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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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About SIMVOTIN EZ 20MG TABLET

SIMVOTIN EZ 20MG TABLET belongs to the class of medicines called 'anti hyperlipidemic drugs' or cholesterol-lowering agents primarily used to lower bad cholesterol and triglycerides (type of fat) and increase good cholesterol levels. This reduces the risk of heart attack and stroke in future. High cholesterol, known as hyperlipidemia or dyslipidemia, occurs when there is an excess of the unhealthy cholesterol balance in the blood. When the cholesterol level is high in the blood, your arteries get narrowed and clogged, contributing to heart diseases like stroke and heart attack. 

SIMVOTIN EZ 20MG TABLET is a combination of Ezetimibe and Simvastatin. Ezetimibe works by reducing the cholesterol absorbed in the digestive tract. Simvastatin belongs to the class of statins or HMG-CoA reductase inhibitors that work by inhibiting the HMG-CoA reductase enzyme in the body that is essential to make cholesterol. Thereby, it decreases the production of LDL (bad cholesterol) by the liver. Also, it reduces the risk of stroke or heart attack by reducing the excess cholesterol deposition in the major blood vessels of the brain and heart. 

Take SIMVOTIN EZ 20MG TABLET as prescribed. Your doctor will advise how often you take SIMVOTIN EZ 20MG TABLET based on your medical condition. Sometimes, this medicine may cause common side effects such as muscle pain, headache, diarrhoea, upper respiratory tract infection or increased liver enzyme levels. Most of these side effects of SIMVOTIN EZ 20MG TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

If you are allergic to Ezetimibe, Simvastatin or other medicines, please tell your doctor. If you are aged 65 years or older, please inform your doctor. Avoid using SIMVOTIN EZ 20MG TABLET if you are pregnant. Also, you are advised to take effective birth control measures while taking SIMVOTIN EZ 20MG TABLET to avoid pregnancy. Please inform your doctor if you are a breastfeeding mother. SIMVOTIN EZ 20MG TABLET is not recommended for children below 10 years of age as the safety and effectiveness were not established. If you feel dizzy after taking SIMVOTIN EZ 20MG TABLET, avoid driving or operating machinery. 

Uses of SIMVOTIN EZ 20MG TABLET

High cholesterol, Prevention of heart attack and stroke

Directions for Use

Take SIMVOTIN EZ 20MG TABLET with or without food as advised by your doctor. Swallow it as a whole with a glass of water. Do not break, crush or chew it.

Medicinal Benefits

SIMVOTIN EZ 20MG TABLET contains Ezetimibe and Simvastatin, used to lower the levels of bad cholesterol and triglycerides (type of fat) and increase good cholesterol levels. This reduces the risk of heart attack and stroke in future. Ezetimibe works by reducing the cholesterol absorbed in the digestive tract. Simvastatin works by inhibiting the production of cholesterol your body makes by itself. Also, it reduces the risk of stroke or heart attack by reducing the excess cholesterol deposition in the major blood vessels of the brain and heart. SIMVOTIN EZ 20MG TABLET is used for patients whose cholesterol levels are not controlled by diet and exercise alone. 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are allergic to Ezetimibe, Simvastatin or any other medicines, please tell your doctor. If you are aged 65 years or older, please inform your doctor. Avoid using SIMVOTIN EZ 20MG TABLET if you are pregnant. Also, you are advised to take effective birth control measures while taking SIMVOTIN EZ 20MG TABLET to avoid pregnancy. Please inform your doctor if you are a breastfeeding mother. SIMVOTIN EZ 20MG TABLET is not recommended for children below 10 years of age as the safety and effectiveness were not established. If you feel dizzy after taking SIMVOTIN EZ 20MG TABLET, avoid driving or operating machinery. Maintain a low-fat diet along with SIMVOTIN EZ 20MG TABLET for effective results. If you have diabetes or are at risk of developing diabetes, your doctor will monitor you closely while on treatment with SIMVOTIN EZ 20MG TABLET. You are likely to be at risk of developing diabetes if you have high levels of sugars and fats in the blood, high blood pressure and are overweight.

Drug-Drug Interactions

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SimvastatinTipranavir
Critical

Drug-Drug Interactions

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How does the drug interact with Simvotin Ez 20mg Tablet:
Combining Ciclosporin and Simvotin Ez 20mg Tablet can increase the blood levels and effects of Simvotin Ez 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Ciclosporin and Simvotin Ez 20mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinTipranavir
Critical
How does the drug interact with Simvotin Ez 20mg Tablet:
Combining Tipranavir and Simvotin Ez 20mg Tablet can increase the blood levels and effects of Simvotin Ez 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Tipranavir and Simvotin Ez 20mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
SimvastatinNelfinavir
Critical
How does the drug interact with Simvotin Ez 20mg Tablet:
Combining Nelfinavir and Simvotin Ez 20mg Tablet can increase the blood levels and effects of Simvotin Ez 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Nelfinavir and Simvotin Ez 20mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Simvotin Ez 20mg Tablet:
Combining Darunavir and Simvotin Ez 20mg Tablet can increase the blood levels and effects of Simvotin Ez 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Darunavir and Simvotin Ez 20mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinTelaprevir
Critical
How does the drug interact with Simvotin Ez 20mg Tablet:
Combining Telaprevir and Simvotin Ez 20mg Tablet can increase the blood levels and effects of Simvotin Ez 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Telaprevir and Simvotin Ez 20mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinNefazodone
Critical
How does the drug interact with Simvotin Ez 20mg Tablet:
Combining Nefazodone and Simvotin Ez 20mg Tablet can increase the blood levels and effects of Simvotin Ez 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Nefazodone and Simvotin Ez 20mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Simvotin Ez 20mg Tablet:
Taking Ritonavir and Simvotin Ez 20mg Tablet may increase the risk of side effects.

How to manage the interaction:
Taking Simvotin Ez 20mg Tablet with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, tiredness, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, contact a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Simvotin Ez 20mg Tablet:
Combining Mifepristone with Simvotin Ez 20mg Tablet can increase the blood levels of Simvotin Ez 20mg Tablet, which may increase the risk of side effects.

How to manage the interaction:
Taking Simvotin Ez 20mg Tablet with Mifepristone is not recommended, but can be taken if prescribed by the doctor. If you experience any symptoms, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Simvotin Ez 20mg Tablet:
Combining Ceritinib and Simvotin Ez 20mg Tablet can increase the blood levels and effects of Simvotin Ez 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Ceritinib and Simvotin Ez 20mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinFosamprenavir
Critical
How does the drug interact with Simvotin Ez 20mg Tablet:
Combining Fosamprenavir and Simvotin Ez 20mg Tablet can increase the blood levels and effects of Simvotin Ez 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Fosamprenavir and Simvotin Ez 20mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a low-fat diet. Limit your intake of dairy products made with whole milk and red meat. Prefer skim milk and fat-free or low-fat dairy products.
  • Eat a healthy diet that includes fruits, vegetables, fish, poultry, whole grains, nuts and cut-down beverages, and processed and sugary foods.
  • Do regular exercises such as swimming, cycling, walking, or dancing and focus on losing weight, as obesity also raises bad cholesterol and lowers good cholesterol.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTILIPEMICS

SIMVOTIN EZ 20MG TABLET Substitute

Substitutes safety advice
  • Simkind E 20mg/10mg Tablet

    by Others

    18.90per tablet

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

SIMVOTIN EZ 20MG TABLET contains Ezetimibe and Simvastatin. Ezetimibe works by reducing the cholesterol absorbed in the digestive tract. Simvastatin works by inhibiting the production of cholesterol your body makes by itself. Also, it reduces the risk of stroke or heart attack by reducing the excess cholesterol deposition in the major blood vessels of the brain and heart.

You are recommended to inform your doctor if you are taking niacin or niacin-containing product, as it may increase the risk of muscle problems.

SIMVOTIN EZ 20MG TABLET may increase the risk of rhabdomyolysis (the breakdown of muscle tissue) in some patients. It is not common for everyone who takes SIMVOTIN EZ 20MG TABLET. However, if you experience unexplained muscle pain, weakness or tenderness, especially along with fever, dark-coloured urine or unusual tiredness, please consult your doctor immediately.

You are not recommended to stop taking SIMVOTIN EZ 20MG TABLET without consulting your doctor as it may worsen the condition and increase the risk of heart attack and stroke. Therefore, take SIMVOTIN EZ 20MG TABLET for as long as your doctor has prescribed it, and if you experience any difficulty while taking SIMVOTIN EZ 20MG TABLET, please consult your doctor so that the dose may be gradually reduced.

Drug-Drug Interactions Checker List

  • POSACONAZOLE
  • KETOCONAZOLE
  • ITRACONAZOLE
  • VORICONAZOLE
  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • TELITHROMYCIN
  • INDINAVIR
  • SAQUINAVIR
  • NELFINAVIR
  • TIPRANAVIR
  • RITONAVIR
  • ATAZANAVIR
  • NEFAZODONE
  • COBICISTAT
  • DANAZOL
  • CYCLOSPORINE
  • TELAPREVIR
  • BOCEPREVIR
  • FENOFIBRATE
  • LOMITAPIDE
  • GEMFIBROZIL
  • AMIODARONE
  • DRONEDARONE
  • DILTIAZEM
  • VERAPAMIL
  • RANOLAZINE
  • AMLODIPINE
  • COLCHICINE
  • NIACIN
  • WARFARIN

Special Advise

  • Regular blood tests are recommended to monitor liver function while on treatment with SIMVOTIN EZ 20MG TABLET.

Disease/Condition Glossary

High cholesterol: It is also known as hyperlipidemia or dyslipidemia and occurs when there is an excess of the unhealthy balance of cholesterol in the blood. When there is a high level of cholesterol in the blood, your arteries get narrowed and clogged, finally contributing to heart diseases like stroke and heart attack. Eating high-fat or high-cholesterol-containing food/drinks and genetic factors are the primary causes of high cholesterol. There are two types of cholesterol found in our body: good cholesterol (high-density lipoprotein) and bad cholesterol (low-density lipoprotein). Good cholesterol is good for our heart and helps in reducing the bad cholesterol in our body. On the other hand, excess bad cholesterol (LDL) leads to the risk of heart diseases like heart attack and stroke.

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