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  1. Home
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  3. Pregulate Injection 5 ml

Pregulate Injection 5 ml, Pack of 1 TABLET
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Know More

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Whats That

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Synonym :

BUSERELIN ACETATE

Composition :

BUSERELIN-0.004MG

Manufacturer/Marketer :

Virbac Animal Health India Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Pregulate Injection 5 ml

Pregulate Injection 5 ml belongs to a group of medicines called gonadotropin-releasing hormone analogues indicated in infertility treatment. Besides this, it can also used to treat endometriosis. Infertility is a condition in which a woman cannot become pregnant even after having carefully timed, unprotected sex for a year. Endometriosis is a painful disorder in which the tissue that generally lines the endometrium (inside the uterus) grows outside the uterus.

Pregulate Injection 5 ml contains Buserelin, a synthetic version of the hormone that naturally occurs in the body. It works by stopping the production of natural hormones that control ovulation. Synthetic hormones are then used to stimulate ovulation artificially. Pregulate Injection 5 ml helps relieve symptoms of endometriosis by reducing the production of female sex hormones by acting on the pituitary gland.

You are advised to use Pregulate Injection 5 ml for as long as your doctor prescribes it, depending on your medical condition. Sometimes, Pregulate Injection 5 ml may cause side effects like diarrhoea, constipation, nausea, vomiting, abdominal pain, and headache. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to the doctor if the side effects persist or worsen.

Avoid using Pregulate Injection 5 ml if you are pregnant, think you are pregnant, breastfeeding, or have abnormal menstrual bleeding. Consult your doctor immediately if you become pregnant while on treatment with Pregulate Injection 5 ml. This medicine may cause dizziness, drowsiness or blurred eyesight; do not drive if you experience these symptoms. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Pregulate Injection 5 ml

Infertility, Endometriosis.

Directions for Use

A healthcare professional will administer Pregulate Injection 5 ml. After receiving proper training, you may be advised to inject the medicine yourself.

Medicinal Benefits

Pregulate Injection 5 ml belongs to a group of medicines called gonadotropin-releasing hormone analogues indicated in the treatment of infertility and endometriosis. Pregulate Injection 5 ml contains Buserelin, a synthetic version of the hormone that naturally occurs in the body. It acts on the pituitary gland in the brain to stop the production of natural hormones that control the release of eggs from the ovaries. Other hormonal treatments are then used to stimulate ovulation artificially. Female hormones such as oestrogen may worsen problems like endometriosis. Pregulate Injection 5 ml helps relieve symptoms of endometriosis by reducing the production of female sex hormones by acting on the pituitary gland.

Storage

Keep Pregulate Injection 5 ml out of reach and sight of children.
Side effects of Pregulate Injection 5 ml
  • If you experience or encounter any severe allergic reaction, stop using medication and consult the doctor right away.
  • Tell your doctor about the allergic reaction, including the medication taken and any symptoms experienced.
  • Your doctor will evaluate the severity of the reaction and determine the best course of action.
  • To ensure a full recovery, follow your doctor's advice, attend scheduled follow-up appointments, and undergo recommended tests to monitor progress and adjust treatment as needed.
  • Stay away from loud places because they can put more stress on hearing.
  • Wear hearing aids if a specialist has suggested it.
  • Unless instructed to do so by a doctor, do not use ototoxic substances, such as some over-the-counter medications.
  • Make an appointment with an audiologist for a hearing test
  • Get nutrients for ear health (e.g., magnesium, zinc).
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Always wear loose-fitting clothes suitable for your activity during hot flashes.
  • Include a diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water and stay hydrated.
  • Stay calm and lower your anxiety by practising yoga or meditation.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.

Drug Warnings

Do not use Pregulate Injection 5 ml if you are allergic to any of its components, if you have abnormal menstrual bleeding, or if you are pregnant or breastfeeding. Stop using Pregulate Injection 5 ml and consult the doctor immediately if you become pregnant while on treatment with Pregulate Injection 5 ml. Pregulate Injection 5 ml is not intended for use in men. Inform the doctor if you have depression, high blood pressure, diabetes, polycystic ovarian disease, heart/blood vessel conditions, heart rhythm problems, metabolic bone disease or risk factors for osteoporosis like smoking, chronic alcohol abuse, a family history of osteoporosis, or if you are on long-term treatment with corticosteroids or anticonvulsants. Stop using Pregulate Injection 5 ml and consult a doctor immediately if you experience symptoms of serious side effect called ovarian hyperstimulation syndrome, such as diarrhoea, weight gain, difficulty breathing, shortness of breath, passing less urine, feeling sick or being sick, pain, swelling or a feeling of tension in your stomach. Ovarian hyperstimulation syndrome is more likely to occur if you are taking other hormones along with Pregulate Injection 5 ml as a part of infertility treatment. Consult the doctor straight away if you notice bruising more easily than usual, signs of infections (fever, sore throat or mouth ulcers), severe headache, eyesight problems, or high blood pressure (crushing chest pain, problems with eyesight, confusion, tiredness and an uneven heartbeat).

Drug-Drug Interactions

verifiedApollotooltip
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Diet & Lifestyle Advise

  • Include fibrous foods, iron-rich foods, foods rich in essential fatty acids, and anti-oxidant-rich foods in the diet.
  • Practice meditation and yoga. 
  • Avoid or limit caffeine intake.
  • Include healthy fruits and vegetables in your diet.
  • Avoid smoking and alcohol consumption.
  • Try relaxation therapy. Read a book or listen to soothing music.
  • Exercise moderately.
  • Do yoga or meditation, as it helps relieve stress.

Habit Forming

No

Therapeutic Class

HORMONES

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:49 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

FAQs

Pregulate Injection 5 ml works by stopping the production of natural hormones that control ovulation and relieves symptoms of endometriosis by reducing the production of female sex hormones.

There have been reports of depression, which might be severe in patients receiving Pregulate Injection 5 ml. Therefore, inform the doctor if you have depression or depressed mood.

Pregulate Injection 5 ml might cause menopausal symptoms such as hot flushes, dry vagina, increased sweating, loss of sex drive, or painful sexual intercourse. If these symptoms become serious or last longer than a few days, consult a doctor.

Pregulate Injection 5 ml might increase the risk of osteoporosis if used for a longer duration due to a lowering in the amount of bone mineral. However, this effect is reversible when the treatment is stopped. Consult a doctor if you experience bone or muscle discomfort, such as shoulder stiffness or pain that lasts longer than a few days.

Pregulate Injection 5 ml may increase the risk of heart rhythm problems. Inform the doctor if you have heart or blood vessel problems, including arrhythmia (heart rhythm problems), or if you are being treated with medicines for these conditions.

Drug-Drug Interactions Checker List

  • QUINIDINE
  • PROCAINAMIDE
  • AMIODARONE
  • SOTALOL
  • METHADONE
  • MOXIFLOXACIN

Special Advise

  • The use of this medicine may lead to positive results in doping tests. Additionally, misuse as a doping agent may harm your health.
  • Pregulate Injection 5 ml might affect certain blood test results; particularly, it may affect the levels of liver enzymes and fats in the blood shown in blood tests. Therefore, if you are undergoing any tests, inform the doctor that you are on treatment with Pregulate Injection 5 ml.
  • Regular monitoring of blood pressure and blood glucose levels is advised.
  • Women are recommended to have a pregnancy test to make sure they are not pregnant before using Pregulate Injection 5 ml.

Disease/Condition Glossary

Endometriosis: Endometriosis is a painful disorder in which the tissue that generally lines the endometrium (inside the uterus) grows outside the uterus. Endometriosis usually occurs when the endometrial tissue grows on the ovaries, pelvis lining, and fallopian tubes. Symptoms include pelvic pain, painful periods, pain in the abdomen during and before menstruation, heavy menstrual bleeding, discomfort during bowel movements, lower back pain during menstruation, pain during sexual intercourse, and cramps 1-2 weeks around menstruation.

Infertility: It is a condition in which a woman cannot become pregnant even after having carefully timed, unprotected sex for a year. Age, hormonal problems, physical problems, lifestyle or environmental factors could be the causes of infertility.

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