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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About ZAVEDOS INJECTION 5MG

ZAVEDOS INJECTION 5MG is an antineoplastic medicine used in the treatment of cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. ZAVEDOS INJECTION 5MG is used in the treatment of Acute Myeloid Leukemia. Leukemia, also known as blood cancer, is the cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections.

ZAVEDOS INJECTION 5MG contains Idarubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis. Thus, ZAVEDOS INJECTION 5MG stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes cancer cell death. ZAVEDOS INJECTION 5MG is used in combination with other medicines for the treatment of acute myeloid leukemia.

ZAVEDOS INJECTION 5MG may cause certain side effects such as vomiting, nausea, mouth ulcers, loss of appetite, diarrhea, dizziness, weakness, stomach pain, headache, pale skin, difficulty urinating, fever, and pain at the site of injection. Most of these side effects of ZAVEDOS INJECTION 5MG do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. ZAVEDOS INJECTION 5MG is a parenteral preparation and will be administered by the oncology doctor. Hence, do not self-administer. Your doctor will decide the dose of the medicine based on the severity of the condition.

ZAVEDOS INJECTION 5MG should be avoided if you are allergic to it or any other component present in it. Inform your doctor about your complete medical and medication history before starting treatment with ZAVEDOS INJECTION 5MG. ZAVEDOS INJECTION 5MG is contraindicated for pregnant women due to serious embryo-fetal toxicity. Inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Inform your doctor if you have /had any pre-existing liver or kidney disease, bone marrow suppression, or heart disease, as it may cause serious adverse effects or worsen the condition. Avoid alcohol consumption with ZAVEDOS INJECTION 5MG as it may increase the risk of liver damage. This medicine is not recommended for children as safety and efficacy are not established.

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Whats That

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Non returnable*
COD available

Online payment accepted

Composition

IDARUBICIN-5MG

Consume Type

PARENTERAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of ZAVEDOS INJECTION 5MG

Acute Myeloid Leukemia.

Medicinal Benefits

ZAVEDOS INJECTION 5MG contains Idarubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis. Thus, ZAVEDOS INJECTION 5MG stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes cancer cell death.

Side Effects of ZAVEDOS INJECTION 5MG

  • Vomiting
  • Nausea
  • Mouth ulcers
  • Loss of appetite
  • Dizziness
  • Weakness
  • Fever
  • Pale skin
  • Headache
  • Difficulty urinating
  • Injection site reactions
  • Pain at the site of injection

Directions for Use

Your doctor will administer ZAVEDOS INJECTION 5MG. Hence, do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

ZAVEDOS INJECTION 5MG should be avoided if you are allergic to it or any other component present in it. Inform your doctor about your complete medical and medication history before starting treatment with ZAVEDOS INJECTION 5MG. ZAVEDOS INJECTION 5MG is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Inform your doctor if you have /had any pre-existing liver or kidney disease, pre-existing bone marrow suppression, or pre-existing heart disease, as it may cause serious adverse effects or worsen the condition. Avoid alcohol consumption with ZAVEDOS INJECTION 5MG as it may increase the risk of liver damage. This medicine is not recommended for children as safety and efficacy are not established.

Therapeutic Class

ANTINEOPLASTIC

Drug-Drug Interactions

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IdarubicinSparfloxacin
Critical
IdarubicinPimozide
Critical

Drug-Drug Interactions

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IdarubicinSparfloxacin
Critical
How does the drug interact with ZAVEDOS INJECTION 5MG:
Co-administration of Sparfloxacin with ZAVEDOS INJECTION 5MG may prolong the QT interval.

How to manage the interaction:
Taking ZAVEDOS INJECTION 5MG with Sparfloxacin is not recommended, please consult a doctor before taking it.
IdarubicinPimozide
Critical
How does the drug interact with ZAVEDOS INJECTION 5MG:
Taking ZAVEDOS INJECTION 5MG and Pimozide together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking ZAVEDOS INJECTION 5MG and Pimozide together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinClozapine
Severe
How does the drug interact with ZAVEDOS INJECTION 5MG:
Co-administration of ZAVEDOS INJECTION 5MG with Clozapine can increase the risk of agranulocytosis that affects white blood cells, a serious abnormal heart rhythm.

How to manage the interaction:
Although there is a possible interaction between ZAVEDOS INJECTION 5MG and Clozapine, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms like fever, chills, diarrhea, sore throat, muscle aches, blood in your coughing fluid, weight loss, red or irritated skin, body sores, discomfort or burning when you urinate, sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
IdarubicinTeriflunomide
Severe
How does the drug interact with ZAVEDOS INJECTION 5MG:
Taking ZAVEDOS INJECTION 5MG and Teriflunomide can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, ZAVEDOS INJECTION 5MG can be taken with Teriflunomide, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
IdarubicinSotalol
Severe
How does the drug interact with ZAVEDOS INJECTION 5MG:
Taking sotalol and ZAVEDOS INJECTION 5MG can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and ZAVEDOS INJECTION 5MG, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
IdarubicinCladribine
Severe
How does the drug interact with ZAVEDOS INJECTION 5MG:
Taking Cladribine along with ZAVEDOS INJECTION 5MG can increase the risk of serious infections.

How to manage the interaction:
Co-administration of ZAVEDOS INJECTION 5MG with Cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, contact a doctor right away. These symptoms include fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not discontinue any medications without consulting a doctor.
IdarubicinGolimumab
Severe
How does the drug interact with ZAVEDOS INJECTION 5MG:
Taking ZAVEDOS INJECTION 5MG and Golimumab can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, ZAVEDOS INJECTION 5MG can be taken with Golimumab, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
IdarubicinIbutilide
Severe
How does the drug interact with ZAVEDOS INJECTION 5MG:
Taking ZAVEDOS INJECTION 5MG and Ibutilide together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking ZAVEDOS INJECTION 5MG and Ibutilide together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinAnagrelide
Severe
How does the drug interact with ZAVEDOS INJECTION 5MG:
Taking ZAVEDOS INJECTION 5MG and Anagrelide together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking ZAVEDOS INJECTION 5MG and Anagrelide together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinChloroquine
Severe
How does the drug interact with ZAVEDOS INJECTION 5MG:
Using chloroquine together with ZAVEDOS INJECTION 5MG can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking ZAVEDOS INJECTION 5MG and Chloroquine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily while taking ZAVEDOS INJECTION 5MG as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking and alcohol consumption.

Habit Forming

No

Special Advise

  • ZAVEDOS INJECTION 5MG is intended for intravenous administration only. 
  • This medicine should be administered only by a well-trained and experienced oncologist in a hospital setting.
  • Regular blood tests are recommended while receiving ZAVEDOS INJECTION 5MG to monitor the number and type of cells in the blood, liver and kidney functioning.
  • Cardiac function should be monitored carefully. Regular ECG should be done to check for any changes.

Disease/Condition Glossary

Acute Myeloid Leukemia (AML): It is a type of cancer that occurs in the bone marrow and blood. It abnormally increases the number of immature white blood cells. The symptoms include unexplained weight loss, excessive sweating, bone pain, frequent nosebleeds, heavier-than-normal periods in females, and shortness of breath. The risk factors include smoking and genetic or blood disorders.

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