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Written By Veda Maddala , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
COD available

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Composition :

SELEGILINE-5MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Selerin 5mg Tablet

Selerin 5mg Tablet belongs to a class of antiparkinson drugs called monoamine oxidase-B inhibitors used in the treatment of Parkinson’s disease. Parkinson’s disease is a central nervous system disorder that affects movement. It causes stiffness, shaking, difficulty in walking, coordination and balance. In Parkinson’s patients, there is a decrease in dopamine (a chemical messenger that is important for movement control) levels as the nerve cells that produce dopamine begin to die.

Selerin 5mg Tablet contains Selegiline that works by inhibiting the action of an enzyme called monoamine oxidase-B that naturally breaks down dopamine. Thereby, increases the level of dopamine and restores its level in the brain thereby improving the symptoms of Parkinson’s disease.

Take Selerin 5mg Tablet with or without food as advised by your doctor and swallow whole with a glass of water. Do not crush, chew or break it. Your doctor will advise you how often you take Selerin 5mg Tablet based on your medical condition. Some people may experience a sore mouth, swollen gums, loss of balance, difficulty in controlling movements, headache, dizziness, nausea, sleep disorders, mouth ulcers or constipation. Most of these side effects of Selerin 5mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Selerin 5mg Tablet or any other medicines, please tell your doctor. Avoid taking Selerin 5mg Tablet if you are pregnant or breastfeeding and consult a doctor. Selerin 5mg Tablet is not recommended for children. If you are about to undergo any surgery, please inform your doctor that you are taking Selerin 5mg Tablet as it may interact with certain medicines used as a part of general anaesthesia. Avoid taking Selerin 5mg Tablet if you have stomach or duodenal ulcers, angina (chest pain), high blood pressure, major heart or blood vessel problems, hyperthyroidism (overactive thyroid gland), fast or irregular heartbeat, narrow-angle glaucoma, pheochromocytoma (tumour of the adrenal gland), prostatic adenoma (tumour of prostate gland), schizophrenia, advanced dementia (loss of memory and other thinking abilities). If you have sleep problems, anxiety, a history of stomach ulcers, kidney or liver problems, any unusual urges like excessive gambling or increased sexual behaviour, inform your doctor before taking Selerin 5mg Tablet.

Uses of Selerin 5mg Tablet

Parkinson’s disease

Directions for Use

Take Selerin 5mg Tablet as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, break or chew it.

Medicinal Benefits

Selerin 5mg Tablet is an antiparkinson agent that is used in the treatment of Parkinson’s disease. In Parkinson’s patients, the nerve cells that produce dopamine (a chemical messenger that is important for movement control) begin to die. So, there is a decrease in dopamine levels. Selerin 5mg Tablet works by inhibiting the action of the monoamine oxidase-B enzyme that naturally breaks down dopamine. Thereby, increases dopamine in the brain and restores its levels. Thus, it improves the symptoms of Parkinson’s disease. Selerin 5mg Tablet can be used alone or in combination with other medicines such as levodopa to reduce uncontrolled movements.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are known to be allergic to Selerin 5mg Tablet or any other medicines, please tell your doctor. Avoid taking Selerin 5mg Tablet if you are pregnant or breastfeeding and consult a doctor. Selerin 5mg Tablet is not recommended for children. If you are about to undergo any surgery, please inform your doctor that you are taking Selerin 5mg Tablet as it may interact with certain medicines used as a part of general anaesthesia. Avoid taking Selerin 5mg Tablet if you have stomach or duodenal ulcers, angina (chest pain), high blood pressure, major heart or blood vessel problems, hyperthyroidism (overactive thyroid gland), fast or irregular heartbeat, narrow-angle glaucoma, pheochromocytoma (tumour of the adrenal gland), prostatic adenoma (tumour of the prostate gland), schizophrenia, advanced dementia (loss of memory and other thinking abilities). If you have sleep problems, anxiety, a history of stomach ulcers, kidney or liver problems, unusual urges like excessive gambling or increased sexual behaviour, inform your doctor before taking Selerin 5mg Tablet.

Drug-Drug Interactions

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SelegilineErgotamine
Critical

Drug-Drug Interactions

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SelegilineErgotamine
Critical
How does the drug interact with Selerin 5mg Tablet:
When Ergotamine is taken with Selerin 5mg Tablet, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Ergotamine and Selerin 5mg Tablet, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, and diarrhea-call a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Selerin 5mg Tablet:
Co-administration of Tapentadol together with Selerin 5mg Tablet can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a mood stabilizer).

How to manage the interaction:
Co-administration of Selerin 5mg Tablet with Tapentadol is generally avoided as it can result in an interaction, but it can be taken if a doctor has advised it. If you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, blurred vision, muscle spasm or stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Selerin 5mg Tablet:
Co-administration of Nortriptyline with Selerin 5mg Tablet might raise serotonin hormone levels in the body (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Nortriptyline with Selerin 5mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Selerin 5mg Tablet:
Taking Selerin 5mg Tablet with Fluvoxamine can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Fluvoxamine with Selerin 5mg Tablet can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience confusion, hallucination (seeing & hearing things that do not exist), seizure(fits), extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor (shaking of hands & legs), incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Selerin 5mg Tablet:
Co-administration of Imipramine with Selerin 5mg Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Imipramine and Selerin 5mg Tablet together is not recommended as it can result in an interaction. It can be taken if a doctor has advised it. However, if you experience confusion, hallucinations, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, shaking, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Selerin 5mg Tablet:
Co-administration of Oxcarbazepine can increase the effects of Selerin 5mg Tablet on serotonin levels (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Selerin 5mg Tablet with Oxcarbazepine together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Selerin 5mg Tablet:
Co-administration of Selerin 5mg Tablet with Rasagiline can increase the risk of high blood pressure.

How to manage the interaction:
Although there is a possible interaction between Selerin 5mg Tablet and Rasagiline, but can be taken together if prescribed by a doctor. However, if you experience confusion, hallucination (seeing or hearing things that do not exist), fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Selerin 5mg Tablet:
When Mephentermine is combined with Selerin 5mg Tablet, may increase the risk of high blood pressure.

How to manage the interaction:
Mephentermine with Selerin 5mg Tablet is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience symptoms such as severe headache, blurred vision, confusion, fits, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Selerin 5mg Tablet:
Taking Selerin 5mg Tablet and Trazodone together can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Co-administration of Selerin 5mg Tablet with Trazodone can possibly result in an interaction but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Selerin 5mg Tablet:
Co-administration of Selerin 5mg Tablet can increase the effects of Clomipramine on serotonin levels (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Selerin 5mg Tablet with Clomipramine together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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SELEGILINE-5MGTyramine-containing food
Moderate

Drug-Food Interactions

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SELEGILINE-5MGTyramine-containing food
Moderate
Common Foods to Avoid:
Pepperoni, Miso Soup, Natto, Ricotta, Salami, Shoyu, Shrimp, Stilton Cheese, Swiss Cheese, Tamari, Tempeh, Fish, Farm Cheese, Fava Beans, Fermented Seafood, Fermented Tofu, Gorgonzola Cheese, Chicken Liver, Chocolates, Cottage Cheese, Cream Cheese, Dried Sausage, Dry-Type Summer Sausages, Cheddar Cheese, Cashews, Camembert, Beef Liver, American Cheese, Almonds, Avocado

How to manage the interaction:
Consuming Selerin 5mg Tablet with Tyramine-containing food it may increase the blood pressure. Avoid consuming Selerin 5mg Tablet with Tyramine-containing food.

Diet & Lifestyle Advise

  • Avoid intake of tyramine rich foods such as broad beans, Bovril, mature cheese, fermented soya bean products or yeast extracts.
  • Eat more fibre rich foods to ease constipation.
  • Drink plenty of water to avoid headaches due to dehydration.
  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Selerin 5mg Tablet contains Selegiline, an antiparkinson agent that works by inhibiting the action of monoamine oxidase-B enzyme that naturally breaks down dopamine. Thereby, increases dopamine in the brain and restores its levels. Thus, improves the symptoms of Parkinson’s disease.

You recommend avoiding tyramine rich foods such as broad beans, Bovril, mature cheese, fermented soya bean products or yeast extracts as it may cause severe high blood pressure.

Selerin 5mg Tablet may cause low blood pressure in some patients, especially while standing up suddenly from a sitting or lying down position and cause symptoms such as dizziness, sweating, nausea or fainting. Hence, to avoid orthostatic hypotension, you are recommended to get up slowly after lying down or sitting.

Selerin 5mg Tablet is not recommended for glaucoma (damage of optic nerve that is essential for good vision) patients as it may increase the fluid pressure inside the eye. However, regular monitoring of pressure in the eyes is recommended while on treatment with Selerin 5mg Tablet.

You are recommended to avoid taking Selerin 5mg Tablet with escitalopram as it may lead to a severe condition called ‘serotonin syndrome’ and cause symptoms such as blurred vision, stomach cramps, diarrhoea, hallucination, extreme changes in blood pressure, confusion, excessive sweating, increased heart rate, fever, shivering or shaking, tremor, incoordination, muscle spasm or stiffness. However, please consult a doctor before taking Selerin 5mg Tablet with other medicines.

No, Selerin 5mg Tablet does not cure Parkinson’s disease. Selerin 5mg Tablet is only used to reduce the symptoms of Parkinson’s disease.

Selerin 5mg Tablet should not be used with pain killers like meperidine, tramadol, methadone, propoxyphene and cough syrups containing dextromethorphan. Using together can cause severe side effects and can worsen your present condition.

Drug-Drug Interactions Checker List

  • RASAGILINE
  • LEVODOPA
  • DOPAMINE
  • AMANTADINE
  • ESCITALOPRAM
  • CITALOPRAM
  • FLUVOXAMINE
  • FLUOXETINE
  • SERTRALINE
  • PAROXETINE
  • PROTRIPTYLINE
  • AMITRIPTYLINE
  • VENLAFAXINE
  • DULOXETINE
  • PETHIDINE
  • TRAMADOL
  • CODEINE
  • MEPERIDINE
  • LINEZOLID
  • SUMATRIPTAN
  • ZOLMITRIPTAN
  • RIZATRIPTAN
  • DIGITALIS
  • CLONAZEPAM
  • IBUPROFEN
  • NARATRIPTAN
  • ALTRETAMINE

Special Advise

  • Selerin 5mg Tablet may cause abnormalities in certain laboratory test results such as liver function tests and blood tests. Therefore, inform your doctor or lab technician that you are on treatment with Selerin 5mg Tablet before undergoing any tests.
  • Selerin 5mg Tablet should not be used at daily doses of more than 2.5 mg/day due to the risks associated with a change in the amount of chemical messenger in the brain called a neurotransmitter. 
  • Selerin 5mg Tablet is contraindicated for use with medicine containing meperidine, as serious reactions have been experienced in patients taking both medications together. 

Disease/Condition Glossary

Parkinson’s disease: It is a disorder of the central nervous system that affects movement due to nerve cell damage in the brain which decreases the levels of dopamine and leads to symptoms such as stiffness, tremor in one hand, shaking, difficulty in walking, coordination, and balance. This condition can last for many years or life-long. Treatment with medicines along with physiotherapy may help to control the symptoms and provide a quality life for as long as possible.

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