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Osimertinib

About

Osimertinib belongs to a class of protein kinase inhibitors primarily used to manage or treat lung cancer. Lung cancer is a disease that causes malignant (cancer) cells to grow in lung tissues.

Osimertinib contains Osimertinib, which blocks proteins on cancer cells that encourage cancer growth. Thus, it reduces or stops the progression of advanced cancer.

To treat your condition effectually, continue using Osimertinib for as long as your doctor has prescribed it. The most common adverse reactions are diarrhoea, rash, dry skin, nail toxicity, stomatitis (inflammation of the oral mucosa), fatigue (feeling overtired), decreased appetite, and low blood cell counts. You should talk to your doctor if you persistently experience these side effects.

Before taking the Osimertinib, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Osimertinib can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant or get pregnant while undergoing therapy and for several months after the treatment. Using effective contraceptive methods is recommended while on therapy with Osimertinib. Contact your doctor immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment. Alcohol should be avoided during treatment with this medicine. Safety and effectiveness in children have not been established.

Uses of Osimertinib

Lung Cancer

Medicinal Benefits

Osimertinib contains Osimertinib, which belongs to a class of protein kinase inhibitors primarily used to manage or treat lung cancer. Osimertinib blocks proteins in cancer cells that encourage the cancer to grow. Osimertinib can temporarily reduce or stop the progression of advanced cancer. Following surgery, Osimertinib may help prevent the cancer from returning.

Directions for Use

Osimertinib should be swallowed as a whole with a glass of water. Do not crush, chew, or break the tablets. The doctor determines the dose and duration of the treatment based on your health condition.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Osimertinib

  • Diarrhea
  • Rash
  • Risk of Infection
  • Bruising and bleeding
  • Sore throat or mouth ulcers
  • Dry skin
  • Nail toxicity
  • Stomatitis (inflammation of the oral mucosa)
  • Fatigue (feeling overtired)
  • Decreased appetite
  • Low blood cell counts
  • Anaemia (few or abnormal red blood cells)

In-Depth Precautions and Warning

Drug Warnings

Before taking the Osimertinib, inform your doctor about all your medical conditions, sensitivities, and medications you are using. Exposure of an unborn child to this medication could cause birth defects, so you should not become pregnant or father a child while on this medication. Effective birth control is required throughout treatment and at least six weeks after treatment for women and four months after treatment for males. You should not breastfeed while taking this medication for two weeks after your last dose. Unless the doctor suggests, do not use any other medicine, including herbal or vitamin supplements. In rare cases, Osimertinib therapy may lead to Interstitial lung disease (ILD)/Pneumonitis. Dyspnea, cough, and fever are the symptoms which may be indicative of ILD. If these symptoms worsen, contact your doctor right away. If ILD is confirmed, your doctor will discontinue the Osimertinib therapy.

Drug Interactions

Drug-Drug Interactions: Osimertinib may interact with medicines used to treat HIV infection (e.g. amprenavir, atazanavir, efavirenz), antibiotics (e.g. erythromycin, gatifloxacin), antidepressants (e.g. escitalopram), immunomodulating medication (e.g. fingolimod), anaesthetics (e.g. halothane) and vaccines (e.g. typhoid vaccine, live, smallpox vaccine, rotavirus vaccine) and antiarrhythmic agent (e.g. quinidine).

Drug-Food Interactions: Avoid the consumption of alcoholic beverages.

Drug-Disease Interactions: Osimertinib interacts with disease conditions, including ILD (Interstitial lung disease)/Pneumonitis (inflammation in your lung tissues without an infection), infections (bacterial/fungal/protozoal/viral), ventricular arrhythmia, arrhythmias, congestive heart failure, dermatitis, ocular infection, pulmonary impairment, fever, renal dysfunction, liver disease.

Drug-Drug Interactions Checker List:

  • AMPRENAVIR
  • ATAZANAVIR
  • EFAVIRENZ
  • ERYTHROMYCIN
  • GATIFLOXACIN
  • ESCITALOPRAM
  • FINGOLIMOD
  • HALOTHANE
  • TYPHOID VACCINE LIVE
  • SMALLPOX VACCINE
  • ROTAVIRUS VACCINE
  • QUINIDINE
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      Avoid alcohol consumption while on treatment with Osimertinib.

    • Safety Warning

      Pregnancy

      unsafe

      Osimertinib should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

    • Safety Warning

      Breast Feeding

      unsafe

      You should not breastfeed for two weeks after your last dose while taking this medication.

    • Safety Warning

      Driving

      caution

      Osimertinib may cause fatigue (feeling overtired), impacting the ability to drive or use machines.

    • Safety Warning

      Liver

      caution

      Osimertinib should be used with caution if you have liver disease. Inform your doctor before taking the Osimertinib if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

    • Safety Warning

      Kidney

      caution

      Osimertinib should be used with caution if you have kidney disease. Inform your doctor before taking the Osimertinib if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

    • Safety Warning

      Children

      unsafe

      Safety and effectiveness in patients below the age of 18 years have not been established. Hence, use is not recommended.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • After your treatment begins, several dietary adjustments can help you control side effects.
    • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
    • Plant-based proteins are among the greatest meals during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans and legumes.
    • Eat a healthy diet and exercise regularly to maintain proper weight.
    • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
    • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
    • Performing yoga may also help in improving both physical and mental health.
    • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
    • Get optimal sleep; rest well.
    • Avoid smoking and alcohol consumption.
    • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

    Special Advise

    • Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to Osimertinib.
    • Pregnancy testing is recommended prior to starting treatment with Osimertinib.

    Patients Concern

    Disease/Condition Glossary

    Lung cancer: Lung cancer is one of the most common and serious types of cancer. Lung cancer is a disease that causes malignant (cancer) cells to grow in lung tissues. Primary lung cancer is cancer that begins in the lungs. Secondary lung cancer is cancer that spreads to the lungs from elsewhere in the body. There are usually no signs or symptoms in the early stages of lung cancer. Still, many people experience symptoms such as a chronic cough, coughing up blood, persistent dyspnea, unexplained tiredness and weight loss, and an ache or pain when breathing or coughing.

    FAQs

    Osimertinib contains Osimertinib, a protein kinase inhibitor that works by blocking the abnormal protein which can cause uncontrolled cell growth and cancer; thus, it slows or stops cancer growth.

    While taking Osimertinib, visit your doctor at all the appointments to ensure treatment works. Regular monitoring of blood and lipid tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Osimertinib.

    This medicine may reduce the quantity of platelets in your blood significantly. Platelets are cells that aid in the clotting of blood. If your platelet count is low, you may bruise or bleed easily. Inform your doctor if you experience any unexplained bruises or bleeding. You may require a drip to receive more platelets. This is referred to as a platelet transfusion.

    Osimertinib may cause infertility. Discuss with your doctor all the risks of taking this medication.

    Available Medicines for

    Osimertinib

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