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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS

About Pramirol-0.125 Tablet 10's

Pramirol-0.125 Tablet 10's belongs to a group of antiparkinson agents or dopamine agonists used to treat the symptoms of Parkinson’s disease and moderate to severe Willis-Ekbom disease (restless legs syndrome) in adults. Parkinson’s disease is a progressive neurological disorder in which the first signs are problems with movements. Willis-Ekbom disease is a condition which causes the uncontrollable urge to move the legs.

Pramirol-0.125 Tablet 10's contains 'Pramipexole' that works by mimicking the action of dopamine (acting in place of dopamine), a natural substance found in the brain needed to control body movement. This triggers the nerve impulses in the brain that control body movements.

In some cases, you may experience certain common side-effects such as sleepiness, nausea, constipation, dizziness, fatigue, hallucinations, dry mouth, muscle spasms, and peripheral oedema (leg swelling due to fluid overload). Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Do not discontinue Pramirol-0.125 Tablet 10's on your own. Consult your doctor if you are pregnant or breastfeeding. Pramirol-0.125 Tablet 10's may cause drowsiness and dizziness, do not drive unless you are alert. Pramirol-0.125 Tablet 10's should not be used in children below 18 years. Avoid consuming alcohol along with Pramirol-0.125 Tablet 10's as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Pramirol-0.125 Tablet 10's may cause orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). 

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Whats That

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Non returnable*
COD available

Online payment accepted

Manufacturer/Marketer

Intas Pharmaceuticals Ltd

Consume Type

ORAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Pramirol-0.125 Tablet 10's

Parkinson’s disease, Willis Ekbom disease (restless legs syndrome)

Medicinal Benefits

Pramirol-0.125 Tablet 10's belongs to a group of antiparkinson agents called dopamine agonists used to treat the symptoms of Parkinson’s disease and moderate to severe Willis-Ekbom disease (restless legs syndrome) in adults. Pramirol-0.125 Tablet 10's binds to the dopamine receptor and mimics its action. Dopamine is a naturally-occurring neurotransmitter in the brain. Dopamine is absent or reduced in people with Parkinson’s disease. Pramirol-0.125 Tablet 10's works by stimulating the dopamine receptors in the brain. This triggers the nerve impulses in the brain that control body movements. Pramirol-0.125 Tablet 10's helps in relieving the symptoms of Parkinson’s disease, such as muscle spasms, tremors, stiffness, and poor muscle control.

Side Effects of Pramirol-0.125 Tablet 10's

  • Nausea
  • Low blood pressure
  • Dizziness
  • Constipation
  • Fatigue
  • Headache
  • Dry mouth
  • Muscle spasms

Directions for Use

Swallow Pramirol-0.125 Tablet 10's as a whole with water; do not crush, break or chew it. For restless leg syndrome: Pramirol-0.125 Tablet 10's should be taken 2-3 hours before bedtime.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Pramirol-0.125 Tablet 10's if you are allergic to any of its contents. Talk to your doctor before taking Pramirol-0.125 Tablet 10's if you have kidney problems, hallucinations, dyskinesia (abnormal limb movements), dystonia (inability to keep the neck straight), sleepiness or suddenly falling asleep, psychosis, vision impairment, severe heart or blood vessel disease, or augmentation (symptoms start earlier). Inform your doctor if you experience symptoms such as apathy, anxiety, depression, fatigue, sweating or pain after dose reduction or stopping Pramirol-0.125 Tablet 10's. Pramirol-0.125 Tablet 10's may cause intense urges such as increased sex drive, gambling, overeating and wasting money. Consult your doctor if you are pregnant or breastfeeding. Pramirol-0.125 Tablet 10's may cause drowsiness and dizziness, do not drive unless you are alert. Pramirol-0.125 Tablet 10's should not be given to children below 18 years. Avoid consuming alcohol along with Pramirol-0.125 Tablet 10's as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Pramirol-0.125 Tablet 10's causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). 

Therapeutic Class

ANTIPARKINSON AGENTS

Drug-Drug Interactions

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PramipexoleRisperidone
Critical
PramipexoleOlanzapine
Critical

Drug-Drug Interactions

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PramipexoleRisperidone
Critical
How does the drug interact with Pramirol-0.125 Tablet 10's:
Taking Risperidone with Pramirol-0.125 Tablet 10's may reduce the effectiveness of Pramirol-0.125 Tablet 10's.

How to manage the interaction:
Taking Risperidone with Pramirol-0.125 Tablet 10's is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, and lightheadedness contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PramipexoleOlanzapine
Critical
How does the drug interact with Pramirol-0.125 Tablet 10's:
Taking Olanzapine with Pramirol-0.125 Tablet 10's can increase the risk and severity of side effects and reduce the effectiveness of Pramirol-0.125 Tablet 10's.

How to manage the interaction:
Co-administration of Olanzapine and Pramirol-0.125 Tablet 10's is not recommended as it leads to an interaction, it can be taken if advised by a doctor. If you experience any symptoms such as drowsiness, dizziness, and lightheadedness, contact a doctor immediately. Avoid driving or operating dangerous machinery, and be careful while getting up from a sitting or lying position. Do not discontinue any medications without consulting a doctor.
PramipexoleEsketamine
Severe
How does the drug interact with Pramirol-0.125 Tablet 10's:
Taking Esketamine with Pramirol-0.125 Tablet 10's may increase the risk of side effects.

How to manage the interaction:
Although taking Pramirol-0.125 Tablet 10's and Esketamine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any symptoms like drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination, consult a doctor. Do not discontinue any medications without a doctor's advice.
PramipexoleAmisulpride
Severe
How does the drug interact with Pramirol-0.125 Tablet 10's:
Taking Amisulpride with Pramirol-0.125 Tablet 10's may decrease the efficacy of both medications.

How to manage the interaction:
Although taking amisulpride along with Pramirol-0.125 Tablet 10's can result in an interaction, it can be taken if a doctor has advised it. Avoid jobs that demand mental awareness and exercise caution while rising from a sitting or sleeping posture. Do not discontinue any medications without a doctor's advice.
PramipexoleSodium oxybate
Severe
How does the drug interact with Pramirol-0.125 Tablet 10's:
Taking Sodium oxybate with Pramirol-0.125 Tablet 10's may increase the risk of side effects.

How to manage the interaction:
Taking Pramirol-0.125 Tablet 10's with Sodium oxybate together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult a doctor. Do not discontinue the medications without consulting a doctor.
PramipexoleSodium oxybate
Severe
How does the drug interact with Pramirol-0.125 Tablet 10's:
Taking Sodium oxybate with Pramirol-0.125 Tablet 10's may increase he risk of side effects.

How to manage the interaction:
Taking Pramirol-0.125 Tablet 10's with Sodium oxybate together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult a doctor. Do not discontinue any medications without a doctor's advice.
PramipexoleEsketamine
Severe
How does the drug interact with Pramirol-0.125 Tablet 10's:
Combining Esketamine with Pramirol-0.125 Tablet 10's may increase side effects

How to manage the interaction:
Although taking Pramirol-0.125 Tablet 10's and Esketamine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any symptoms like drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination, consult a doctor. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • AMITRIPTYLINE
  • DULOXETINE
  • TRAZODONE
  • FLUOXETINE
  • DIPHENHYDRAMINE
  • CETIRIZINE
  • GABAPENTIN
  • PREGABALIN
  • MEMANTINE
  • ACETAMINOPHEN
  • HYDROCODONE
  • TRAMADOL

Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly.
  • Include a diet rich in iron, folate and magnesium. 
  • Regularly attend therapy sessions.
  • Perform meditation and yoga.
  • Follow a regular sleep pattern.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Special Advise

Patients and their caretakers (midwife/nurse) should be alerted as Pramirol-0.125 Tablet 10's may cause intense urges such as increased sex drive, gambling, overeating and wasting money.

Author Details

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Disease/Condition Glossary

Parkinson’s disease: It is a progressive neurological disorder in which the first signs are problems with movements. Dopamine is a naturally-occurring neurotransmitter in the brain which is reduced or absent in people with Parkinson’s disease. Due to this problems arise with smooth and coordinated movements. Symptoms include decreased ability to smell, stooped posture, changes in voice, constipation, small/cramped handwriting, tremor, slow movements, stiffness of arms, legs, and trunk, and problems with balance. 

Willis-Ekbom disease (restless leg syndrome): It is a condition which causes the uncontrollable urge to move the legs. The urge to move their legs is more intense when a person is trying to sleep or relax. This interferes with sleep leading to daytime sleepiness and fatigue. Symptoms include an uncontrollable urge to move the legs, tingling, crawling or pulling sensations in the legs.

Pramirol-0.125 Tablet 10's Substitute

Substitutes safety advice
  • Pramipex 0.125 Tablet 10's

    5.36per tablet
  • Prexol-0.125mg Tablet 15's

    by AYUR

    5.64per tablet
  • Mirator 0.125mg Tablet 10's

    5.99per tablet
  • Pexopram 0.125 Tablet 10's

    5.13per tablet
  • Pramiset-0.125 Tablet 10's

    5.40per tablet
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