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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
COD available

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Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Pramitrem 0.125 mg Tablet 10's

Pramitrem 0.125 mg Tablet 10's belongs to a group of antiparkinson agents or dopamine agonists used to treat the symptoms of Parkinson’s disease and moderate to severe Willis-Ekbom disease (restless legs syndrome) in adults. Parkinson’s disease is a progressive neurological disorder in which the first signs are problems with movements. Willis-Ekbom disease is a condition which causes the uncontrollable urge to move the legs.

Pramitrem 0.125 mg Tablet 10's contains 'Pramipexole' that works by mimicking the action of dopamine (acting in place of dopamine), a natural substance found in the brain needed to control body movement. This triggers the nerve impulses in the brain that control body movements.

In some cases, you may experience certain common side-effects such as sleepiness, nausea, constipation, dizziness, fatigue, hallucinations, dry mouth, muscle spasms, and peripheral oedema (leg swelling due to fluid overload). Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Do not discontinue Pramitrem 0.125 mg Tablet 10's on your own. Consult your doctor if you are pregnant or breastfeeding. Pramitrem 0.125 mg Tablet 10's may cause drowsiness and dizziness, do not drive unless you are alert. Pramitrem 0.125 mg Tablet 10's should not be used in children below 18 years. Avoid consuming alcohol along with Pramitrem 0.125 mg Tablet 10's as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Pramitrem 0.125 mg Tablet 10's may cause orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). 

Uses of Pramitrem 0.125 mg Tablet 10's

Parkinson’s disease, Willis Ekbom disease (restless legs syndrome)

Directions for Use

Swallow Pramitrem 0.125 mg Tablet 10's as a whole with water; do not crush, break or chew it. For restless leg syndrome: Pramitrem 0.125 mg Tablet 10's should be taken 2-3 hours before bedtime.

Medicinal Benefits

Pramitrem 0.125 mg Tablet 10's belongs to a group of antiparkinson agents called dopamine agonists used to treat the symptoms of Parkinson’s disease and moderate to severe Willis-Ekbom disease (restless legs syndrome) in adults. Pramitrem 0.125 mg Tablet 10's binds to the dopamine receptor and mimics its action. Dopamine is a naturally-occurring neurotransmitter in the brain. Dopamine is absent or reduced in people with Parkinson’s disease. Pramitrem 0.125 mg Tablet 10's works by stimulating the dopamine receptors in the brain. This triggers the nerve impulses in the brain that control body movements. Pramitrem 0.125 mg Tablet 10's helps in relieving the symptoms of Parkinson’s disease, such as muscle spasms, tremors, stiffness, and poor muscle control.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Pramitrem 0.125 mg Tablet 10's

  • Nausea
  • Low blood pressure
  • Dizziness
  • Constipation
  • Fatigue
  • Headache
  • Dry mouth
  • Muscle spasms

Drug Warnings

Do not take Pramitrem 0.125 mg Tablet 10's if you are allergic to any of its contents. Talk to your doctor before taking Pramitrem 0.125 mg Tablet 10's if you have kidney problems, hallucinations, dyskinesia (abnormal limb movements), dystonia (inability to keep the neck straight), sleepiness or suddenly falling asleep, psychosis, vision impairment, severe heart or blood vessel disease, or augmentation (symptoms start earlier). Inform your doctor if you experience symptoms such as apathy, anxiety, depression, fatigue, sweating or pain after dose reduction or stopping Pramitrem 0.125 mg Tablet 10's. Pramitrem 0.125 mg Tablet 10's may cause intense urges such as increased sex drive, gambling, overeating and wasting money. Consult your doctor if you are pregnant or breastfeeding. Pramitrem 0.125 mg Tablet 10's may cause drowsiness and dizziness, do not drive unless you are alert. Pramitrem 0.125 mg Tablet 10's should not be given to children below 18 years. Avoid consuming alcohol along with Pramitrem 0.125 mg Tablet 10's as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Pramitrem 0.125 mg Tablet 10's causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). 

Drug-Drug Interactions

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PramipexoleOlanzapine
Critical
PramipexoleRisperidone
Critical

Drug-Drug Interactions

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PramipexoleOlanzapine
Critical
How does the drug interact with Pramitrem 0.125 mg Tablet:
Taking Olanzapine with Pramitrem 0.125 mg Tablet can increase the risk and severity of side effects and reduce the effectiveness of Pramitrem 0.125 mg Tablet.

How to manage the interaction:
Co-administration of Olanzapine and Pramitrem 0.125 mg Tablet is not recommended as it leads to an interaction, it can be taken if advised by a doctor. If you experience any symptoms such as drowsiness, dizziness, and lightheadedness, contact a doctor immediately. Avoid driving or operating dangerous machinery, and be careful while getting up from a sitting or lying position. Do not discontinue any medications without consulting a doctor.
PramipexoleRisperidone
Critical
How does the drug interact with Pramitrem 0.125 mg Tablet:
Taking Risperidone with Pramitrem 0.125 mg Tablet may reduce the effectiveness of Pramitrem 0.125 mg Tablet.

How to manage the interaction:
Taking Risperidone with Pramitrem 0.125 mg Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, and lightheadedness contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PramipexoleEsketamine
Severe
How does the drug interact with Pramitrem 0.125 mg Tablet:
Combining Esketamine with Pramitrem 0.125 mg Tablet may increase side effects

How to manage the interaction:
Although taking Pramitrem 0.125 mg Tablet and Esketamine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any symptoms like drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination, consult a doctor. Do not discontinue the medication without consulting a doctor.
PramipexoleSodium oxybate
Severe
How does the drug interact with Pramitrem 0.125 mg Tablet:
Taking Sodium oxybate with Pramitrem 0.125 mg Tablet may increase the risk of side effects.

How to manage the interaction:
Taking Pramitrem 0.125 mg Tablet with Sodium oxybate together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult a doctor. Do not discontinue the medications without consulting a doctor.
PramipexoleSodium oxybate
Severe
How does the drug interact with Pramitrem 0.125 mg Tablet:
Taking Sodium oxybate with Pramitrem 0.125 mg Tablet may increase he risk of side effects.

How to manage the interaction:
Taking Pramitrem 0.125 mg Tablet with Sodium oxybate together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult a doctor. Do not discontinue any medications without a doctor's advice.
PramipexoleAmisulpride
Severe
How does the drug interact with Pramitrem 0.125 mg Tablet:
Taking Amisulpride with Pramitrem 0.125 mg Tablet may decrease the efficacy of both medications.

How to manage the interaction:
Although taking amisulpride along with Pramitrem 0.125 mg Tablet can result in an interaction, it can be taken if a doctor has advised it. Avoid jobs that demand mental awareness and exercise caution while rising from a sitting or sleeping posture. Do not discontinue any medications without a doctor's advice.
PramipexoleEsketamine
Severe
How does the drug interact with Pramitrem 0.125 mg Tablet:
Taking Esketamine with Pramitrem 0.125 mg Tablet may increase the risk of side effects.

How to manage the interaction:
Although taking Pramitrem 0.125 mg Tablet and Esketamine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any symptoms like drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination, consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly.
  • Include a diet rich in iron, folate and magnesium. 
  • Regularly attend therapy sessions.
  • Perform meditation and yoga.
  • Follow a regular sleep pattern.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

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Author Details

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • AMITRIPTYLINE
  • DULOXETINE
  • TRAZODONE
  • FLUOXETINE
  • DIPHENHYDRAMINE
  • CETIRIZINE
  • GABAPENTIN
  • PREGABALIN
  • MEMANTINE
  • ACETAMINOPHEN
  • HYDROCODONE
  • TRAMADOL

Special Advise

Patients and their caretakers (midwife/nurse) should be alerted as Pramitrem 0.125 mg Tablet 10's may cause intense urges such as increased sex drive, gambling, overeating and wasting money.

Disease/Condition Glossary

Parkinson’s disease: It is a progressive neurological disorder in which the first signs are problems with movements. Dopamine is a naturally-occurring neurotransmitter in the brain which is reduced or absent in people with Parkinson’s disease. Due to this problems arise with smooth and coordinated movements. Symptoms include decreased ability to smell, stooped posture, changes in voice, constipation, small/cramped handwriting, tremor, slow movements, stiffness of arms, legs, and trunk, and problems with balance. 

Willis-Ekbom disease (restless leg syndrome): It is a condition which causes the uncontrollable urge to move the legs. The urge to move their legs is more intense when a person is trying to sleep or relax. This interferes with sleep leading to daytime sleepiness and fatigue. Symptoms include an uncontrollable urge to move the legs, tingling, crawling or pulling sensations in the legs.

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