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  1. Home
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  3. Trustretin-25 Capsule 10's

Trustretin-25 Capsule 10's, Pack of 10 CAPSULES
Written By ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Whats That

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Composition :

ACITRETIN-25MG

Manufacturer/Marketer :

USV Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Trustretin-25 Capsule

Trustretin-25 Capsule belongs to a group of medications called ‘retinoids’ used to treat psoriasis. Psoriasis is an autoimmune (immune system attacks healthy cells) skin disorder in which the skin becomes scaly, swollen, and itchy. It mostly affects the knee, elbows, scalp, and trunk. It is a lifelong condition, and treatment is given to remove affected skin cells and avoid flare-ups of the disease.

The Trustretin-25 Capsule contains ‘Acitretin’, which belongs to the class of retinoids derived from vitamin A. It has anti-inflammatory and antiproliferative (decreases skin cell multiplication) properties. It works by slowing down the progression of the disease. It reduces the speed of skin cell growth and gradually clears the affected skin. It helps reduce the redness, scaling, and thickness of psoriasis rashes.

Trustretin-25 Capsule is available in the form of tablets/capsules. You should take this medicine exactly as prescribed by your doctor. Trustretin-25 Capsule may cause side-effects such as dry lips, peeling of the skin, especially the palms of the hands and soles of the feet, nose bleed, scaling and thinning of healthy skin, reddening of the skin, itching, burning sensation on the skin, sticky skin, hair loss, swelling and pain in the area around your nails, fragile nails, inflammation of the eye (conjunctivitis), increased thirst, and feeling cold. These side effects usually go away after discontinuing the treatment. However, if any of these side effects persist or worsen, inform your doctor immediately.

Do not take Trustretin-25 Capsule if you are allergic to Acitretin or any other ingredients present in it. Trustretin-25 Capsule should not be used in patients with liver or kidney failure, high cholesterol, and taking other medicines containing retinoids or supplements containing vitamin A. Trustretin-25 Capsule should not be used in pregnant and breastfeeding women. Trustretin-25 Capsule should be used with caution in children as it may affect growth and bone development. Trustretin-25 Capsule may require dose adjustments when used in older people. Do not take alcohol, as it may increase the risk of side effects. Trustretin-25 Capsule may cause vision problems, especially in the dark, so do not drive or operate heavy machinery if you notice any vision problems.

Uses of Trustretin-25 Capsule

Psoriasis

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Trustretin-25 Capsule contains ‘Acitretin’ that belongs to the class of ‘retinoids’. Retinoids are derived from vitamin A (retinol) and have anti-inflammatory and antiproliferative (reduces rapid skin cell division) action. Trustretin-25 Capsule works by slowing down the progression of the diseases. Trustretin-25 Capsule is used when the skin condition doesn’t improve with other conventional therapies. It can treat severe or extensive skin problems where the skin has become thick and scaly such as psoriasis. It can be long-term maintenance therapy for psoriasis patients. It can also be used in the treatment of other skin conditions such as ichthyosis (genetic skin disorder), pityriasis (skin rashes that appear as large spots on the chest, abdomen, or back), and lichen planus (itchy, non-infectious rashes on arms and legs).

Storage

Keep Trustretin-25 Capsule out of the sight and reach of children.
Side effects of Trustretin-25 Capsule
  • Know your allergens that cause dermatitis and avoid them.
  • Use fragrance-free detergents and soaps.
  • Apply moisturizer after taking bath to retain moisture in the skin.
  • Apply cool, moist compresses to the rash.
  • Talk to your doctor about creams and ointments to manage your dermatitis.
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage angioedema (Swelling Under The Skin) as a side effect of medication:
  • If you experience angioedema, inform your doctor immediately. Treatment can help keep the swelling under control.
  • Seek medical attention if symptoms are severe, such as difficulty breathing or swallowing.
  • Follow your doctor's instructions to manage symptoms, which may include stopping or adjusting the medication that triggered angioedema.
  • Your doctor may also recommend antihistamines, steroids, or other treatments to reduce swelling and inflammation.
  • Make dietary and lifestyle changes as recommended, such as avoiding trigger foods or reducing stress.
  • Monitor your condition closely and track your symptoms to report them to your doctor.
  • Consult your doctor again if symptoms worsen or do not improve or if you experience any new or concerning symptoms.
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.
  • Try to practice deep breathing exercises or repeat calming words or phrases.
  • Seek for medical help if aggression occurs frequently, as it can worsen gradually if not attended.
  • You can also try listening to music or relaxing or writing a journal to express the feeling that aggravates to find a solution.
  • Suicidal thoughts need immediate medical attention else they can be uncontrollable.
  • Try to be in a comfortable space where there is someone to share your thoughts and discuss your problem.
  • Regularly do strengthening exercises to divert your thought process.
  • Prevent smoking and drinking alcohol, as they can affect your mind and increase suicidal thoughts.
  • Keep yourself engaged in any activity that prevents suicidal thoughts.
  • Practice yoga and meditation to improve your mental and overall health.
  • Eat fiber-rich foods like broccoli, cauliflower, leafy greens, and Brussels sprouts.
  • Limit sugar and refined carbs like avoid sugary drinks, white bread, and processed foods.
  • Choose lean protein sources like chicken, fish, and tofu.
  • Choose low-sugar fruits like berries, citrus fruits, and apples in moderation.
  • Maintain good hygiene and keep affected areas clean and dry.
  • Wear breathable clothing to reduce moisture.
  • Consider natural antifungal agents like coconut oil, tea tree oil, and garlic (consult a healthcare professional before use).

Drug Warnings

Trustretin-25 Capsule should not be used in pregnant and breastfeeding women. So, the doctor may advise you to take a pregnancy test before using Trustretin-25 Capsule . You should also take effective and reliable contraception (such as an intrauterine device, contraceptive implant, or contraceptive pill and condom) during the treatment and after three years of discontinuing the treatment. You should take reliable contraception even if your periods are not regular or not sexually active unless your doctor decides that this is unnecessary. You should not donate blood during the treatment and after three years of discontinuing the treatment. Trustretin-25 Capsule should be used in caution in patients with diabetes as it can alter blood glucose levels. Trustretin-25 Capsule may cause vision problems, especially in the night-time. So, inform your doctor if you notice vision problems. Do not wear contact lenses during the treatment as the Trustretin-25 Capsule may cause dry eyes. Trustretin-25 Capsule may increase skin sensitivity, so avoid going in strong sunlight and using a sunbed. Trustretin-25 Capsule may affect your mood, so inform your doctor if you have mental health problems like depression. Also, inform your doctor if you notice drastic mood changes while using Trustretin-25 Capsule .

Drug-Drug Interactions

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AcitretinEtonogestrel
Critical
AcitretinTetracycline
Critical

Drug-Drug Interactions

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AcitretinEtonogestrel
Critical
How does the drug interact with Trustretin-25 Capsule:
Coadministration of Trustretin-25 Capsule with Etonogestrel can increase the risk and severity of birth defects when taken in pregnant women.

How to manage the interaction:
Taking Trustretin-25 Capsule with Etonogestrel together is generally avoided as it can result in an interaction which can be serious, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
AcitretinTetracycline
Critical
How does the drug interact with Trustretin-25 Capsule:
Coadministration of Trustretin-25 Capsule with Tetracycline can increase the risk and severity of pseudotumor cerebri (caused by increased pressure in the brain).

How to manage the interaction:
Taking Trustretin-25 Capsule with Tetracycline together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcitretinLevonorgestrel
Critical
How does the drug interact with Trustretin-25 Capsule:
Coadministration of Trustretin-25 Capsule with Levonorgestrel can increase the risk and severity of birth defects in unborn when taken by a pregnant woman.

How to manage the interaction:
Taking Trustretin-25 Capsule with Levonorgestrel together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Never use Trustretin-25 Capsule if you are pregnant. Do not stop using any medications without talking to a doctor.
AcitretinOxytetracycline
Critical
How does the drug interact with Trustretin-25 Capsule:
Co-administration of Trustretin-25 Capsule with Oxytetracycline can increase the risk of a rare and serious condition called pseudotumor cerebri (caused by increased pressure in the brain).

How to manage the interaction:
Taking Trustretin-25 Capsule with Oxytetracycline together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcitretinEthanol
Critical
How does the drug interact with Trustretin-25 Capsule:
Coadministration of Trustretin-25 Capsule with Ethanol can increase the risk and severity of birth defects.

How to manage the interaction:
Taking Trustretin-25 Capsule with Ethanol together is avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcitretinDoxycycline
Critical
How does the drug interact with Trustretin-25 Capsule:
Coadministration of Trustretin-25 Capsule with Doxycycline can increase the risk and severity of vision problems.

How to manage the interaction:
Taking Trustretin-25 Capsule with Doxycycline together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcitretinMinocycline
Critical
How does the drug interact with Trustretin-25 Capsule:
Co-administration of Trustretin-25 Capsule with Minocycline may increase the risk of a serious condition called pseudomotor cerebral (false brain tumour).

How to manage the interaction:
There's a possible interaction between Trustretin-25 Capsule and Minocycline should be used together only if prescribed by a doctor. However, if you develop symptoms such as nausea, vomiting, headache, or visual disturbances during treatment with either medication, contact a doctor immediately. Do not discontinue any medication without consulting a doctor.
AcitretinMedroxyprogesterone
Critical
How does the drug interact with Trustretin-25 Capsule:
Coadministration of Trustretin-25 Capsule with Medroxyprogesterone can increase the risk and severity of birth defects when taken by a pregnant woman.

How to manage the interaction:
Taking Trustretin-25 Capsule with Medroxyprogesterone together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Do not discontinue any medications without consulting a doctor.
AcitretinDemeclocycline
Critical
How does the drug interact with Trustretin-25 Capsule:
Coadministration of Trustretin-25 Capsule with Demeclocycline can increase the risk and severity of pseudotumor cerebri (caused by increased pressure in the brain).

How to manage the interaction:
Taking Trustretin-25 Capsule with Demeclocycline together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcitretinEtretinate
Severe
How does the drug interact with Trustretin-25 Capsule:
Using etretinate together with Trustretin-25 Capsule may increase the risk of hypervitaminosis A (having too much vitamin A in the body).

How to manage the interaction:
There may be a possibility of interaction between Trustretin-25 Capsule and Etretinate, but it can be taken if prescribed by a doctor. If you experience symptoms like too much vitamin A in your body, increased pressure in your brain, high levels of cholesterol and triglycerides, inflammation in your liver or pancreas, bleeding gums or lips, hair loss, headache, dizziness, nausea, vomiting, problems with your vision, liver damage, fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, feeling tired, dark colored urine, or bleeding consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Use mild soap while taking baths and prefer warm baths.
  • Do not scratch or pick your skin to avoid infecting the affected area.
  • Avoid harsh products on your skin.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Limit intake of food that might trigger allergies such as dairy products, soy, eggs, and nuts.
  • Avoid consuming foods with excess sugar, as it may flare up inflammation.
  • Include fruits, vegetables, whole grains, healthy fats, and fish in your diet.
  • Avoid getting in contact with harsh soaps, detergents, and rough fabrics. 

Side Effects of Trustretin-25 Capsule

  • Dry lips
  • Peeling of the skin, especially the palms of the hands and soles of the feet
  • Nose bleed
  • Scaling and thinning of healthy skin
  • Reddening of the skin
  • Itching
  • Burning sensation on the skin
  • Sticky skin
  • Hair loss
  • Swelling and pain in the area around your nails
  • Fragile nails
  • Inflammation of the eye (conjunctivitis)
  • Increased thirst
  • Feeling cold

Habit Forming

No

Therapeutic Class

RETINOIDS

Trustretin-25 Capsule Substitute

Substitutes safety advice

Product Substitutes

Drug-Diseases Interactions

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ACITRETIN-25MGDisorders of lipoprotein metabolism and other lipidaemias
Severe
ACITRETIN-25MGOther disorders of kidney and ureter, not elsewhere classified
Severe

Drug-Diseases Interactions

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ACITRETIN-25MGDisorders of lipoprotein metabolism and other lipidaemias
Severe
How does the disease interact with Trustretin-25 Capsule:
Trustretin-25 Capsule is contraindicated in patients with chronic abnormally elevated blood lipid values.

How to manage the interaction:
Serum lipids must be more closely monitored in high-risk patients and during long-term treatment with Trustretin-25 Capsule. Dietary modifications, reduction in dose of Trustretin-25 Capsule, or drug therapy should be employed to control significant elevations of triglycerides, and if hypertriglyceridemia and low HDL levels persist, discontinuation of Trustretin-25 Capsule should be considered.
ACITRETIN-25MGOther disorders of kidney and ureter, not elsewhere classified
Severe
How does the disease interact with Trustretin-25 Capsule:
Trustretin-25 Capsule is contraindicated in patients with severely impaired kidney function.

How to manage the interaction:
It is recommended to monitor kidney function as per clinical guidelines.
ACITRETIN-25MGOther disorders of brain
Severe
How does the disease interact with Trustretin-25 Capsule:
The use of retinoids has been associated with causing of intracranial hypertension.

How to manage the interaction:
If you develop early signs and symptoms of pseudomotor cerbri (false brain tumor) such as nausea, vomiting, headache and visual disturbances, contact your doctor immediately.
ACITRETIN-25MGAlcoholic liver disease
Moderate
How does the disease interact with Trustretin-25 Capsule:
The use of retinoids has been associated with elevations in liver enzymes and toxic hepatitis. Therapy with Trustretin-25 Capsule is contraindicated in patients with severely impaired liver function.

How to manage the interaction:
This medicine should be used with caution in patients with liver disease. Monitoring liver enzymes is recommended in these patients.
ACITRETIN-25MGType 1 diabetes mellitus
Moderate
How does the disease interact with Trustretin-25 Capsule:
The use of Trustretin-25 Capsule its affect by the blood sugar levels and result in problems with blood sugar control.

How to manage the interaction:
It should be used with caution in diabetic patients, and regular monitoring of blood sugar levels is recommended during therapy.
ACITRETIN-25MGTopical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
Moderate
How does the disease interact with Trustretin-25 Capsule:
Ophthalmologic manifestations have been reported with the use of Trustretin-25 Capsule.

How to manage the interaction:
If you experience visual difficulties while taking Trustretin-25 Capsule, contact your doctor.

FAQs

Trustretin-25 Capsule contains 'Acitretin', which belongs to the class of 'retinoids' and is used to treat severe psoriasis. It has anti-inflammatory action and reduces the rashes' redness, scaling, and thickness. It also has antiproliferative properties and slows down the disease's progression by reducing the speed of skin cell growth.

Trustretin-25 Capsule may cause vision problems suddenly, especially in the dark. So, inform your doctor immediately if you experience vision problems. Also, refrain from activities such as driving or operating heavy machinery if you have a problem with your vision.

You should not donate blood during the treatment with Trustretin-25 Capsule and within three years of discontinuing the treatment. An unborn baby may get harmed if a pregnant woman receives your donated blood.

Trustretin-25 Capsule may not affect your immune system. It is not an immunosuppressant. It controls psoriasis by slowing down the progression of the disease.

Trustretin-25 Capsule may affect blood glucose levels and should be used with caution in patients with diabetes. You may have to regularly monitor blood glucose levels while using this medicine.

Drug-Drug Interactions Checker List

  • TETRACYCLINE
  • METHOTREXATE
  • PHENYTOIN

Special Advise

  • Growth and bone development should be regularly monitored if the Trustretin-25 Capsule is given to children.
  • Patients with diabetes are advised to monitor blood glucose levels while using this medicine regularly.
  • Patients with high cholesterol should regularly monitor fat levels in the blood while using this medicine.
  • Your doctor may also check liver function before, during, and after three weeks of discontinuing Trustretin-25 Capsule , as this medicine may affect liver function.
  • If Trustretin-25 Capsule is prescribed for the long-term, your doctor may perform an x-ray of certain bones once a year, as this medicine may affect bone development.
  • Trustretin-25 Capsule may cause birth defects, so women planning for pregnancy are advised to the regular pregnancy test and should not become pregnant for the next three years after using Trustretin-25 Capsule .

Disease/Condition Glossary

Psoriasis: Psoriasis is an autoimmune skin disease characterized by red, itchy, and scaly rashes. It occurs when the immune system mistakenly attacks healthy skin cells. In this condition, skin cells grow and build up rapidly, resulting in scaly rashes, mostly on the knees, elbows, scalp, and trunk. Stress and cold can act as triggers for this disease. It is a chronic disease and doesn’t have a permanent cure. Treatment is given to control the disease and prevent flare-ups.

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Alcohol

Unsafe

Trustretin-25 Capsule may interact with alcohol and increase the risk of side-effects. So, it is not recommended to take alcohol, especially women of childbearing potential during the treatment and at least 2 months after completing the treatment.

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Pregnancy

Caution

Trustretin-25 Capsule should not be used in pregnant women as it may cause harmful effects to the unborn baby or fetus. Consult your doctor for further advice.

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Breast Feeding

Caution

Trustretin-25 Capsule should not be given to breastfeeding mothers as it may pass into breast milk and harm the nursing baby. Consult your doctor for further advice.

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Driving

Unsafe

Trustretin-25 Capsule may cause vision problems suddenly, especially in the dark. So, do not drive or operate heavy machinery if you notice any vision problems, especially at night.

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Liver

Caution

Trustretin-25 Capsule should not be used in patients with severe liver failure as Trustretin-25 Capsule may cause liver damage. In mild to moderate liver diseases, the dose may have to be adjusted by your doctor.

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Kidney

Caution

Trustretin-25 Capsule should not be used in patients with severe kidney failure. In mild to moderate kidney diseases, the dose may have to be adjusted by your doctor.

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Children

Caution

Trustretin-25 Capsule should be used in children only if clinically needed as it may affect growth and bone development. The dose may have to be adjusted by your doctor.

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