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  3. ZAVEDOS INJECTION 5MG

ZAVEDOS INJECTION 5MG, Pack of 1 INJECTION
ZAVEDOS INJECTION 5MG, Pack of 1 INJECTION
Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Whats That

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Composition :

IDARUBICIN-5MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About ZAVEDOS INJECTION 5MG

ZAVEDOS INJECTION 5MG is an antineoplastic medicine used in the treatment of cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. ZAVEDOS INJECTION 5MG is used in the treatment of Acute Myeloid Leukemia. Leukemia, also known as blood cancer, is the cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections.

ZAVEDOS INJECTION 5MG contains Idarubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis. Thus, ZAVEDOS INJECTION 5MG stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes cancer cell death. ZAVEDOS INJECTION 5MG is used in combination with other medicines for the treatment of acute myeloid leukemia.

ZAVEDOS INJECTION 5MG may cause certain side effects such as vomiting, nausea, mouth ulcers, loss of appetite, diarrhea, dizziness, weakness, stomach pain, headache, pale skin, difficulty urinating, fever, and pain at the site of injection. Most of these side effects of ZAVEDOS INJECTION 5MG do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. ZAVEDOS INJECTION 5MG is a parenteral preparation and will be administered by the oncology doctor. Hence, do not self-administer. Your doctor will decide the dose of the medicine based on the severity of the condition.

ZAVEDOS INJECTION 5MG should be avoided if you are allergic to it or any other component present in it. Inform your doctor about your complete medical and medication history before starting treatment with ZAVEDOS INJECTION 5MG. ZAVEDOS INJECTION 5MG is contraindicated for pregnant women due to serious embryo-fetal toxicity. Inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Inform your doctor if you have /had any pre-existing liver or kidney disease, bone marrow suppression, or heart disease, as it may cause serious adverse effects or worsen the condition. Avoid alcohol consumption with ZAVEDOS INJECTION 5MG as it may increase the risk of liver damage. This medicine is not recommended for children as safety and efficacy are not established.

Uses of ZAVEDOS INJECTION 5MG

Acute Myeloid Leukemia.

Directions for Use

Your doctor will administer ZAVEDOS INJECTION 5MG. Hence, do not self-administer.

Medicinal Benefits

ZAVEDOS INJECTION 5MG contains Idarubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis. Thus, ZAVEDOS INJECTION 5MG stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes cancer cell death.

Storage

Store in a cool and dry place away from sunlight
Side effects of Zavedos Injection 5mg
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Severe leukopenia needs immediate medical attention if the levels of WBC drop.
  • Boost your immunity by including immune-rich foods and stay hydrated.
  • Get sufficient sleep and manage stress, which helps improve white blood cell count.
  • Consult your doctor for effective treatment to improve your blood cell count and get regular body checks to monitor changes in the count.
  • Try to prevent the factors that cause severe leukopenia and may lead to impaired immunity.
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Heart failure needs immediate medical attention. To manage this effect, the doctor's instructions must be followed strictly.
  • Take care of change in your weight as there can be sudden changes.
  • Rest and refrain from physical activity, and restart after a few days.
  • Reduce your salt intake and control your diet with the help of a dietician.
  • Track your symptoms and keep your follow-up appointments to manage severe side effects.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.

Drug Warnings

ZAVEDOS INJECTION 5MG should be avoided if you are allergic to it or any other component present in it. Inform your doctor about your complete medical and medication history before starting treatment with ZAVEDOS INJECTION 5MG. ZAVEDOS INJECTION 5MG is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Inform your doctor if you are pregnant, planning to become pregnant or breastfeeding. Inform your doctor if you have /had any pre-existing liver or kidney disease, pre-existing bone marrow suppression, or pre-existing heart disease, as it may cause serious adverse effects or worsen the condition. Avoid alcohol consumption with ZAVEDOS INJECTION 5MG as it may increase the risk of liver damage. This medicine is not recommended for children as safety and efficacy are not established.

Drug-Drug Interactions

verifiedApollotooltip
IdarubicinSparfloxacin
Critical
IdarubicinPimozide
Critical

Drug-Drug Interactions

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IdarubicinSparfloxacin
Critical
How does the drug interact with Zavedos Injection 5mg:
Co-administration of Sparfloxacin with Zavedos Injection 5mg may prolong the QT interval.

How to manage the interaction:
Taking Zavedos Injection 5mg with Sparfloxacin is not recommended, please consult a doctor before taking it.
IdarubicinPimozide
Critical
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Pimozide together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Zavedos Injection 5mg and Pimozide together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinCeritinib
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Ceritinib together can increase the risk of serious abnormal heart rhythm.

How to manage the interaction:
Taking Zavedos Injection 5mg and ceritinib together can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
IdarubicinDisopyramide
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Disopyramide together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Zavedos Injection 5mg and Disopyramide together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinTrastuzumab
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Trastuzumab with Zavedos Injection 5mg can increase the risk of heart problems.

How to manage the interaction:
Co-administration of Trastuzumab with Zavedos Injection 5mg can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience difficulty breathing, fluid retention, or chest pain, consult a doctor. Do not discontinue any medications without a doctor's advice.
IdarubicinGolimumab
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Golimumab can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Zavedos Injection 5mg can be taken with Golimumab, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
IdarubicinIbutilide
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Ibutilide together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Zavedos Injection 5mg and Ibutilide together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinNilotinib
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Nilotinib together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Zavedos Injection 5mg and Nilotinib together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinMoxifloxacin
Severe
How does the drug interact with Zavedos Injection 5mg:
Taking Zavedos Injection 5mg and Moxifloxacin together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Zavedos Injection 5mg and Moxifloxacin together can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
IdarubicinInfliximab
Severe
How does the drug interact with Zavedos Injection 5mg:
When Zavedos Injection 5mg is taken with Infliximab, can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Zavedos Injection 5mg with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily while taking ZAVEDOS INJECTION 5MG as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

ZAVEDOS INJECTION 5MG Substitute

Substitutes safety advice

  • Idarubitec 5 Injection 1's

    by Others

    ₹8850.00per tablet

Product Substitutes

Author Details

Lakshmithulasi YarraguntaDoctor badge

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 20, 2024 | 1:17 PM IST

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

ZAVEDOS INJECTION 5MG contains Idarubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis.

If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella and polio vaccines, it is advised to inform your doctor that you are on treatment with ZAVEDOS INJECTION 5MG as it may cause infections.

Special Advise

  • ZAVEDOS INJECTION 5MG is intended for intravenous administration only. 
  • This medicine should be administered only by a well-trained and experienced oncologist in a hospital setting.
  • Regular blood tests are recommended while receiving ZAVEDOS INJECTION 5MG to monitor the number and type of cells in the blood, liver and kidney functioning.
  • Cardiac function should be monitored carefully. Regular ECG should be done to check for any changes.

Disease/Condition Glossary

Acute Myeloid Leukemia (AML): It is a type of cancer that occurs in the bone marrow and blood. It abnormally increases the number of immature white blood cells. The symptoms include unexplained weight loss, excessive sweating, bone pain, frequent nosebleeds, heavier-than-normal periods in females, and shortness of breath. The risk factors include smoking and genetic or blood disorders.

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