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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
COD available

Online payment accepted

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Manufacturer/Marketer :

Zuventus Healthcare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Setolac-MR Tablet

Setolac-MR Tablet belongs to a group of medicines called analgesics used to treat osteoarthritis, rheumatoid arthritis, pain, and muscle spasms. Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering (cartilage). Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage.
 
Setolac-MR Tablet is a combination of two drugs, namely: Etodolac (NSAID) and Thiocolchicoside (Muscle relaxant). Etodolac blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins. By blocking the effect of COX enzymes, lesser prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helps relieve pain due to muscle spasms.
 
You are advised to take Setolac-MR Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Setolac-MR Tablet may cause common side effects such as nausea, vomiting, heartburn, stomach pain, and indigestion. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Setolac-MR Tablet may cause drowsiness and dizziness, so drive with caution. Setolac-MR Tablet is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol along with Setolac-MR Tablet as it could lead to increased dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Uses of Setolac-MR Tablet

Osteoarthritis, rheumatoid arthritis, pain and muscle spasms

Directions for Use

Take Setolac-MR Tablet with food to avoid stomach upset. Swallow Setolac-MR Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Setolac-MR Tablet is a combination of two drugs: Etodolac (Non-Steroidal Anti-Inflammatory Drugs) and Thiocolchicoside (Muscle relaxant). Setolac-MR Tablet is used to treat osteoarthritis, rheumatoid arthritis, pain, and muscle spasms. Etodolac blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical, prostaglandins, which are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helping relieve pain due to muscle spasms.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Setolac-MR Tablet if you are allergic to any of its contents; if you have stomach ulcers, bleeding problems, clotting problems, inflammatory bowel disease, severe heart, liver or kidney problems, galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Inform your doctor if you have/had stomach bleeding or ulcers, heart failure, high blood pressure, diabetes, high cholesterol, kidney or liver impairment. Consult your doctor if you are pregnant or breastfeeding. Setolac-MR Tablet may cause drowsiness and dizziness, so drive only if you are alert. Setolac-MR Tablet is not recommended for children as safety has not been established. Stop taking Setolac-MR Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with Setolac-MR Tablet unless prescribed.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Setolac-MR Tablet:
Co-administration of Setolac-MR Tablet with Meloxicam can raise the adverse consequences in the digestive system, including inflammation, bleeding, ulceration, and, in rare cases, perforation(rupture).

How to manage the interaction:
Taking Meloxicam with Setolac-MR Tablet is not recommended can result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Setolac-MR Tablet:
Using ketorolac together with Setolac-MR Tablet may increase the risk of side effects in the gastrointestinal tract (inflammation, bleeding and ulceration).

How to manage the interaction:
Taking Setolac-MR Tablet with Ketorolac is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
EtodolacPonatinib
Severe
How does the drug interact with Setolac-MR Tablet:
Taking Ponatinib with Setolac-MR Tablet may increase the risk of bleeding and severe hemorrhage.

How to manage the interaction:
Co-administration of Setolac-MR Tablet with Ponatinib can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, a severe headache, and/or weakness, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Setolac-MR Tablet:
Use of Panobinostat with Setolac-MR Tablet may increase the risk of bleeding and severe hemorrhage.

How to manage the interaction:
Taking Setolac-MR Tablet with Panobinostat together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, a severe headache, and/or weakness, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Setolac-MR Tablet:
Taking Celecoxib with Setolac-MR Tablet can increase the risk of stomach inflammation, bleeding, and ulceration.

How to manage the interaction:
Although there is a interaction between Setolac-MR Tablet and Celecoxib, but it can be taken if your doctor has advised it. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Setolac-MR Tablet:
Combining Adefovir dipivoxil with Setolac-MR Tablet can increase the risk of kidney damage.

How to manage the interaction:
Co-administration of Setolac-MR Tablet with Adefovir dipivoxil can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
EtodolacOmacetaxine mepesuccinate
Severe
How does the drug interact with Setolac-MR Tablet:
Use of Omacetaxine mepesuccinate with Setolac-MR Tablet may increase the risk of bleeding and severe haemorrhage.

How to manage the interaction:
There may be a possibility of interaction between Setolac-MR Tablet and Omacetaxine mepesuccinate, but it can be taken if prescribed by a doctor. However, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, a severe headache, and/or weakness, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
EtodolacIomeprol
Severe
How does the drug interact with Setolac-MR Tablet:
Taking Setolac-MR Tablet and Iomeprol can increase the risk of kidney damage.

How to manage the interaction:
Taking Setolac-MR Tablet with Iomeprol together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor immediately. Drink lots of fluid after the procedure to stay hydrated and to flush the contrast agent out of your kidneys. Do not stop using any medications without talking to a doctor.
How does the drug interact with Setolac-MR Tablet:
When Setolac-MR Tablet is taken with Dabigatran etexilate may increase the risk or severity of bleeding and hemorrhage.

How to manage the interaction:
Taking Dabigatran etexilate with Setolac-MR Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you happen to have any unusual bleeding or bruising, or other signs and symptoms of bleeding, such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
EtodolacDicoumarol
Severe
How does the drug interact with Setolac-MR Tablet:
Taking Setolac-MR Tablet with dicumarol may increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Setolac-MR Tablet and Dicoumarol, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANALGESICS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Setolac-MR Tablet is a combination of two drugs: Etodolac and Thiocolchicoside. Etodolac blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical, 'prostaglandins'. This helps reduce mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helping relieve pain due to muscle spasms.

Setolac-MR Tablet is used to reduce and relieve pain and inflammation associated with osteoarthritis and rheumatoid arthritis. Arthritis is tenderness and swelling in the joints.

Avoid taking Setolac-MR Tablet if you have stomach ulcers, bleeding problems, or heart problems. Talk to your doctor regarding your concerns; he/she may prescribe alternate medicine.

Diarrhoea might be a side-effect of Setolac-MR Tablet . Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in your stools (tarry stools) or severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Setolac-MR Tablet contains etodolac, which might make the skin sensitive to sunlight and may result in sunburn. Avoid exposure to sunlight and artificial UV rays such as tanning beds and sunlamps while taking Setolac-MR Tablet . Whenever you step out of the home, try to apply sunscreen.

Setolac-MR Tablet may increase the risk of fatal heart attack or stroke. If you have any recent heart bypass surgery, do not use Setolac-MR Tablet . Talk to your doctor before taking Setolac-MR Tablet if you have heart problems.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • IBUPROFEN
  • NAPROXEN
  • DICLOFENAC
  • DULOXETINE
  • ESCITALOPRAM
  • DIGOXIN
  • METOPROLOL
  • WARFARIN
  • LITHIUM
  • CYCLOSPORINE
  • MIFEPRESTONE

Disease/Condition Glossary

Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp; it might be constant or may come and go. The tolerance level of pain might vary from person to person. Pain can be generalized (overall body aches) or localized (affecting a specific area of the body). The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures, and arthritis.

Osteoarthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation and tenderness.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function. 

Muscle spasms: The sudden involuntary contractions of the muscle can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms. Symptoms include muscle tightness, joint stiffness, unusual posture, difficulty in moving, and pain in affected muscles and joints. Fatigue (weakness), stress, extreme heat or cold, infection and tight clothing can trigger muscle spasms. 

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