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Written By Divya L , PharmaD
Reviewed By Veda Maddala , M Pharmacy
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Composition :

CHLOROQUINE-64.5MG

Manufacturer/Marketer :

Prem Pharmaceuticals Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Premoquin 64.5mg Injection

Premoquin 64.5mg Injection belongs to the class of 'anti-malarial drugs', primarily used to treat and prevent malaria. It may also be used to treat extraintestinal amebiasis/amoebiasis. Malaria is a disease caused by a plasmodium parasite transmitted by the bite of infected Anopheles mosquitoes. When an infected mosquito bites a healthy person, it transmits the 'Plasmodium parasite' into the bloodstream, which affects the red blood cells and liver cells. Extraintestinal amebiasis is a parasitic infection caused by Entamoeba histolytica that spreads to various organs, most commonly the liver.

Premoquin 64.5mg Injection contains Chloroquine. It works by increasing the concentration of a toxic compound in the parasite that leads to its death. It is also amoebicidal in action and destroys the parasitic amoebas causing amoebiasis. Thereby treats malaria ans extraintestinal amebiasis.

Your doctor will decide the dose and duration based on your medical condition. Common side effects of Premoquin 64.5mg Injection include nausea, vomiting, diarrhoea, stomach cramps, headache, hair loss, changes in mood/confusion, vision changes/blurred vision, black or tarry stools, bleeding gums, and dizziness. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you are allergic to any of the components in Premoquin 64.5mg Injection. Inform your doctor if you have any liver or kidney problems, fits, heart diseases, hearing problems, vision-related issues, fits, and damaged retina or vision problems before starting Premoquin 64.5mg Injection. It is essential to let your doctor know if you are pregnant, planning to conceive, or are a breastfeeding mother. Premoquin 64.5mg Injection may cause dizziness; hence do not drive or operate machinery until you are alert. Avoiding alcohol during the treatment is recommended to rule out any possibility of worsening side effects. Premoquin 64.5mg Injection should be used for children only when prescribed by a doctor.

Uses of Premoquin 64.5mg Injection

Malaria and Extraintestinal Amebiasis.

Directions for Use

Premoquin 64.5mg Injection will be injected by a healthcare professional. Do not self-administer.

Medicinal Benefits

Premoquin 64.5mg Injection contains Chloroquine. It works by increasing the concentration of a toxic compound in the parasite that leads to its death. It is effective against parasitic species, including Plasmodium vivax, Plasmodium malariae, and susceptible strains of Plasmodium falciparum. Premoquin 64.5mg Injection is useful in extending the interval between treatment and relapse in patients with malaria or vivax malaria. It is also amoebicidal in action and destroys the parasitic amoebas causing amoebiasis. Chloroquine also has off-label uses in treating autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus.

Storage

Keep out of sight and reach of children.

Drug Warnings

Before using Premoquin 64.5mg Injection, inform your doctor if you have recently used any prescription and non-prescription medications, including other anti-malarial drugs. Inform your doctor if you have any allergic reactions, liver or kidney problems, heart diseases, diabetes, G-6-PD (glucose-6 phosphate dehydrogenase) deficiency, electrolyte imbalance, psoriasis, alcoholism, porphyria, hearing problems, vision-related issues, fits, and damaged retina or vision problems. Please seek medical advice if you are pregnant or breastfeeding before taking Premoquin 64.5mg Injection. This medicine may cause dizziness; hence drive or operate machinery only when you are alert. Do not consume alcohol while being treated with Premoquin 64.5mg Injection.

Drug-Drug Interactions

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ChloroquineAurothioglucose
Critical
ChloroquineBepridil
Critical

Drug-Drug Interactions

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ChloroquineAurothioglucose
Critical
How does the drug interact with Premoquin 64.5mg Injection:
Taking Aurothioglucose with Premoquin 64.5mg Injection can cause blood disorders and other severe side effects

How to manage the interaction:
Taking Aurothioglucose with Premoquin 64.5mg Injection is not recommended, as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
ChloroquineBepridil
Critical
How does the drug interact with Premoquin 64.5mg Injection:
Using Premoquin 64.5mg Injection together with bepridil can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Premoquin 64.5mg Injection with Bepridil is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately.
How does the drug interact with Premoquin 64.5mg Injection:
Using Premoquin 64.5mg Injection together with sparfloxacin can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Premoquin 64.5mg Injection with Sparfloxacin is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Premoquin 64.5mg Injection:
When Thioridazine and Premoquin 64.5mg Injection are taken together, can increase the chance of a serious abnormal heart rhythm

How to manage the interaction:
Taking Premoquin 64.5mg Injection with Thioridazine is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChloroquineLevacetylmethadol
Critical
How does the drug interact with Premoquin 64.5mg Injection:
Using Levacetylmethadol together with Premoquin 64.5mg Injection can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Premoquin 64.5mg Injection with Levacetylmethadol is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Premoquin 64.5mg Injection:
Taking Premoquin 64.5mg Injection with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Premoquin 64.5mg Injection with Ziprasidone is not recommended, it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, drowsiness, confusion, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
ChloroquineSaquinavir
Critical
How does the drug interact with Premoquin 64.5mg Injection:
Using saquinavir together with Premoquin 64.5mg Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Premoquin 64.5mg Injection with Saquinavir is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Premoquin 64.5mg Injection:
Taking pazopanib with Premoquin 64.5mg Injection can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Pazopanib with Premoquin 64.5mg Injection is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Premoquin 64.5mg Injection:
Taking Premoquin 64.5mg Injection with Cisapride can increase the risk of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Premoquin 64.5mg Injection with Cisapride is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately.
ChloroquineAgalsidase alfa
Critical
How does the drug interact with Premoquin 64.5mg Injection:
When Agalsidase alfa is used with Premoquin 64.5mg Injection, it may decrease the effectiveness of the Agalsidase alfa.

How to manage the interaction:
Taking Agalsidase alfa with Premoquin 64.5mg Injection is not recommended, it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Malaria:

  • Take nutritious food, including fresh fruits and vegetables, to help recover from malarial fever.
  • During malarial fever, the patient may experience appetite loss. In such cases, drink glucose water, fresh fruit juices, and coconut water.
  • Include high-fibre foods like green leafy vegetables and fruits to aid digestion.
  • Take proper rest to help your body relax and heal faster.
  • Avoid or limit the intake of alcohol and caffeine.

Extra intestinal Amebiasis:

  • Include fruits, vegetables, whole-grain bread, low-fat dairy products, beans, lean meats, and fish in your diet.
  • Avoid alcohol consumption that can further damage your liver in liver abscess.
  • Wash your hands often to prevent infection.
  • Stay away from patients who are infected with amebiasis.

Side Effects of Premoquin 64.5mg Injection

  • Nausea 
  • Vomiting 
  • Diarrhoea 
  • Stomach cramps 
  • Headache 
  • Hair loss 
  • Changes in mood/confusion 
  • Vision changes/blurred vision 
  • Black or tarry stools 
  • Bleeding gums 
  • Dizziness 

Habit Forming

No

Therapeutic Class

ANTI- MALARIALS

Premoquin 64.5mg Injection Substitute

Substitutes safety advice

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Drug-Diseases Interactions

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CHLOROQUINE-64.5MGDisorders of porphyrin and bilirubin metabolism
Severe
CHLOROQUINE-64.5MGOther cardiac arrhythmias
Moderate

Drug-Diseases Interactions

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CHLOROQUINE-64.5MGDisorders of porphyrin and bilirubin metabolism
Severe
How does the disease interact with Premoquin 64.5mg Injection:
Porphyria: In porphyria the use of Premoquin 64.5mg Injection may aggravate this condition. Avoid Premoquin 64.5mg Injection use until it is required.

How to manage the interaction:
If the risks aren't expected to outweigh the possible advantages, Premoquin 64.5mg Injection shouldn't be utilized on these patients.
CHLOROQUINE-64.5MGOther cardiac arrhythmias
Moderate
How does the disease interact with Premoquin 64.5mg Injection:
Arrhythmias:Premoquin 64.5mg Injection has adverse effect like prolongation of QT interval, ventricular arrhythmias and torsades de pointes. Monitor ECG before initiation and during the therapy.

How to manage the interaction:
If you have sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat while taking these medications, whether they are taken together or separately, you should seek immediate assistance from a doctor. A close monitoring of ECG is required.
CHLOROQUINE-64.5MGEpilepsy
Moderate
How does the disease interact with Premoquin 64.5mg Injection:
Seizures: Premoquin 64.5mg Injection may cause epileptic seizures in susceptible patients. Administer Premoquin 64.5mg Injection in patients with history of epilepsy.

How to manage the interaction:
In those who are vulnerable, Premoquin 64.5mg Injection may result in epileptic fits. Patients who already have epileptic fits or have a low tolerance for seizures may be at greater risk.
CHLOROQUINE-64.5MGOther diseases of blood and blood-forming organs
Moderate
How does the disease interact with Premoquin 64.5mg Injection:
Bone marrow suppression: With the use of Premoquin 64.5mg Injection adverse effects such as neutropenia, agranulocytosis, aplastic anemia, and thrombocytopenia. In patients with preexisting bone marrow suppression use cautiously and monitor for complete blood count. Discontinue the Premoquin 64.5mg Injection if any serious blood disorder is suspected.

How to manage the interaction:
It is important to inform your doctor if you have prior conditions like bone marrow suppression, a complete blood picture is advised to be taken if you are on a long term therapy with Premoquin 64.5mg Injection. If you suspect any blood disorders, please inform it to your doctor immediately.
CHLOROQUINE-64.5MGOther hearing loss
Moderate
How does the disease interact with Premoquin 64.5mg Injection:
Ototoxicity: Rarely, Premoquin 64.5mg Injection was been associated with ototoxicity.The use of Premoquin 64.5mg Injection has been associated rarely with ototoxicity. With long-term, high-dose Premoquin 64.5mg Injection therapy which is irreversible nerve-type deafness may occur. In some patients with preexisting auditory damage, tinnitus, decrease in hearing may occur. Use with caution and discontinue therapy if new auditory defects occur or if hearing loss becomes worse.

How to manage the interaction:
If you any existing hearing damage, do not forget to inform it your doctor, so that a close monitoring can be done during the treatment with Premoquin 64.5mg Injection.
CHLOROQUINE-64.5MGPsoriasis
Moderate
How does the disease interact with Premoquin 64.5mg Injection:
In psoriasis patients, the Premoquin 64.5mg Injection use may exacerbate severe attack of psoriasis. Do not use Premoquin 64.5mg Injection unless the potential benefits vs risks outweighs.

How to manage the interaction:
It is important to tell your doctor if you have any existing skin conditions like psoriasis. Your doctor may prescribe the medication, if the benefits are more than the risks.
CHLOROQUINE-64.5MGMyasthenia gravis and other myoneural disorders
Moderate
How does the disease interact with Premoquin 64.5mg Injection:
myasthenia gravis Use of Premoquin 64.5mg Injection may exacerbate new onset of symptoms in patients with previously diagnosed myasthenia gravis. Use cautiously.

How to manage the interaction:
If you are suffering from myasthenia gravis, do not forget to tell it to your doctor. If you are taking Premoquin 64.5mg Injection and experiencing symptoms like muscle weakness or weakness of the arms and legs, drooping of upper eyelid, difficulty speaking, difficulty swallowing, double vision, tiredness, or shortness of breath please inform your doctor.

FAQs

Premoquin 64.5mg Injection treats malaria by increasing the concentration of a toxic compound in the parasite that leads to its death.

Premoquin 64.5mg Injection may cause irreversible retinal damage with long-term therapy. Retinopathy (disease related to the retina) is also reported with Chloroquine usage. You may not be advised Premoquin 64.5mg Injection by your doctor if you have vision changes or retina damage. If the doctor has prescribed you this medicine knowing your medical history, you may be further advised to take ophthalmological examinations, including visual acuity, expert slit-lamp, funduscopic, and visual field tests. If there are any changes in these examinations, you may be asked to discontinue the treatment.

Inform your doctor in advance if you have any liver or kidney problems, heart diseases, diabetes, G-6-PD (glucose-6 phosphate dehydrogenase) deficiency (a genetic enzyme deficiency), electrolyte imbalance, psoriasis, alcoholism, porphyria (a blood disorder), hearing problems, vision-related issues, fits, and damaged retina or vision problems before starting Premoquin 64.5mg Injection. Also, let your doctor know if you have recently undergone treatment with other anti-malarial drugs.

It is advised not to use Premoquin 64.5mg Injection for the long term since it may produce retinal toxicity leading to blindness.

Drug-Drug Interactions Checker List

  • CIMETIDINE
  • AMPICILLIN
  • CYCLOSPORIN
  • KAOLIN

Special Advise

Let your doctor/laboratory staff know that you are taking Premoquin 64.5mg Injection if you are undergoing any medical tests.

Disease/Condition Glossary

Malaria: It is a life-threatening disease caused by parasites that enter the body through a mosquito's bite. This is a common disease in Africa, South America, and Southern Asia. This disease usually occurs when an Anopheles mosquito (infected with the parasite 'Plasmodium') bites a healthy individual and transfers the parasite into the bloodstream. Parasites that cause malaria include Plasmodium vivax, P. ovale, P. malaria, and P. falciparum. Malaria symptoms usually start ten days to 4 weeks after the infection. They include chills, high fever, profuse sweating, headache, nausea, vomiting, abdominal pain, diarrhoea, anaemia, muscle pain, convulsions, coma, and bloody stools.

Extraintestinal Amebiasis: It is a parasitic infection caused by Entamoeba histolytica that spreads to various organs, most commonly the liver. When the parasite infects the liver, it leads to an amoebic liver abscess (collection of pus in the liver). An amoebic liver abscess can further cause fever and right upper quadrant abdominal pain. Apart from the liver, other body areas that can be affected by extraintestinal amebiasis include pleuropulmonary (pleura and the lungs), cardiac (heart), cerebral (brain), renal (kidneys), genitourinary (genital and urinary tracts), and cutaneous (related to skin) sites.

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