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Manufacturer/Marketer :

Panacea Biotec Ltd

Consume Type :

ORAL

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Not Returnable

About Threpro 10 mg/75 mg/2.5 mg Capsule

Threpro 10 mg/75 mg/2.5 mg Capsule is a combination drug of blood thinners, cholesterol-lowering agents and blood pressure-lowering agents primarily used to prevent heart attack and stroke. Besides this, it also lowers the raised level of bad cholesterol (especially for those at high risk of heart disease). A heart attack generally refers to a blocked flow of blood to the heart due to the blockage of arteries. The blockage is most often a build-up of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries).

Threpro 10 mg/75 mg/2.5 mg Capsule is composed of three medicines: Atorvastatin, Ramipril, and Aspirin. Atorvastatin is a cholesterol-lowering medication that blocks the enzyme required to make fat in the body. It reduces the bad cholesterol (also known as low-density lipoproteins or LDL) and triglycerides (TG) and increases the levels of good cholesterol (also known as high-density lipoproteins or HDL). Aspirin is blood thinners or antiplatelet (anticoagulant) that collectively prevent clots in the blood vessels. Ramipril is an angiotensin-converting enzyme or ACE inhibitor that lowers increased blood pressure by blocking a naturally occurring substance known as angiotensin II that tightens your blood vessels, thereby relaxing blood vessels in the body and reducing overload on the heart to pump more blood. Together Threpro 10 mg/75 mg/2.5 mg Capsuleminimisess the risk of heart attack, stroke, and heart-related chest pain (angina).

Depending upon your medical condition, you are advised to take Threpro 10 mg/75 mg/2.5 mg Capsule for as long as your doctor has prescribed it for you. The most common side effects of Threpro 10 mg/75 mg/2.5 mg Capsule are increased bleeding tendency, constipation, headache, muscle pain, weakness, headaches, decreased blood pressure, dizziness, muscle pain, increased blood glucose level, and cough in some cases. Most of these side effects of Threpro 10 mg/75 mg/2.5 mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Stopping Threpro 10 mg/75 mg/2.5 mg Capsule abruptly may worsen your condition and increase your risk of a future heart attack. Let your doctor know if you are sensitive to atorvastatin, or aspirin, have any active liver disease, active bleeding issues (like peptic ulcer, brain haemorrhage), muscle problems (myopathy, rhabdomyolysis), are pregnant or planning to become pregnant or breastfeeding. Atorvastatin, present in Threpro 10 mg/75 mg/2.5 mg Capsule, is a pregnancy category X drug, so it is contraindicated in pregnant women. As it may cause harm to the fetus if administered to pregnant women. Disclose to your doctor that you are taking Threpro 10 mg/75 mg/2.5 mg Capsule if you are going to have any surgery.

Uses of Threpro 10 mg/75 mg/2.5 mg Capsule

Prevention of heart attack, Prevention of stroke, Angina (heart-related chest pain)

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Threpro 10 mg/75 mg/2.5 mg Capsule is a combination drug of a blood-thinning agent (aspirin), cholesterol-lowering agent (atorvastatin) and blood pressure-lowering agent (ramipril) primarily taken to prevent heart attack and stroke in people with heart problems. It also lowers the raised level of bad cholesterol (especially for those at high risk of heart disease). Additionally, it is also given to patients who had a recent heart bypass surgery to control cholesterol levels and prevent blood clots. Threpro 10 mg/75 mg/2.5 mg Capsule is composed of three medicines: Atorvastatin, Ramipril, and Aspirin. Atorvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. It reduces the bad cholesterol (also known as low-density lipoproteins or LDL) and triglycerides (TG) and increases the levels of good cholesterol (also known as high-density lipoproteins or HDL). Aspirin is blood thinners or antiplatelet (anticoagulant) that collectively prevent clots in the blood vessels. Ramipril is an angiotensin-converting enzyme or ACE inhibitor that lower increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). It allows these constricted blood vessels to relax and helps lower high blood pressure. Together Threpro 10 mg/75 mg/2.5 mg Capsule reduces the risk of heart attack, stroke, and heart-related chest pain (angina).

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Inform your doctor if you are highly sensitive to atorvastatin, ramipril or aspirin, have any active liver disease, have active bleeding issues (like a peptic ulcer or brain haemorrhage), are pregnant or planning to become pregnant, or breastfeeding. The patient should inform the doctor they are taking Threpro 10 mg/75 mg/2.5 mg Capsule before any surgery or any new medicine is taken. Atorvastatin, present in Threpro 10 mg/75 mg/2.5 mg Capsule, is a pregnancy category X drug, so it is contraindicated in pregnant women. As it may cause harm to the fetus if administered to a pregnant woman. Co-administration with anticoagulants like warfarin may cause gastric bleeding and other bleeding problems. So, if you are using any blood-thinning agents, let your doctor know about this. Threpro 10 mg/75 mg/2.5 mg Capsule contains atorvastatin which can cause muscle problems like myopathy and rhabdomyolysis. So, any signs of muscle pain, tenderness, or weakness, during the initial months of the treatment should be closely monitored. Patients with active liver disease should use Threpro 10 mg/75 mg/2.5 mg Capsule with caution. The safety and effectiveness of Threpro 10 mg/75 mg/2.5 mg Capsule have not been established, so its use should be avoided in pediatric patients or children less than 12 years of age. Discontinuation of Threpro 10 mg/75 mg/2.5 mg Capsule may lead to cardiovascular events like heart attack, stroke, and angina (heart-related chest pain). Hence, you should consult a doctor before stopping the dose of Threpro 10 mg/75 mg/2.5 mg Capsule.

Drug-Drug Interactions

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RamiprilAliskiren
Critical
AspirinKetorolac tromethamine
Critical

Drug-Drug Interactions

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RamiprilAliskiren
Critical
How does the drug interact with Threpro 10 mg/75 mg/2.5 mg Capsule:
Taking aliskiren together with Threpro 10 mg/75 mg/2.5 mg Capsule may increase the risk of serious side effects such as kidney problems, low blood pressure, and high potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney problems, muscle paralysis and irregular heart rhythm.

How to manage the interaction:
Taking Threpro 10 mg/75 mg/2.5 mg Capsule with Aliskiren is not recommended, but can be taken if prescribed by a doctor. However, consult your doctor if you feel nausea, vomiting, weakness, confusion, tingling in the hands and feet, a sensation of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. You must drink enough fluids while taking these medications. It is advised to reduce the intake of foods high in potassium, including tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes. Do not discontinue any medications without a doctor's advice.
AspirinKetorolac tromethamine
Critical
How does the drug interact with Threpro 10 mg/75 mg/2.5 mg Capsule:
Combining Ketorolac tromethamine with Threpro 10 mg/75 mg/2.5 mg Capsule can increase the risk of adverse effects.

How to manage the interaction:
Taking Threpro 10 mg/75 mg/2.5 mg Capsule with Ketorolac tromethamine is not recommended, as it results in an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor’s advice.
AspirinKetorolac
Critical
How does the drug interact with Threpro 10 mg/75 mg/2.5 mg Capsule:
Co-administration of Ketorolac and Threpro 10 mg/75 mg/2.5 mg Capsule may increase the risk of side effects.

How to manage the interaction:
Taking Ketorolac with Threpro 10 mg/75 mg/2.5 mg Capsule is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience unusual bleeding or bruising, dizziness, tarry stools, coughing up or vomiting fresh or dried blood, severe headache and weakness. Do not stop using any medications without talking to a doctor.
AtorvastatinPosaconazole
Critical
How does the drug interact with Threpro 10 mg/75 mg/2.5 mg Capsule:
Taking Threpro 10 mg/75 mg/2.5 mg Capsule with Posaconazole can increase the blood levels of Threpro 10 mg/75 mg/2.5 mg Capsule. This can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between posaconazole with Threpro 10 mg/75 mg/2.5 mg Capsule, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
RamiprilTizanidine
Severe
How does the drug interact with Threpro 10 mg/75 mg/2.5 mg Capsule:
Taking Threpro 10 mg/75 mg/2.5 mg Capsule with Tizanidine may have additive effects in lowering your blood pressure

How to manage the interaction:
Although taking Threpro 10 mg/75 mg/2.5 mg Capsule together with Tizanidine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor if you feel headache, dizziness, lightheadedness, fainting, and changes in pulse or heart rate. If you have the above symptoms, avoid tasks requiring attentiveness, such as driving or using dangerous machinery. Be careful when you stand up from a sitting or lying position. Do not stop taking any medication without consulting your doctor.
RamiprilAllopurinol
Severe
How does the drug interact with Threpro 10 mg/75 mg/2.5 mg Capsule:
Co-administration of Allopurinol with Threpro 10 mg/75 mg/2.5 mg Capsule may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Allopurinol and Threpro 10 mg/75 mg/2.5 mg Capsule, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
RamiprilPotassium iodide
Severe
How does the drug interact with Threpro 10 mg/75 mg/2.5 mg Capsule:
Taking Potassium Iodide with Threpro 10 mg/75 mg/2.5 mg Capsule may significantly increase potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney problems, muscle paralysis and irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Potassium iodide and Threpro 10 mg/75 mg/2.5 mg Capsule, you can take these medicines together if prescribed by a doctor. However, if you notice any nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, or irregular heartbeat, you should contact a doctor immediately. Avoid taking a potassium-rich diet (tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes) while taking these medications. Do not stop using any medications without talking to a doctor.
RamiprilTrimethoprim
Severe
How does the drug interact with Threpro 10 mg/75 mg/2.5 mg Capsule:
Taking Threpro 10 mg/75 mg/2.5 mg Capsule with Trimethoprim can increase the potassium levels in the blood, increasing the risk of kidney problems.

How to manage the interaction:
Although there is an interaction between Threpro 10 mg/75 mg/2.5 mg Capsule and trimethoprim, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience weakness, confusion, numbness or tingling, and uneven heartbeats. Do not stop taking any medication without consulting your doctor.
RamiprilTelmisartan
Severe
How does the drug interact with Threpro 10 mg/75 mg/2.5 mg Capsule:
Taking Threpro 10 mg/75 mg/2.5 mg Capsule with telmisartan may increase the risk of side effects such as low blood pressure, kidney function impairment, and high blood potassium.

How to manage the interaction:
Although there is a possible interaction, telmisartan can be taken with Threpro 10 mg/75 mg/2.5 mg Capsule if prescribed by the doctor. Consult the prescriber if you experience symptoms of high potassium such as nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Maintain adequate fluid intake during treatment with these medications. Do not discontinue the medications without consulting a doctor.
RamiprilPotassium citrate
Severe
How does the drug interact with Threpro 10 mg/75 mg/2.5 mg Capsule:
Taking Potassium citrate with Threpro 10 mg/75 mg/2.5 mg Capsule may increase potassium levels in the blood. High potassium levels can lead to kidney problems, muscle paralysis, and abnormal heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium citrate and Threpro 10 mg/75 mg/2.5 mg Capsule, you can take these medicines together if prescribed by your doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. It is advised to reduce the intake of potassium-rich foods. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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ASPIRIN-75MG+ATORVASTATIN-10MG+RAMIPRIL-2.5MGPotassium rich foods, Grapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ASPIRIN-75MG+ATORVASTATIN-10MG+RAMIPRIL-2.5MGPotassium rich foods, Grapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Tomatoes, Sweet Potatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt, Grapefruit, Grapefruit Juice

How to manage the interaction:
Taking potassium rich food, grapefruit and grape juice while on the treatment withRamipril, Atorvastatin and Aspirin can increase the levels of potassium salt in blood and other side effects like nausea, vomiting, weakness, confusion, tingling in hands or feet, feeling of heaviness in the legs, confusion, or slow or rapid heartbeat. Limit or avoid caking potassium rich food, grapefruit and grape juice while on the treatment with Ramipril, Atorvastatin and Aspirin.

Diet & Lifestyle Advise

  • Eat a healthy diet rich in soluble fibre like beans, legumes, whole grains, flax, apples, and citrus fruits.
  • Try to replace most of your saturated fats with unsaturated fats that can reduce total cholesterol and LDL cholesterol quickly. Foods like avocados, olive oil, fatty fish, and nuts contain many heart-healthy unsaturated fats, so it’s beneficial to eat them regularly.
  • Try to adopt a Mediterranean-style diet rich in olive oil, fruits, vegetables, nuts, whole grains, and fish, low in red meat and most dairy.
  • Try to give priority to more fruits and veggies in your daily meal as these contain antioxidants that help to lower LDL - low-density lipoprotein (bad cholesterol)
  • Minimize the intake of added sugar. The American Heart Association (ADA) recommends one should not eat more than 100 calories (25 grams) of added sugar for women and children and no more than 150 calories (37.5 grams) for men every day.
  • American Heart Association recommends sodium chloride intake (table salt) should not exceed more than 2,300 mg per day as part of a healthy eating pattern.
  • As a precautionary measure, do not consume alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

CARDIOVASCULAR AGENTS

Threpro 10 mg/75 mg/2.5 mg Capsule Substitute

Substitutes safety advice
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    94.50per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Threpro 10 mg/75 mg/2.5 mg Capsule is composed of three medicines: Atorvastatin, Ramipril, and Aspirin. Atorvastatin lowers raised fat/cholesterol; aspirin prevents blood clots in the arteries, and ramipril lowers increased blood pressure. Thus, together Threpro 10 mg/75 mg/2.5 mg Capsule reduces the risk of heart attack, stroke, and heart-related chest pain (angina).

Usually, Threpro 10 mg/75 mg/2.5 mg Capsule is prescribed for long-term treatment ranging from weeks to months for treating heart-related conditions and disorders. However, taking it on your own for years without a doctor's consent can be fatal. Hence, only take it as long as your doctor prescribes it.

Threpro 10 mg/75 mg/2.5 mg Capsule can raise your blood sugar, so if you already have type 2 diabetes, please consult your doctor. The doctor will weigh the benefits and potential risks before prescribing them.

Threpro 10 mg/75 mg/2.5 mg Capsule contains aspirin, which can increase your bleeding risk and increase the blood clot time. Please consult your doctor if the Threpro 10 mg/75 mg/2.5 mg Capsule needs to be stopped before surgery. The doctor might ask you to stop taking Threpro 10 mg/75 mg/2.5 mg Capsule a few days before surgery to avoid the increased risk of bleeding during the procedure.

If you forget to take Threpro 10 mg/75 mg/2.5 mg Capsule at any time, take it as soon as you remember, then continue to take it at the usual times. Do not take a double dose to make up for a forgotten dose.

Yes, taking Threpro 10 mg/75 mg/2.5 mg Capsule can increase the risk of bleeding as it contains aspirin, which is a blood thinner. So, please be very cautious while shaving, cutting fingernails or toenails, or using sharp objects to avoid bleeding.

Musculoskeletal pain, abdomen pain, cough, dizziness, low blood pressure, stomach ulcer/bleeding, and bleeding problems are the common side effects of Threpro 10 mg/75 mg/2.5 mg Capsule, which can be reported in some patients.

Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • RITONAVIR
  • LOPINAVIR
  • DARUNAVIR
  • ATAZANAVIR
  • INDINAVIR
  • ITRACONAZOLE
  • WARFARIN
  • HEPARIN
  • COLCHICINE
  • DIGOXIN
  • CYCLOSPORINE

Special Advise

  • Please monitor your blood sugar (H1b1AC) level regularly.

Disease/Condition Glossary

Heart attack: A heart attack generally refers to a blocked flow of blood to the heart due to the blockage of arteries. The blockage is most often a build-up of fat, cholesterol, and other substances, which form a plaque in the arteries that feed the heart (coronary arteries).

Stroke: Stroke occurs when the blood and oxygen supply to the brain is limited or stopped. When the brain does not receive sufficient oxygen and nutrients, it starts dying within a few minutes. If not treated early, it is a life-threatening condition that can lead to brain damage, coma, and even death.

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