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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Manufacturer/Marketer :

V Aid Biotech

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Preloxetin 50/20 Capsules

Preloxetin 50/20 Capsules belongs to an anticonvulsant class of medicines. It is used in the treatment of diabetic neuropathic pain and fibromyalgia. Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged. Diabetic neuropathic pain/diabetic neuropathy is a condition causing moderate to severe pain due to damage of nerves in the thigh, hip, buttock and leg regions. Symptoms may include tingling, shooting pain, burning, or even an electric shock sensation. Fibromyalgia is a chronic condition with moderate pain and tenderness all over the body resulting in fatigue and trouble sleeping.

Preloxetin 50/20 Capsules is a combination of Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.

Preloxetin 50/20 Capsules can be taken with or without food or as prescribed by your doctor. Preloxetin 50/20 Capsules may cause certain side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation. These side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist, inform your doctor.

Preloxetin 50/20 Capsules should be avoided if you are allergic to it. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, glaucoma (an eye condition), bleeding disorders, or are at risk of hyponatremia (low sodium levels, especially in patients taking diuretics or water pills). If you are pregnant or breastfeeding, inform your doctor before taking this medicine. It is not recommended for use in children and young adults as it increases the risk of suicidal tendencies. 

Uses of Preloxetin 50/20 Capsules

Diabetic Neuropathic Pain, Fibromyalgia

Directions for Use

Take Preloxetin 50/20 Capsules as prescribed by your doctor. Swallow it as a whole with water. It can be taken with or without food. Do not crush, break or chew it.

Medicinal Benefits

Preloxetin 50/20 Capsules contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain. Preloxetin 50/20 Capsules effectively treats neuropathic pain, and improves nerve conduction for proper nerve signal functioning in the body. 

Storage

Store in a cool and dry place away from sunlight

Side Effects of Preloxetin 50/20 Capsules

  • Burning sensation
  • Drowsiness
  • Nausea
  • Constipation
  • Headache
  • Dry mouth
  • Increased sweating
  • Loss of appetite

Drug Warnings

Preloxetin 50/20 Capsules should be avoided if you are allergic to any of the components in it. Do not stop taking Preloxetin 50/20 Capsules suddenly without your doctor’s advice, as it may cause withdrawal symptoms like dizziness, tingling sensation, sleep disturbances, restlessness, nausea or vomiting, headache, or excessive sweating. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, or glaucoma (an eye condition). Preloxetin 50/20 Capsules may increase suicidal thoughts, so it is advised to use caution in patients with mania, bipolar disorder or depression. It is not recommended for use in children below 18 years of age as the safety and efficacy of this medicine are not established. Pregnant or breastfeeding mothers should inform the doctor before using Preloxetin 50/20 Capsules .

Drug-Drug Interactions

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DuloxetineTranylcypromine
Critical
DuloxetineLinezolid
Critical

Drug-Drug Interactions

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DuloxetineTranylcypromine
Critical
How does the drug interact with Preloxetin 50/20 Capsules:
Taking Tranylcypromine with Preloxetin 50/20 Capsules can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Preloxetin 50/20 Capsules is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineLinezolid
Critical
How does the drug interact with Preloxetin 50/20 Capsules:
Taking Preloxetin 50/20 Capsules with Linezolid can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking Preloxetin 50/20 Capsules with Linezolid is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting a doctor.
DuloxetineRasagiline
Critical
How does the drug interact with Preloxetin 50/20 Capsules:
Taking Rasagiline with Preloxetin 50/20 Capsules can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Rasagiline and Preloxetin 50/20 Capsules is not recommended as they can possibly result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DuloxetineSelegiline
Critical
How does the drug interact with Preloxetin 50/20 Capsules:
Taking Preloxetin 50/20 Capsules with selegiline may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Although there is an interaction between Preloxetin 50/20 Capsules and Selegiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetinePhenelzine
Critical
How does the drug interact with Preloxetin 50/20 Capsules:
Taking phenelzine with Preloxetin 50/20 Capsules can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Preloxetin 50/20 Capsules with Phenelzine is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineSafinamide
Critical
How does the drug interact with Preloxetin 50/20 Capsules:
Coadministration of safinamide with Preloxetin 50/20 Capsules can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Safinamide with Preloxetin 50/20 Capsules is not recommended as it can result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DuloxetineEliglustat
Critical
How does the drug interact with Preloxetin 50/20 Capsules:
Coadministration of eliglustat and Preloxetin 50/20 Capsules can significantly increase the blood levels of eliglustat. This may increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Preloxetin 50/20 Capsules with Eliglustat is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, or weak pulse. Do not discontinue any medications without consulting your doctor.
DuloxetineMetoclopramide
Critical
How does the drug interact with Preloxetin 50/20 Capsules:
Coadministration of metoclopramide with Preloxetin 50/20 Capsules increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Metoclopramide with Preloxetin 50/20 Capsules is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
DuloxetineProcarbazine
Critical
How does the drug interact with Preloxetin 50/20 Capsules:
Taking Preloxetin 50/20 Capsules with procarbazine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Preloxetin 50/20 Capsules with Procarbazine is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
PregabalinHydrocodone
Severe
How does the drug interact with Preloxetin 50/20 Capsules:
Using Preloxetin 50/20 Capsules together with Hydrocodone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydrocodone and Preloxetin 50/20 Capsules together can result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercise regularly, which helps in reducing pain.
  • Rest well, and get enough sleep.
  • Always take a warm bath, as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity, and improves coping skills.

Habit Forming

Yes

Therapeutic Class

ANTICONVULSANT

Preloxetin 50/20 Capsules Substitute

Substitutes safety advice
  • Pregaba-D 50/20 Capsule 10's

    by Others

    16.61per tablet
  • Maxdulin 50 mg/20 mg Capsule 10's

    by Others

    13.68per tablet
  • Pregeb D 50/20 Capsule 10's

    by Others

    15.12per tablet
  • Pregabid D 50/20 Capsule 10's

    by Others

    15.03per tablet
  • Dulane PG 50/20 Capsule 10's

    by Others

    14.94per tablet

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Preloxetin 50/20 Capsules contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.

Do not stop using Preloxetin 50/20 Capsules suddenly as it can cause withdrawal symptoms. Your doctor will gradually reduce the dose based on your clinical condition.

Seek medical attention immediately if you notice any depressive thoughts while using Preloxetin 50/20 Capsules . Your doctor may change the dose or medicine to treat your condition.

Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged.

Drug-Drug Interactions Checker List

  • TRAMADOL
  • FLUOXETINE
  • MOCLOBEMIDE
  • VENLAFAXINE
  • AMITRIPTYLINE

Special Advise

  • Do not stop taking Preloxetin 50/20 Capsules suddenly, as it may cause withdrawal symptoms.
  • Do frequent blood tests to check your fasting blood glucose, HbA1c, and total cholesterol (TC) levels to reduce any serious side effects.

Disease/Condition Glossary

Diabetic Neuropathy: Diabetic neuropathic pain/diabetic neuropathy is a condition causing moderate to severe pain due to damage of nerves in the thigh, hip, buttock and leg regions. Symptoms may include tingling, shooting pain, burning, or even an electric shock sensation. It mainly occurs in patients suffering from Type II Diabetes.

Fibromyalgia: It is a chronic condition with moderate pain and tenderness of the muscle all over the body. It mainly occurs due to physical or psychological stress. Symptoms may include fatigue, tiredness, trouble sleeping, anxiety, headache and depression.

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