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Manufacturer/Marketer :

Solvate Laboratories Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Pregalex-MNT Tablet 10's

Pregalex-MNT Tablet 10's is a combination medicine indicated to manage neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, and evoked pain (pain caused by events usually not painful).

Pregalex-MNT Tablet 10's is a combination of three drugs: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a vitamin that aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Pregalex-MNT Tablet 10's helps to treat neuropathic pain.

Take Pregalex-MNT Tablet 10's as prescribed. Based on your medical condition, your doctor will decide the dose and duration. In some cases, Pregalex-MNT Tablet 10's may cause dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. The majority of these side effects do not necessitate medical attention and will subside gradually over time. However, if you are experiencing these side effects regularly, you should consult your doctor.

Please do not take Pregalex-MNT Tablet 10's if you are allergic to any of its ingredients. Consult your doctor before taking Pregalex-MNT Tablet 10's if you are pregnant or breastfeeding. Pregalex-MNT Tablet 10's may cause drowsiness and dizziness, so drive only if you are alert. Pregalex-MNT Tablet 10's should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Pregalex-MNT Tablet 10's as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Pregalex-MNT Tablet 10's

Neuropathic pain

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Pregalex-MNT Tablet 10's is a combination of three drugs: Methylcobalamin (a form of vitamin B), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Pregalex-MNT Tablet 10's is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Pregalex-MNT Tablet 10's helps to treat neuropathic pain.

Storage

Keep Pregalex-MNT Tablet 10's out of the sight and reach of children.

Drug Warnings

If you are allergic to any of the ingredients in Pregalex-MNT Tablet 10's, do not consume it. Please do not stop taking Pregalex-MNT Tablet 10's without first consulting your doctor, as this may result in withdrawal symptoms. If you are pregnant or breastfeeding, do not take Pregalex-MNT Tablet 10's unless your doctor has prescribed it. Pregalex-MNT Tablet 10's may cause drowsiness and dizziness, therefore drive only if you are alert. Pregalex-MNT Tablet 10's is not recommended for children as safety and effectiveness have not been established. Avoid drinking alcohol while taking Pregalex-MNT Tablet 10's as it may cause drowsiness and sleepiness. If you have suicidal thoughts, consult your doctor right away.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Pregalex-MNT Tablet:
Coadministration of Pregalex-MNT Tablet with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Pregalex-MNT Tablet with Linezolid together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pregalex-MNT Tablet:
Coadministration of Pregalex-MNT Tablet with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Pregalex-MNT Tablet with Tranylcypromine together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Pregalex-MNT Tablet:
Co-administration of Pregalex-MNT Tablet with Selegiline might raise serotonin hormone levels in the body (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Pregalex-MNT Tablet with Selegiline together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylineIsocarboxazid
Critical
How does the drug interact with Pregalex-MNT Tablet:
Using Pregalex-MNT Tablet together with Isocarboxazid can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Taking Isocarboxazid with Pregalex-MNT Tablet is not recommended, please consult your doctor before taking it. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pregalex-MNT Tablet:
Coadministration of Pregalex-MNT Tablet with Ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Pregalex-MNT Tablet with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, severe or prolonged diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pregalex-MNT Tablet:
Coadministration of Pregalex-MNT Tablet with Safinamide may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Pregalex-MNT Tablet with Safinamide together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
NortriptylinePotassium citrate
Critical
How does the drug interact with Pregalex-MNT Tablet:
Coadministration of Pregalex-MNT Tablet with Potassium citrate can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Pregalex-MNT Tablet with Potassium citrate together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pregalex-MNT Tablet:
Coadministration of Pregalex-MNT Tablet with Iloperidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Pregalex-MNT Tablet with Iloperidone together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, severe or prolonged diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pregalex-MNT Tablet:
Although it is a rare adverse effect, Coadministration of Pregalex-MNT Tablet with Desvenlafaxine might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Pregalex-MNT Tablet with Desvenlafaxine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pregalex-MNT Tablet:
Coadministration of Pregalex-MNT Tablet with Moxifloxacin can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Pregalex-MNT Tablet with Moxifloxacin together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience dizziness, shortness of breath, rapid heartbeat. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include vitamin B and D-rich foods in your diet.
  • Cayenne pepper should be included in your diet because it can help with neuropathic pain.
  • Exercising regularly helps to improve overall health and combat pain.
  • Rest well and get plenty of rest.
  • Taking a warm bath can be very relaxing.
  • Avoid smoking and drinking alcohol.
  • Meditation and yoga can reduce stress, pain sensitivity and improve coping skills.
  • Acupuncture, by stimulating pressure points, can be beneficial.
  • Massages with essential oils can help increase circulation.

Side Effects of Pregalex-MNT Tablet 10's

  • Constipation
  • Dry mouth
  • Headache
  • Feeling sleepy, tired or dizzy
  • Diarrhoea

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Pregalex-MNT Tablet 10's contains Methylcobalamin, Nortriptyline, and Pregabalin. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline alters the way nerves receive pain signals, thereby decreasing pain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Pregalex-MNT Tablet 10's helps to treat neuropathic pain.

Pregalex-MNT Tablet 10's contains pregabalin. It may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a proper diet.

Dry mouth could be a side-effect of Pregalex-MNT Tablet 10's. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Do not stop taking Pregalex-MNT Tablet 10's without consulting your doctor, as this could result in withdrawal symptoms. Continue taking Pregalex-MNT Tablet 10's for as long as prescribed to treat your condition effectively. If you experience any difficulty while taking Pregalex-MNT Tablet 10's, do not be afraid to speak with your doctor.

Pregalex-MNT Tablet 10's is used to treat diabetic neuropathy. Diabetic neuropathy is a condition that causes nerve damage due to high blood glucose levels. It primarily affects the nerves in the legs and feet.

Pregalex-MNT Tablet 10's may cause peripheral oedema. The swelling of the hands and lower legs are known as peripheral oedema. If you experience oedema, avoid sitting or standing for extended periods. Raise your legs by laying down and placing a pillow under them.

Drug-Drug Interactions Checker List

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  • ZOLPIDEM
  • DIPHENHYDRAMINE
  • CETIRIZINE
  • CYCLOBENZAPRINE
  • ONDANSETRON
  • ST JOHN'S WORT

Special Advise

Pregalex-MNT Tablet 10's contains Nortriptyline (antidepressant), which can lead to suicidal thoughts. Suicidal thoughts or behaviour should be closely monitored in people taking Pregalex-MNT Tablet 10's. If you have suicidal thoughts, don't be afraid to talk to your doctor right away.

Disease/Condition Glossary

Neuropathic pain: Neuropathic pain is caused due to damaged sensory nerves. It is caused by chronic progressive nerve disease or due to infection or injury. The pain could be intermittent or continuous, which is felt as prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensations is also familiar with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury. The body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping and evoked pain (pain caused by events usually not painful).

Have a query?

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Pregalex-MNT Tablet 10's as it may increase drowsiness and sleepiness.

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Pregnancy

Caution

If you're pregnant, don't take Pregalex-MNT Tablet 10's unless your doctor tells you to. Please consult your doctor if you have any concerns about this; your doctor will only prescribe if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor as there is no substantial research yet on the use of Pregalex-MNT Tablet 10's in breastfeeding/nursing mothers.

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Driving

Unsafe

Pregalex-MNT Tablet 10's causes drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Pregalex-MNT Tablet 10's should not be given to children as the safety and efficacy have not been established.

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