Prebris-MNT Tablet 10's
MRP ₹218.5
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About Prebris-MNT Tablet
Prebris-MNT Tablet is a combination medicine indicated to manage neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, and evoked pain (pain caused by events usually not painful).
Prebris-MNT Tablet is a combination of three drugs: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a vitamin that aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Prebris-MNT Tablet helps to treat neuropathic pain.
Take Prebris-MNT Tablet as prescribed. Based on your medical condition, your doctor will decide the dose and duration. In some cases, Prebris-MNT Tablet may cause dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. The majority of these side effects do not necessitate medical attention and will subside gradually over time. However, if you are experiencing these side effects regularly, you should consult your doctor.
Please do not take Prebris-MNT Tablet if you are allergic to any of its ingredients. Consult your doctor before taking Prebris-MNT Tablet if you are pregnant or breastfeeding. Prebris-MNT Tablet may cause drowsiness and dizziness, so drive only if you are alert. Prebris-MNT Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Prebris-MNT Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.
Uses of Prebris-MNT Tablet
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Key Benefits
Prebris-MNT Tablet is a combination of three drugs: Methylcobalamin (a form of vitamin B), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Prebris-MNT Tablet is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Prebris-MNT Tablet helps to treat neuropathic pain.
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Drug Warnings
If you are allergic to any of the ingredients in Prebris-MNT Tablet , do not consume it. Please do not stop taking Prebris-MNT Tablet without first consulting your doctor, as this may result in withdrawal symptoms. If you are pregnant or breastfeeding, do not take Prebris-MNT Tablet unless your doctor has prescribed it. Prebris-MNT Tablet may cause drowsiness and dizziness, therefore drive only if you are alert. Prebris-MNT Tablet is not recommended for children as safety and effectiveness have not been established. Avoid drinking alcohol while taking Prebris-MNT Tablet as it may cause drowsiness and sleepiness. If you have suicidal thoughts, consult your doctor right away.
Drug-Drug Interactions
Drug-Drug Interactions
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Coadministration of Prebris-MNT Tablet with Ziprasidone can increase the risk or severity of irregular heart rhythm.
How to manage the interaction:
Taking Prebris-MNT Tablet with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, severe or prolonged diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
Coadministration of Prebris-MNT Tablet with Safinamide may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).
How to manage the interaction:
Taking Prebris-MNT Tablet with Safinamide together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
Using Prebris-MNT Tablet together with Isocarboxazid can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).
How to manage the interaction:
Taking Isocarboxazid with Prebris-MNT Tablet is not recommended, please consult your doctor before taking it. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
Coadministration of Prebris-MNT Tablet with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).
How to manage the interaction:
Taking Prebris-MNT Tablet with Tranylcypromine together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
Coadministration of Prebris-MNT Tablet with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.
How to manage the interaction:
Taking Prebris-MNT Tablet with Linezolid together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Coadministration of Prebris-MNT Tablet with Potassium citrate can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.
How to manage the interaction:
Taking Prebris-MNT Tablet with Potassium citrate together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Co-administration of Prebris-MNT Tablet with Selegiline might raise serotonin hormone levels in the body (A condition in which a chemical called serotonin builds up in your body).
How to manage the interaction:
Taking Prebris-MNT Tablet with Selegiline together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Co-administration of Ephedrine and Prebris-MNT Tablet together may increase the risk of side effects.
How to manage the interaction:
Taking Prebris-MNT Tablet with Ephedrine can result in an interaction, but it can be taken if a doctor has advised it. It's important to maintain your blood pressure while using these medications. Do not discontinue any medications without consulting the doctor.
Using Prebris-MNT Tablet together with Pethidine can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).
How to manage the interaction:
Taking Prebris-MNT Tablet with Pethidine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, dry mouth, blurred vision, constipation, urinary retention, nausea, vomiting, or diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Coadministration of Prebris-MNT Tablet with Cabozantinib can increase the risk or severity of irregular heart rhythm.
How to manage the interaction:
Taking Prebris-MNT Tablet with Cabozantinib together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Drug-Food Interactions
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Diet & Lifestyle Advise
- Include vitamin B and D-rich foods in your diet.
- Cayenne pepper should be included in your diet because it can help with neuropathic pain.
- Exercising regularly helps to improve overall health and combat pain.
- Rest well and get plenty of rest.
- Taking a warm bath can be very relaxing.
- Avoid smoking and drinking alcohol.
- Meditation and yoga can reduce stress, pain sensitivity and improve coping skills.
- Acupuncture, by stimulating pressure points, can be beneficial.
- Massages with essential oils can help increase circulation.
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Special Advise
Prebris-MNT Tablet contains Nortriptyline (antidepressant), which can lead to suicidal thoughts. Suicidal thoughts or behaviour should be closely monitored in people taking Prebris-MNT Tablet . If you have suicidal thoughts, don't be afraid to talk to your doctor right away.
FAQs
Prebris-MNT Tablet contains Methylcobalamin, Nortriptyline, and Pregabalin. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline alters the way nerves receive pain signals, thereby decreasing pain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Prebris-MNT Tablet helps to treat neuropathic pain.
Prebris-MNT Tablet contains pregabalin. It may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a proper diet.
Dry mouth could be a side-effect of Prebris-MNT Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Do not stop taking Prebris-MNT Tablet without consulting your doctor, as this could result in withdrawal symptoms. Continue taking Prebris-MNT Tablet for as long as prescribed to treat your condition effectively. If you experience any difficulty while taking Prebris-MNT Tablet , do not be afraid to speak with your doctor.
Prebris-MNT Tablet is used to treat diabetic neuropathy. Diabetic neuropathy is a condition that causes nerve damage due to high blood glucose levels. It primarily affects the nerves in the legs and feet.
Prebris-MNT Tablet may cause peripheral oedema. The swelling of the hands and lower legs are known as peripheral oedema. If you experience oedema, avoid sitting or standing for extended periods. Raise your legs by laying down and placing a pillow under them.
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Author Details
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Reference
- https://www.nhs.uk/medicines/nortriptyline/
- https://www.nhs.uk/medicines/pregabalin/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888748/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003018/
- https://vibcare.co.in/pregabalin-nortriptyline/
- https://www.drugs.com/drug-interactions/pregabalin.html
- https://www.drugs.com/drug-interactions/nortriptyline.html
- https://www.medicines.org.uk/emc/files/pil.5044.pdf
- https://www.medicines.org.uk/emc/files/pil.7057.pdf
