills, joint pain or swelling, unusual bleeding or bruises, skin rash, itching, lack of hunger, tiredness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, or yellowing of the skin or eyes. Do not stop taking any medications without visiting a doctor.
PirfenidoneKetoconazole
Severe
How does the drug interact with Pirvac 200 mg Tablet:
Coadministration of Ketoconazole and Pirvac 200 mg Tablet may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Pirvac 200 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
PirfenidoneRucaparib
Severe
How does the drug interact with Pirvac 200 mg Tablet:
Taking Pirvac 200 mg Tablet with Rucaparib can increase the risk or severity of its side effects such as liver disease or gastric problems.

How to manage the interaction:
Co-administration of Pirvac 200 mg Tablet with Rucaparib can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately.
PirfenidoneCiprofloxacin
Severe
How does the drug interact with Pirvac 200 mg Tablet:
When ciprofloxacin is taken Pirvac 200 mg Tablet, the blood levels of Pirvac 200 mg Tablet may increase, which may lead to side effects.

How to manage the interaction:
Although taking ciprofloxacin and Pirvac 200 mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you have any of the following symptoms, fever, chills, joint pain or swelling, unusual bleeding or wounds, skin rash, itching, tiredness, nausea, vomiting, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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PIRFENIDONE-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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PIRFENIDONE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grape fruit and its products while using Pirvac 200 mg Tablet can increase the risk of side effects. Avoid grape fruit and its products during treatment with Pirvac 200 mg Tablet.

Diet & Lifestyle Advise

  • Watch out for triggers that make the cough worse, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow the pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and fruit juices.
  • Avoid processed and refined foods.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Pirvac 200 mg Tablet Substitute

Substitutes safety advice
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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Pirvac 200 mg Tablet helps in reducing the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better.

Pirvac 200 mg Tablet might make you photosensitive (sensitivity to sunlight). Avoid exposure to sunlight and sunlamps. Wear SPF 50+ sunscreen and protective clothing to reduce exposure to sunlight. Talk to your doctor if you are taking any medicines known to cause photosensitivity. If you notice any symptoms of photosensitivity, consult a doctor.

Do not discontinue Pirvac 200 mg Tablet without consulting your doctor. To treat your condition effectually, continue taking Pirvac 200 mg Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Pirvac 200 mg Tablet .

Diarrhoea might be a side-effect of Pirvac 200 mg Tablet . Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you have severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

No, avoid smoking prior to the start of the treatment and while taking Pirvac 200 mg Tablet as smoking might alter the effectiveness of Pirvac 200 mg Tablet .

Weight loss could occur due to loss of appetite. Maintain proper weight by eating healthy food. Your doctor might monitor your weight whilst taking Pirvac 200 mg Tablet . Consult your doctor if you notice severe weight loss.

Drug-Drug Interactions Checker List

  • FLUVOXAMINE
  • CIPROFLOXACIN
  • ENOXACIN
  • RIFAMPICIN
  • AMIODARONE
  • PROPAFENONE
  • OMEPRAZOLE

Special Advise

  • Your doctor may advise liver function tests prior to the start of the treatment.
  • Regular blood tests are advised at the start of treatment with Pirvac 200 mg Tablet and monthly for every 6 months, and then for every 3 months thereafter to check the liver functioning.

Disease/Condition Glossary

Idiopathic pulmonary fibrosis (IPF): Idiopathic pulmonary fibrosis belongs to a group of interstitial lung diseases. It is an irreversible chronic disease marked by a progressive decline in lung function. The tissues in the lungs become inflamed and scarred over time, due to which it gets difficult to breathe properly. The scar tissue, known as fibrosis, becomes thick /stiff over time, making it hard for the lungs to work efficiently. This causes decreased lung function, which leads to increased breathlessness and coughing. Breathing difficulties can lead to other medical problems. Symptoms of IPF are shortness of breath, persistent dry cough, loss of appetite, weight loss, rounded and widened tips of the fingers and toes.

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