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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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About Rantac RD Capsule

Rantac RD Capsule is a gastrointestinal medicine composed of Rabeprazole (stomach acid reducer) and Domperidone (nausea/vomiting reducer). Together they reduce the amount of acid your stomach makes and decrease the symptoms of nausea and vomiting. It treats symptoms of acid reflux due to hyperacidity, stomach ulcer (Peptic ulcer disease), and Zollinger Ellison syndrome (overproduction of acid due to a pancreatic tumour). Besides this, it is used short-term to treat gastroesophageal reflux disease (GERD) symptoms. GERD is a condition in which the sphincter (valve) located at the uppermost part of the stomach gets irritated and damaged due to excessive stomach acid production. As a result, the stomach acid and juice flow back into the food pipe, leading to stomach upset and heartburn. Heartburn is the post-effect of acid reflux with a burning-like feeling that rises from the stomach towards the neck.

Rantac RD Capsule contains two medicines, namely Rabeprazole and Domperidone. Rabeprazole is a proton pump inhibitor that helps reduce stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This gastric proton pump lies in the cells of the stomach wall. It is responsible for releasing gastric acid secretion and damaging tissues in the food pipe, stomach, and duodenum (uppermost part of the small intestine). On the other hand, Domperidone is a prokinetic agent that increases the motility of the upper gastrointestinal tract and blocks the vomiting-inducing centre (chemoreceptor trigger zone-CTZ).

It is better to take Rantac RD Capsule an hour before a meal or without a meal for its best results. Rantac RD Capsule should be swallowed whole with a glass of water. Do not chew, crush, or break it. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early, your symptoms may come back, and your condition may worsen. An adult taking Rantac RD Capsule might have common side effects like headache, diarrhoea, nausea, abdominal pain, vomiting, flatulence, dizziness, and arthralgia (joint pain). In the case of children taking Rantac RD Capsule might report upper respiratory tract infections (URI), headache, fever, diarrhoea, vomiting, rash, and abdominal pain. These side effects are temporary and may resolve after some time; however, if this persists, contact the doctor.

You can increase the efficacy of Rantac RD Capsule by taking a small meal or snacks frequently. Avoid caffeine-containing beverages (coffee, tea), spicy/deep-fried/processed foods, carbonated drinks, and acidic foods like citrus fruits/vegetables (tomatoes). Tell your doctor if you have stomach or intestinal cancer, liver problem, are allergic to Rantac RD Capsule or will have an endoscopy in the future. Prolonged intake of Rantac RD Capsule may cause deficiency of Vitamin B-12 and low levels of calcium, magnesium, and Vitamin D leading to osteoporosis (brittle or weak bones).

Uses of Rantac RD Capsule

Gastro-Esophagal Reflux Disease (GERD), Acid reflux, Heartburn, Peptic ulcer, stomach ulcers, Dyspepsia (stomach discomfort due to indigestion).

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Rantac RD Capsule helps in reducing the excess amount of stomach. In turn, it prevents the formation of an ulcer in the upper part of the intestine (duodenal ulcer), gastro-esophagal reflux disease (GERD) with or without ulcer and Zollinger-Ellison Syndrome, in which the stomach makes exceptionally high amounts of acid. Besides, the Rantac RD Capsule also treats symptoms of nausea and vomiting in adults and children over 12 years of age (with at least 35 kg or more).

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

You should avoid taking Rantac RD Capsule if you are allergic to Rantac RD Capsule or proton pump inhibitors, have gastric cancer, liver disease, low magnesium level (osteoporosis), low vitamin B12, are pregnant or planning for pregnancy, and breastfeeding mothers. Rantac RD Capsule may interact with a blood thinner (warfarin), antifungal (ketoconazole), anti-HIV drug (atazanavir, nelfinavir), iron supplements, ampicillin antibiotic, anti-cancer drug (methotrexate). Let your doctor know if you are taking these medicines. Prolonged intake of Rantac RD Capsule may cause lupus erythematosus (an inflammatory condition in which the immune system attacks its tissues), Vitamin B-12, and magnesium deficiency. Intake of Rantac RD Capsule may mask the symptom of gastric cancer, so if you have any severe stomach pain or gastric bleeding (blood in mucous or stool), immediately consult the doctor. Tell your doctor that you are using before having a specific blood test known as Chromogranin A.

Drug-Drug Interactions

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OmeprazoleRilpivirine
Critical

Drug-Drug Interactions

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OmeprazoleRilpivirine
Critical
How does the drug interact with Rantac RD Capsule:
Using rilpivirine together with Rantac RD Capsule can decrease the absorption and blood levels of rilpivirine.

How to manage the interaction:
Taking Rantac RD Capsule with Rilpivirine can cause an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Rantac RD Capsule:
Rantac RD Capsule can make Erlotinib less effective by reducing its absorption in the body. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Rantac RD Capsule and Erlotinib together is not recommended as it can result in an interaction; it should be taken only if a doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Rantac RD Capsule:
When taken together, Rantac RD Capsule, through decreasing stomach acid, can reduce atazanavir absorption and blood levels, making the medication less effective.

How to manage the interaction:
Although taking Rantac RD Capsule with atazanavir can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Rantac RD Capsule:
Taking Rantac RD Capsule and carbamazepine may possibly reduce the effects of Rantac RD Capsule, which could reduce its capacity to treat the condition.

How to manage the interaction:
Although taking Rantac RD Capsule and carbamazepine together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Rantac RD Capsule:
When taken together Rantac RD Capsule may interfere with the absorption of gefitinib into the bloodstream and reduce its effectiveness.

How to manage the interaction:
Although taking Rantac RD Capsule with gefitinib can lead to interaction, they can be taken if recommended by a doctor. However, if you have no other treatment options, it is suggested that you take gefitinib 12 hours before or after Rantac RD Capsule to reduce the impact of the interaction. Do not stop using any medications without talking to a doctor.
How does the drug interact with Rantac RD Capsule:
Rantac RD Capsule may interfere with pazopanib absorption and reduces its effectiveness.

How to manage the interaction:
Although taking Rantac RD Capsule with pazopanib can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Rantac RD Capsule:
Coadministration of Rantac RD Capsule with methotrexate may increase the levels and side effects of Rantac RD Capsule.

How to manage the interaction:
Although there is a possible interaction between Rantac RD Capsule and methotrexate, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without consulting to a doctor.
How does the drug interact with Rantac RD Capsule:
When Rantac RD Capsule is used with citalopram the blood levels of citalopram may increase, increasing the risk of certain adverse effects, such as an abnormal heart rhythm, which can be serious.

How to manage the interaction:
Although taking Rantac RD Capsule and citalopram together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid/pounding heartbeats while taking these medications, consult the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Rantac RD Capsule:
When taken together Rantac RD Capsule can lower the levels of Clopidogrel in the blood, which can result in a decreased effectiveness of clopidogrel.

How to manage the interaction:
Taking Rantac RD Capsule and clopidogrel together has an interaction, but you can take these medications together if a doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Rantac RD Capsule:
Taking Rantac RD Capsule and Dasatinib together may decrease the blood levels of Dasatinib.

How to manage the interaction:
Although taking Rantac RD Capsule with Dasatinib can lead to interaction, they can be taken if recommended by a doctor. If you experience any unusual symptoms, visit a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid intake of acid or heartburn-triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes and high-fat and spicy foods.
  • Avoid taking alcohol and smoking cigarette. Alcohol can raise the level of production of stomach acid leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter), preventing stomach acid backflow into the food pipe.
  • Avoid regular sitting continuously, as it can increase stomach acid production. Try to take a break of 5 minutes in 1 hour by brisk walking or stretching.
  • Before going to sleep, try to raise your bedhead so that your head and chest are higher than your feet. Do not use piles of pillows, instead, one raised block is fine. This will not allow the stomach acid to backflow through your food pipe.
  • Include high fibre containing foods, berries, cherries, leafy green veggies (kale, spinach) and black peppers in your meal. These foods are full of antioxidants, calcium and vitamin B 12 that can help cope with the long-term effects of the medicine. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics which help in the prevention of excess stomach acid production. Cranberry juice can be beneficial in the peptic ulcer and H Pylori infection.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

No. Rantac RD Capsule prevents excess production of stomach acid causing acid reflux and heartburn. If blood is coming in your stool or mucous immediately contact the doctor.

Yes, Rantac RD Capsule can cause dry mouth and it is due to domperidone. In case you fell excessive thirsty, please increase your fluid intake and do frequent mouth rinses.

Diarrhoea might be a side-effect of Rantac RD Capsule . Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you have severe diarrhoea or any other discomfort.

Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting on a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.

Drug-Drug Interactions Checker List

  • CLOPIDOGREL
  • WARFARIN
  • KETOCONAZOLE
  • VORICONAZOLE
  • ITRACONAZOLE
  • FLUCONAZOLE
  • ATAZANAVIR
  • AMPRENAVIR
  • NELFINAVIR
  • MAGNESIUM+ALUMINIUM HYDROXIDE
  • CIMETIDINE
  • IRON
  • ERYTHROMYCIN
  • RIFAMPICIN
  • ATROPINE
  • DIGOXIN
  • AMIODARONE
  • DILTIAZEM
  • METHOTREXATE
  • CLARITHROMYCIN

Special Advise

  • Do not take Rantac RD Capsule for more than four weeks of duration without consulting the doctor.

Disease/Condition Glossary

Usually, a thick layer of mucous usually protects the stomach against its acid secretion. But, in the long run, it gets eroded by excessive stomach acid production leading to complications like GERD, peptic ulcer, and Zollinger Ellison syndrome. Gastroesophageal reflux disease (GERD) is a gastrointestinal problem that occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe that causes heartburn. On the other hand, a peptic ulcer is a painful condition followed by the development of sores or ulcers in the stomach lining or duodenum (first part of the small intestine) (the duodenum). Zollinger Ellison syndrome is a rare condition in which a gastrin-secreting pancreas tumour causes excessive acid production leading to peptic ulcers.

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