Spegra Tablet 30's belongs to the group of antiretroviral agents indicated for the treatment of HIV-1 infection in adults and children above 12years weighing at least 40kgs. HIV is a virus that attacks the body's immune system, making it compromised and susceptible to various infections and diseases.

Spegra Tablet 30's contains 'Dolutegravir, Emtricitabine and Tenofovir alafenamide'. Spegra Tablet 30's works by interfering with the working of HIV-1 reverse transcriptase enzymes which are necessary for the replication of the virus. Together, Spegra Tablet 30's helps in treating HIV infection.

Take Spegra Tablet 30's as prescribed. In some cases, Spegra Tablet 30's may cause certain side effects such as trouble sleeping, headache, nausea, and tiredness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

Consult your doctor if you are pregnant, or planning to get pregnant. Avoid breastfeeding while taking Spegra Tablet 30's. Spegra Tablet 30's does not help reduce the risk of getting HIV-1 infection by sexual contact; therefore, it is important to practise safe sex to avoid transmitting HIV to your partner. Avoid alcohol consumption while on treatment with Spegra Tablet 30's.

Spegra Tablet 30's is an anti-retroviral drug used in the treatment of HIV-1 infection. Spegra Tablet 30's works by interfering with the replication of HIV and preventing its further progression. It contains Dolutegravir, Emtricitabine and Tenofovir alafenamide. Dolutegravir works by blocking HIV integrase, which is responsible for integrating viral DNA into the host cell. Thus, it inhibits the integration of the viral component into the human body cells. Emtricitabine works by inhibiting reverse transcriptase, which is responsible for transcribing RNA to DNA. By blocking this action, emtricitabine prevents the proliferation of the virus. Tenofovir alafenamide blocks the enzyme polymerase, thereby preventing aggregation of viral components and terminating the DNA chain, thus effectively nipping viral replication in the bud.

• Headache
• Tiredness
• Trouble sleeping
• Nausea

Inform the doctor if you are allergic to any of the components of Spegra Tablet 30's. Consult your doctor if you are pregnant, or planning to get pregnant before taking Spegra Tablet 30's. Avoid breastfeeding while on treatment with Spegra Tablet 30's. Avoid alcohol consumption. It is important to practise safe sex to avoid transmitting HIV to your partner. Inform your doctor if you have liver problems, hepatitis infections, heart or kidney problems. Keep your doctor informed about your health condition and medications to rule out any interactions.

Drug-Drug Interactions: Spegra Tablet 30's may interact with antiviral/anti-HIV drug (adefovir dipivoxil, atazanavir, bictegravir, lamivudine), anti-Tb drug (rifampicin), antidepressant (St John’s wort), ulcer medicine (sucralfate), antibiotics (azithromycin, clarithromycin, rifabutin), immunosuppressants (cyclosporine), anti-epileptics (phenobarbital or phenytoin), antacids, iron supplements and vitamins.

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Spegra Tablet 30's should be used with caution in patients with a known hypersensitivity disorder, diabetes, hypertension, hepatitis, liver disease, kidney disease and/or heart disease.

• ADEFOVIR
• ATAZANAVIR
• LAMIVUDINE
• SUCRALFATE
• RIFAMPICIN
• ST JOHN'S WORT
• AZITHROMYCIN
• CLARITHROMYCIN
• RIFABUTIN
• CYCLOSPORINE
• PHENYTOIN
• PHENOBARBITAL
• IRON

• Practise safe sex to prevent transmitting HIV to your partner. Educate yourself and your partner about pre and post-exposure prophylaxis and ART (anti-retroviral therapy). Use a condom as far as possible.
• Meditation and yoga have also proven very effective in helping HIV patients maintain a healthy attitude and body.
• Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods.
• Take good care of your oral hygiene. HIV often affects the mouth and causes sores. See a dentist regularly. Brush, floss and scrape your tongue well and keep your mouth clean.
• Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 

HIV infection: HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system and destroys the white blood cells that help in fighting infection, making the individual susceptible to other infections or illnesses. People with HIV experience flu-like symptoms such as fever, chills, rash, night sweats, muscle aches, tiredness, and sore throat. These symptoms usually last for days to several weeks. HIV spreads through body fluids such as semen, vaginal fluid, and blood. If left untreated, this condition can lead to AIDS (Acquired Immunodeficiency Syndrome). It is a life-long condition, and there is no definite cure for it. However, it can be controlled by treating with antiretroviral drugs.