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Spegra Tablet 90's

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Reviewed By Santoshini Reddy G , M Pharmacy

Non returnable*

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COD available

Online payment accepted

Composition :

DOLUTEGRAVIR-50MG + EMTRICITABINE-200MG + TENOFOVIR ALAFENAMIDE-25MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Spegra Tablet

Spegra Tablet belongs to the group of antiretroviral agents indicated for the treatment of HIV-1 infection in adults and children above 12years weighing at least 40kgs. HIV is a virus that attacks the body's immune system, making it compromised and susceptible to various infections and diseases.

Spegra Tablet contains 'Dolutegravir, Emtricitabine and Tenofovir alafenamide'. Spegra Tablet works by interfering with the working of HIV-1 reverse transcriptase enzymes which are necessary for the replication of the virus. Together, Spegra Tablet helps in treating HIV infection.

Take Spegra Tablet as prescribed. In some cases, Spegra Tablet may cause certain side effects such as trouble sleeping, headache, nausea, and tiredness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist.

Consult your doctor if you are pregnant, or planning to get pregnant. Avoid breastfeeding while taking Spegra Tablet . Spegra Tablet does not help reduce the risk of getting HIV-1 infection by sexual contact; therefore, it is important to practise safe sex to avoid transmitting HIV to your partner. Avoid alcohol consumption while on treatment with Spegra Tablet .

Uses of Spegra Tablet

HIV-1 infection

Directions for Use

Swallow Spegra Tablet as a whole with water. Do not crush, chew or break it.

Medicinal Benefits

Spegra Tablet is an anti-retroviral drug used in the treatment of HIV-1 infection. Spegra Tablet works by interfering with the replication of HIV and preventing its further progression. It contains Dolutegravir, Emtricitabine and Tenofovir alafenamide. Dolutegravir works by blocking HIV integrase, which is responsible for integrating viral DNA into the host cell. Thus, it inhibits the integration of the viral component into the human body cells. Emtricitabine works by inhibiting reverse transcriptase, which is responsible for transcribing RNA to DNA. By blocking this action, emtricitabine prevents the proliferation of the virus. Tenofovir alafenamide blocks the enzyme polymerase, thereby preventing aggregation of viral components and terminating the DNA chain, thus effectively nipping viral replication in the bud.

Storage

Keep Spegra Tablet out of reach and sight of children.

Side effects of Spegra Tablet

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Dizziness

Here are the 7 steps to manage Dizziness caused by medication:

Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
When standing up, do so slowly and carefully to avoid sudden dizziness.
Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Abnormal Dreams

Keep regular sleeping hours.
Don’t consume nicotine, caffeine, or alcohol in the hours leading up to bed.
Practice relaxation exercises before bedtime.
Regular physical activity can promote deeper and better sleep. However, avoid intense exercise within 2-3 hours of bedtime, as it can disrupt your sleep.
If nightmares continue, cognitive behavioral therapy (CBT) may be a helpful treatment option. Your doctor may recommend CBT to address underlying issues and provide coping strategies to manage nightmares.

Stomach Ache

Drink water or other clear fluids.
To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
Include bland foods like rice, toast, crackers, and rice in your diet.
Avoid lying down immediately after eating as it may cause indigestion or heartburn.
Avoid acidic and spicy food as it may cause indigestion.

Drug Warnings

Inform the doctor if you are allergic to any of the components of Spegra Tablet . Consult your doctor if you are pregnant, or planning to get pregnant before taking Spegra Tablet . Avoid breastfeeding while on treatment with Spegra Tablet . Avoid alcohol consumption. It is important to practise safe sex to avoid transmitting HIV to your partner. Inform your doctor if you have liver problems, hepatitis infections, heart or kidney problems. Keep your doctor informed about your health condition and medications to rule out any interactions.

Drug-Drug Interactions

DolutegravirDofetilide

Critical

EmtricitabineLamivudine

Critical

Drug-Drug Interactions

DolutegravirDofetilide

Critical

How does the drug interact with Spegra Tablet:
Taking Spegra Tablet with dofetilide may possibly reduce the blood levels and effects of Spegra Tablet. This can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Spegra Tablet with Dofetilide is not recommended, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.

EmtricitabineLamivudine

Critical

How does the drug interact with Spegra Tablet:
Combining these two medications may reduce overall effectiveness due to potential antagonistic effects (opposite actions).

How to manage the interaction:
Taking Spegra Tablet with Lamivudine is not recommended, but it can be taken if your doctor prescribes it. Contact your doctor if your symptoms do not improve. Do not stop taking any medication without consulting your doctor.

Tenofovir disoproxilDidanosine

Critical

How does the drug interact with Spegra Tablet:
Coadministration of Didanosine with Spegra Tablet can increase the levels and risk of Didanosine side effects.

How to manage the interaction:
Taking Didanosine with Spegra Tablet is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. However, if you experience severe headaches, confusion, weakness, trouble walking, muscle pain, or high fever, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Tenofovir disoproxilStreptozocin

Critical

How does the drug interact with Spegra Tablet:
Combining Spegra Tablet and Streptozocin can increase the risk of kidney problems.

How to manage the interaction:
Taking Spegra Tablet with Streptozocin is not recommended, as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to your doctor.

DolutegravirEtravirine

Severe

How does the drug interact with Spegra Tablet:
Taking Spegra Tablet with etravirine can reduce the blood levels and effectiveness of Spegra Tablet.

How to manage the interaction:
Although taking Spegra Tablet and Etravirine together can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not discontinue using any medications without consulting a doctor.

DolutegravirMagnesium lactate

Severe

How does the drug interact with Spegra Tablet:
Taking Spegra Tablet with magnesium lactate can reduce the effectiveness of Spegra Tablet.

How to manage the interaction:
Although taking Spegra Tablet and Magnesium lactate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Spegra Tablet either two hours before or six hours after taking a dose of Magnesium lactate. Do not discontinue using any medications without consulting a doctor.

DolutegravirZinc gluconate

Severe

How does the drug interact with Spegra Tablet:
Zinc gluconate reduces the absorption of Spegra Tablet, resulting in reduced efficacy of Spegra Tablet in treating HIV.

How to manage the interaction:
Although taking Spegra Tablet and Zinc gluconate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Spegra Tablet either two hours before or six hours after taking a dose of Zinc gluconate. If your condition worsens or develops new infections while taking these medications, it is important to contact a doctor immediately. Do not discontinue using any medications without consulting a doctor.

DolutegravirFosphenytoin

Severe

How does the drug interact with Spegra Tablet:
Taking Spegra Tablet with fosphenytoin can reduce the effectiveness of Spegra Tablet.

How to manage the interaction:
Although taking Spegra Tablet and Fosphenytoin together can result in an interaction, they can be taken together if prescribed by your doctor. Do not discontinue using any medications without consulting a doctor.

DolutegravirRifampicin

Severe

How does the drug interact with Spegra Tablet:
Taking Spegra Tablet with rifampicin can decrease the blood levels of Spegra Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Spegra Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

DolutegravirZinc sulfate

Severe

How does the drug interact with Spegra Tablet:
Coadministration of Spegra Tablet with zinc sulfate can reduce the efficacy of Spegra Tablet.

How to manage the interaction:
Although taking Spegra Tablet and Zinc sulfate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Spegra Tablet either two hours before or six hours after taking a dose of Zinc sulfate. Do not discontinue using any medications without consulting a doctor.

Drug-Food Interactions

DOLUTEGRAVIR-50MG+EMTRICITABINE-200MG+TENOFOVIR ALAFENAMIDE-25MGHerbal products/medicines

Moderate

Drug-Food Interactions

DOLUTEGRAVIR-50MG+EMTRICITABINE-200MG+TENOFOVIR ALAFENAMIDE-25MGHerbal products/medicines

Moderate

Common Foods to Avoid:
St. John’S Wort

How to manage the interaction:
Consuming St.John's Wort while taking Spegra Tablet can increase the risk of side effects. Avoid consuming St.John's Wort with Spegra Tablet as it can lead to an interaction.

Diet & Lifestyle Advise

Practise safe sex to prevent transmitting HIV to your partner. Educate yourself and your partner about pre and post-exposure prophylaxis and ART (anti-retroviral therapy). Use a condom as far as possible.
Meditation and yoga have also proven very effective in helping HIV patients maintain a healthy attitude and body.
Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods.
Take good care of your oral hygiene. HIV often affects the mouth and causes sores. See a dentist regularly. Brush, floss and scrape your tongue well and keep your mouth clean.
Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired.

Side Effects of Spegra Tablet

Headache
Tiredness
Trouble sleeping
Nausea

Habit Forming

Therapeutic Class

ANTIVIRALS

Spegra Tablet Substitute

Spegra Tablet 30's

by Others

₹131.82per tablet

Product Substitutes

Spegra Tablet 30's

₹4822.5

Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

FAQs

How does Spegra Tablet work?

Spegra Tablet works by inhibiting the replication of viral DNA and by preventing it from being integrated into the human body. Thereby, Spegra Tablet helps treat HIV infection.

I suffer from hepatitis. Can I take Spegra Tablet ?

It is not known if Spegra Tablet is safe for patients who have HIV-1 and hepatitis-B infections. Please consult your doctor for any concerns.

Can I stop taking Spegra Tablet on my own?

Do not stop taking Spegra Tablet without consulting your doctor as it may reduce the effectiveness of anti-HIV therapy. Continue taking Spegra Tablet for as long as your doctor has prescribed it to you to treat your condition effectually. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Spegra Tablet .

Does Spegra Tablet cause lactic acidosis?

Spegra Tablet might cause lactic acidosis (excess of lactic acid in the blood). Consult a doctor immediately if you experience stomach pain, vomiting, nausea, drowsiness, or deep rapid breathing.

Drug-Drug Interactions Checker List

ADEFOVIR
ATAZANAVIR
LAMIVUDINE
SUCRALFATE
RIFAMPICIN
ST JOHN'S WORT
AZITHROMYCIN
CLARITHROMYCIN
RIFABUTIN
CYCLOSPORINE
PHENYTOIN
PHENOBARBITAL
IRON

Disease/Condition Glossary

HIV infection: HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system and destroys the white blood cells that help in fighting infection, making the individual susceptible to other infections or illnesses. People with HIV experience flu-like symptoms such as fever, chills, rash, night sweats, muscle aches, tiredness, and sore throat. These symptoms usually last for days to several weeks. HIV spreads through body fluids such as semen, vaginal fluid, and blood. If left untreated, this condition can lead to AIDS (Acquired Immunodeficiency Syndrome). It is a life-long condition, and there is no definite cure for it. However, it can be controlled by treating with antiretroviral drugs.