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Written By Divya L , PharmaD
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Satrogyl-O Dry Syrup

Satrogyl-O Dry Syrup belongs to the class of ‘antibiotics’, primarily used to treat diarrhoea and dysentery. It helps treat bacterial infections, including intra-abdominal infection, gynaecological and pelvic infections, foot ulcers in diabetes, post-operative infections, dental infections, and infections in immunocompromised patients. Diarrhoea is a condition that causes the frequent passing of loose or watery stools. Dysentery is an intestinal inflammation that leads to severe diarrhoea accompanied by mucus or blood in the stools. Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body.

Satrogyl-O Dry Syrup contains two antibiotic medicines, namely: Ofloxacin and Satranidazole. Ofloxacin belongs to a class of drugs called quinolone antibiotics. It works by inhibiting bacterial DNA gyrase, an enzyme required to replicate, transcription, and repair the DNA. Satranidazole is an anti-amoebic, antiprotozoal, and anti-bacterial medicine that treats various infections caused by bacteria and parasites (amoeba). It is bactericidal and kills harmful bacteria and parasites (amoeba) by damaging its DNA. It prevents the division of bacterial cells and inhibits the repairing of bacterial cells.

Please take Satrogyl-O Dry Syrup in the dose and duration prescribed by your doctor based on your medical condition. Satrogyl-O Dry Syrup is generally safe to use. However, some may experience side effects like nausea, vomiting, stomach pain, loss of appetite, dizziness, and headache. Most of these side effects of Satrogyl-O Dry Syrup do not require medical attention and gradually resolve over time. If these side effects persist longer, please consult your doctor.

If you are allergic to Satrogyl-O Dry Syrup or any other medicines, please tell your doctor. Do not suddenly stop this medicine to avoid unpleasant side effects and sudden withdrawal symptoms. Intake of probiotics, prebiotics, and plenty of fluids is recommended if you suffer from dysentery and diarrhoea. Do not drive or operate heavy machinery after taking Satrogyl-O Dry Syrup as it may cause dizziness. Please try avoiding alcoholic beverages during your treatment as it can cause flushing and a general sick feeling. Pregnant and breastfeeding women should use Satrogyl-O Dry Syrup with proper consultation and caution.

Uses of Satrogyl-O Dry Syrup

Bacterial infections, dysentery, and diarrhoea.

Directions for Use

Tablet: Swallow it as a whole with water; do not crush, break or chew it.Suspension/Syrup: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Medicinal Benefits

Satrogyl-O Dry Syrup contains two antibiotic medicines, namely: Ofloxacin and Satranidazole. Ofloxacin is a quinolone antibiotic that inhibits bacterial DNA gyrase, an enzyme required for replicating, transcription, and repairing the DNA. Satranidazole is an anti-amoebic, antiprotozoal, and anti-bacterial medicine effective against a wide range of gram-positive and gram-negative bacteria. It kills the harmful anaerobic bacteria and certain anaerobic protozoa (Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia) causing diarrhoea. It is bactericidal and kills harmful bacteria and parasites (amoeba) by damaging its DNA. It also prevents the division of bacterial cells and inhibits the repairing of bacterial cells.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Brief your medical history to the doctor if you are allergic to Satrogyl-O Dry Syrup or any of its components. Please let your doctor know in advance if you have liver or kidney diseases, tendonitis, fits, blood dyscrasia, colitis, diabetes, myasthenia gravis (muscle weakness), dehydration, high blood pressure, nerve problems (peripheral neuropathy), mental/mood disorders (depression) or undergoing dialysis treatment. Please consult your doctor if you are planning to become pregnant or already pregnant before starting Satrogyl-O Dry Syrup. Do not drive or operate heavy machinery after taking Satrogyl-O Dry Syrup as it may cause dizziness and visual disturbances. Please try avoiding alcoholic beverages during your treatment as it can cause flushing and a general sick feeling. Satrogyl-O Dry Syrup is not recommended for children less than 18 years of age.

Drug-Drug Interactions

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OfloxacinSaquinavir
Critical

Drug-Drug Interactions

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OfloxacinSaquinavir
Critical
How does the drug interact with Satrogyl-O Dry Syrup 30 ml:
Coadministration of Satrogyl-O Dry Syrup 30 ml with Saquinavir can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Satrogyl-O Dry Syrup 30 ml with Saquinavir together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Satrogyl-O Dry Syrup 30 ml:
Coadministration of Satrogyl-O Dry Syrup 30 ml with Disopyramide can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Satrogyl-O Dry Syrup 30 ml with Disopyramide together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Satrogyl-O Dry Syrup 30 ml:
Coadministration of Satrogyl-O Dry Syrup 30 ml with Ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Satrogyl-O Dry Syrup 30 ml with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinBepridil
Critical
How does the drug interact with Satrogyl-O Dry Syrup 30 ml:
Using bepridil together with Satrogyl-O Dry Syrup 30 ml drugs can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Satrogyl-O Dry Syrup 30 ml with Bepridil can cause an interaction, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop using any medications without consulting a doctor.
How does the drug interact with Satrogyl-O Dry Syrup 30 ml:
The combination of Amiodarone and Satrogyl-O Dry Syrup 30 ml may significantly increase the risk of an abnormal heart rhythm.

How to manage the interaction:
Although Amiodarone and Satrogyl-O Dry Syrup 30 ml interact, it can be taken if prescribed by a doctor. If you get dizziness, lightheadedness, fainting, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Satrogyl-O Dry Syrup 30 ml:
Coadministration of Satrogyl-O Dry Syrup 30 ml with Cisapride can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Satrogyl-O Dry Syrup 30 ml with Cisapride together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor. Note: Cisapride is no longer available on the market. Cisapride should only be taken if prescribed by a doctor and closely monitored.
OfloxacinQuinidine
Critical
How does the drug interact with Satrogyl-O Dry Syrup 30 ml:
Coadministration of Satrogyl-O Dry Syrup 30 ml with Quinidine can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Satrogyl-O Dry Syrup 30 ml with Quinidine together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Satrogyl-O Dry Syrup 30 ml:
Coadministration of Satrogyl-O Dry Syrup 30 ml with Dronedarone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Satrogyl-O Dry Syrup 30 ml with Dronedarone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinMesoridazine
Critical
How does the drug interact with Satrogyl-O Dry Syrup 30 ml:
Using Mesoridazine together with Satrogyl-O Dry Syrup 30 ml can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Mesoridazine with Satrogyl-O Dry Syrup 30 ml is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
OfloxacinHalofantrine
Critical
How does the drug interact with Satrogyl-O Dry Syrup 30 ml:
Using halofantrine together with Satrogyl-O Dry Syrup 30 ml can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Satrogyl-O Dry Syrup 30 ml with Halofantrine can cause an interaction, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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OFLOXACIN-50MG+SATRANIDAZOLE-75MGCalcium rich foods, Caffeine containing foods/drinks
Moderate

Drug-Food Interactions

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OFLOXACIN-50MG+SATRANIDAZOLE-75MGCalcium rich foods, Caffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Tofu Set With Calcium, Ragi, Seasame Seeds, Kale, Milk, Almonds, Bok Choy, Calcium-Fortified Soy Milk, Cheese, Yogurt, Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Consumption of caffeine, calcium, iron, magnesium, and aluminum containing food while on the treatment with Ofloxacin can lead to decrease in blood levels of Ofloxacin. Avoid or limit consumption of caffeine, calcium, iron, magnesium, and aluminum containing food while on the treatment with Ofloxacin.

Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto, and cheese.
  • Eat fibre rich food like whole grains, beans, lentils, berries, broccoli, peas, and bananas.
  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
  • If you have diarrhoea try to drink appropriate amounts of fluids to avoid dehydration.
  • If you have minor diarrhoea (less than four stools daily) drinking caffeine-free soft drinks, juices, or sport rehydration drinks can be sufficient.
  • If the diarrhoea is more severe, specially formulated rehydration drinks should be taken.
  • Avoid alcoholic beverages with Satrogyl-O Dry Syrup as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Satrogyl-O Dry Syrup in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTIBIOTIC COMBINATION

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Satrogyl-O Dry Syrup contains Ofloxacin and Satranidazole. These drugs are antibiotics that kill and prevent the bacterial growth that causes diarrhoea, dysentery, and other bacterial infections.

Please let your doctor know if you have a history of allergic reactions to medicines, liver or kidney diseases, high blood pressure, nerve problems (peripheral neuropathy), mental/mood disorders (depression), tendonitis (inflammation of the tendon, a tissue connecting muscle and bone), fits, blood dyscrasia (decreased peripheral blood cell counts), colitis (inflammation of the colon), diabetes, myasthenia gravis (muscle weakness), dehydration and undergoing dialysis treatment.

Satrogyl-O Dry Syrup consists of Ofloxacin, a quinolone antibiotic that may cause hypoglycaemia (low blood sugar levels) or hyperglycaemia (high blood sugar levels). It is advised to consult your doctor before using Satrogyl-O Dry Syrup and monitor your blood sugar levels regularly.

Do not stop using Satrogyl-O Dry Syrup even if you feel better until the doctor's advised course is finished. Your symptoms may improve, but the infection may not be cured completely.

Satrogyl-O Dry Syrup, when taken along with Ibuprofen, may cause seizures in a few patients. This is very unlikely and rare to happen. However, it is better to avoid Ibuprofen while taking Satrogyl-O Dry Syrup. Please seek medical advice for further information.

Satrogyl-O Dry Syrup contains a quinolone antibiotic, Ofloxacin that can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor before you start Satrogyl-O Dry Syrup if you are undergoing any vaccinations.

It is recommended to maintain a minimum gap of two hours between magnesium/aluminium antacids, sucralfate, zinc or iron preparations and Satrogyl-O Dry Syrup.

Drug-Drug Interactions Checker List

  • ACENOCOUMAROL
  • WARFARIN
  • ASPIRIN
  • ALBUTEROL
  • DISULFIRAM
  • GINKGO

Special Advise

  • Satrogyl-O Dry Syrup contains Ofloxacin which might produce false-positive urine screening results for opiates. Inform the laboratory staff that you are taking Satrogyl-O Dry Syrup.
  • Monitor your blood sugar levels regularly since Ofloxacin in Satrogyl-O Dry Syrup may affect your glucose levels in diabetes.
  • Satrogyl-O Dry Syrup may affect coagulation test or prothrombin time (time is taken for blood clotting), liver function tests, and serum tests. Hence, it is advised to inform your doctor and laboratory staff beforehand if you are undergoing these examinations.
  • Quinolone antibiotics like Ofloxacin may cause QT prolongation (heart muscle takes longer than normal to recharge between beats) in electrocardiogram (ECG) in some patients.

Disease/Condition Glossary

Diarrhoea is a condition that causes the frequent passing of loose or watery stools. It is caused by bacteria (campylobacter and Escherichia coli), virus (norovirus or rotavirus), and parasites in contaminated food and water.

Dysentery is an intestinal inflammation that leads to severe diarrhoea accompanied by mucus or blood in the stools. It is mostly caused by shigella bacteria (shigellosis) or an amoeba.

Bacterial infection occurs when harmful bacteria grow in the body and causes infection. It can infect any part of the body and multiply very quickly. Bacteria occur in three basic shapes, spherical, rod and spiral-shaped. Bacteria may be gram-positive (have thick cell wall) or gram-negative (do not have a cell wall). Some common symptoms of a bacterial infection include cough, fever, and tiredness.

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