Preva RS 5mg/75mg Capsule is a combination drug composed of a blood-thinning agent and cholesterol-lowering agent, primarily used to prevent heart attack and stroke in the future. It lowers the raised level of cholesterol and fats (triglycerides) in our body. A heart attack is a condition in which your coronary arteries (blood vessel supplying blood and oxygen to the heart) becomes blocked due to build-up of fats (plaque) including cholesterol. These plaques narrow the arteries, leading to atherosclerosis and coronary artery disease, mainly for most heart attacks.

Preva RS 5mg/75mg Capsule is composed of two medicines, namely: Rosuvastatin and Clopidogrel. Rosuvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. As a result, it lowers the bad cholesterol (low-density lipoproteins or LDL), triglycerides (TG) and increases the levels of good cholesterol (high-density lipoproteins or HDL). Clopidogrel is a blood thinner (anticoagulant) that collectively prevents a clot in the blood vessels. Together Preva RS 5mg/75mg Capsule reduces the increased levels of bad cholesterol (low-density lipoprotein and triglycerides) and prevents blood clots, thereby reducing and preventing the risk of heart attack, stroke and heart-related chest pain (angina).

Take Preva RS 5mg/75mg Capsule exactly as directed by your doctor. The dose and duration of Preva RS 5mg/75mg Capsule may differ depending on the reason why you're taking it and your responses to treatment. In some cases, you may experience headaches, ankle swelling due to fluid retention (oedema), slow heart rate, and nausea. Preva RS 5mg/75mg Capsule is known to cause dizziness, so driving should be avoided. Most of these side effects of Preva RS 5mg/75mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking Preva RS 5mg/75mg Capsule of your own. Suddenly stopping Preva RS 5mg/75mg Capsule may worsen your condition and increase your risk of a future heart attack. Inform your doctor know if you are allergic to rosuvastatin, clopidogrel, or have any active liver disease (liver enzymes abnormalities), active bleeding issues (like peptic ulcer, brain haemorrhage), or muscle problem (myopathy, rhabdomyolysis). The patient should inform the doctor that they are taking Preva RS 5mg/75mg Capsule before any surgery is scheduled or any new medicine is taken. Rosuvastatin present in Preva RS 5mg/75mg Capsule is a pregnancy category X drug, so it should not be given to pregnant women. It may cause harm to the fetus if administered to pregnant or breastfeeding women.

Rosuvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. As a result, it lowers the bad cholesterol (low-density lipoproteins or LDL), triglycerides (TG) and increases the levels of good cholesterol (high-density lipoproteins or HDL). Clopidogrel is a blood thinner (anticoagulant) that collectively prevents a clot in the blood vessels. Together Preva RS 5mg/75mg Capsule reduces the increased levels of bad cholesterol (low-density lipoprotein and triglycerides) and prevents blood clots, thereby reducing the risk of heart attack, stroke, and heart-related chest pain (angina).

• Stomach bleeding
• Gastrointestinal bleeding
• Nose bleeding
• Rash
• Diarrhoea
• Stomach ulcer
• Muscle disease (myopathy, rhabdomyolysis)
• Abdominal pain

Tell your doctor if you are allergic to rosuvastatin, clopidogrel, or any of its ingredients. If you have any active liver disease, active bleeding issues (like peptic ulcers, brain haemorrhage), pregnant, or plan to become pregnant or breastfeeding, do not take Preva RS 5mg/75mg Capsule until prescribed. The patient should inform the doctor that they are taking Preva RS 5mg/75mg Capsule before any surgery is scheduled or any new medicine is taken. Rosuvastatin present in Preva RS 5mg/75mg Capsule is a pregnancy category X drug, so it is contraindicated in pregnant women. As it may cause harm to the fetus if administered to pregnant women. The risk of muscle problems might increase if Preva RS 5mg/75mg Capsule is taken with an antibiotic (clarithromycin), anti-HIV drugs (ritonavir, lopinavir, darunavir, atazanavir, indinavir) and antifungal (itraconazole). Coadministration with anticoagulants like warfarin may cause gastric bleeding and other bleeding problems. So, if you are using any blood-thinning agents, let your doctor know about this. Preva RS 5mg/75mg Capsule contains rosuvastatin, which can cause muscle problems like myopathy and rhabdomyolysis. Patients with active liver disease should use the Preva RS 5mg/75mg Capsule with caution. Safety and effectiveness of Preva RS 5mg/75mg Capsule have not been established, so its use should be avoided in paediatric patients less than ten years of age. Discontinuation of Preva RS 5mg/75mg Capsule may lead to cardiovascular events like heart attack, stroke, and angina (heart-related chest pain). Hence, you should consult a doctor before stopping the dose of Preva RS 5mg/75mg Capsule.

Drug-Drug Interactions: Preva RS 5mg/75mg Capsule may interact with antibiotics (erythromycin, clarithromycin), anti-HIV drugs (ritonavir, lopinavir, darunavir, atazanavir, indinavir) and antifungal (itraconazole), blood thinners (warfarin, heparin), anti-arthritis drug (colchicine), oral contraceptives, heart-related medicine (digoxin) and immune system affecting drug (cyclosporine).

Drug-Food Interactions: Alcoholic beverages and grapefruit or its juice intake should be avoided with Preva RS 5mg/75mg Capsule as it may interact with Preva RS 5mg/75mg Capsule to produce unpleasant side effects like muscle problems and bleeding disorder.

Drug-Disease Interactions: Preva RS 5mg/75mg Capsule should not be given to the patients with active liver disease, active bleeding issues (like peptic ulcer, brain haemorrhage), muscle problems or musculoskeletal problems (myopathy, rhabdomyolysis), asthma, and purpura (blood leakage under the skin).

• ERYTHROMYCIN
• CLARITHROMYCIN
• RITONAVIR
• LOPINAVIR
• DARUNAVIR
• ATAZANAVIR
• INDINAVIR
• ITRACONAZOLE
• WARFARIN
• HEPARIN
• COLCHICINE
• DIGOXIN
• CYCLOSPORINE

• A low cholesterol diet and a regular exercise regime effectively complement treatment with Preva RS 5mg/75mg Capsule.
• Stick to a freshly prepared home-cooked meal and avoid processed, packed foods that contain hidden sugar and extra calories.
• Try to replace most of your saturated fats with unsaturated fats to reduce total cholesterol and LDL cholesterol (bad cholesterol) quickly.
• Foods like avocados, olive oil, fatty fish, and nuts contain too many heart-healthy unsaturated fats, so eating them regularly is beneficial.
• Include a diet enriched in fats like fish oils, polyunsaturated oils, and omega-3 fatty acids, which are good for heart health.
• Quit smoking and avoid excessive intake of alcohol.

Heart attack: Heart attack is when your coronary arteries (blood vessels supplying blood and oxygen to the heart) become blocked due to the build-up of fats (plaque), including cholesterol. These plaques narrow the arteries, leading to atherosclerosis and coronary artery disease, mainly for most heart attacks.

Stroke: Stroke occurs when the blood and oxygen supply to the brain is blocked or minimized. As a result, the brain tissue is deprived of getting oxygen and nutrients. After a few minutes, brain cells (neurons) start to die. A stroke is a medical emergency; immediate treatment is required; else can cause brain damage, coma or even death. 

Atherosclerosis: Atherosclerosis occurs when fats, cholesterol, and other substances known as plaque deposit on your artery walls that restrict blood flow. This plaque formation triggers blood clots, narrows the artery's size, and hardens it. This, in turn, can lead to various heart complications like atherosclerosis, heart attack, heart-related chest pain (angina), and stroke. However, it can also affect the body's arteries apart from the heart.