Duloxetine+pregabalin
About
Duloxetine+pregabalin belongs to an anticonvulsant class of medicines. It is used in the treatment of diabetic neuropathic pain and fibromyalgia. Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged. Diabetic neuropathic pain/diabetic neuropathy is a condition causing moderate to severe pain due to damage of nerves in the thigh, hip, buttock and leg regions. Symptoms may include tingling, shooting pain, burning, or even an electric shock sensation. Fibromyalgia is a chronic condition with moderate pain and tenderness all over the body resulting in fatigue and trouble sleeping.
Duloxetine+pregabalin is a combination of Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.
Duloxetine+pregabalin can be taken with or without food or as prescribed by your doctor. Duloxetine+pregabalin may cause certain side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation. These side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist, inform your doctor.
Duloxetine+pregabalin should be avoided if you are allergic to it. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, glaucoma (an eye condition), bleeding disorders, or are at risk of hyponatremia (low sodium levels, especially in patients taking diuretics or water pills). If you are pregnant or breastfeeding, inform your doctor before taking this medicine. It is not recommended for use in children and young adults as it increases the risk of suicidal tendencies.
Uses of Duloxetine+pregabalin
Medicinal Benefits
Duloxetine+pregabalin contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain. Duloxetine+pregabalin effectively treats neuropathic pain, and improves nerve conduction for proper nerve signal functioning in the body.
Directions for Use
Storage
Side Effects of Duloxetine+pregabalin
- Burning sensation
- Drowsiness
- Nausea
- Constipation
- Headache
- Dry mouth
- Increased sweating
- Loss of appetite
In-Depth Precautions and Warning
Drug Warnings
Duloxetine+pregabalin should be avoided if you are allergic to any of the components in it. Do not stop taking Duloxetine+pregabalin suddenly without your doctor’s advice, as it may cause withdrawal symptoms like dizziness, tingling sensation, sleep disturbances, restlessness, nausea or vomiting, headache, or excessive sweating. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, or glaucoma (an eye condition). Duloxetine+pregabalin may increase suicidal thoughts, so it is advised to use caution in patients with mania, bipolar disorder or depression. It is not recommended for use in children below 18 years of age as the safety and efficacy of this medicine are not established. Pregnant or breastfeeding mothers should inform the doctor before using Duloxetine+pregabalin.
Drug Interactions
Drug-Drug Interactions: Duloxetine+pregabalin may interact with antidepressants (moclobemide, paroxetine, fluoxetine, venlafaxine, clomipramine, and amitriptyline), antibiotic (linezolid), opioid analgesic (tramadol).
Drug-Food Interactions: Avoid alcohol consumption and smoking while using Duloxetine+pregabalin.
Drug-Disease Interactions: Duloxetine+pregabalin should be used with caution in patients with liver diseases, kidney diseases, heart problems, glaucoma (increased pressure in the eye), alcoholism, drug abuse, and suicidal tendencies.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid alcohol consumption during treatment with $nmae as it may increase the risk of serious side effects and worsen your health.
Pregnancy
cautionIf you are pregnant, especially in the last trimester or planning pregnancy, inform your doctor before taking Duloxetine+pregabalin. It may cause foetal abnormalities if taken in the last trimester of pregnancy. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Breast Feeding
cautionIf you are breastfeeding, inform your doctor before taking Duloxetine+pregabalin. Your doctor may prescribe this medicine if the benefits outweigh the risks.
Driving
unsafeDuloxetine+pregabalin may cause drowsiness. Hence, avoid driving vehicles or operating machines after taking Duloxetine+pregabalin.
Liver
cautionIf you have liver conditions, inform your doctor before taking Duloxetine+pregabalin. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Kidney
cautionIf you have kidney conditions, inform your doctor before taking Duloxetine+pregabalin. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Children
unsafeDuloxetine+pregabalin is not recommended for children below 18 years as the safety and efficacy of use for this medicine are not established. Please seek medical advice for more information.
Habit Forming
Diet & Lifestyle Advise
- Exercise regularly, which helps in reducing pain.
- Rest well, and get enough sleep.
- Always take a warm bath, as it can be soothing.
- Avoid smoking and alcohol consumption.
- Meditation and yoga can help lower stress, decrease pain sensitivity, and improves coping skills.
Special Advise
- Do not stop taking Duloxetine+pregabalin suddenly, as it may cause withdrawal symptoms.
- Do frequent blood tests to check your fasting blood glucose, HbA1c, and total cholesterol (TC) levels to reduce any serious side effects.
Patients Concern
Disease/Condition Glossary
Diabetic Neuropathy: Diabetic neuropathic pain/diabetic neuropathy is a condition causing moderate to severe pain due to damage of nerves in the thigh, hip, buttock and leg regions. Symptoms may include tingling, shooting pain, burning, or even an electric shock sensation. It mainly occurs in patients suffering from Type II Diabetes.
Fibromyalgia: It is a chronic condition with moderate pain and tenderness of the muscle all over the body. It mainly occurs due to physical or psychological stress. Symptoms may include fatigue, tiredness, trouble sleeping, anxiety, headache and depression.
FAQs
Duloxetine+pregabalin contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.
Do not stop using Duloxetine+pregabalin suddenly as it can cause withdrawal symptoms. Your doctor will gradually reduce the dose based on your clinical condition.
Seek medical attention immediately if you notice any depressive thoughts while using Duloxetine+pregabalin. Your doctor may change the dose or medicine to treat your condition.
Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged.
