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Reviewed By Hari Kumar , MBBS
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Composition

NALBUPHINE-10MG

Consume Type

PARENTERAL

Return Policy

Not Returnable

for this medicine

About Rubuphine 10 mg Injection 1 ml

Rubuphine 10 mg Injection 1 ml belongs to the group of opioid analgesics used to relieve severe pain. It may also be used as an adjunct to balanced anaesthesia for pre/post-operative analgesia, during labour and delivery. Pain is defined as an unpleasant sensation produced in the body in response to external changes, stress, or trauma.

Rubuphine 10 mg Injection 1 ml contains 'Nalbuphine' that works by reducing the production of inflammatory substances (prostaglandins) and thus, relieves the body of swelling and subsequent pain. Rubuphine 10 mg Injection 1 ml also blocks pain-producing nerve transmitters, leading to a reduced sensation of pain and offering massive pain relief.

Rubuphine 10 mg Injection 1 ml will be administered by a qualified health care professional. Do not self-inject. Rubuphine 10 mg Injection 1 ml may cause certain common side effects such as drowsiness, dry mouth, nausea, vomiting, and constipation. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist.

It is advisable to inform the doctor if you are allergic to any of the components of Rubuphine 10 mg Injection 1 ml. Consult your doctor if you are pregnant, planning to get pregnant, or breastfeeding as Rubuphine 10 mg Injection 1 ml should be used with caution in these states. Rubuphine 10 mg Injection 1 ml may cause drowsiness, so avoid driving or operating machinery.

Uses of Rubuphine 10 mg Injection 1 ml

Pain Relief

Directions for Use

A qualified healthcare professional will administer Rubuphine 10 mg Injection 1 ml. Do not self-administer.

Medicinal Benefits

Rubuphine 10 mg Injection 1 ml is an analgesic that is used as a painkiller for short-term management of severe pain. Rubuphine 10 mg Injection 1 ml blocks pain signals, so the brain doesn't perceive the severity of pain, hence increasing the body's threshold for pain. Rubuphine 10 mg Injection 1 ml may also be used as an adjunct to balanced anaesthesia for pre/post-operative analgesia, during labour and delivery.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Rubuphine 10 mg Injection 1 ml

  • Drowsiness
  • Nausea
  • Constipation
  • Vomiting
  • Dry mouth

Drug Warnings

Do not take Rubuphine 10 mg Injection 1 ml if you are allergic to any of the contents; if you have acute or severe asthma, respiratory depression, gastrointestinal obstruction, or paralytic ileus. Rubuphine 10 mg Injection 1 ml should not be taken with other opioid analgesics, CNS depressant drugs, or benzodiazepines as it might lead to life-threatening respiratory depression. Inform your doctor if you have asthma, COPD, adrenal insufficiency, severe hypotension, increased intracranial pressure, brain problems, head injury, gastrointestinal problems, seizures, kidney or liver problems. Avoid driving or operating machinery as Rubuphine 10 mg Injection 1 ml may impair your mental and physical ability. You are advised not to take alcohol with Rubuphine 10 mg Injection 1 ml as it might cause increased sedation and respiratory depression. Keep your doctor informed if you or anyone in your family have a history of substance abuse as Rubuphine 10 mg Injection 1 ml may cause addiction, abuse, and misuse.

Drug-Drug Interactions

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NalbuphineOxazepam
Severe
NalbuphineHydroxyzine
Severe

Drug-Drug Interactions

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NalbuphineOxazepam
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
The risk or severity of adverse effects can be increased when Rubuphine 10 mg Injection 1 ml is combined with Oxazepam.

How to manage the interaction:
Although taking Oxazepam and Rubuphine 10 mg Injection 1 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like dizziness, drowsiness, difficulty concentrating, impairment in judgment, reduced reaction speed, and motor coordination, make sure to contact your doctor immediately. Avoid driving or operating hazardous machinery. Do not discontinue any medications without first consulting your doctor.
NalbuphineHydroxyzine
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Using Hydroxyzine together with Rubuphine 10 mg Injection 1 ml can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydroxyzine and Rubuphine 10 mg Injection 1 ml together can cause an interaction, it can be taken if a doctor has suggested it. Consult a doctor if you experience dizziness, sleepiness, trouble focusing, and impairment in judgment, response speed, and motor coordination, you should avoid driving or operating dangerous machinery until you know how they affect you. Do not discontinue any medications without consulting a doctor.
NalbuphineCyclobenzaprine
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Coadministration of Cyclobenzaprine with Rubuphine 10 mg Injection 1 ml can increase the risk of developing side effects.

How to manage the interaction:
Although taking Cyclobenzaprine and Rubuphine 10 mg Injection 1 ml together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience dizziness, shortness of breath, palpitations, or chest discomfort, consult your doctor. Do not stop using any medications without talking to a doctor.
NalbuphineLurasidone
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Using Lurasidone together with Rubuphine 10 mg Injection 1 ml can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Despite the fact that Rubuphine 10 mg Injection 1 ml and Lurasidone interact, it can be taken if prescribed by a doctor. Consult a doctor if you develop dizziness, drowsiness, difficulty concentrating, or problems in judgment, reaction speed, or movement control. Do not discontinue any medications without consulting a doctor.
NalbuphineZiprasidone
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Taking Rubuphine 10 mg Injection 1 ml with Ziprasidone can increase the risk of side effects.

How to manage the interaction:
Although there is a interaction between Ziprasidone and Rubuphine 10 mg Injection 1 ml, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment. Do not discontinue any medications without consulting a doctor.
NalbuphineAripiprazole
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Using Aripiprazole together with Rubuphine 10 mg Injection 1 ml can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Co-administration of Aripiprazole with Rubuphine 10 mg Injection 1 ml can result in an interaction, but it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Furthermore, because these medications may induce dizziness, sleepiness, trouble focusing, and impairment in judgement, response speed, and motor coordination, you should avoid driving or operating dangerous machinery. Do not stop using any medications without a doctor's advice.
NalbuphineClonazepam
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Co-administration of Rubuphine 10 mg Injection 1 ml with Clonazepam can make the side effects worse.

How to manage the interaction:
Although there is a possible interaction between Clonazepam and Rubuphine 10 mg Injection 1 ml, you can take these medicines together if prescribed by a doctor. If you notice any symptoms like feeling dizzy, having trouble breathing, or feeling very tired, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
NalbuphinePregabalin
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Using Pregabalin together with Rubuphine 10 mg Injection 1 ml causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking Rubuphine 10 mg Injection 1 ml and Pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
NalbuphineChlordiazepoxide
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Co-administration of Rubuphine 10 mg Injection 1 ml with chlordiazepoxide can increase the risk or severity of side effects like decreased breathing rate, irregular heart rhythms, or problems with movement and memory.

How to manage the interaction:
Taking Rubuphine 10 mg Injection 1 ml and chlordiazepoxide together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms such as dizziness, shortness of breath, numbness in hands and feet, or palpitations consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
NalbuphineOlanzapine
Severe
How does the drug interact with Rubuphine 10 mg Injection 1 ml:
Combining Olanzapine with Rubuphine 10 mg Injection 1 ml can cause central nervous system depression such as Olanzapine can lead to serious side effects including respiratory distress, intestinal obstruction, fecal impaction.

How to manage the interaction:
Although taking Olanzapine and Rubuphine 10 mg Injection 1 ml together can lead to an interaction, it can be taken if your doctor has suggested it. If you experience any symptoms like feeling tired, having trouble breathing, feeling dizzy or drowsy, difficulty focusing, taking pain or cough medications, constipation, blockage in your intestines, difficulty passing stool, hard or dry stool, less frequent bowel movements, stomach problems, feeling sick, feeling bloated, having stomach pain, or swelling contact the doctor immediately. you should avoid driving or operating hazardous machinery until you know how they affect you and do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Stay hydrated by drinking plenty of water.
  • Invest in a balanced diet. Load up on lean meats, fruits, green leafy vegetables, nuts, oily fish etc. Limit your intake of sweets and sugars as these can worsen inflammation. 
  • Cut back on alcohol as this can have an adverse effect on pain states as well as the quality of your sleep.
  • Try meditation and deep breathing to reduce overall stress and pain. 
  • Stop smoking as smoking is known to worsen pain conditions. 
  • Engage in mild physical exercise daily and keep your body active.

Habit Forming

Yes

Therapeutic Class

ANALGESICS

Rubuphine 10 mg Injection 1 ml Substitute

Substitutes safety advice
  • Nacphin Injection 1 ml

    by AYUR

    61.70per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Special Advise

 

Disease/Condition Glossary

Pain: Pain is a sensation that occurs in response to external injury, stress, infection and travels as an impulse through body cells, producing an unpleasant feeling and alerting the body to act. Pain relief in pharmacological terms is called analgesia. Various neurotransmitters and their equilibrium are instrumental in producing pain sensation.

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