Ofloxacin+satranidazole
About
Ofloxacin+satranidazole belongs to the class of ‘antibiotics’, primarily used to treat diarrhoea and dysentery. It helps treat bacterial infections, including intra-abdominal infection, gynaecological and pelvic infections, foot ulcers in diabetes, post-operative infections, dental infections, and infections in immunocompromised patients. Diarrhoea is a condition that causes the frequent passing of loose or watery stools. Dysentery is an intestinal inflammation that leads to severe diarrhoea accompanied by mucus or blood in the stools. Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body.
Ofloxacin+satranidazole contains two antibiotic medicines, namely: Ofloxacin and Satranidazole. Ofloxacin belongs to a class of drugs called quinolone antibiotics. It works by inhibiting bacterial DNA gyrase, an enzyme required to replicate, transcription, and repair the DNA. Satranidazole is an anti-amoebic, antiprotozoal, and anti-bacterial medicine that treats various infections caused by bacteria and parasites (amoeba). It is bactericidal and kills harmful bacteria and parasites (amoeba) by damaging its DNA. It prevents the division of bacterial cells and inhibits the repairing of bacterial cells.
Please take Ofloxacin+satranidazole in the dose and duration prescribed by your doctor based on your medical condition. Ofloxacin+satranidazole is generally safe to use. However, some may experience side effects like nausea, vomiting, stomach pain, loss of appetite, dizziness, and headache. Most of these side effects of Ofloxacin+satranidazole do not require medical attention and gradually resolve over time. If these side effects persist longer, please consult your doctor.
If you are allergic to Ofloxacin+satranidazole or any other medicines, please tell your doctor. Do not suddenly stop this medicine to avoid unpleasant side effects and sudden withdrawal symptoms. Intake of probiotics, prebiotics, and plenty of fluids is recommended if you suffer from dysentery and diarrhoea. Do not drive or operate heavy machinery after taking Ofloxacin+satranidazole as it may cause dizziness. Please try avoiding alcoholic beverages during your treatment as it can cause flushing and a general sick feeling. Pregnant and breastfeeding women should use Ofloxacin+satranidazole with proper consultation and caution.
Uses of Ofloxacin+satranidazole
Medicinal Benefits
Ofloxacin+satranidazole contains two antibiotic medicines, namely: Ofloxacin and Satranidazole. Ofloxacin is a quinolone antibiotic that inhibits bacterial DNA gyrase, an enzyme required for replicating, transcription, and repairing the DNA. Satranidazole is an anti-amoebic, antiprotozoal, and anti-bacterial medicine effective against a wide range of gram-positive and gram-negative bacteria. It kills the harmful anaerobic bacteria and certain anaerobic protozoa (Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia) causing diarrhoea. It is bactericidal and kills harmful bacteria and parasites (amoeba) by damaging its DNA. It also prevents the division of bacterial cells and inhibits the repairing of bacterial cells.
Directions for Use
Storage
Side Effects of Ofloxacin+satranidazole
- Nausea
- Vomiting
- Stomach pain
- Loss of appetite
- Dizziness
- Headache
In-Depth Precautions and Warning
Drug Warnings
Brief your medical history to the doctor if you are allergic to Ofloxacin+satranidazole or any of its components. Please let your doctor know in advance if you have liver or kidney diseases, tendonitis, fits, blood dyscrasia, colitis, diabetes, myasthenia gravis (muscle weakness), dehydration, high blood pressure, nerve problems (peripheral neuropathy), mental/mood disorders (depression) or undergoing dialysis treatment. Please consult your doctor if you are planning to become pregnant or already pregnant before starting Ofloxacin+satranidazole. Do not drive or operate heavy machinery after taking Ofloxacin+satranidazole as it may cause dizziness and visual disturbances. Please try avoiding alcoholic beverages during your treatment as it can cause flushing and a general sick feeling. Ofloxacin+satranidazole is not recommended for children less than 18 years of age.
Drug Interactions
Drug-Drug Interaction: Ofloxacin+satranidazole may interact with blood thinners (acenocoumarol, warfarin), pain killers (aspirin), herbal products (ginkgo), respiratory drugs (albuterol), and medicines used to treat alcohol addiction (disulfiram).
Drug-Food Interaction: The consumption of alcoholic beverages should be avoided as it may lead to flushing, drowsiness, and dizziness.
Drug-Disease Interaction: Inform your doctor before starting Ofloxacin+satranidazole if you have liver or kidney diseases, tendonitis, fits, blood dyscrasia, colitis, diabetes, myasthenia gravis, dehydration, dialysis, high blood pressure, nerve problems, and mental/mood disorders (depression).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAlcohol consumption may worsen the side effects of Ofloxacin+satranidazole like dizziness and visual disturbances. It is better to avoid alcohol while you are being treated with Ofloxacin+satranidazole.
Pregnancy
cautionThere is limited data on how the Ofloxacin+satranidazole affects pregnancy. Please consult your doctor if you are planning to become pregnant or already pregnant before starting Ofloxacin+satranidazole.
Breast Feeding
cautionOfloxacin+satranidazole is excreted into the breast milk and may affect the nursing infants. Please consult your doctor before taking Ofloxacin+satranidazole if you are breastfeeding.
Driving
cautionDo not drive or operate machinery if you experience any impairment of skills, dizziness and visual disturbances while using Ofloxacin+satranidazole.
Liver
cautionPlease take Ofloxacin+satranidazole with caution and doctor’s advice if you have a history of liver diseases/conditions.
Kidney
cautionPlease take Ofloxacin+satranidazole with caution and doctor’s advice if you have a history of kidney diseases/conditions.
Children
unsafeOfloxacin+satranidazole is not recommended for children less than 18 years of age.
Habit Forming
Diet & Lifestyle Advise
- Antibiotics can alter the useful bacteria in the stomach. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto, and cheese.
- Eat fibre rich food like whole grains, beans, lentils, berries, broccoli, peas, and bananas.
- Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
- If you have diarrhoea try to drink appropriate amounts of fluids to avoid dehydration.
- If you have minor diarrhoea (less than four stools daily) drinking caffeine-free soft drinks, juices, or sport rehydration drinks can be sufficient.
- If the diarrhoea is more severe, specially formulated rehydration drinks should be taken.
- Avoid alcoholic beverages with Ofloxacin+satranidazole as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Ofloxacin+satranidazole in fighting off infections.
Special Advise
- Ofloxacin+satranidazole contains Ofloxacin which might produce false-positive urine screening results for opiates. Inform the laboratory staff that you are taking Ofloxacin+satranidazole.
- Monitor your blood sugar levels regularly since Ofloxacin in Ofloxacin+satranidazole may affect your glucose levels in diabetes.
- Ofloxacin+satranidazole may affect coagulation test or prothrombin time (time is taken for blood clotting), liver function tests, and serum tests. Hence, it is advised to inform your doctor and laboratory staff beforehand if you are undergoing these examinations.
- Quinolone antibiotics like Ofloxacin may cause QT prolongation (heart muscle takes longer than normal to recharge between beats) in electrocardiogram (ECG) in some patients.
Patients Concern
Disease/Condition Glossary
Diarrhoea is a condition that causes the frequent passing of loose or watery stools. It is caused by bacteria (campylobacter and Escherichia coli), virus (norovirus or rotavirus), and parasites in contaminated food and water.
Dysentery is an intestinal inflammation that leads to severe diarrhoea accompanied by mucus or blood in the stools. It is mostly caused by shigella bacteria (shigellosis) or an amoeba.
Bacterial infection occurs when harmful bacteria grow in the body and causes infection. It can infect any part of the body and multiply very quickly. Bacteria occur in three basic shapes, spherical, rod and spiral-shaped. Bacteria may be gram-positive (have thick cell wall) or gram-negative (do not have a cell wall). Some common symptoms of a bacterial infection include cough, fever, and tiredness.
FAQs
Ofloxacin+satranidazole contains Ofloxacin and Satranidazole. These drugs are antibiotics that kill and prevent the bacterial growth that causes diarrhoea, dysentery, and other bacterial infections.
Please let your doctor know if you have a history of allergic reactions to medicines, liver or kidney diseases, high blood pressure, nerve problems (peripheral neuropathy), mental/mood disorders (depression), tendonitis (inflammation of the tendon, a tissue connecting muscle and bone), fits, blood dyscrasia (decreased peripheral blood cell counts), colitis (inflammation of the colon), diabetes, myasthenia gravis (muscle weakness), dehydration and undergoing dialysis treatment.
Ofloxacin+satranidazole consists of Ofloxacin, a quinolone antibiotic that may cause hypoglycaemia (low blood sugar levels) or hyperglycaemia (high blood sugar levels). It is advised to consult your doctor before using Ofloxacin+satranidazole and monitor your blood sugar levels regularly.
Do not stop using Ofloxacin+satranidazole even if you feel better until the doctor's advised course is finished. Your symptoms may improve, but the infection may not be cured completely.
Ofloxacin+satranidazole, when taken along with Ibuprofen, may cause seizures in a few patients. This is very unlikely and rare to happen. However, it is better to avoid Ibuprofen while taking Ofloxacin+satranidazole. Please seek medical advice for further information.
Ofloxacin+satranidazole contains a quinolone antibiotic, Ofloxacin that can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor before you start Ofloxacin+satranidazole if you are undergoing any vaccinations.
It is recommended to maintain a minimum gap of two hours between magnesium/aluminium antacids, sucralfate, zinc or iron preparations and Ofloxacin+satranidazole.
