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Reviewed By Sureshvarma D , MPharma
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Manufacturer/Marketer :

Lupin Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Tonact Plus Tablet

Tonact Plus Tablet belongs to a class of medications called antilipemic (cholesterol-lowering agent). Tonact Plus Tablet is used to treat raised cholesterol levels in our body. Tonact Plus Tablet helps lower the level of low-density lipoprotein (LDL) or bad cholesterol in the blood and increases high-density lipoprotein (HDL) or good cholesterol. Dyslipidaemia is the deposition of unhealthy levels of fats (lipid) in the blood. In this condition, there is always a high level of low-density lipoprotein (LDL or bad cholesterol), triglycerides (TG), and a low level of high-density lipoprotein (HDL or good cholesterol). Tonact Plus Tablet is an extended-release formulation that releases slowly for a longer duration of time.

Tonact Plus Tablet contains two medicines, namely atorvastatin and nicotinic acid (vitamin B3). Atorvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. It reduces the bad cholesterol (also known as low-density lipoproteins or LDL), triglycerides (TG) and increases the levels of good cholesterol (also known as high-density lipoproteins or HDL). On the other hand, Tonact Plus Tablet contains nicotinic acid, which is a form of vitamin B that further increases good cholesterol levels (HDL).

Take Tonact Plus Tablet as prescribed by your doctor. You are advised to take Tonact Plus Tablet for as long as your doctor has prescribed it for you, depending on your medical conditions. You may experience constipation, nausea, stomach pain, weakness, muscle pain, headache, dizziness, itching, flushing of the skin, the increased glucose level in the blood. Most of these side effects of Tonact Plus Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not take Tonact Plus Tablet if you are allergic to Tonact Plus Tablet , or any other ingredients present in it. Tonact Plus Tablet should not be taken in conditions like liver disease or kidney disease. Tonact Plus Tablet should not be prescribed to children less than 10 years of age. Immediately inform your doctor before taking Tonact Plus Tablet if you are pregnant or planning to get pregnant, breastfeeding. Tonact Plus Tablet has negligible influence on the ability to drive and use machines. Do not drink too much while taking this medicine.

Uses of Tonact Plus Tablet

High cholesterol.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Tonact Plus Tablet taken with dietary measures helps treat high cholesterol, especially for heart patients when initial dietary measures fail to lower cholesterol. It helps lower the bad cholesterol (LDL) and increases the level of good cholesterol (HDL) in the state of dyslipidemia or hyperlipidemia. Tonact Plus Tablet is considered more effective compared to other cholesterol-lowering medicines. Tonact Plus Tablet also lowers the amount of fat or cholesterol deposition (plaque) in the heart's arteries, thereby reducing the chance of having a heart attack or stroke in the future. Tonact Plus Tablet contains nicotinic acid, which is a form of vitamin B that further increases good cholesterol levels (HDL). 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Tonact Plus Tablet may cause a breakdown of skeletal muscle tissue, leading to kidney failure. This condition usually occurs in the elderly, people with kidney disease, and poorly controlled hypothyroidism (underactive thyroid). Tonact Plus Tablet should not be prescribed to children less than 10 years of age. You should contact a doctor before if you have had an allergic reaction to Tonact Plus Tablet , have a liver problem (jaundice, liver cirrhosis), or kidney problems, pregnant or planning to get pregnant, breastfeeding, have severe lung disease, have a previous heart attack or stroke caused by bleeding in the brain, have hypothyroidism, drink more than 2 servings of alcohol per day and have a muscle disorder (fibromyalgia) and damaged muscle tissue (rhabdomyolysis).

Drug-Drug Interactions

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AtorvastatinTipranavir
Severe

Drug-Drug Interactions

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How does the drug interact with Tonact Plus Tablet:
Taking Tonact Plus Tablet with Posaconazole can increase the blood levels of Tonact Plus Tablet. This can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between posaconazole with Tonact Plus Tablet, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AtorvastatinTipranavir
Severe
How does the drug interact with Tonact Plus Tablet:
Using tipranavir together with Tonact Plus Tablet may significantly increase the blood levels of Tonact Plus Tablet.

How to manage the interaction:
Although taking Tipranavir and Tonact Plus Tablet together can cause an interaction, it can be taken if a doctor has suggested it. You should seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tonact Plus Tablet:
Coadministration of Fenofibrate with Tonact Plus Tablet can raise the chance of side effects (liver injury and rhabdomyolysis - an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Although taking Fenofibrate and Tonact Plus Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience muscle pain, tenderness, or weakness, accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
AtorvastatinNefazodone
Severe
How does the drug interact with Tonact Plus Tablet:
Using Tonact Plus Tablet together with nefazodone may significantly increase the blood levels of Tonact Plus Tablet.

How to manage the interaction:
Taking Tonact Plus Tablet with Nefazodone together can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
How does the drug interact with Tonact Plus Tablet:
Combining Tonact Plus Tablet with atazanavir may drastically elevate Tonact Plus Tablet levels in the blood. This can raise the chance of side effects (liver damage and rhabdomyolysis - an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Taking Tonact Plus Tablet with atazanavir can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness, accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
AtorvastatinClofibrate
Severe
How does the drug interact with Tonact Plus Tablet:
Using clofibrate together with Tonact Plus Tablet can increase the risk of side effects.

How to manage the interaction:
Co-administration of Clofibrate with Tonact Plus Tablet can result in an interaction, but it can be taken if a doctor has advised it. It's important to keep an eye on your health and contact a doctor right away if you notice any of these signs - liver problems, muscle damage, kidney problems, complications, pain, weakness, fever, dark urine, chills, joint pain, swelling, bruising, rash, itching, loss of appetite, tiredness, feeling sick, throwing up, or bleeding. Do not stop using any medications without a doctor's advice.
How does the drug interact with Tonact Plus Tablet:
Taking Tonact Plus Tablet with indinavir may considerably raise Tonact Plus Tablet levels in the blood.

How to manage the interaction:
Taking Tonact Plus Tablet and indinavir together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness especially accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
AtorvastatinFosamprenavir
Severe
How does the drug interact with Tonact Plus Tablet:
Using Tonact Plus Tablet together with fosamprenavir may significantly increase the blood levels of Tonact Plus Tablet.

How to manage the interaction:
Although there is a possible interaction between Tonact Plus Tablet and Fosamprenavir, you can take these medicines together if prescribed by a doctor. You should seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not stop using any medications without talking to a doctor.
How does the drug interact with Tonact Plus Tablet:
Combining Tonact Plus Tablet with darunavir may profoundly enhance Tonact Plus Tablet levels in the blood. This can raise the chance of side effects (liver injury and rhabdomyolysis, an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Taking Tonact Plus Tablet with darunavir can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness, accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Tonact Plus Tablet:
Using Tonact Plus Tablet with ketoconazole, may raise the chance of side effects (liver injury and rhabdomyolysis, an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).

How to manage the interaction:
Taking Tonact Plus Tablet with ketoconazole can result in an interaction, it can be taken if a doctor has recommended it. However, if you experience muscle pain, tenderness, or weakness especially accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try aromatherapy, yoga, meditation to help relax your body and mind.
  • Try to do breathing exercises to get more oxygen.
  • Eat a healthy diet rich in soluble fiber like beans, legumes, whole grain, flax, apples, and citrus fruits.
  • Try to replace most of your saturated fats with unsaturated fats that can reduce total cholesterol and LDL cholesterol in a short span of time. Foods like avocados, olive oil, fatty fish, and nuts contain many heart-healthy unsaturated fats, so it’s beneficial to eat them regularly.
  • Try to adopt a Mediterranean-style diet rich in olive oil, fruits, vegetables, nuts, whole grains, fish, and low in red meat and most dairy.
  • Try to give priority to more fruits and veggies in your daily meal as these contain antioxidants that help to lower LDL
  • Minimize the intake of added sugar. The American Heart Association (ADA) recommends, one should not eat more than 100 calories (25 grams) of added sugar for women and children and no more than 150 calories (37.5 grams) for men every day.
  • American Heart Association recommends sodium chloride intake (table salt) should not exceed more than 2,300 mg per day as part of a healthy eating pattern.
  • As a precautionary measure, do not consume alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTILIPEMICS

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Tonact Plus Tablet is used to treat raised cholesterol levels in our body. Tonact Plus Tablet is a combination of two medicines, namely atorvastatin and nicotinic acid (vitamin B3). Atorvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. It reduces the bad cholesterol (also known as low-density lipoproteins or LDL), triglycerides (TG) and increases the levels of good cholesterol (also known as high-density lipoproteins or HDL). On the other hand, Tonact Plus Tablet contains nicotinic acid, which is a form of vitamin B that further increases good cholesterol levels (HDL).

Yes. Muscle weakness can be the long-term side effects of Tonact Plus Tablet . You may have muscle fatigue or muscle pain which affects your daily activity. Try to contact a doctor if you have muscle weakness or fatigue.

Tonact Plus Tablet can raise your blood sugar a little. If you already have type 2 diabetes, please consult your doctor. Your doctor may adjust the dosage of Tonact Plus Tablet .

Yogurt has the ability to lower cholesterol to its probiotic content. Yogurt eaters have a better metabolic profile than those who did not eat yogurt.

Most of the time, high cholesterol levels are associated with an unhealthy lifestyle. The most common causes include obesity, smoking, genetic factors, sedentary lifestyle, unhealthy eating habits, and family history.

Drug-Drug Interactions Checker List

  • CYCLOSPORINE
  • GEMFIBROZIL
  • ITRACONAZOLE
  • RITONAVIR
  • DIGOXIN
  • WARFARIN
  • VERAPAMIL
  • DILTIAZEM

Special Advise

If muscle fatigue or muscle pain affects your daily activity. Try to contact a doctor if you have muscle weakness or fatigue.

Disease/Condition Glossary

High cholesterol: Cholesterol is a waxy substance produced by the liver to protect nerves, make tissue, and various hormones. Our body also receives cholesterol from the food we eat, like cooking oils, eggs, meats, and dairy products. Excess cholesterol is bad for our health. There are two types of cholesterol, namely 'bad cholesterol' and 'good cholesterol'. Bad cholesterol comprises low-density lipoprotein (LDL) and triglycerides (TG), while good cholesterol consists of high-density lipoprotein (HDL). Usually, there are no specific symptoms of raised or high cholesterol levels but a large deposition of cholesterol in the arteries (plaque) or heart blockage. Blocked artery or plaque formation in the heart's arteries can lead to chest pain (angina), heart attack, or stroke. It is advisable to have complete cholesterol tests (lipid profile test) at least once a year. It will help you to closely monitor your heart health and risk of heart attack and stroke. 

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