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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
COD available

Online payment accepted

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Whats That

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Composition

SIMVASTATIN-5MG

Manufacturer/Marketer

Ipca Laboratories Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Simlo 5mg Tablet 10's

Simlo 5mg Tablet 10's belongs to a group of antilipemic medicines called 'lipid-lowering agents' used to lower the levels of increased cholesterol in the body. Additionally, Simlo 5mg Tablet 10's is also used to lower the risk of heart diseases such as heart attack or stroke. High cholesterol levels might cause a build-up of cholesterol on the arteries walls, leading to blockage of blood flow to the heart and other body parts that could cause heart disease, heart attack or stroke.

Simlo 5mg Tablet 10's contains 'Simvastatin' that works by blocking HMG-CoA reductase, an enzyme necessary for cholesterol production in the body. Simlo 5mg Tablet 10's helps lower the levels of LDL (bad) cholesterol, and triglycerides and raises the levels of HDL (good) cholesterol. Thereby, Simlo 5mg Tablet 10's lowers the raised levels of fats, triglycerides and cholesterol, which lowers the risk of heart attack or stroke. 

You are advised to take Simlo 5mg Tablet 10's for as long as your doctor has prescribed it for you depending on your medical condition. You may experience certain common side-effects such as headache, stomach pain, constipation, and nausea in some cases. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Do not take Simlo 5mg Tablet 10's if you are pregnant, think you may be pregnant or if you are trying for pregnancy. Stop taking Simlo 5mg Tablet 10's and consult a doctor immediately if you become pregnant while taking Simlo 5mg Tablet 10's. Simlo 5mg Tablet 10's may cause dizziness, so be cautious while driving. Avoid consuming alcohol with Simlo 5mg Tablet 10's as it could lead to increased dizziness. Simlo 5mg Tablet 10's is not recommended for children below 10 years as safety and effectiveness have not been established. Inform your doctor regarding your health condition and the medicines you are taking to rule out any side effects or interactions.

Uses of Simlo 5mg Tablet 10's

Hyperlipidaemia (high cholesterol)

Directions for Use

Swallow Simlo 5mg Tablet 10's a whole with a glass of water; do not chew, or break it.

Medicinal Benefits

Simlo 5mg Tablet 10's contains 'Simvastatin', which belongs to a group of lipid-lowering agents called HMG-CoA reductase inhibitors to lower the increased levels of cholesterol or fat. Simlo 5mg Tablet 10's works by blocking the HMG-CoA reductase enzyme, which is necessary for cholesterol production in the body. Simlo 5mg Tablet 10's helps lower the levels of LDL (bad) cholesterol and triglycerides and raises the levels of HDL (good) cholesterol. Thereby, Simlo 5mg Tablet 10's lowers the blood level of fats and cholesterol and helps prevent a heart attack or stroke. Simlo 5mg Tablet 10's as an adjunct to dietary measures is used to reduce the risk of having a heart event due to cardiovascular diseases, the incidence of non-fatal heart attack or stroke, the need for revascularisation procedures (restoration of blood flow to the heart), people with diabetes, pre-existing heart disease, and peripheral vascular disease.  

Storage

Store in a cool and dry place away from sunlight

Side Effects of Simlo 5mg Tablet 10's

  • Headache
  • Stomach pain
  • Constipation
  • Nausea

Drug Warnings

Do not take Simlo 5mg Tablet 10's if you are allergic to any of its contents; if you are taking fusidic acid or have taken it in the past 7 days. Inform your doctor if you are due to have surgery, drink large amounts of alcohol; if you have liver or kidney problems. Do not take Simlo 5mg Tablet 10's if you are pregnant, breastfeeding, think you may be pregnant or if you are trying for pregnancy. Stop taking Simlo 5mg Tablet 10's and consult a doctor immediately if you become pregnant while taking Simlo 5mg Tablet 10's. Simlo 5mg Tablet 10's may cause dizziness, so be cautious while driving. Avoid consuming alcohol with Simlo 5mg Tablet 10's as it could lead to increased dizziness. Simlo 5mg Tablet 10's is not recommended for children below 10 years as safety and effectiveness have not been established.

Drug-Drug Interactions

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SimvastatinRitonavir
Critical
SimvastatinItraconazole
Critical

Drug-Drug Interactions

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SimvastatinRitonavir
Critical
How does the drug interact with Simlo 5mg Tablet:
Taking Ritonavir and Simlo 5mg Tablet may increase the risk of side effects.

How to manage the interaction:
Taking Simlo 5mg Tablet with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, tiredness, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, contact a doctor. Do not discontinue any medications without consulting a doctor.
SimvastatinItraconazole
Critical
How does the drug interact with Simlo 5mg Tablet:
Simlo 5mg Tablet's blood levels and effects may be greatly increased when combined with itraconazole.

How to manage the interaction:
Simlo 5mg Tablet and itraconazole may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you have side effects such unexplained pain in the muscles or tenderness, muscle weakness, fever or flu-like symptoms, or dark urine. Without consulting a doctor, never stop taking any medication.
SimvastatinFosamprenavir
Critical
How does the drug interact with Simlo 5mg Tablet:
Combining Fosamprenavir and Simlo 5mg Tablet can increase the blood levels and effects of Simlo 5mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Fosamprenavir and Simlo 5mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinSaquinavir
Critical
How does the drug interact with Simlo 5mg Tablet:
Combining Saquinavir and Simlo 5mg Tablet can increase the blood levels and effects of Simlo 5mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Saquinavir and Simlo 5mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinBoceprevir
Critical
How does the drug interact with Simlo 5mg Tablet:
Combining Boceprevir and Simlo 5mg Tablet can increase the blood levels and effects of Simlo 5mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Boceprevir and Simlo 5mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinErythromycin
Critical
How does the drug interact with Simlo 5mg Tablet:
Coadministration of erythromycin and Simlo 5mg Tablet can increase the blood levels and effects of Simlo 5mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Erythromycin and Simlo 5mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain or weakness, dark-colored urine, joint pain, itching, fatigue, or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinClarithromycin
Critical
How does the drug interact with Simlo 5mg Tablet:
Co-administration of Clarithromycin and Simlo 5mg Tablet can increase the blood levels and effects of Simlo 5mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis(which involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Clarithromycin and Simlo 5mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinTroleandomycin
Critical
How does the drug interact with Simlo 5mg Tablet:
Combining Troleandomycin and Simlo 5mg Tablet can increase the blood levels and effects of Simlo 5mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Troleandomycin and Simlo 5mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinPosaconazole
Critical
How does the drug interact with Simlo 5mg Tablet:
Taking Posaconazole with Simlo 5mg Tablet can increase the blood levels and effects of Simlo 5mg Tablet. This can increase the risk of side effects such as liver problems and rhabdomyolysis (which involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Posaconazole and Simlo 5mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by a doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
SimvastatinAmprenavir
Critical
How does the drug interact with Simlo 5mg Tablet:
Combining Amprenavir and Simlo 5mg Tablet can increase the blood levels and effects of Simlo 5mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Amprenavir and Simlo 5mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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SIMVASTATIN-5MGGrapefruit and Grapefruit Juice, Vitamin-K rich foods
Severe

Drug-Food Interactions

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SIMVASTATIN-5MGGrapefruit and Grapefruit Juice, Vitamin-K rich foods
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit, Green Tea

How to manage the interaction:
Taking grapefruit or grape juice and green tea or green tea extracts can increase the blood levels of Simlo 5mg Tablet and can increase the risk of liver damage and rhabdomyolysis (breakdown of skeletal muscle tissue). Taking grapefruit or grape juice and green tea or green tea extracts can lead to an interaction. However, if you experience any symptoms like muscle pain, tenderness, or weakness during treatment, fever or dark-colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, consult the doctor immediately. Avoid taking grapefruit or grape juice and green tea or green tea extracts.

Diet & Lifestyle Advise

  • Follow a cholesterol-lowering diet.
  • Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.
  • Limit salt and sugar intake.
  • Avoid smoking and alcohol consumption. 
  • Choose healthy fats and cut down on trans-fat.
  • Include omega-3 fatty acids, fibre-rich food, fruits and vegetables.
  • Get active by doing any physical activity such as swimming, brisk walking or jogging. Take the stairs instead of elevators/lifts.

Habit Forming

No

Therapeutic Class

ANTILIPEMICS

Simlo 5mg Tablet 10's Substitute

Substitutes safety advice
  • SIMVAS 5MG TABLET

    by Others

    3.96per tablet
  • SIMVOTIN 5MG TABLET

    by Others

    7.02per tablet
  • SIMCARD 5MG TABLET

    by Others

    5.57per tablet
  • Starstat 5 mg Tablet 10's

    by Others

    1.17per tablet
  • Zosta 5 mg Tablet 10's

    by Others

    9.64per tablet

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • FUSIDIC ACID
  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • INDINAVIR
  • SAQUINAVIR
  • RITONAVIR
  • NELFINAVIR
  • ITRACONAZOLE
  • KETOCONAZOLE
  • POSACONAZOLE
  • VORICONAZOLE
  • BOCEPREVIR
  • TELAPREVIR
  • NEFAZODONE
  • GEMFIBROZIL
  • CYCLOSPORINE
  • DANAZOL
  • COBICISTAT

Special Advise

  • Regular blood tests are advised to determine the effect of Simlo 5mg Tablet 10's on lipids. 
  • Consult your doctor immediately if you experience muscle pain, weakness, or tenderness, especially if associated with fever or tiredness.
  • Your doctor may recommend blood tests to monitor liver function prior to the start of treatment and during the treatment with Simlo 5mg Tablet 10's. Inform your doctor if you notice yellowing of skin or eyes, unusually dark urine, and tiredness.
  • Simlo 5mg Tablet 10's might affect test results for liver function and muscle enzyme (creatin-kinase). Inform the person doing the tests that you are taking Simlo 5mg Tablet 10's.
  • It is advisable to have complete cholesterol tests (lipid profile test) at least once a year. It will help you to closely monitor your heart health and risk of heart attack and stroke. 

Disease/Condition Glossary

Hyperlipidaemia: Hyperlipidaemia is commonly known as high cholesterol. Cholesterol is a fatty substance that is naturally produced in the liver because every cell uses it. Cholesterol is also found in fatty foods such as cheese, red meat, and eggs. High cholesterol levels might cause a build-up of fat on the arteries' walls, leading to blockage of blood flow to the heart and other body parts that could cause heart disease, heart attack or stroke. Cholesterol is mainly of two types, namely 'bad cholesterol' and 'good cholesterol'. Bad cholesterol comprises low-density lipoprotein (LDL) and triglycerides (TG) which deposit fat in the arteries leading to their blockage. Good cholesterol consists of high-density lipoprotein (HDL), which prevents the deposition of fats. Risk factors of high cholesterol are a high-fat diet, obesity, lack of physical exercise, and smoking. Usually, there are no specific symptoms of raised or high cholesterol levels, so it is advisable to have complete cholesterol tests (lipid profile tests) at least once a year. It will help monitor your heart health and risk of heart attack or stroke. 

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