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Written By Divya L , PharmaD
Reviewed By Sunny S , MBBS
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Composition :

ELTROMBOPAG-25MG

Manufacturer/Marketer :

Aureate Healthcare

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Thromplat 25 mg Tablet

Thromplat 25 mg Tablet belongs to the class of 'platelet-stimulating agents' primarily used to treat low blood platelet count in patients with idiopathic thrombocytopenic purpura (ITP) and hepatitis C virus (HCV) infections. Thromplat 25 mg Tablet is also used to treat severe aplastic anaemia (SAA) in adults. Idiopathic thrombocytopenic purpura is an immune condition associated with low levels of platelets. Hepatitis C is an infection and inflammation of the liver caused due to hepatitis C virus. Severe aplastic anaemia is a condition in which the bone marrow doesn't make enough blood cells.

Thromplat 25 mg Tablet contains 'Eltrombopag' which belongs to the class of 'thrombopoietin receptor agonists'. Thrombopoietin is a glycoprotein hormone that stimulates the formation of megakaryocytes (large bone marrow cells) and further regulates platelet's production. Thromplat 25 mg Tablet works by increasing these large bone marrow cells responsible for the production of platelets. Thus, Thromplat 25 mg Tablet helps increase these bone marrow cells, thereby stimulating the number of platelets, which further lowers the risk of bleeding.

Take Thromplat 25 mg Tablet as prescribed by your doctor. In some cases, Thromplat 25 mg Tablet can cause common side effects like nausea, diarrhoea, headache, muscle pain, tiredness, loss of appetite, fever, anaemia (lack of blood cells), cough and tingling numbness. These side effects are not familiar to everyone who take Thromplat 25 mg Tablet and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you have any allergic reactions to Thromplat 25 mg Tablet or any other medicines, before starting Thromplat 25 mg Tablet . It is essential to inform your doctor if you have any heart, kidney or liver problems, blood disorders, blood clotting problems and cataracts before starting Thromplat 25 mg Tablet . It is advised to consult the doctor if you are pregnant or planning to conceive. Thromplat 25 mg Tablet is not indicated for use in breastfeeding since it passes into the breast milk. Thromplat 25 mg Tablet may make you dizzy, hence drive or operate machinery only when you are mentally alert. 

Uses of Thromplat 25 mg Tablet

Low platelet count and Severe aplastic anaemia (SAA).

Directions for Use

Tablet: Swallow it as a whole with a glass of water. Take it on an empty stomach as prescribed by the doctor. Do not crush, chew or break it. Oral suspension: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.Powder: Mix the powder with the prescribed amount of water. Take it with or without food with an oral syringe in the dose and duration prescribed by the doctor.

Medicinal Benefits

Thromplat 25 mg Tablet contains 'Eltrombopag,' which belongs to the class of 'thrombopoietin receptor agonists' used to treat low blood platelet count in patients with immune (idiopathic) thrombocytopenic purpura (ITP), hepatitis C virus (HCV) infections and severe aplastic anaemia (SAA) in adults. Thromplat 25 mg Tablet works by increasing megakaryocytes, the large bone marrow cells responsible for the production of platelets. The increase in these bone marrow cells stimulates the production of platelets. Thus Thromplat 25 mg Tablet prevents bleeding episodes by increasing the number of platelets in the blood.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are known to be allergic to Thromplat 25 mg Tablet or other medicines, please inform your doctor in advance. Brief your medical history if you have blood clots, clotting disorders (Factor V Leiden), blood disorders like blood cancer, myelodysplastic syndrome, cataracts, liver or kidney diseases before starting Thromplat 25 mg Tablet . Take Thromplat 25 mg Tablet at least two hours before or four hours after consuming antacids, mineral and vitamin supplements (iron, calcium, magnesium, aluminium, selenium and zinc), dairy products, calcium-enriched foods and fortified juices since they interfere with the absorption of Thromplat 25 mg Tablet . Thromplat 25 mg Tablet is not recommended during pregnancy since it may have harmful effects on the foetus. Consult your doctor before using Thromplat 25 mg Tablet if you are a breastfeeding mother. Do not drive or operate machinery since Thromplat 25 mg Tablet may cause side effects like dizziness and tiredness, affecting your ability to concentrate and drive. Avoid or limit alcohol consumption with Thromplat 25 mg Tablet as it may affect the efficacy of Thromplat 25 mg Tablet . Thromplat 25 mg Tablet is not recommended for children less than one year of age in ITP and children less than two years of age in SAA. 

Diet & Lifestyle Advise

  • Eat natural and healthy foods by cutting down on fatty and sodium processed foods.
  • Exercise regularly to maintain good health.
  • Avoid smoking and alcohol intake.
  • Avoid activities like contact sports and use sharp objects like nail cutters and razors to decrease bleeding risk.
  • High protein diet such as lean meat, chicken, crab, turkey, beef and fish can help increase the platelet count.
  • Eating Papaya is the best natural remedy to increase your platelet count, you can also use papaya leave's mixture.
  • Include iron-rich foods like pomegranate, beetroot, green leafy vegetables, carrots, raisins, oranges, peanuts, kidney beans, and black-eyed peas in your diet.
  • Vitamin C sources like guava, black currant, red pepper, kiwi, green peppers, orange, strawberries, pineapple, peas, mango, grapefruit and broccoli can also boost your platelet count.

Habit Forming

No

Therapeutic Class

PLATELET STIMULATING AGENTS

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Author Details

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FAQs

Thromplat 25 mg Tablet contains Eltrombopag that stimulates platelet's production (helps in clotting) from megakaryocytes (bone marrow cells). Thus Thromplat 25 mg Tablet lowers the risk of bleeding episodes in diseases like immune (idiopathic) thrombocytopenic purpura (ITP), hepatitis C virus (HCV) infections and severe aplastic anaemia (SAA).

Do not stop using Thromplat 25 mg Tablet even if you feel better. It should be strictly used as advised by your doctor to avoid the recurrence of symptoms and worsening of the disease.

Thromplat 25 mg Tablet should be used with caution and only under doctor's supervision in cases of any allergic reactions, blood clots, clotting disorders (Factor V Leiden), blood disorders like blood cancer, myelodysplastic syndrome, cataracts, liver or kidney diseases.

Thromplat 25 mg Tablet decreases the risk of bleeding by increasing the platelet count in your body. However, you are advised to stay away from activities that may increase your risk of bleeding like contact sports and using sharp objects like razors and nail cutters.

It is advised to take Thromplat 25 mg Tablet on an empty stomach. Please take Thromplat 25 mg Tablet at least two hours before or four hours after consuming antacids, mineral and vitamin supplements (iron, calcium, magnesium, aluminium, selenium and zinc), dairy products, calcium-enriched foods and fortified juices since they interfere with the absorption of Thromplat 25 mg Tablet .

Drug-Drug Interactions Checker List

  • METHOTREXATE
  • TOPOTECAN
  • CICLOSPORIN
  • AZATHIOPRINE
  • LOPINAVIR
  • RITONAVIR
  • DANAZOL
  • IRON
  • CALCIUM
  • ZINC+ZINC GLUCONATE

Special Advise

  • Keep a check on your daily blood pressure and blood sugar levels and if you notice any fluctuations, please consult a doctor.
  • Since Thromplat 25 mg Tablet affects liver enzymes, your doctor may suggest liver function tests to check your aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin levels before starting treatment and every two weeks after the treatment with Thromplat 25 mg Tablet .
  • Thromplat 25 mg Tablet may also interfere with creatinine and bilirubin lab tests, hence, please inform your doctor and laboratory staff in advance.

Disease/Condition Glossary

Immune (idiopathic) thrombocytopenic purpura (ITP): It is an immune condition associated with low levels of platelets, and the blood doesn't clot normally. It occurs when the immune system mistakenly attacks its own platelets. ITP also occurs in children, followed by a viral infection. Symptoms of ITP may include easy bruising, bleeding from gums and nose, blood in urine and stools, heavy menstrual flow and pinpoint-sized reddish-purple spots on the lower legs.

Hepatitis C: It is an infection and inflammation of the liver caused due to hepatitis C virus. This virus can cause both acute and chronic hepatitis. Acute hepatitis C is a short term illness that may range for six months. Chronic hepatitis C is a long-lasting disease that may lead to other severe liver cancer problems or cirrhosis (inflammation of the liver). Symptoms of hepatitis C include fatigue, nausea, loss of appetite and yellowing of the eyes and skin.

Severe aplastic anaemia (SAA): Aplastic anaemia is also called bone marrow aplasia. It is a condition in which the bone marrow doesn't make enough blood cells. SAA is commonly caused due to the damage of bone marrow. This damage can be a congenital disability or may occur because of radiation, chemotherapy, toxic chemicals, certain drugs and infections. Symptoms of SAA include fatigue, frequent infections, rapid heart rate and bleeding. 

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