Premizen 0.5 Tablet belongs to a group of antiparkinson agents or dopamine agonists used to treat the symptoms of Parkinson’s disease and moderate to severe Willis-Ekbom disease (restless legs syndrome) in adults. Parkinson’s disease is a progressive neurological disorder in which the first signs are problems with movements. Willis-Ekbom disease is a condition which causes the uncontrollable urge to move the legs.

Premizen 0.5 Tablet contains 'Pramipexole' that works by mimicking the action of dopamine (acting in place of dopamine), a natural substance found in the brain needed to control body movement. This triggers the nerve impulses in the brain that control body movements.

In some cases, you may experience certain common side-effects such as sleepiness, nausea, constipation, dizziness, fatigue, hallucinations, dry mouth, muscle spasms, and peripheral oedema (leg swelling due to fluid overload). Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Do not discontinue Premizen 0.5 Tablet on your own. Consult your doctor if you are pregnant or breastfeeding. Premizen 0.5 Tablet may cause drowsiness and dizziness, do not drive unless you are alert. Premizen 0.5 Tablet should not be used in children below 18 years. Avoid consuming alcohol along with Premizen 0.5 Tablet as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Premizen 0.5 Tablet may cause orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). 

Premizen 0.5 Tablet belongs to a group of antiparkinson agents called dopamine agonists used to treat the symptoms of Parkinson’s disease and moderate to severe Willis-Ekbom disease (restless legs syndrome) in adults. Premizen 0.5 Tablet binds to the dopamine receptor and mimics its action. Dopamine is a naturally-occurring neurotransmitter in the brain. Dopamine is absent or reduced in people with Parkinson’s disease. Premizen 0.5 Tablet works by stimulating the dopamine receptors in the brain. This triggers the nerve impulses in the brain that control body movements. Premizen 0.5 Tablet helps in relieving the symptoms of Parkinson’s disease, such as muscle spasms, tremors, stiffness, and poor muscle control.

• Nausea
• Low blood pressure
• Dizziness
• Constipation
• Fatigue
• Headache
• Dry mouth
• Muscle spasms

Do not take Premizen 0.5 Tablet if you are allergic to any of its contents. Talk to your doctor before taking Premizen 0.5 Tablet if you have kidney problems, hallucinations, dyskinesia (abnormal limb movements), dystonia (inability to keep the neck straight), sleepiness or suddenly falling asleep, psychosis, vision impairment, severe heart or blood vessel disease, or augmentation (symptoms start earlier). Inform your doctor if you experience symptoms such as apathy, anxiety, depression, fatigue, sweating or pain after dose reduction or stopping Premizen 0.5 Tablet. Premizen 0.5 Tablet may cause intense urges such as increased sex drive, gambling, overeating and wasting money. Consult your doctor if you are pregnant or breastfeeding. Premizen 0.5 Tablet may cause drowsiness and dizziness, do not drive unless you are alert. Premizen 0.5 Tablet should not be given to children below 18 years. Avoid consuming alcohol along with Premizen 0.5 Tablet as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Premizen 0.5 Tablet causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). 

Drug-Drug Interactions: Premizen 0.5 Tablet may interact with anti-depressants (amitriptyline, duloxetine, trazodone, and fluoxetine), antihistamine (diphenhydramine, and cetirizine), anticonvulsants (gabapentin, and pregabalin), a drug used to treat Alzheimer’s (memantine), and pain killers (acetaminophen, hydrocodone, tramadol).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have disease conditions such as low blood pressure, neuroleptic malignant syndrome, psychosis, and renal function disorders.

• AMITRIPTYLINE
• DULOXETINE
• TRAZODONE
• FLUOXETINE
• DIPHENHYDRAMINE
• CETIRIZINE
• GABAPENTIN
• PREGABALIN
• MEMANTINE
• ACETAMINOPHEN
• HYDROCODONE
• TRAMADOL

• Maintain a healthy diet and exercise regularly.
• Include a diet rich in iron, folate and magnesium. 
• Regularly attend therapy sessions.
• Perform meditation and yoga.
• Follow a regular sleep pattern.
• Avoid smoking and alcohol consumption.
• Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Patients and their caretakers (midwife/nurse) should be alerted as Premizen 0.5 Tablet may cause intense urges such as increased sex drive, gambling, overeating and wasting money.

Parkinson’s disease: It is a progressive neurological disorder in which the first signs are problems with movements. Dopamine is a naturally-occurring neurotransmitter in the brain which is reduced or absent in people with Parkinson’s disease. Due to this problems arise with smooth and coordinated movements. Symptoms include decreased ability to smell, stooped posture, changes in voice, constipation, small/cramped handwriting, tremor, slow movements, stiffness of arms, legs, and trunk, and problems with balance. 

Willis-Ekbom disease (restless leg syndrome): It is a condition which causes the uncontrollable urge to move the legs. The urge to move their legs is more intense when a person is trying to sleep or relax. This interferes with sleep leading to daytime sleepiness and fatigue. Symptoms include an uncontrollable urge to move the legs, tingling, crawling or pulling sensations in the legs.