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Reviewed By Sunny S , MBBS
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Composition

RANOLAZINE-500MG

Manufacturer/Marketer

Orris Pharmaceuticals

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Ranolife 500 mg ER Tablet

Ranolife 500 mg ER Tablet belongs to the class of anti-anginal medications. It is used alone or with other medicines to treat angina pectoris. Angina pectoris is discomfort in the chest or chest pain, which generally occurs due to coronary artery disease (CAD) when an adequate amount of oxygen and blood is not reaching the heart and its muscles. It can also be due to the blockage of the heart's arteries. It helps prevent any further attack of angina by making the heart work more efficiently, and it is used as an add-on to existing treatment in patients whose disease is not adequately controlled by other medicines for angina pectoris, such as beta-blockers or calcium antagonists, or in patients who cannot take these medicines.

The active substance in Ranolife 500 mg ER Tablet is Ranolazine, which reduces sodium ions flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called 'sodium-dependent calcium channels through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Ranolife 500 mg ER Tablet is thought to help the heart to relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

Your doctor will tell you how to take the Ranolife 500 mg ER Tablet based on your medical condition. You may sometimes experience constipation, dizziness, headache, or feeling sick. Most of these side effects of Ranolife 500 mg ER Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not consume Ranolife 500 mg ER Tablet if you are allergic to any component in this medicine. Ranolife 500 mg ER Tablet should not be stopped even if you feel better for the best results as it prevents any future harm. If you stop taking the Ranolife 500 mg ER Tablet on your own, your chest pain can come back in more severe form. If you plan to get pregnant or are pregnant or breastfeeding, please consult your doctor to avoid any unwanted harm to the baby. Some lifestyle modifications are important for best results when taking Ranolife 500 mg ER Tablet like smoking cessation, decreasing alcohol intake, eating well, regular exercise, and managing stress. Ranolife 500 mg ER Tablet should be taken with caution if you have any liver or kidney problems. Also, inform your doctor if you are taking other medications to avoid unwanted side effects or contraindications.

Uses of Ranolife 500 mg ER Tablet

Angina Pectoris

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Ranolife 500 mg ER Tablet is prescribed for treating angina. Ranolife 500 mg ER Tablet is an anti-anginal medication used to treat angina pectoris. It reduces sodium ions' flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called ‘sodium-dependent calcium channels’ through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Ranolife 500 mg ER Tablet is thought to help the heart to relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Ranolife 500 mg ER Tablet

  • Constipation
  • Dizziness
  • Headache
  • Feeling sick

Drug Warnings

Ranolife 500 mg ER Tablet should be taken with caution in liver/kidney disease, are pregnant, plan to become pregnant, or are breastfeeding, history of heart disease. Also, grapefruit juice should be avoided while taking Ranolife 500 mg ER Tablet . As a precautionary measure, junk food items from outside and stick to freshly prepared home-cooked meals for a speedy recovery. Do regular exercise to avoid the feeling of heaviness in the abdomen.

Drug-Drug Interactions

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RanolazineArmodafinil
Critical
RanolazineMesoridazine
Critical

Drug-Drug Interactions

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RanolazineArmodafinil
Critical
How does the drug interact with Ranolife 500 mg ER Tablet:
When Armodafinil is taken with Ranolife 500 mg ER Tablet, the metabolism of Ranolife 500 mg ER Tablet can be increased when combined with Armodafinil.

How to manage the interaction:
Taking Ranolife 500 mg ER Tablet with Armodafinil is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
RanolazineMesoridazine
Critical
How does the drug interact with Ranolife 500 mg ER Tablet:
Co-administration of Mesoridazine and Ranolife 500 mg ER Tablet may significantly increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Phenylbutazone with Ranolife 500 mg ER Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop taking any medications without consulting a doctor.
RanolazineCeritinib
Critical
How does the drug interact with Ranolife 500 mg ER Tablet:
When Ceritinib is taken with Ranolife 500 mg ER Tablet, may significantly increase the blood levels and effects of Ranolife 500 mg ER Tablet.

How to manage the interaction:
Taking Ranolife 500 mg ER Tablet with Ceritinib together can possibly result in an interaction, but it can be taken if a doctor has advised it. In case you experience any side effects like lightheadedness, fainting, dizziness, or fast or pounding heartbeats, consult a doctor. Do not discontinue any medications without consulting a doctor.
RanolazinePrimidone
Critical
How does the drug interact with Ranolife 500 mg ER Tablet:
Coadministration of Ranolife 500 mg ER Tablet with primidone can reduce the blood levels and effects of Ranolife 500 mg ER Tablet.

How to manage the interaction:
Although there is an interaction between Primidone and Ranolife 500 mg ER Tablet, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RanolazineItraconazole
Critical
How does the drug interact with Ranolife 500 mg ER Tablet:
The blood levels and effects of Ranolife 500 mg ER Tablet may be greatly increased when it is used with Itraconazole.

How to manage the interaction:
Although Ranolife 500 mg ER Tablet and Itraconazole may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you develop any negative symptoms, including fainting, lightheadedness, dizziness, or rapid heartbeat. Without consulting a doctor, never stop taking any medication.
RanolazineRitonavir
Critical
How does the drug interact with Ranolife 500 mg ER Tablet:
Taking Ritonavir and Ranolife 500 mg ER Tablet may significantly increase the blood levels and effects of Ranolife 500 mg ER Tablet.

How to manage the interaction:
Co-administration of Ranolife 500 mg ER Tablet with Ritonavir can possibly result in an interaction, but it can be taken if a doctor has advised it. In case you experience any symptoms like feeling lightheaded, fainting, or rapid heartbeats, consult a doctor. Do not stop using any medications without a doctor's advice.
RanolazinePentobarbital
Critical
How does the drug interact with Ranolife 500 mg ER Tablet:
When Ranolife 500 mg ER Tablet is taken with Pentobarbital, may significantly reduce the blood levels of Ranolife 500 mg ER Tablet, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Phenobarbital with Ranolife 500 mg ER Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
RanolazineGrepafloxacin
Critical
How does the drug interact with Ranolife 500 mg ER Tablet:
Co-administration of Grepafloxacin and Ranolife 500 mg ER Tablet may significantly increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Grepafloxacin with Ranolife 500 mg ER Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
RanolazinePhenylbutazone
Critical
How does the drug interact with Ranolife 500 mg ER Tablet:
Co-administration of Phenylbutazone and Ranolife 500 mg ER Tablet may significantly reduce the blood levels of Ranolife 500 mg ER Tablet, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Phenylbutazone with Ranolife 500 mg ER Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
RanolazineFosamprenavir
Critical
How does the drug interact with Ranolife 500 mg ER Tablet:
Co-administration of Fosamprenavir and Ranolife 500 mg ER Tablet may significantly can occasionally cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Fosamprenavir with Ranolife 500 mg ER Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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RANOLAZINE-500MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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RANOLAZINE-500MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Grapefruit juice can increase the levels of Ranolife 500 mg ER Tablet, and high blood levels of food can occasionally cause an irregular heart rhythm that may be serious. Grapefruit and grapefruit juice should be avoided while taking Ranolife 500 mg ER Tablet if possible.

Diet & Lifestyle Advise

  • Maintain a healthy lifestyle by exercising regularly, maintaining weight, and eating a healthy diet.
  • If you suffer from kidney or liver disease, please inform your doctor before taking the Ranolife 500 mg ER Tablet .
  • Alcohol consumption along with Ranolife 500 mg ER Tablet should be avoided as it may cause excessive drowsiness and increase muscle pain.
  • As a precautionary measure, junk food items from outside and stick to freshly prepared home-cooked meals for a speedy recovery.

Habit Forming

No

Therapeutic Class

ANTIANGINALS

Ranolife 500 mg ER Tablet Substitute

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

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  • QUINIDINE
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  • KETOCONAZOLE
  • ITRACONAZOLE

Disease/Condition Glossary

Angina pectoris: Angina pectoris is discomfort in the chest or chest pain that generally occurs due to coronary artery disease (CAD) when you adequate amount of oxygen and blood is not reaching the heart and its muscles. It can also be due to the blockage of the heart's arteries. It helps prevent any further attack of angina by making the heart work more efficiently, but it does not stop an acute attack of angina pectoris.

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