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  3. SIMVOFIX 10MG TABLET

SIMVOFIX 10MG TABLET, Pack of 10 TABLETS
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Composition :

SIMVASTATIN-10MG

Manufacturer/Marketer :

Bal Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About SIMVOFIX 10MG TABLET

SIMVOFIX 10MG TABLET belongs to a group of antilipemic medicines called 'lipid-lowering agents' used to lower the levels of increased cholesterol in the body. Additionally, SIMVOFIX 10MG TABLET is also used to lower the risk of heart diseases such as heart attack or stroke. High cholesterol levels might cause a build-up of cholesterol on the arteries walls, leading to blockage of blood flow to the heart and other body parts that could cause heart disease, heart attack or stroke.

SIMVOFIX 10MG TABLET contains 'Simvastatin' that works by blocking HMG-CoA reductase, an enzyme necessary for cholesterol production in the body. SIMVOFIX 10MG TABLET helps lower the levels of LDL (bad) cholesterol, and triglycerides and raises the levels of HDL (good) cholesterol. Thereby, SIMVOFIX 10MG TABLET lowers the raised levels of fats, triglycerides and cholesterol, which lowers the risk of heart attack or stroke. 

You are advised to take SIMVOFIX 10MG TABLET for as long as your doctor has prescribed it for you depending on your medical condition. You may experience certain common side-effects such as headache, stomach pain, constipation, and nausea in some cases. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Do not take SIMVOFIX 10MG TABLET if you are pregnant, think you may be pregnant or if you are trying for pregnancy. Stop taking SIMVOFIX 10MG TABLET and consult a doctor immediately if you become pregnant while taking SIMVOFIX 10MG TABLET. SIMVOFIX 10MG TABLET may cause dizziness, so be cautious while driving. Avoid consuming alcohol with SIMVOFIX 10MG TABLET as it could lead to increased dizziness. SIMVOFIX 10MG TABLET is not recommended for children below 10 years as safety and effectiveness have not been established. Inform your doctor regarding your health condition and the medicines you are taking to rule out any side effects or interactions.

Uses of SIMVOFIX 10MG TABLET

Hyperlipidaemia (high cholesterol)

Directions for Use

Swallow SIMVOFIX 10MG TABLET a whole with a glass of water; do not chew, or break it.

Medicinal Benefits

SIMVOFIX 10MG TABLET contains 'Simvastatin', which belongs to a group of lipid-lowering agents called HMG-CoA reductase inhibitors to lower the increased levels of cholesterol or fat. SIMVOFIX 10MG TABLET works by blocking the HMG-CoA reductase enzyme, which is necessary for cholesterol production in the body. SIMVOFIX 10MG TABLET helps lower the levels of LDL (bad) cholesterol and triglycerides and raises the levels of HDL (good) cholesterol. Thereby, SIMVOFIX 10MG TABLET lowers the blood level of fats and cholesterol and helps prevent a heart attack or stroke. SIMVOFIX 10MG TABLET as an adjunct to dietary measures is used to reduce the risk of having a heart event due to cardiovascular diseases, the incidence of non-fatal heart attack or stroke, the need for revascularisation procedures (restoration of blood flow to the heart), people with diabetes, pre-existing heart disease, and peripheral vascular disease.  

Storage

Store in a cool and dry place away from sunlight
Side effects of Simvofix 10mg Tablet
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. Use extra pillows to elevate your position and prop your chest up while sleeping.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.
  • Get plenty of rest and avoid activities that tire you out to allow your body fight the infection.
  • Drink lots of fluids to help loosen mucus in the lungs.
  • Use over-the-counter medications like paracetamol or ibuprofen to manage fever.
  • Use a humidifier as it helps soothe irritated airways.
  • Do not make changes to your medication schedule or take over-the-counter medicines without consulting your doctor.

Drug Warnings

Do not take SIMVOFIX 10MG TABLET if you are allergic to any of its contents; if you are taking fusidic acid or have taken it in the past 7 days. Inform your doctor if you are due to have surgery, drink large amounts of alcohol; if you have liver or kidney problems. Do not take SIMVOFIX 10MG TABLET if you are pregnant, breastfeeding, think you may be pregnant or if you are trying for pregnancy. Stop taking SIMVOFIX 10MG TABLET and consult a doctor immediately if you become pregnant while taking SIMVOFIX 10MG TABLET. SIMVOFIX 10MG TABLET may cause dizziness, so be cautious while driving. Avoid consuming alcohol with SIMVOFIX 10MG TABLET as it could lead to increased dizziness. SIMVOFIX 10MG TABLET is not recommended for children below 10 years as safety and effectiveness have not been established.

Drug-Drug Interactions

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SimvastatinVoriconazole
Critical
SimvastatinBoceprevir
Critical

Drug-Drug Interactions

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SimvastatinVoriconazole
Critical
How does the drug interact with Simvofix 10mg Tablet:
Taking Voriconazole and Simvofix 10mg Tablet can increase the blood levels and effects of Simvofix 10mg Tablet. This can increase the risk of side effects (liver damage and rhabdomyolysis - involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Voriconazole and Simvofix 10mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if a doctor advises. However, if you experience muscle pain, fever or dark-colored urine, vomiting, and yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
SimvastatinBoceprevir
Critical
How does the drug interact with Simvofix 10mg Tablet:
Combining Boceprevir and Simvofix 10mg Tablet can increase the blood levels and effects of Simvofix 10mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Boceprevir and Simvofix 10mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinClarithromycin
Critical
How does the drug interact with Simvofix 10mg Tablet:
Co-administration of Clarithromycin and Simvofix 10mg Tablet can increase the blood levels and effects of Simvofix 10mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis(which involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Clarithromycin and Simvofix 10mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinTelaprevir
Critical
How does the drug interact with Simvofix 10mg Tablet:
Combining Telaprevir and Simvofix 10mg Tablet can increase the blood levels and effects of Simvofix 10mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Telaprevir and Simvofix 10mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinCobicistat
Critical
How does the drug interact with Simvofix 10mg Tablet:
Combining Cobicistat and Simvofix 10mg Tablet can increase the blood levels and effects of Simvofix 10mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Cobicistat and Simvofix 10mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinDanazol
Critical
How does the drug interact with Simvofix 10mg Tablet:
Combining Danazol and Simvofix 10mg Tablet can increase the blood levels and effects of Simvofix 10mg Tablet.

How to manage the interaction:
Taking Danazol and Simvofix 10mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinSaquinavir
Critical
How does the drug interact with Simvofix 10mg Tablet:
Combining Saquinavir and Simvofix 10mg Tablet can increase the blood levels and effects of Simvofix 10mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Saquinavir and Simvofix 10mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinTroleandomycin
Critical
How does the drug interact with Simvofix 10mg Tablet:
Combining Troleandomycin and Simvofix 10mg Tablet can increase the blood levels and effects of Simvofix 10mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Troleandomycin and Simvofix 10mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinNefazodone
Critical
How does the drug interact with Simvofix 10mg Tablet:
Combining Nefazodone and Simvofix 10mg Tablet can increase the blood levels and effects of Simvofix 10mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Nefazodone and Simvofix 10mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinTelithromycin
Critical
How does the drug interact with Simvofix 10mg Tablet:
Combining Telithromycin and Simvofix 10mg Tablet can increase the blood levels and effects of Simvofix 10mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Telithromycin and Simvofix 10mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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SIMVASTATIN-10MGGrapefruit and Grapefruit Juice, Vitamin-K rich foods
Severe

Drug-Food Interactions

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SIMVASTATIN-10MGGrapefruit and Grapefruit Juice, Vitamin-K rich foods
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit, Green Tea

How to manage the interaction:
Taking grapefruit or grape juice and green tea or green tea extracts can increase the blood levels of Simvofix 10mg Tablet and can increase the risk of liver damage and rhabdomyolysis (breakdown of skeletal muscle tissue). Taking grapefruit or grape juice and green tea or green tea extracts can lead to an interaction. However, if you experience any symptoms like muscle pain, tenderness, or weakness during treatment, fever or dark-colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, consult the doctor immediately. Avoid taking grapefruit or grape juice and green tea or green tea extracts.

Diet & Lifestyle Advise

  • Follow a cholesterol-lowering diet.
  • Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.
  • Limit salt and sugar intake.
  • Avoid smoking and alcohol consumption. 
  • Choose healthy fats and cut down on trans-fat.
  • Include omega-3 fatty acids, fibre-rich food, fruits and vegetables.
  • Get active by doing any physical activity such as swimming, brisk walking or jogging. Take the stairs instead of elevators/lifts.

Habit Forming

No

Therapeutic Class

ANTILIPEMICS

SIMVOFIX 10MG TABLET Substitute

Substitutes safety advice

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Sunny S

Reviewed By

Sunny S

MBBS

Last Updated

Jul 8, 2025 | 9:36 AM IST

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

SIMVOFIX 10MG TABLET works by blocking HMG-CoA reductase, an enzyme necessary for the production of cholesterol in the body. SIMVOFIX 10MG TABLET helps lower the levels of LDL (bad) cholesterol and triglycerides and raises the levels of HDL (good) cholesterol. Thereby, SIMVOFIX 10MG TABLET lowers the blood level of raised fats and cholesterol and helps prevent a heart attack or stroke.

Do not discontinue SIMVOFIX 10MG TABLET without consulting your doctor as it could lead to the rise of cholesterol. To treat your condition effectually, continue taking SIMVOFIX 10MG TABLET for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking SIMVOFIX 10MG TABLET.

Constipation could be a side-effect of SIMVOFIX 10MG TABLET. Drink plenty of fluids and eat fibre-rich food if you experience constipation. Consult your doctor if you have severe constipation.

SIMVOFIX 10MG TABLET can be taken by diabetes patients if prescribed by the doctor. Your doctor will monitor your condition closely if you have diabetes. Regular monitoring of blood sugar levels is advised.

SIMVOFIX 10MG TABLET should not be taken with antibiotics such as fusidic acid as it could lead to a serious muscle problem called rhabdomyolysis (the breakdown of muscle tissue). Inform the doctor that you are taking SIMVOFIX 10MG TABLET if your doctor has prescribed fusidic acid, the doctor may ask you to temporarily stop taking SIMVOFIX 10MG TABLET to treat your infection. Your doctor will decide when it is safe to restart treatment with SIMVOFIX 10MG TABLET.

SIMVOFIX 10MG TABLET might cause muscle problems, particularly when taken at high doses. In rare conditions, SIMVOFIX 10MG TABLET might cause serious muscle problems such as rhabdomyolysis (muscle tissue breakdown). Consult your doctor immediately if you experience muscle pain, weakness, and tenderness, especially if associated with fever or tiredness.

Drug-Drug Interactions Checker List

  • FUSIDIC ACID
  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • INDINAVIR
  • SAQUINAVIR
  • RITONAVIR
  • NELFINAVIR
  • ITRACONAZOLE
  • KETOCONAZOLE
  • POSACONAZOLE
  • VORICONAZOLE
  • BOCEPREVIR
  • TELAPREVIR
  • NEFAZODONE
  • GEMFIBROZIL
  • CYCLOSPORINE
  • DANAZOL
  • COBICISTAT

Special Advise

  • Regular blood tests are advised to determine the effect of SIMVOFIX 10MG TABLET on lipids. 
  • Consult your doctor immediately if you experience muscle pain, weakness, or tenderness, especially if associated with fever or tiredness.
  • Your doctor may recommend blood tests to monitor liver function prior to the start of treatment and during the treatment with SIMVOFIX 10MG TABLET. Inform your doctor if you notice yellowing of skin or eyes, unusually dark urine, and tiredness.
  • SIMVOFIX 10MG TABLET might affect test results for liver function and muscle enzyme (creatin-kinase). Inform the person doing the tests that you are taking SIMVOFIX 10MG TABLET.
  • It is advisable to have complete cholesterol tests (lipid profile test) at least once a year. It will help you to closely monitor your heart health and risk of heart attack and stroke. 

Disease/Condition Glossary

Hyperlipidaemia: Hyperlipidaemia is commonly known as high cholesterol. Cholesterol is a fatty substance that is naturally produced in the liver because every cell uses it. Cholesterol is also found in fatty foods such as cheese, red meat, and eggs. High cholesterol levels might cause a build-up of fat on the arteries' walls, leading to blockage of blood flow to the heart and other body parts that could cause heart disease, heart attack or stroke. Cholesterol is mainly of two types, namely 'bad cholesterol' and 'good cholesterol'. Bad cholesterol comprises low-density lipoprotein (LDL) and triglycerides (TG) which deposit fat in the arteries leading to their blockage. Good cholesterol consists of high-density lipoprotein (HDL), which prevents the deposition of fats. Risk factors of high cholesterol are a high-fat diet, obesity, lack of physical exercise, and smoking. Usually, there are no specific symptoms of raised or high cholesterol levels, so it is advisable to have complete cholesterol tests (lipid profile tests) at least once a year. It will help monitor your heart health and risk of heart attack or stroke. 

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