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Written By ,
Reviewed By Sunny S , MBBS

About ROLAZIN TABLET

ROLAZIN TABLET belongs to the class of anti-anginal medications. It is used alone or with other medicines to treat angina pectoris. Angina pectoris is discomfort in the chest or chest pain, which generally occurs due to coronary artery disease (CAD) when an adequate amount of oxygen and blood is not reaching the heart and its muscles. It can also be due to the blockage of the heart's arteries. It helps prevent any further attack of angina by making the heart work more efficiently, and it is used as an add-on to existing treatment in patients whose disease is not adequately controlled by other medicines for angina pectoris, such as beta-blockers or calcium antagonists, or in patients who cannot take these medicines.

The active substance in ROLAZIN TABLET is Ranolazine, which reduces sodium ions flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called 'sodium-dependent calcium channels through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, ROLAZIN TABLET is thought to help the heart to relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

Your doctor will tell you how to take the ROLAZIN TABLET based on your medical condition. You may sometimes experience constipation, dizziness, headache, or feeling sick. Most of these side effects of ROLAZIN TABLET do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not consume ROLAZIN TABLET if you are allergic to any component in this medicine. ROLAZIN TABLET should not be stopped even if you feel better for the best results as it prevents any future harm. If you stop taking the ROLAZIN TABLET on your own, your chest pain can come back in more severe form. If you plan to get pregnant or are pregnant or breastfeeding, please consult your doctor to avoid any unwanted harm to the baby. Some lifestyle modifications are important for best results when taking ROLAZIN TABLET like smoking cessation, decreasing alcohol intake, eating well, regular exercise, and managing stress. ROLAZIN TABLET should be taken with caution if you have any liver or kidney problems. Also, inform your doctor if you are taking other medications to avoid unwanted side effects or contraindications.

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Whats That

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Non returnable*
COD available

Online payment accepted

Composition

RANOLAZINE-500MG

Manufacturer/Marketer

Macleods Pharmaceuticals Ltd.

Consume Type

ORAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of ROLAZIN TABLET

Angina Pectoris

Medicinal Benefits

ROLAZIN TABLET is prescribed for treating angina. ROLAZIN TABLET is an anti-anginal medication used to treat angina pectoris. It reduces sodium ions' flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called ‘sodium-dependent calcium channels’ through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, ROLAZIN TABLET is thought to help the heart to relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

Side Effects of ROLAZIN TABLET

  • Constipation
  • Dizziness
  • Headache
  • Feeling sick

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

ROLAZIN TABLET should be taken with caution in liver/kidney disease, are pregnant, plan to become pregnant, or are breastfeeding, history of heart disease. Also, grapefruit juice should be avoided while taking ROLAZIN TABLET. As a precautionary measure, junk food items from outside and stick to freshly prepared home-cooked meals for a speedy recovery. Do regular exercise to avoid the feeling of heaviness in the abdomen.

Therapeutic Class

ANTIANGINALS

Drug-Drug Interactions

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RanolazinePhenobarbital
Critical
RanolazineClarithromycin
Critical

Drug-Drug Interactions

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RanolazinePhenobarbital
Critical
How does the drug interact with ROLAZIN TABLET:
When ROLAZIN TABLET is taken with Phenobarbital, may significantly reduce the blood levels of ROLAZIN TABLET, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Phenobarbital with ROLAZIN TABLET can lead to an interaction, consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
RanolazineClarithromycin
Critical
How does the drug interact with ROLAZIN TABLET:
When ROLAZIN TABLET and Clarithromycin are taken together, significantly increases the blood levels and effects of ROLAZIN TABLET.

How to manage the interaction:
Co-administration of Clarithromycin and Ranozaline can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
RanolazinePhenytoin
Critical
How does the drug interact with ROLAZIN TABLET:
Using ROLAZIN TABLET together with phenytoin may significantly reduce the blood levels of ROLAZIN TABLET leading to dreceased effectiveness of ROLAZIN TABLET in treating your condition.

How to manage the interaction:
Taking Phenytoin with ROLAZIN TABLET is not recommended. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
RanolazineEfavirenz
Critical
How does the drug interact with ROLAZIN TABLET:
When Efavirenz is taken with ROLAZIN TABLET, it can lower the levels of ROLAZIN TABLET.

How to manage the interaction:
Taking ROLAZIN TABLET with Efavirenz is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medication without consulting a doctor.
RanolazineFosamprenavir
Critical
How does the drug interact with ROLAZIN TABLET:
Co-administration of Fosamprenavir and ROLAZIN TABLET may significantly can occasionally cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Fosamprenavir with ROLAZIN TABLET can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
RanolazineRifampicin
Critical
How does the drug interact with ROLAZIN TABLET:
When ROLAZIN TABLET is taken with rifampicin, it can reduce the blood levels and effects of ROLAZIN TABLET.

How to manage the interaction:
Although there is an interaction between ROLAZIN TABLET and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RanolazinePrimidone
Critical
How does the drug interact with ROLAZIN TABLET:
Coadministration of ROLAZIN TABLET with primidone can reduce the blood levels and effects of ROLAZIN TABLET.

How to manage the interaction:
Although there is an interaction between Primidone and ROLAZIN TABLET, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RanolazineCeritinib
Critical
How does the drug interact with ROLAZIN TABLET:
When Ceritinib is taken with ROLAZIN TABLET, may significantly increase the blood levels and effects of ROLAZIN TABLET.

How to manage the interaction:
Taking ROLAZIN TABLET with Ceritinib together can possibly result in an interaction, but it can be taken if a doctor has advised it. In case you experience any side effects like lightheadedness, fainting, dizziness, or fast or pounding heartbeats, consult a doctor. Do not discontinue any medications without consulting a doctor.
RanolazineOxcarbazepine
Critical
How does the drug interact with ROLAZIN TABLET:
When ROLAZIN TABLET is taken with Oxcarbazepine, may significantly reduce the blood levels of ROLAZIN TABLET, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Oxcarbazepine with ROLAZIN TABLET is not recommended as it can lead to an interaction, they can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.
RanolazineNafcillin
Critical
How does the drug interact with ROLAZIN TABLET:
When Nafcillin is taken with ROLAZIN TABLET, may significantly reduce the blood levels of ROLAZIN TABLET, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Nafcillin with ROLAZIN TABLET can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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RANOLAZINE-500MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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RANOLAZINE-500MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Grapefruit juice can increase the levels of ROLAZIN TABLET, and high blood levels of food can occasionally cause an irregular heart rhythm that may be serious. Grapefruit and grapefruit juice should be avoided while taking ROLAZIN TABLET if possible.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • QUINIDINE
  • DOFETILIDE
  • SOTALOL
  • KETOCONAZOLE
  • ITRACONAZOLE

Diet & Lifestyle Advise

  • Maintain a healthy lifestyle by exercising regularly, maintaining weight, and eating a healthy diet.
  • If you suffer from kidney or liver disease, please inform your doctor before taking the ROLAZIN TABLET.
  • Alcohol consumption along with ROLAZIN TABLET should be avoided as it may cause excessive drowsiness and increase muscle pain.
  • As a precautionary measure, junk food items from outside and stick to freshly prepared home-cooked meals for a speedy recovery.

Habit Forming

No

Disease/Condition Glossary

Angina pectoris: Angina pectoris is discomfort in the chest or chest pain that generally occurs due to coronary artery disease (CAD) when you adequate amount of oxygen and blood is not reaching the heart and its muscles. It can also be due to the blockage of the heart's arteries. It helps prevent any further attack of angina by making the heart work more efficiently, but it does not stop an acute attack of angina pectoris.

ROLAZIN TABLET Substitute

Substitutes safety advice
  • Ranozex Tablet 10's

    17.91per tablet
  • Ranolaz 500 mg Tablet 15's

    18.96per tablet
  • Ranx 500 Tablet 15's

    20.61per tablet
  • Rancad Tablet 15's

    by AYUR

    20.73per tablet
  • Ranogard 500 Tablet 10's

    by AYUR

    9.54per tablet
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