Methylcobalamin+nortriptyline+pregabalin
About
Methylcobalamin+nortriptyline+pregabalin is a combination medicine indicated to manage neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, and evoked pain (pain caused by events usually not painful).
Methylcobalamin+nortriptyline+pregabalin is a combination of three drugs: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a vitamin that aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Methylcobalamin+nortriptyline+pregabalin helps to treat neuropathic pain.
Take Methylcobalamin+nortriptyline+pregabalin as prescribed. Based on your medical condition, your doctor will decide the dose and duration. In some cases, Methylcobalamin+nortriptyline+pregabalin may cause dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. The majority of these side effects do not necessitate medical attention and will subside gradually over time. However, if you are experiencing these side effects regularly, you should consult your doctor.
Please do not take Methylcobalamin+nortriptyline+pregabalin if you are allergic to any of its ingredients. Consult your doctor before taking Methylcobalamin+nortriptyline+pregabalin if you are pregnant or breastfeeding. Methylcobalamin+nortriptyline+pregabalin may cause drowsiness and dizziness, so drive only if you are alert. Methylcobalamin+nortriptyline+pregabalin should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Methylcobalamin+nortriptyline+pregabalin as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.
Uses of Methylcobalamin+nortriptyline+pregabalin
Medicinal Benefits
Methylcobalamin+nortriptyline+pregabalin is a combination of three drugs: Methylcobalamin (a form of vitamin B), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin+nortriptyline+pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Methylcobalamin+nortriptyline+pregabalin helps to treat neuropathic pain.
Directions for Use
Storage
Side Effects of Methylcobalamin+nortriptyline+pregabalin
- Constipation
- Dry mouth
- Headache
- Feeling sleepy, tired or dizzy
- Diarrhoea
In-Depth Precautions and Warning
Drug Warnings
If you are allergic to any of the ingredients in Methylcobalamin+nortriptyline+pregabalin, do not consume it. Please do not stop taking Methylcobalamin+nortriptyline+pregabalin without first consulting your doctor, as this may result in withdrawal symptoms. If you are pregnant or breastfeeding, do not take Methylcobalamin+nortriptyline+pregabalin unless your doctor has prescribed it. Methylcobalamin+nortriptyline+pregabalin may cause drowsiness and dizziness, therefore drive only if you are alert. Methylcobalamin+nortriptyline+pregabalin is not recommended for children as safety and effectiveness have not been established. Avoid drinking alcohol while taking Methylcobalamin+nortriptyline+pregabalin as it may cause drowsiness and sleepiness. If you have suicidal thoughts, consult your doctor right away.
Drug Interactions
Drug-Drug Interactions: Methylcobalamin+nortriptyline+pregabalin may have interaction with antidepressant medications (e.g. duloxetine, sertraline, escitalopram), pain killer medications (e.g. codeine, hydrocodone, morphine, oxycodone, tramadol, acetaminophen), anti-convulsant medications (e.g. topiramate), anti-anxiety medications (e.g. alprazolam), sedative-hypnotics medications (e.g. zolpidem), antihistamine medications (e.g. diphenhydramine, cetirizine), muscle relaxant medications (e.g. cyclobenzaprine), antiemetic medications (e.g. ondansetron), and herbal medications to treat depression (e.g. St John's wort).
Drug-Food Interactions: Avoid alcohol consumption while taking Methylcobalamin+nortriptyline+pregabalin as it might cause increased drowsiness and sleepiness.
Drug-Disease Interactions: Use Methylcobalamin+nortriptyline+pregabalin with medical advice if you have had anticholinergic effects, cardiovascular disease, pheochromocytoma, acute myocardial infarction recovery, cardiovascular disease, depression, seizure disorders, drug dependence, suicidal tendency, angioedema, creatine kinase elevations, peripheral oedema, PR interval prolongation, bone marrow suppression, diabetes, renal/liver disease, schizophrenia/bipolar disorder, hyper/hypoglycemia, schizophrenia, thyroid disorders and urinary retention.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Methylcobalamin+nortriptyline+pregabalin as it may increase drowsiness and sleepiness.
Pregnancy
cautionIf you're pregnant, don't take Methylcobalamin+nortriptyline+pregabalin unless your doctor tells you to. Please consult your doctor if you have any concerns about this; your doctor will only prescribe if the benefits outweigh the risks.
Breast Feeding
cautionConsult your doctor as there is no substantial research yet on the use of Methylcobalamin+nortriptyline+pregabalin in breastfeeding/nursing mothers.
Driving
unsafeMethylcobalamin+nortriptyline+pregabalin causes drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.
Kidney
cautionDose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.
Children
unsafeMethylcobalamin+nortriptyline+pregabalin should not be given to children as the safety and efficacy have not been established.
Habit Forming
Diet & Lifestyle Advise
- Include vitamin B and D-rich foods in your diet.
- Cayenne pepper should be included in your diet because it can help with neuropathic pain.
- Exercising regularly helps to improve overall health and combat pain.
- Rest well and get plenty of rest.
- Taking a warm bath can be very relaxing.
- Avoid smoking and drinking alcohol.
- Meditation and yoga can reduce stress, pain sensitivity and improve coping skills.
- Acupuncture, by stimulating pressure points, can be beneficial.
- Massages with essential oils can help increase circulation.
Special Advise
Methylcobalamin+nortriptyline+pregabalin contains Nortriptyline (antidepressant), which can lead to suicidal thoughts. Suicidal thoughts or behaviour should be closely monitored in people taking Methylcobalamin+nortriptyline+pregabalin. If you have suicidal thoughts, don't be afraid to talk to your doctor right away.
Patients Concern
Disease/Condition Glossary
Neuropathic pain: Neuropathic pain is caused due to damaged sensory nerves. It is caused by chronic progressive nerve disease or due to infection or injury. The pain could be intermittent or continuous, which is felt as prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensations is also familiar with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury. The body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping and evoked pain (pain caused by events usually not painful).
FAQs
Methylcobalamin+nortriptyline+pregabalin contains Methylcobalamin, Nortriptyline, and Pregabalin. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline alters the way nerves receive pain signals, thereby decreasing pain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Methylcobalamin+nortriptyline+pregabalin helps to treat neuropathic pain.
Methylcobalamin+nortriptyline+pregabalin contains pregabalin. It may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a proper diet.
Dry mouth could be a side-effect of Methylcobalamin+nortriptyline+pregabalin. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Do not stop taking Methylcobalamin+nortriptyline+pregabalin without consulting your doctor, as this could result in withdrawal symptoms. Continue taking Methylcobalamin+nortriptyline+pregabalin for as long as prescribed to treat your condition effectively. If you experience any difficulty while taking Methylcobalamin+nortriptyline+pregabalin, do not be afraid to speak with your doctor.
Methylcobalamin+nortriptyline+pregabalin is used to treat diabetic neuropathy. Diabetic neuropathy is a condition that causes nerve damage due to high blood glucose levels. It primarily affects the nerves in the legs and feet.
Methylcobalamin+nortriptyline+pregabalin may cause peripheral oedema. The swelling of the hands and lower legs are known as peripheral oedema. If you experience oedema, avoid sitting or standing for extended periods. Raise your legs by laying down and placing a pillow under them.
