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Written By ,
Reviewed By Santoshini Reddy G , M Pharmacy

About Spegra Tablet 30's

Spegra Tablet 30's belongs to the group of antiretroviral agents indicated for the treatment of HIV-1 infection in adults and children above 12years weighing at least 40kgs. HIV is a virus that attacks the body's immune system, making it compromised and susceptible to various infections and diseases.

Spegra Tablet 30's contains 'Dolutegravir, Emtricitabine and Tenofovir alafenamide'. Spegra Tablet 30's works by interfering with the working of HIV-1 reverse transcriptase enzymes which are necessary for the replication of the virus. Together, Spegra Tablet 30's helps in treating HIV infection.

Take Spegra Tablet 30's as prescribed. In some cases, Spegra Tablet 30's may cause certain side effects such as trouble sleeping, headache, nausea, and tiredness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

Consult your doctor if you are pregnant, or planning to get pregnant. Avoid breastfeeding while taking Spegra Tablet 30's. Spegra Tablet 30's does not help reduce the risk of getting HIV-1 infection by sexual contact; therefore, it is important to practise safe sex to avoid transmitting HIV to your partner. Avoid alcohol consumption while on treatment with Spegra Tablet 30's.

rxMedicinePrescription drug

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Non returnable*
COD available

Online payment accepted

Consume Type

ORAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Spegra Tablet 30's

HIV-1 infection

Medicinal Benefits

Spegra Tablet 30's is an anti-retroviral drug used in the treatment of HIV-1 infection. Spegra Tablet 30's works by interfering with the replication of HIV and preventing its further progression. It contains Dolutegravir, Emtricitabine and Tenofovir alafenamide. Dolutegravir works by blocking HIV integrase, which is responsible for integrating viral DNA into the host cell. Thus, it inhibits the integration of the viral component into the human body cells. Emtricitabine works by inhibiting reverse transcriptase, which is responsible for transcribing RNA to DNA. By blocking this action, emtricitabine prevents the proliferation of the virus. Tenofovir alafenamide blocks the enzyme polymerase, thereby preventing aggregation of viral components and terminating the DNA chain, thus effectively nipping viral replication in the bud.

Side Effects of Spegra Tablet 30's

  • Headache
  • Tiredness
  • Trouble sleeping
  • Nausea

Directions for Use

Swallow Spegra Tablet 30's as a whole with water. Do not crush, chew or break it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Inform the doctor if you are allergic to any of the components of Spegra Tablet 30's. Consult your doctor if you are pregnant, or planning to get pregnant before taking Spegra Tablet 30's. Avoid breastfeeding while on treatment with Spegra Tablet 30's. Avoid alcohol consumption. It is important to practise safe sex to avoid transmitting HIV to your partner. Inform your doctor if you have liver problems, hepatitis infections, heart or kidney problems. Keep your doctor informed about your health condition and medications to rule out any interactions.

Therapeutic Class

ANTIVIRALS

Drug-Drug Interactions

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DolutegravirDofetilide
Critical
EmtricitabineLamivudine
Critical

Drug-Drug Interactions

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DolutegravirDofetilide
Critical
How does the drug interact with Spegra Tablet 30's:
Taking Spegra Tablet 30's with dofetilide may possibly reduce the blood levels and effects of Spegra Tablet 30's. This can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Spegra Tablet 30's with Dofetilide is not recommended, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
EmtricitabineLamivudine
Critical
How does the drug interact with Spegra Tablet 30's:
Combining these two medications may reduce overall effectiveness due to potential antagonistic effects (opposite actions).

How to manage the interaction:
Taking Spegra Tablet 30's with Lamivudine is not recommended, but it can be taken if your doctor prescribes it. Contact your doctor if your symptoms do not improve. Do not stop taking any medication without consulting your doctor.
Tenofovir disoproxilDidanosine
Critical
How does the drug interact with Spegra Tablet 30's:
Coadministration of Didanosine with Spegra Tablet 30's can increase the levels and risk of Didanosine side effects.

How to manage the interaction:
Taking Didanosine with Spegra Tablet 30's is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. However, if you experience severe headaches, confusion, weakness, trouble walking, muscle pain, or high fever, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Tenofovir disoproxilStreptozocin
Critical
How does the drug interact with Spegra Tablet 30's:
Combining Spegra Tablet 30's and Streptozocin can increase the risk of kidney problems.

How to manage the interaction:
Taking Spegra Tablet 30's with Streptozocin is not recommended, as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to your doctor.
DolutegravirMagnesium lactate
Severe
How does the drug interact with Spegra Tablet 30's:
Taking Spegra Tablet 30's with magnesium lactate can reduce the effectiveness of Spegra Tablet 30's.

How to manage the interaction:
Although taking Spegra Tablet 30's and Magnesium lactate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Spegra Tablet 30's either two hours before or six hours after taking a dose of Magnesium lactate. Do not discontinue using any medications without consulting a doctor.
DolutegravirCarbamazepine
Severe
How does the drug interact with Spegra Tablet 30's:
Taking carbamazepine and Spegra Tablet 30's may possibly reduce the blood levels and effects of Spegra Tablet 30's.

How to manage the interaction:
Although taking carbamazepine and Spegra Tablet 30's together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not stop using any medications without first talking to your doctor.
DolutegravirCalcium lactate
Severe
How does the drug interact with Spegra Tablet 30's:
Co-administration of Spegra Tablet 30's with Calcium lactate can reduce the effectiveness of Spegra Tablet 30's.

How to manage the interaction:
Although there is an interaction, Calcium lactate can be taken with Spegra Tablet 30's if prescribed by the doctor. However, Spegra Tablet 30's and calcium carbonate should not be taken orally at the same time. Maintain a gap of 2-6 hours between both medicines. Do not discontinue using any medications without consulting a doctor.
DolutegravirFosamprenavir
Severe
How does the drug interact with Spegra Tablet 30's:
Coadministration of Spegra Tablet 30's and fosamprenavir may decrease the blood levels of Spegra Tablet 30's.

How to manage the interaction:
Although taking Spegra Tablet 30's and Fosamprenavir together can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not discontinue using any medications without consulting a doctor.
DolutegravirPhenytoin
Severe
How does the drug interact with Spegra Tablet 30's:
Taking Spegra Tablet 30's with phenytoin may significantly reduce the blood levels of Spegra Tablet 30's, which may make the medication less effective in treating infections.

How to manage the interaction:
Although taking Spegra Tablet 30's and Phenytoin together can result in an interaction, they can be taken together if prescribed by a doctor. Do not discontinue using any medications without consulting a doctor.
DolutegravirFerric citrate
Severe
How does the drug interact with Spegra Tablet 30's:
Taking Spegra Tablet 30's with ferric citrate can reduce the effectiveness of Spegra Tablet 30's.

How to manage the interaction:
Although taking Spegra Tablet 30's and Ferric citrate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Spegra Tablet 30's either two hours before or six hours after taking a dose of Ferric citrate. Do not discontinue using any medications without consulting a doctor.

Drug-Food Interactions

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DOLUTEGRAVIR-50MG+EMTRICITABINE-200MG+TENOFOVIR ALAFENAMIDE-25MGHerbal products/medicines
Moderate

Drug-Food Interactions

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DOLUTEGRAVIR-50MG+EMTRICITABINE-200MG+TENOFOVIR ALAFENAMIDE-25MGHerbal products/medicines
Moderate
Common Foods to Avoid:
St. John’S Wort

How to manage the interaction:
Consuming St.John's Wort while taking Spegra Tablet 30's can increase the risk of side effects. Avoid consuming St.John's Wort with Spegra Tablet 30's as it can lead to an interaction.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ADEFOVIR
  • ATAZANAVIR
  • LAMIVUDINE
  • SUCRALFATE
  • RIFAMPICIN
  • ST JOHN'S WORT
  • AZITHROMYCIN
  • CLARITHROMYCIN
  • RIFABUTIN
  • CYCLOSPORINE
  • PHENYTOIN
  • PHENOBARBITAL
  • IRON

Diet & Lifestyle Advise

  • Practise safe sex to prevent transmitting HIV to your partner. Educate yourself and your partner about pre and post-exposure prophylaxis and ART (anti-retroviral therapy). Use a condom as far as possible.
  • Meditation and yoga have also proven very effective in helping HIV patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods.
  • Take good care of your oral hygiene. HIV often affects the mouth and causes sores. See a dentist regularly. Brush, floss and scrape your tongue well and keep your mouth clean.
  • Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 

Habit Forming

No

Disease/Condition Glossary

HIV infection: HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system and destroys the white blood cells that help in fighting infection, making the individual susceptible to other infections or illnesses. People with HIV experience flu-like symptoms such as fever, chills, rash, night sweats, muscle aches, tiredness, and sore throat. These symptoms usually last for days to several weeks. HIV spreads through body fluids such as semen, vaginal fluid, and blood. If left untreated, this condition can lead to AIDS (Acquired Immunodeficiency Syndrome). It is a life-long condition, and there is no definite cure for it. However, it can be controlled by treating with antiretroviral drugs. 

Spegra Tablet 30's Substitute

Substitutes safety advice
  • Spegra Tablet 90's

    131.82per tablet
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