Tysabri 300 mg Injection 15 ml

Tysabri 300 mg Injection belongs to the class of monoclonal antibodies. It is used in the treatment of multiple sclerosis (a condition in which the immune system attacks the protective covering of the nerves called myelin, causing disrupted communication between the brain and body) and moderately to severe Crohn’s disease (a chronic bowel disease that affects any part of the gastrointestinal tract, mainly small and large intestine) in patients who are unable to tolerate conventional Crohn’s disease therapy and inhibitors of TNF-α.

Tysabri 300 mg Injection consists of Natalizumab, which belongs to the class of integrin receptor antagonists. It works by binding to the chemical substance called α4β7 integrin (present on the surface of the WBC that enters the gut), which is responsible for inflammation.

Tysabri 300 mg Injection may cause certain side effects, such as nausea, headache, fever, joint pain, upper respiratory tract infections, abdominal discomfort, diarrhoea, tiredness, back pain, itching, depression, and injection site reactions. Most of these side effects do not require medical attention. However, if these side effects persist, please consult your doctor. Tysabri 300 mg Injection will be administered by a trained healthcare doctor. Hence, do not self-administer. 

Tysabri 300 mg Injection should be avoided if you are allergic to any of its components.  Inform your doctor if you have any history of serious infections, tuberculosis, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Tysabri 300 mg Injection is contraindicated in patients with Progressive Multifocal Leukoencephalopathy (PML), as it can cause serious adverse effects. Consult the doctor if you are pregnant or breastfeeding.

Tysabri 300 mg Injection consists of Natalizumab, which belongs to the class of integrin receptor antagonists. It works by binding to the chemical substance called α4β7 integrin (present on the surface of the WBC that enters the gut), which is responsible for inflammation. This causes inhibition and alters the gene expression of blood monocytes and thus helps reduce inflammation of the bowel disease. It is used in the treatment of moderately to severe Crohn’s disease and multiple sclerosis.

Inform your doctor if you have any history of serious infections, tuberculosis, liver, or kidney diseases, or a weak immune system, as it can worsen your health condition. This medicine is contraindicated in patients with leukemia or lymphoma, or an organ transplant as it can cause life-threatening conditions. Tysabri 300 mg Injection may cause serious reactions including infusion-related or allergic reactions. This medicine may also increase the risk of serious infections and hypersensitivity reactions in some patients. Hence, patients should be carefully monitored for any changes during and after the treatment course. Tysabri 300 mg Injection is not recommended for use in children below 18 years of age as safety and efficacy are not established. This medicine can cause Progressive Multifocal Leukoencephalopathy (PML) in most patients with compromised immune system. The chance of getting PML is more if the patient is exposed to John Cunningham Virus, if received Tysabri 300 mg Injection for longer than 2 years or treated with other medicine that weakens your immune system. Hence it is important to inform your doctor about your complete medication history and previous medical history before receiving Tysabri 300 mg Injection.

• Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley and berries, which help heal faster.
• Eat more fibre-rich foods such as fruits and vegetables.
• Eat smaller meals all day and drink small amounts of water throughout the day.
• If you are intolerant to lactose, lower your intake of milk.
• Avoid foods high in sugar, fat, and processed foods, as these may cause inflammation.
• Try to avoid alcohol as it can affect your stomach and intestine and also limits the absorption of the important nutrients required by your body.
• Try to stay active. Choose moderate exercises.
• Prevent stress by doing meditation or yoga.

• It is advised to closely monitor the patient for infections like active tuberculosis, and HIV infection during and after the treatment.
• It is essential to inform your doctor if you have any active viral, bacterial, and fungal infections before starting Tysabri 300 mg Injection.
• Tysabri 300 mg Injection is used to treat the condition but does not cure it.
• This medicine is administered only once every four weeks by a trained oncologist.
• Tysabri 300 mg Injection will be only given to patients who have enrolled in to TOUCH program.

Multiple sclerosis: Multiple sclerosis is a condition that affects the brain and spinal cord. The immune system attacks the protective covering of the nerves (myelin) and causes disrupted communication between the brain and body due to nerve damage.  This causes symptoms such as problems with sensation, balance, vision, pain, impaired coordination, and fatigue.

Crohn’s disease: Crohn’s disease is a type of chronic inflammatory bowel disease that can affect any part of the gastrointestinal tract, from mouth to anus. But mostly occurs in the small intestine and large intestine. The symptoms include blood in stools, stomach cramps, tiredness, diarrhoea, fever, weight loss, or loss of appetite.